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Editing gene: NEK4 (CAeditome ID:6787)

Gene summary for NEK4

Gene summary

Gene information	Gene symbol	NEK4
	Gene ID	6787
	Gene name	NIMA related kinase 4
	Synonyms	NRK2\|STK2\|pp12301
	Cytomap	3p21.1
	Type of gene	protein-coding
	Description	serine/threonine-protein kinase Nek4NIMA (never in mitosis gene a)-related kinase 4never in mitosis A-related kinase 4nimA-related protein kinase 4serine/threonine kinase 2serine/threonine protein kinase-2serine/threonine-protein kinase NRK2serine/
	Modification date	20210518
	UniProtAcc	P51957
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
NEK4	GO:0005829	Serine/threonine-protein kinase Nek4	0000052

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RNA A-to-I events for NEK4

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000114904.11

RNA A-to-I editing events in Cancer.

CAediting_285362(52711463, -), CAediting_285363(52715498, -), CAediting_285364(52718089, -), CAediting_285365(52723372, -), CAediting_285366(52723380, -), CAediting_285367(52725463, -), CAediting_285368(52726342, -), CAediting_285369(52726364, -), CAediting_285370(52726547, -), CAediting_285371(52726740, -), CAediting_285372(52726818, -), CAediting_285373(52726821, -), CAediting_285374(52726852, -), CAediting_285375(52726857, -), CAediting_285376(52727032, -), CAediting_285377(52727042, -), CAediting_285378(52727043, -), CAediting_285379(52727047, -), CAediting_285380(52727060, -), CAediting_285381(52727072, -), CAediting_285382(52727083, -), CAediting_285383(52727086, -), CAediting_285384(52727103, -), CAediting_285385(52727112, -), CAediting_285386(52727121, -), CAediting_285387(52727151, -), CAediting_285388(52727152, -), CAediting_285389(52727247, -), CAediting_285390(52727543, -), CAediting_285391(52727596, -), CAediting_285392(52727597, -), CAediting_285393(52727617, -), CAediting_285394(52727637, -), CAediting_285395(52727641, -), CAediting_285396(52727642, -), CAediting_285397(52727649, -), CAediting_285398(52727650, -), CAediting_285399(52727651, -), CAediting_285400(52727652, -), CAediting_285401(52727667, -), CAediting_285402(52727676, -), CAediting_285403(52727708, -), CAediting_285404(52727720, -), CAediting_285405(52727743, -), CAediting_285406(52727760, -), CAediting_285407(52727762, -), CAediting_285408(52727771, -), CAediting_285409(52727954, -), CAediting_285410(52727976, -), CAediting_285411(52727988, -), CAediting_285412(52727989, -), CAediting_285413(52727990, -), CAediting_285414(52728012, -), CAediting_285415(52728060, -), CAediting_285416(52728085, -), CAediting_285417(52728125, -), CAediting_285418(52728128, -), CAediting_285419(52728266, -), CAediting_285420(52728269, -), CAediting_285421(52728276, -), CAediting_285422(52728281, -), CAediting_285423(52728300, -), CAediting_285424(52728307, -), CAediting_285425(52729986, -), CAediting_285426(52730772, -), CAediting_285427(52732286, -), CAediting_285428(52732294, -), CAediting_285429(52732305, -), CAediting_285430(52732322, -), CAediting_285431(52732358, -), CAediting_285432(52732390, -), CAediting_285433(52732468, -), CAediting_285434(52734115, -), CAediting_285435(52736342, -), CAediting_285436(52737026, -), CAediting_285437(52739358, -), CAediting_285438(52739385, -), CAediting_285439(52741862, -), CAediting_285440(52741887, -), CAediting_285441(52741908, -), CAediting_285442(52741918, -), CAediting_285443(52742051, -), CAediting_285444(52742245, -), CAediting_285445(52742898, -), CAediting_285446(52742936, -), CAediting_285447(52742946, -), CAediting_285448(52742953, -), CAediting_285449(52743027, -), CAediting_285450(52743060, -), CAediting_285451(52749702, -), CAediting_285452(52749715, -), CAediting_285453(52749725, -), CAediting_285454(52749728, -), CAediting_285455(52749737, -), CAediting_285456(52749743, -), CAediting_285457(52749774, -), CAediting_285458(52749775, -), CAediting_285459(52749778, -), CAediting_285460(52749791, -), CAediting_285461(52749793, -), CAediting_285462(52749799, -), CAediting_285463(52758845, -), CAediting_285464(52760489, -),

