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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: AURKA (CAeditome ID:6790) |
Gene summary for AURKA |
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Gene information | Gene symbol | AURKA | Gene ID | 6790 |
Gene name | aurora kinase A | |
Synonyms | AIK|ARK1|AURA|BTAK|PPP1R47|STK15|STK6|STK7 | |
Cytomap | 20q13.2 | |
Type of gene | protein-coding | |
Description | aurora kinase Aaurora 2aurora/IPL1-like kinaseaurora/IPL1-related kinase 1breast tumor-amplified kinaseprotein phosphatase 1, regulatory subunit 47serine/threonine protein kinase 15serine/threonine-protein kinase 6serine/threonine-protein kinase a | |
Modification date | 20210531 | |
UniProtAcc | O14965 | |
Context |
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Gene | GO ID | GO term | PubMed ID |
AURKA | GO:0006468 | Aurora kinase A | 21600873 |
AURKA | GO:0009611 | Aurora kinase A | 19435814 |
AURKA | GO:0097421 | Aurora kinase A | 19435814 |
AURKA | GO:0005876 | Aurora kinase A | 19801554 |
AURKA | GO:0004672 | Aurora kinase A | 14580337 |
AURKA | GO:0004672 | Aurora kinase A | 19801554 |
AURKA | GO:0004672 | Aurora kinase A | 21600873 |
AURKA | GO:0006468 | Aurora kinase A | 21820309 |
AURKA | GO:0032091 | Aurora kinase A | 21820309 |
AURKA | GO:0005634 | Aurora kinase A | 20531406 |
AURKA | GO:0005654 | Aurora kinase A | 0000052 |
AURKA | GO:0005813 | Aurora kinase A | 0000052 |
AURKA | GO:0005813 | Aurora kinase A | 17726514 |
AURKA | GO:0005813 | Aurora kinase A | 21399614 |
AURKA | GO:0005813 | Aurora kinase A | 21600873 |
AURKA | GO:0005813 | Aurora kinase A | 23213400 |
AURKA | GO:0005813 | Aurora kinase A | 25657325 |
AURKA | GO:0005813 | Aurora kinase A | 30538148 |
AURKA | GO:0005829 | Aurora kinase A | 0000052 |
AURKA | GO:0015630 | Aurora kinase A | 19801554 |
AURKA | GO:0031616 | Aurora kinase A | 19801554 |
AURKA | GO:0048471 | Aurora kinase A | 20531406 |
AURKA | GO:0097431 | Aurora kinase A | 25657325 |
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RNA A-to-I events for AURKA |
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CAediting_1440414(56373785, -), CAediting_1440415(56374791, -), CAediting_1440416(56374920, -), CAediting_1440417(56375187, -), CAediting_1440418(56375217, -), CAediting_1440419(56375223, -), CAediting_1440420(56375276, -), CAediting_1440421(56375353, -), CAediting_1440422(56375395, -), CAediting_1440423(56375396, -), CAediting_1440424(56375417, -), CAediting_1440425(56375418, -), CAediting_1440426(56375431, -), CAediting_1440427(56378320, -), CAediting_1440428(56378321, -), CAediting_1440429(56378325, -), CAediting_1440430(56378347, -), CAediting_1440431(56378348, -), CAediting_1440432(56378389, -), CAediting_1440433(56378390, -), CAediting_1440434(56378425, -), CAediting_1440435(56379131, -), CAediting_1440436(56379139, -), CAediting_1440437(56379152, -), CAediting_1440438(56379173, -), CAediting_1440439(56379209, -), CAediting_1440440(56388690, -), CAediting_1440441(56388700, -), CAediting_1440442(56388712, -), CAediting_1440443(56388729, -), CAediting_1440444(56388730, -), CAediting_1440445(56388749, -), CAediting_1440446(56388760, -), CAediting_1440447(56390419, -), CAediting_1440448(56390485, -), |
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RNA editing positional annotations for AURKA using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
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CAeditome ID | Position | Variant type |
CAediting_1440414 | chr20_56373785_- | intronic |
CAediting_1440415 | chr20_56374791_- | intronic |
CAediting_1440416 | chr20_56374920_- | intronic |
CAediting_1440417 | chr20_56375187_- | intronic |
CAediting_1440418 | chr20_56375217_- | intronic |
CAediting_1440419 | chr20_56375223_- | intronic |
CAediting_1440420 | chr20_56375276_- | intronic |
CAediting_1440421 | chr20_56375353_- | intronic |
CAediting_1440422 | chr20_56375395_- | intronic |
CAediting_1440423 | chr20_56375396_- | intronic |
CAediting_1440424 | chr20_56375417_- | intronic |
CAediting_1440425 | chr20_56375418_- | intronic |
CAediting_1440426 | chr20_56375431_- | intronic |
CAediting_1440427 | chr20_56378320_- | intronic |
CAediting_1440428 | chr20_56378321_- | intronic |
CAediting_1440429 | chr20_56378325_- | intronic |
CAediting_1440430 | chr20_56378347_- | intronic |
CAediting_1440431 | chr20_56378348_- | intronic |
CAediting_1440432 | chr20_56378389_- | intronic |
CAediting_1440433 | chr20_56378390_- | intronic |
CAediting_1440434 | chr20_56378425_- | intronic |
CAediting_1440435 | chr20_56379131_- | intronic |
CAediting_1440436 | chr20_56379139_- | intronic |
CAediting_1440437 | chr20_56379152_- | intronic |
CAediting_1440438 | chr20_56379173_- | intronic |
CAediting_1440439 | chr20_56379209_- | intronic |
CAediting_1440440 | chr20_56388690_- | UTR5 |
CAediting_1440441 | chr20_56388700_- | UTR5 |
CAediting_1440442 | chr20_56388712_- | UTR5 |
CAediting_1440443 | chr20_56388729_- | UTR5 |
CAediting_1440444 | chr20_56388730_- | UTR5 |
CAediting_1440445 | chr20_56388749_- | UTR5 |
CAediting_1440446 | chr20_56388760_- | UTR5 |
CAediting_1440447 | chr20_56390419_- | intronic |
CAediting_1440448 | chr20_56390485_- | intronic |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
CAediting_1440414 | chr20_56373785_- | SINE | Alu | AluJo |
CAediting_1440415 | chr20_56374791_- | SINE | Alu | AluSq2 |
CAediting_1440416 | chr20_56374920_- | SINE | Alu | AluSq2 |
CAediting_1440417 | chr20_56375187_- | SINE | Alu | AluJr |
CAediting_1440418 | chr20_56375217_- | SINE | Alu | AluJr |
CAediting_1440419 | chr20_56375223_- | SINE | Alu | AluJr |
CAediting_1440420 | chr20_56375276_- | SINE | Alu | AluJr |
CAediting_1440421 | chr20_56375353_- | SINE | Alu | AluJr |
CAediting_1440422 | chr20_56375395_- | SINE | Alu | AluJr |
CAediting_1440423 | chr20_56375396_- | SINE | Alu | AluJr |
CAediting_1440424 | chr20_56375417_- | SINE | Alu | AluJr |
CAediting_1440425 | chr20_56375418_- | SINE | Alu | AluJr |
CAediting_1440426 | chr20_56375431_- | SINE | Alu | AluJr |
CAediting_1440427 | chr20_56378320_- | LINE | L1 | L1MC3 |
CAediting_1440428 | chr20_56378321_- | LINE | L1 | L1MC3 |
CAediting_1440429 | chr20_56378325_- | LINE | L1 | L1MC3 |
CAediting_1440430 | chr20_56378347_- | LINE | L1 | L1MC3 |
CAediting_1440431 | chr20_56378348_- | LINE | L1 | L1MC3 |
CAediting_1440432 | chr20_56378389_- | LINE | L1 | L1MC3 |
CAediting_1440433 | chr20_56378390_- | LINE | L1 | L1MC3 |
CAediting_1440434 | chr20_56378425_- | LINE | L1 | L1MC3 |
CAediting_1440435 | chr20_56379131_- | LINE | L1 | L1MC3 |
CAediting_1440436 | chr20_56379139_- | LINE | L1 | L1MC3 |
CAediting_1440437 | chr20_56379152_- | LINE | L1 | L1MC3 |