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RNA editing positional annotations for NEK4 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_285451	chr3_52749702_-	nonsynonymous SNV	ENST00000233027.8	c.A1496G	p.H499R	D	B	N
CAediting_285451	chr3_52749702_-	nonsynonymous SNV	ENST00000461689.4	c.A1229G	p.H410R	D	B	N
CAediting_285451	chr3_52749702_-	nonsynonymous SNV	ENST00000535191.4	c.A1229G	p.H410R	D	B	N
CAediting_285461	chr3_52749793_-	nonsynonymous SNV	ENST00000233027.8	c.A1405G	p.T469A	D	B	N
CAediting_285461	chr3_52749793_-	nonsynonymous SNV	ENST00000461689.4	c.A1138G	p.T380A	D	B	N
CAediting_285461	chr3_52749793_-	nonsynonymous SNV	ENST00000535191.4	c.A1138G	p.T380A	D	B	N

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_285362	chr3_52711463_-	UTR3
CAediting_285363	chr3_52715498_-	intronic
CAediting_285364	chr3_52718089_-	intronic
CAediting_285365	chr3_52723372_-	intronic
CAediting_285366	chr3_52723380_-	intronic
CAediting_285367	chr3_52725463_-	intronic
CAediting_285368	chr3_52726342_-	intronic
CAediting_285369	chr3_52726364_-	intronic
CAediting_285370	chr3_52726547_-	intronic
CAediting_285371	chr3_52726740_-	intronic
CAediting_285372	chr3_52726818_-	intronic
CAediting_285373	chr3_52726821_-	intronic
CAediting_285374	chr3_52726852_-	intronic
CAediting_285375	chr3_52726857_-	intronic
CAediting_285376	chr3_52727032_-	intronic
CAediting_285377	chr3_52727042_-	intronic
CAediting_285378	chr3_52727043_-	intronic
CAediting_285379	chr3_52727047_-	intronic
CAediting_285380	chr3_52727060_-	intronic
CAediting_285381	chr3_52727072_-	intronic
CAediting_285382	chr3_52727083_-	intronic
CAediting_285383	chr3_52727086_-	intronic
CAediting_285384	chr3_52727103_-	intronic
CAediting_285385	chr3_52727112_-	intronic
CAediting_285386	chr3_52727121_-	intronic
CAediting_285387	chr3_52727151_-	intronic
CAediting_285388	chr3_52727152_-	intronic
CAediting_285389	chr3_52727247_-	intronic
CAediting_285390	chr3_52727543_-	intronic
CAediting_285391	chr3_52727596_-	intronic
CAediting_285392	chr3_52727597_-	intronic
CAediting_285393	chr3_52727617_-	intronic
CAediting_285394	chr3_52727637_-	intronic
CAediting_285395	chr3_52727641_-	intronic
CAediting_285396	chr3_52727642_-	intronic
CAediting_285397	chr3_52727649_-	intronic
CAediting_285398	chr3_52727650_-	intronic
CAediting_285399	chr3_52727651_-	intronic
CAediting_285400	chr3_52727652_-	intronic
CAediting_285401	chr3_52727667_-	intronic
CAediting_285402	chr3_52727676_-	intronic
CAediting_285403	chr3_52727708_-	intronic
CAediting_285404	chr3_52727720_-	intronic
CAediting_285405	chr3_52727743_-	intronic
CAediting_285406	chr3_52727760_-	intronic
CAediting_285407	chr3_52727762_-	intronic
CAediting_285408	chr3_52727771_-	intronic
CAediting_285409	chr3_52727954_-	intronic
CAediting_285410	chr3_52727976_-	intronic
CAediting_285411	chr3_52727988_-	intronic
CAediting_285412	chr3_52727989_-	intronic
CAediting_285413	chr3_52727990_-	intronic
CAediting_285414	chr3_52728012_-	intronic
CAediting_285415	chr3_52728060_-	intronic
CAediting_285416	chr3_52728085_-	intronic
CAediting_285417	chr3_52728125_-	intronic
CAediting_285418	chr3_52728128_-	intronic
CAediting_285419	chr3_52728266_-	intronic
CAediting_285420	chr3_52728269_-	intronic
CAediting_285421	chr3_52728276_-	intronic
CAediting_285422	chr3_52728281_-	intronic
CAediting_285423	chr3_52728300_-	intronic
CAediting_285424	chr3_52728307_-	intronic
CAediting_285425	chr3_52729986_-	intronic
CAediting_285426	chr3_52730772_-	intronic
CAediting_285427	chr3_52732286_-	intronic
CAediting_285428	chr3_52732294_-	intronic
CAediting_285429	chr3_52732305_-	intronic
CAediting_285430	chr3_52732322_-	intronic
CAediting_285431	chr3_52732358_-	intronic
CAediting_285432	chr3_52732390_-	intronic
CAediting_285433	chr3_52732468_-	intronic
CAediting_285434	chr3_52734115_-	intronic
CAediting_285435	chr3_52736342_-	intronic
CAediting_285436	chr3_52737026_-	intronic
CAediting_285437	chr3_52739358_-	intronic
CAediting_285438	chr3_52739385_-	intronic
CAediting_285439	chr3_52741862_-	intronic
CAediting_285440	chr3_52741887_-	intronic
CAediting_285441	chr3_52741908_-	intronic
CAediting_285442	chr3_52741918_-	intronic
CAediting_285443	chr3_52742051_-	intronic
CAediting_285444	chr3_52742245_-	intronic
CAediting_285445	chr3_52742898_-	intronic
CAediting_285446	chr3_52742936_-	intronic
CAediting_285447	chr3_52742946_-	intronic
CAediting_285448	chr3_52742953_-	intronic
CAediting_285449	chr3_52743027_-	intronic
CAediting_285450	chr3_52743060_-	intronic
CAediting_285451	chr3_52749702_-	exonic
CAediting_285452	chr3_52749715_-	exonic
CAediting_285453	chr3_52749725_-	exonic
CAediting_285454	chr3_52749728_-	exonic
CAediting_285455	chr3_52749737_-	exonic
CAediting_285456	chr3_52749743_-	exonic
CAediting_285457	chr3_52749774_-	exonic
CAediting_285458	chr3_52749775_-	exonic
CAediting_285459	chr3_52749778_-	exonic
CAediting_285460	chr3_52749791_-	exonic
CAediting_285461	chr3_52749793_-	exonic
CAediting_285462	chr3_52749799_-	exonic
CAediting_285463	chr3_52758845_-	intronic
CAediting_285464	chr3_52760489_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_285363	chr3_52715498_-	SINE	Alu	AluSx3
CAediting_285364	chr3_52718089_-	SINE	Alu	AluSz
CAediting_285365	chr3_52723372_-	SINE	Alu	AluSz
CAediting_285366	chr3_52723380_-	SINE	Alu	AluSz
CAediting_285367	chr3_52725463_-	SINE	Alu	AluY
CAediting_285368	chr3_52726342_-	SINE	Alu	AluY
CAediting_285369	chr3_52726364_-	SINE	Alu	AluY
CAediting_285370	chr3_52726547_-	SINE	Alu	AluY
CAediting_285371	chr3_52726740_-	SINE	Alu	AluSg7
CAediting_285372	chr3_52726818_-	SINE	Alu	AluSg7
CAediting_285373	chr3_52726821_-	SINE	Alu	AluSg7
CAediting_285374	chr3_52726852_-	SINE	Alu	AluSg7
CAediting_285375	chr3_52726857_-	SINE	Alu	AluSg7
CAediting_285376	chr3_52727032_-	SINE	Alu	AluSp
CAediting_285377	chr3_52727042_-	SINE	Alu	AluSp
CAediting_285378	chr3_52727043_-	SINE	Alu	AluSp
CAediting_285379	chr3_52727047_-	SINE	Alu	AluSp
CAediting_285380	chr3_52727060_-	SINE	Alu	AluSp
CAediting_285381	chr3_52727072_-	SINE	Alu	AluSp
CAediting_285382	chr3_52727083_-	SINE	Alu	AluSp
CAediting_285383	chr3_52727086_-	SINE	Alu	AluSp
CAediting_285384	chr3_52727103_-	SINE	Alu	AluSp
CAediting_285385	chr3_52727112_-	SINE	Alu	AluSp
CAediting_285386	chr3_52727121_-	SINE	Alu	AluSp
CAediting_285387	chr3_52727151_-	SINE	Alu	AluSp
CAediting_285388	chr3_52727152_-	SINE	Alu	AluSp
CAediting_285389	chr3_52727247_-	SINE	Alu	AluSp
CAediting_285390	chr3_52727543_-	SINE	Alu	AluSx1
CAediting_285391	chr3_52727596_-	SINE	Alu	AluSx1
CAediting_285392	chr3_52727597_-	SINE	Alu	AluSx1
CAediting_285393	chr3_52727617_-	SINE	Alu	AluSx1
CAediting_285394	chr3_52727637_-	SINE	Alu	AluSx1