CAediting_1440438 | chr20_56379173_- | LINE | L1 | L1MC3 |
CAediting_1440439 | chr20_56379209_- | LINE | L1 | L1MC3 |
CAediting_1440440 | chr20_56388690_- | SINE | Alu | AluSq2 |
CAediting_1440441 | chr20_56388700_- | SINE | Alu | AluSq2 |
CAediting_1440442 | chr20_56388712_- | SINE | Alu | AluSq2 |
CAediting_1440443 | chr20_56388729_- | SINE | Alu | AluSq2 |
CAediting_1440444 | chr20_56388730_- | SINE | Alu | AluSq2 |
CAediting_1440445 | chr20_56388749_- | SINE | Alu | AluSq2 |
CAediting_1440446 | chr20_56388760_- | SINE | Alu | AluSq2 |
CAediting_1440447 | chr20_56390419_- | SINE | Alu | AluSp |
CAediting_1440448 | chr20_56390485_- | SINE | Alu | AluSp |
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RNA A-to-I editing events in the alternative splicing sites for AURKA |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for AURKA |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for AURKA |
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The effects of the RNA editing to the miRNA binding sites for AURKA |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_748296 | chr10_51299626_+ | ENSG00000087586.16 | ENST00000395914 | hsa-miR-605-3p | 56370061 | 56370068 | 8mer-1a | 56370061 | 56370082 | 145 | -13.18 |
CAediting_748296 | chr10_51299626_+ | ENSG00000087586.16 | ENST00000371356 | hsa-miR-605-3p | 56370061 | 56370068 | 8mer-1a | 56370061 | 56370082 | 145 | -13.18 |
CAediting_748296 | chr10_51299626_+ | ENSG00000087586.16 | ENST00000347343 | hsa-miR-605-3p | 56370061 | 56370068 | 8mer-1a | 56370061 | 56370082 | 145 | -13.18 |
CAediting_748296 | chr10_51299626_+ | ENSG00000087586.16 | ENST00000395911 | hsa-miR-605-3p | 56370061 | 56370068 | 8mer-1a | 56370061 | 56370082 | 145 | -13.18 |
CAediting_748296 | chr10_51299626_+ | ENSG00000087586.16 | ENST00000395915 | hsa-miR-605-3p | 56370061 | 56370068 | 8mer-1a | 56370061 | 56370082 | 145 | -13.18 |
CAediting_748296 | chr10_51299626_+ | ENSG00000087586.16 | ENST00000312783 | hsa-miR-605-3p | 56370061 | 56370068 | 8mer-1a | 56370061 | 56370082 | 145 | -13.18 |
CAediting_748296 | chr10_51299626_+ | ENSG00000087586.16 | ENST00000395913 | hsa-miR-605-3p | 56370061 | 56370068 | 8mer-1a | 56370061 | 56370082 | 145 | -13.18 |
CAediting_748296 | chr10_51299626_+ | ENSG00000087586.16 | ENST00000395907 | hsa-miR-605-3p | 56370061 | 56370068 | 8mer-1a | 56370061 | 56370082 | 145 | -13.18 |
CAediting_1160181 | chr17_7017644_- | ENSG00000087586.16 | ENST00000395914 | hsa-miR-195-3p | 56369444 | 56369450 | 7mer-m8 | 56369443 | 56369464 | 140 | -10.93 |
CAediting_1160181 | chr17_7017644_- | ENSG00000087586.16 | ENST00000371356 | hsa-miR-195-3p | 56369444 | 56369450 | 7mer-m8 | 56369443 | 56369464 | 140 | -10.93 |
CAediting_1160181 | chr17_7017644_- | ENSG00000087586.16 | ENST00000347343 | hsa-miR-195-3p | 56369444 | 56369450 | 7mer-m8 | 56369443 | 56369464 | 140 | -10.93 |
CAediting_1160181 | chr17_7017644_- | ENSG00000087586.16 | ENST00000395911 | hsa-miR-195-3p | 56369444 | 56369450 | 7mer-m8 | 56369443 | 56369464 | 140 | -10.93 |
CAediting_1160181 | chr17_7017644_- | ENSG00000087586.16 | ENST00000395915 | hsa-miR-195-3p | 56369444 | 56369450 | 7mer-m8 | 56369443 | 56369464 | 140 | -10.93 |
CAediting_1160181 | chr17_7017644_- | ENSG00000087586.16 | ENST00000312783 | hsa-miR-195-3p | 56369444 | 56369450 | 7mer-m8 | 56369443 | 56369464 | 140 | -10.93 |
CAediting_1160181 | chr17_7017644_- | ENSG00000087586.16 | ENST00000395913 | hsa-miR-195-3p | 56369444 | 56369450 | 7mer-m8 | 56369443 | 56369464 | 140 | -10.93 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_688080 | chr9_63819626_+ | ENSG00000087586.16 | ENST00000395914 | hsa-miR-4477b | 56369573 | 56369579 | 7mer-m8 | 56369572 | 56369594 | 146 | -7.77 |
CAediting_688080 | chr9_63819626_+ | ENSG00000087586.16 | ENST00000371356 | hsa-miR-4477b | 56369573 | 56369579 | 7mer-m8 | 56369572 | 56369594 | 146 | -7.77 |
CAediting_688080 | chr9_63819626_+ | ENSG00000087586.16 | ENST00000347343 | hsa-miR-4477b | 56369573 | 56369579 | 7mer-m8 | 56369572 | 56369594 | 146 | -7.77 |
CAediting_688080 | chr9_63819626_+ | ENSG00000087586.16 | ENST00000395911 | hsa-miR-4477b | 56369573 | 56369579 | 7mer-m8 | 56369572 | 56369594 | 146 | -7.77 |
CAediting_688080 | chr9_63819626_+ | ENSG00000087586.16 | ENST00000395915 | hsa-miR-4477b | 56369573 | 56369579 | 7mer-m8 | 56369572 | 56369594 | 146 | -7.77 |
CAediting_688080 | chr9_63819626_+ | ENSG00000087586.16 | ENST00000312783 | hsa-miR-4477b | 56369573 | 56369579 | 7mer-m8 | 56369572 | 56369594 | 146 | -7.77 |
CAediting_688080 | chr9_63819626_+ | ENSG00000087586.16 | ENST00000395913 | hsa-miR-4477b | 56369573 | 56369579 | 7mer-m8 | 56369572 | 56369594 | 146 | -7.77 |
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The effects of the RNA editing to the stability of the RNA structures for AURKA |
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ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for AURKA |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
BRCA | CAediting_1440446 | chr20_56388760_- | . | . | . | . | 0.0360045191431618 | 0.222618123662056 |
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Relation with cancer stages for AURKA |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for AURKA |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for AURKA |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
AURKA | O14965 | DB12010 | Fostamatinib | Aurora kinase A | SmallMoleculeDrug | approved|investigational |
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RelatedDiseases for AURKA |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
AURKA | C0002938 | Aneuploidy | 1 | CTD_human |
AURKA | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
AURKA | C0009402 | Colorectal Carcinoma | 1 | CTD_human |
AURKA | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
AURKA | C0022665 | Kidney Neoplasm | 1 | CTD_human |
AURKA | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
AURKA | C0025202 | melanoma | 1 | CTD_human |
AURKA | C0027819 | Neuroblastoma | 1 | CTD_human |
AURKA | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
AURKA | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
AURKA | C0678222 | Breast Carcinoma | 1 | CTD_human |
AURKA | C0740457 | Malignant neoplasm of kidney | 1 | CTD_human |
AURKA | C1257806 | Chromosomal Instability | 1 | CTD_human |
AURKA | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
AURKA | C1458155 | Mammary Neoplasms | 1 | CTD_human |
AURKA | C2239176 | Liver carcinoma | 1 | CTD_human |
AURKA | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
AURKA | C4721453 | Peripheral Nervous System Diseases | 1 | CTD_human |