CAediting_285395	chr3_52727641_-	SINE	Alu	AluSx1
CAediting_285396	chr3_52727642_-	SINE	Alu	AluSx1
CAediting_285397	chr3_52727649_-	SINE	Alu	AluSx1
CAediting_285398	chr3_52727650_-	SINE	Alu	AluSx1
CAediting_285399	chr3_52727651_-	SINE	Alu	AluSx1
CAediting_285400	chr3_52727652_-	SINE	Alu	AluSx1
CAediting_285401	chr3_52727667_-	SINE	Alu	AluSx1
CAediting_285402	chr3_52727676_-	SINE	Alu	AluSx1
CAediting_285403	chr3_52727708_-	SINE	Alu	AluSx1
CAediting_285404	chr3_52727720_-	SINE	Alu	AluSx1
CAediting_285405	chr3_52727743_-	SINE	Alu	AluSx1
CAediting_285406	chr3_52727760_-	SINE	Alu	AluSx1
CAediting_285407	chr3_52727762_-	SINE	Alu	AluSx1
CAediting_285408	chr3_52727771_-	LINE	L1	L1M4c
CAediting_285409	chr3_52727954_-	SINE	Alu	AluJr4
CAediting_285410	chr3_52727976_-	SINE	Alu	AluJr4
CAediting_285411	chr3_52727988_-	SINE	Alu	AluJr4
CAediting_285412	chr3_52727989_-	SINE	Alu	AluJr4
CAediting_285413	chr3_52727990_-	SINE	Alu	AluJr4
CAediting_285414	chr3_52728012_-	SINE	Alu	AluJr4
CAediting_285415	chr3_52728060_-	SINE	Alu	AluJr4
CAediting_285417	chr3_52728125_-	SINE	Alu	AluJb
CAediting_285418	chr3_52728128_-	SINE	Alu	AluJb
CAediting_285419	chr3_52728266_-	SINE	Alu	AluJb
CAediting_285420	chr3_52728269_-	SINE	Alu	AluJb
CAediting_285421	chr3_52728276_-	SINE	Alu	AluJb
CAediting_285422	chr3_52728281_-	SINE	Alu	AluJb
CAediting_285423	chr3_52728300_-	SINE	Alu	AluJb
CAediting_285424	chr3_52728307_-	SINE	Alu	AluJb
CAediting_285425	chr3_52729986_-	SINE	Alu	AluSc5
CAediting_285426	chr3_52730772_-	LINE	L1	L1M5
CAediting_285427	chr3_52732286_-	SINE	Alu	AluY
CAediting_285428	chr3_52732294_-	SINE	Alu	AluY
CAediting_285429	chr3_52732305_-	SINE	Alu	AluY
CAediting_285430	chr3_52732322_-	SINE	Alu	AluY
CAediting_285431	chr3_52732358_-	SINE	Alu	AluY
CAediting_285432	chr3_52732390_-	SINE	Alu	AluY
CAediting_285433	chr3_52732468_-	SINE	Alu	AluY
CAediting_285434	chr3_52734115_-	SINE	Alu	AluSc
CAediting_285435	chr3_52736342_-	SINE	Alu	AluYh3
CAediting_285436	chr3_52737026_-	SINE	Alu	AluSx
CAediting_285437	chr3_52739358_-	SINE	Alu	AluSx
CAediting_285438	chr3_52739385_-	SINE	Alu	AluSx
CAediting_285439	chr3_52741862_-	SINE	Alu	AluSc5
CAediting_285440	chr3_52741887_-	SINE	Alu	AluSc5
CAediting_285441	chr3_52741908_-	SINE	Alu	AluSc5
CAediting_285442	chr3_52741918_-	SINE	Alu	AluSc5
CAediting_285443	chr3_52742051_-	SINE	Alu	AluSc5
CAediting_285444	chr3_52742245_-	SINE	Alu	FLAM_A
CAediting_285445	chr3_52742898_-	SINE	Alu	AluJo
CAediting_285446	chr3_52742936_-	SINE	Alu	AluJo
CAediting_285447	chr3_52742946_-	SINE	Alu	AluJo
CAediting_285448	chr3_52742953_-	SINE	Alu	AluJo
CAediting_285449	chr3_52743027_-	SINE	Alu	AluJo
CAediting_285450	chr3_52743060_-	SINE	Alu	AluJo
CAediting_285451	chr3_52749702_-	SINE	Alu	AluSz
CAediting_285452	chr3_52749715_-	SINE	Alu	AluSz
CAediting_285453	chr3_52749725_-	SINE	Alu	AluSz
CAediting_285454	chr3_52749728_-	SINE	Alu	AluSz
CAediting_285455	chr3_52749737_-	SINE	Alu	AluSz
CAediting_285456	chr3_52749743_-	SINE	Alu	AluSz
CAediting_285457	chr3_52749774_-	SINE	Alu	AluSz
CAediting_285458	chr3_52749775_-	SINE	Alu	AluSz
CAediting_285459	chr3_52749778_-	SINE	Alu	AluSz
CAediting_285460	chr3_52749791_-	SINE	Alu	AluSz
CAediting_285461	chr3_52749793_-	SINE	Alu	AluSz
CAediting_285462	chr3_52749799_-	SINE	Alu	AluSz
CAediting_285463	chr3_52758845_-	SINE	Alu	AluJo
CAediting_285464	chr3_52760489_-	SINE	Alu	AluSx

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RNA A-to-I editing events in the alternative splicing sites for NEK4

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000114904.11.NEK4.

Correlation between RNA A-to-I editing and PSI for ENSG00000114904.11.NEK4.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for NEK4

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for NEK4

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for NEK4

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_86358	chr1_109598906_+	ENSG00000114904.11	ENST00000487068	hsa-miR-197-5p	52746854	52746861	8mer-1a	52746854	52746876	142	-19.86
CAediting_1229415	chr17_67471547_+	ENSG00000114904.11	ENST00000496822	hsa-miR-548aa	52768342	52768348	7mer-m8	52768341	52768365	150	-9.82
CAediting_1160181	chr17_7017644_-	ENSG00000114904.11	ENST00000496822	hsa-miR-195-3p	52768502	52768508	7mer-m8	52768501	52768521	161	-18.04

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for NEK4

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000233027.8	protein_coding
ENST00000535191.4	protein_coding
ENST00000461689.4	protein_coding
ENST00000487068.1	nonsense_mediated_decay

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_285362	ENST00000233027.8	chr3_52711463_-	-1794.70	-1794.70	-1807.90
CAediting_285451	ENST00000233027.8	chr3_52749702_-	-1796.50	-1794.70	-1807.90
CAediting_285452	ENST00000233027.8	chr3_52749715_-	-1794.60	-1794.70	-1807.90
CAediting_285453	ENST00000233027.8	chr3_52749725_-	-1798.20	-1794.70	-1807.90
CAediting_285454	ENST00000233027.8	chr3_52749728_-	-1797.30	-1794.70	-1807.90
CAediting_285455	ENST00000233027.8	chr3_52749737_-	-1799.50	-1794.70	-1807.90
CAediting_285456	ENST00000233027.8	chr3_52749743_-	-1794.40	-1794.70	-1807.90
CAediting_285457	ENST00000233027.8	chr3_52749774_-	-1798.40	-1794.70	-1807.90
CAediting_285458	ENST00000233027.8	chr3_52749775_-	-1796.10	-1794.70	-1807.90
CAediting_285459	ENST00000233027.8	chr3_52749778_-	-1797.10	-1794.70	-1807.90
CAediting_285460	ENST00000233027.8	chr3_52749791_-	-1796.30	-1794.70	-1807.90
CAediting_285461	ENST00000233027.8	chr3_52749793_-	-1794.70	-1794.70	-1807.90
CAediting_285462	ENST00000233027.8	chr3_52749799_-	-1798.60	-1794.70	-1807.90
CAediting_285451	ENST00000535191.4	chr3_52749702_-	-791.20	-790.80	-798.00
CAediting_285452	ENST00000535191.4	chr3_52749715_-	-791.00	-790.80	-798.00
CAediting_285453	ENST00000535191.4	chr3_52749725_-	-792.30	-790.80	-798.00
CAediting_285454	ENST00000535191.4	chr3_52749728_-	-793.70	-790.80	-798.00
CAediting_285455	ENST00000535191.4	chr3_52749737_-	-794.20	-790.80	-798.00
CAediting_285456	ENST00000535191.4	chr3_52749743_-	-790.80	-790.80	-798.00
CAediting_285457	ENST00000535191.4	chr3_52749774_-	-792.20	-790.80	-798.00
CAediting_285458	ENST00000535191.4	chr3_52749775_-	-791.60	-790.80	-798.00
CAediting_285459	ENST00000535191.4	chr3_52749778_-	-790.10	-790.80	-798.00
CAediting_285460	ENST00000535191.4	chr3_52749791_-	-791.40	-790.80	-798.00
CAediting_285461	ENST00000535191.4	chr3_52749793_-	-790.80	-790.80	-798.00
CAediting_285462	ENST00000535191.4	chr3_52749799_-	-790.10	-790.80	-798.00
CAediting_285451	ENST00000461689.4	chr3_52749702_-	-717.70	-717.30	-722.80
CAediting_285452	ENST00000461689.4	chr3_52749715_-	-717.50	-717.30	-722.80
CAediting_285453	ENST00000461689.4	chr3_52749725_-	-718.80	-717.30	-722.80
CAediting_285454	ENST00000461689.4	chr3_52749728_-	-720.20	-717.30	-722.80
CAediting_285455	ENST00000461689.4	chr3_52749737_-	-720.70	-717.30	-722.80
CAediting_285456	ENST00000461689.4	chr3_52749743_-	-717.30	-717.30	-722.80
CAediting_285457	ENST00000461689.4	chr3_52749774_-	-718.70	-717.30	-722.80
CAediting_285458	ENST00000461689.4	chr3_52749775_-	-718.10	-717.30	-722.80
CAediting_285459	ENST00000461689.4	chr3_52749778_-	-716.60	-717.30	-722.80
CAediting_285460	ENST00000461689.4	chr3_52749791_-	-717.90	-717.30	-722.80
CAediting_285461	ENST00000461689.4	chr3_52749793_-	-717.30	-717.30	-722.80
CAediting_285462	ENST00000461689.4	chr3_52749799_-	-716.60	-717.30	-722.80
CAediting_285451	ENST00000487068.1	chr3_52749702_-	-210.40	-210.40	-222.80
CAediting_285452	ENST00000487068.1	chr3_52749715_-	-210.60	-210.40	-222.80
CAediting_285453	ENST00000487068.1	chr3_52749725_-	-214.70	-210.40	-222.80
CAediting_285454	ENST00000487068.1	chr3_52749728_-	-212.20	-210.40	-222.80
CAediting_285455	ENST00000487068.1	chr3_52749737_-	-211.80	-210.40	-222.80
CAediting_285456	ENST00000487068.1	chr3_52749743_-	-211.40	-210.40	-222.80
CAediting_285457	ENST00000487068.1	chr3_52749774_-	-210.50	-210.40	-222.80
CAediting_285458	ENST00000487068.1	chr3_52749775_-	-212.20	-210.40	-222.80
CAediting_285459	ENST00000487068.1	chr3_52749778_-	-211.70	-210.40	-222.80
CAediting_285460	ENST00000487068.1	chr3_52749791_-	-214.10	-210.40	-222.80
CAediting_285461	ENST00000487068.1	chr3_52749793_-	-210.40	-210.40	-222.80
CAediting_285462	ENST00000487068.1	chr3_52749799_-	-209.70	-210.40	-222.80

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Relation with ADAR for NEK4

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for NEK4

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for NEK4

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for NEK4

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
NEK4	P51957	DB12010	Fostamatinib	Serine/threonine-protein kinase Nek4	SmallMoleculeDrug	approved\|investigational

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RelatedDiseases for NEK4

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
NEK4	C0005586	Bipolar Disorder	2	PSYGENET

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene