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Editing gene: BRCA2 (CAeditome ID:675)

Gene summary for BRCA2

Gene summary

Gene information	Gene symbol	BRCA2
	Gene ID	675
	Gene name	BRCA2 DNA repair associated
	Synonyms	BRCC2\|BROVCA2\|FACD\|FAD\|FAD1\|FANCD\|FANCD1\|GLM3\|PNCA2\|XRCC11
	Cytomap	13q13.1
	Type of gene	protein-coding
	Description	breast cancer type 2 susceptibility proteinBRCA1/BRCA2-containing complex, subunit 2Fanconi anemia group D1 proteinbreast and ovarian cancer susceptibility gene, early onsetbreast and ovarian cancer susceptibility protein 2breast cancer 2 tumor suppr
	Modification date	20210531
	UniProtAcc	P51587
	Context	- 29988080(The functional impact of variants of uncertain significance in BRCA2)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
BRCA2	GO:0004402	Breast cancer type 2 susceptibility protein	9824164
BRCA2	GO:0003697	Breast cancer type 2 susceptibility protein	20729832
BRCA2	GO:0008022	Breast cancer type 2 susceptibility protein	9774970
BRCA2	GO:0010484	Breast cancer type 2 susceptibility protein	9619837
BRCA2	GO:0010485	Breast cancer type 2 susceptibility protein	9619837
BRCA2	GO:0000724	Breast cancer type 2 susceptibility protein	20729832
BRCA2	GO:0033600	Breast cancer type 2 susceptibility protein	15930293
BRCA2	GO:0043966	Breast cancer type 2 susceptibility protein	9619837
BRCA2	GO:0043967	Breast cancer type 2 susceptibility protein	9619837
BRCA2	GO:0045893	Breast cancer type 2 susceptibility protein	9126734
BRCA2	GO:0070200	Breast cancer type 2 susceptibility protein	21076401
BRCA2	GO:0000781	Breast cancer type 2 susceptibility protein	21076401
BRCA2	GO:0000800	Breast cancer type 2 susceptibility protein	9774970
BRCA2	GO:0005634	Breast cancer type 2 susceptibility protein	17286961
BRCA2	GO:0005634	Breast cancer type 2 susceptibility protein	26833090
BRCA2	GO:0005634	Breast cancer type 2 susceptibility protein	9560268
BRCA2	GO:0005634	Breast cancer type 2 susceptibility protein	9774970
BRCA2	GO:0005654	Breast cancer type 2 susceptibility protein	0000052
BRCA2	GO:0005813	Breast cancer type 2 susceptibility protein	17286961
BRCA2	GO:0005813	Breast cancer type 2 susceptibility protein	21276791
BRCA2	GO:0005829	Breast cancer type 2 susceptibility protein	0000052
BRCA2	GO:0030141	Breast cancer type 2 susceptibility protein	8589722
BRCA2	GO:0032991	Breast cancer type 2 susceptibility protein	26833090
BRCA2	GO:0032991	Breast cancer type 2 susceptibility protein	9774970
BRCA2	GO:0032991	Breast cancer type 2 susceptibility protein	9774970
BRCA2	GO:0033593	Breast cancer type 2 susceptibility protein	15930293

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RNA A-to-I events for BRCA2

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000139618.13

RNA A-to-I editing events in Cancer.

CAediting_956540(32327862, +), CAediting_956541(32327896, +), CAediting_956542(32327897, +), CAediting_956543(32334420, +), CAediting_956544(32334421, +), CAediting_956545(32334442, +), CAediting_956546(32334443, +), CAediting_956547(32334469, +), CAediting_956548(32334474, +), CAediting_956549(32334531, +), CAediting_956550(32334589, +), CAediting_956551(32334600, +), CAediting_956552(32334623, +), CAediting_956553(32334624, +), CAediting_956554(32335913, +), CAediting_956555(32335951, +), CAediting_956556(32335956, +), CAediting_956557(32335985, +), CAediting_956558(32336012, +), CAediting_956559(32367548, +), CAediting_956560(32373092, +), CAediting_956561(32373355, +), CAediting_956562(32373359, +), CAediting_956563(32373438, +), CAediting_956564(32373450, +), CAediting_956565(32373489, +), CAediting_956566(32373494, +), CAediting_956567(32376259, +), CAediting_956568(32376346, +), CAediting_956569(32376357, +), CAediting_956570(32376360, +), CAediting_956571(32376361, +), CAediting_956572(32376362, +), CAediting_956573(32376363, +), CAediting_956574(32376364, +), CAediting_956575(32376375, +), CAediting_956576(32376406, +), CAediting_956577(32376427, +), CAediting_956578(32399009, +), CAediting_956579(32399010, +), CAediting_956580(32399011, +), CAediting_956581(32399024, +), CAediting_956582(32399037, +), CAediting_956583(32399045, +), CAediting_956584(32399051, +), CAediting_956585(32399054, +), CAediting_956586(32399060, +), CAediting_956587(32399063, +), CAediting_956588(32399068, +), CAediting_956589(32399086, +), CAediting_956590(32399094, +), CAediting_956591(32399099, +), CAediting_956592(32399100, +), CAediting_956593(32399119, +), CAediting_956594(32399123, +), CAediting_956595(32399141, +), CAediting_956596(32399804, +), CAediting_956597(32399806, +), CAediting_956598(32399849, +), CAediting_956599(32399859, +), CAediting_956600(32399864, +), CAediting_956601(32399884, +), CAediting_956602(32399888, +), CAediting_956603(32399912, +), CAediting_956604(32399925, +), CAediting_956605(32399947, +), CAediting_956606(32399969, +), CAediting_956607(32399971, +), CAediting_956608(32399973, +), CAediting_956609(32399983, +), CAediting_956610(32399986, +), CAediting_956611(32399996, +), CAediting_956612(32400006, +), CAediting_956613(32400007, +), CAediting_956614(32400015, +), CAediting_956615(32400020, +), CAediting_956616(32400025, +), CAediting_956617(32400038, +), CAediting_956618(32400046, +), CAediting_956619(32400047, +), CAediting_956620(32400048, +), CAediting_956621(32400060, +), CAediting_956622(32400069, +),

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RNA editing positional annotations for BRCA2 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_956540	chr13_32327862_+	ncRNA_intronic
CAediting_956541	chr13_32327896_+	ncRNA_intronic
CAediting_956542	chr13_32327897_+	ncRNA_intronic
CAediting_956543	chr13_32334420_+	ncRNA_intronic
CAediting_956544	chr13_32334421_+	ncRNA_intronic
CAediting_956545	chr13_32334442_+	ncRNA_intronic
CAediting_956546	chr13_32334443_+	ncRNA_intronic
CAediting_956547	chr13_32334469_+	ncRNA_intronic
CAediting_956548	chr13_32334474_+	ncRNA_intronic
CAediting_956549	chr13_32334531_+	ncRNA_intronic
CAediting_956550	chr13_32334589_+	ncRNA_intronic
CAediting_956551	chr13_32334600_+	ncRNA_intronic
CAediting_956552	chr13_32334623_+	ncRNA_intronic
CAediting_956553	chr13_32334624_+	ncRNA_intronic
CAediting_956554	chr13_32335913_+	ncRNA_intronic
CAediting_956555	chr13_32335951_+	ncRNA_intronic
CAediting_956556	chr13_32335956_+	ncRNA_intronic
CAediting_956557	chr13_32335985_+	ncRNA_intronic
CAediting_956558	chr13_32336012_+	ncRNA_intronic
CAediting_956559	chr13_32367548_+	intronic
CAediting_956560	chr13_32373092_+	intronic
CAediting_956561	chr13_32373355_+	intronic
CAediting_956562	chr13_32373359_+	intronic
CAediting_956563	chr13_32373438_+	intronic
CAediting_956564	chr13_32373450_+	intronic
CAediting_956565	chr13_32373489_+	intronic
CAediting_956566	chr13_32373494_+	intronic
CAediting_956567	chr13_32376259_+	intronic
CAediting_956568	chr13_32376346_+	intronic
CAediting_956569	chr13_32376357_+	intronic
CAediting_956570	chr13_32376360_+	intronic
CAediting_956571	chr13_32376361_+	intronic
CAediting_956572	chr13_32376362_+	intronic
CAediting_956573	chr13_32376363_+	intronic
CAediting_956574	chr13_32376364_+	intronic
CAediting_956575	chr13_32376375_+	intronic
CAediting_956576	chr13_32376406_+	intronic
CAediting_956577	chr13_32376427_+	intronic
CAediting_956578	chr13_32399009_+	UTR3
CAediting_956579	chr13_32399010_+	UTR3
CAediting_956580	chr13_32399011_+	UTR3
CAediting_956581	chr13_32399024_+	UTR3
CAediting_956582	chr13_32399037_+	UTR3
CAediting_956583	chr13_32399045_+	UTR3
CAediting_956584	chr13_32399051_+	UTR3
CAediting_956585	chr13_32399054_+	UTR3
CAediting_956586	chr13_32399060_+	UTR3
CAediting_956587	chr13_32399063_+	UTR3
CAediting_956588	chr13_32399068_+	UTR3
CAediting_956589	chr13_32399086_+	UTR3
CAediting_956590	chr13_32399094_+	UTR3
CAediting_956591	chr13_32399099_+	UTR3
CAediting_956592	chr13_32399100_+	UTR3
CAediting_956593	chr13_32399119_+	UTR3
CAediting_956594	chr13_32399123_+	UTR3
CAediting_956595	chr13_32399141_+	UTR3
CAediting_956596	chr13_32399804_+	UTR3
CAediting_956597	chr13_32399806_+	UTR3
CAediting_956598	chr13_32399849_+	UTR3
CAediting_956599	chr13_32399859_+	UTR3
CAediting_956600	chr13_32399864_+	UTR3
CAediting_956601	chr13_32399884_+	UTR3
CAediting_956602	chr13_32399888_+	UTR3
CAediting_956603	chr13_32399912_+	UTR3
CAediting_956604	chr13_32399925_+	UTR3
CAediting_956605	chr13_32399947_+	UTR3
CAediting_956606	chr13_32399969_+	UTR3
CAediting_956607	chr13_32399971_+	UTR3
CAediting_956608	chr13_32399973_+	UTR3
CAediting_956609	chr13_32399983_+	UTR3
CAediting_956610	chr13_32399986_+	UTR3
CAediting_956611	chr13_32399996_+	UTR3
CAediting_956612	chr13_32400006_+	UTR3
CAediting_956613	chr13_32400007_+	UTR3
CAediting_956614	chr13_32400015_+	UTR3
CAediting_956615	chr13_32400020_+	UTR3
CAediting_956616	chr13_32400025_+	UTR3
CAediting_956617	chr13_32400038_+	UTR3
CAediting_956618	chr13_32400046_+	UTR3
CAediting_956619	chr13_32400047_+	UTR3
CAediting_956620	chr13_32400048_+	UTR3
CAediting_956621	chr13_32400060_+	UTR3
CAediting_956622	chr13_32400069_+	UTR3

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_956540	chr13_32327862_+	SINE	Alu	AluJb
CAediting_956541	chr13_32327896_+	SINE	Alu	AluJb
CAediting_956542	chr13_32327897_+	SINE	Alu	AluJb
CAediting_956543	chr13_32334420_+	SINE	Alu	AluJr4
CAediting_956544	chr13_32334421_+	SINE	Alu	AluJr4
CAediting_956545	chr13_32334442_+	SINE	Alu	AluJr4
CAediting_956546	chr13_32334443_+	SINE	Alu	AluJr4
CAediting_956547	chr13_32334469_+	SINE	Alu	AluJr4
CAediting_956548	chr13_32334474_+	SINE	Alu	AluJr4
CAediting_956549	chr13_32334531_+	SINE	Alu	AluJr4
CAediting_956550	chr13_32334589_+	SINE	Alu	AluJr4
CAediting_956551	chr13_32334600_+	SINE	Alu	AluJr4
CAediting_956552	chr13_32334623_+	SINE	Alu	AluJr4
CAediting_956553	chr13_32334624_+	SINE	Alu	AluJr4
CAediting_956554	chr13_32335913_+	SINE	Alu	AluJo
CAediting_956555	chr13_32335951_+	SINE	Alu	AluJo
CAediting_956556	chr13_32335956_+	SINE	Alu	AluJo
CAediting_956557	chr13_32335985_+	SINE	Alu	AluJo
CAediting_956558	chr13_32336012_+	SINE	Alu	AluJo
CAediting_956559	chr13_32367548_+	SINE	Alu	AluJb
CAediting_956560	chr13_32373092_+	SINE	Alu	AluSz6
CAediting_956561	chr13_32373355_+	SINE	Alu	AluSg
CAediting_956562	chr13_32373359_+	SINE	Alu	AluSg
CAediting_956563	chr13_32373438_+	SINE	Alu	AluSg
CAediting_956564	chr13_32373450_+	SINE	Alu	AluSg
CAediting_956565	chr13_32373489_+	SINE	Alu	AluSg
CAediting_956566	chr13_32373494_+	SINE	Alu	AluSg
CAediting_956567	chr13_32376259_+	SINE	Alu	AluSz
CAediting_956568	chr13_32376346_+	SINE	Alu	AluSz
CAediting_956569	chr13_32376357_+	SINE	Alu	AluSz
CAediting_956570	chr13_32376360_+	SINE	Alu	AluSz
CAediting_956571	chr13_32376361_+	SINE	Alu	AluSz
CAediting_956572	chr13_32376362_+	SINE	Alu	AluSz
CAediting_956573	chr13_32376363_+	SINE	Alu	AluSz
CAediting_956574	chr13_32376364_+	SINE	Alu	AluSz
CAediting_956575	chr13_32376375_+	SINE	Alu	AluSz
CAediting_956576	chr13_32376406_+	SINE	Alu	AluSz
CAediting_956577	chr13_32376427_+	SINE	Alu	AluSz
CAediting_956581	chr13_32399024_+	SINE	Alu	FLAM_C
CAediting_956582	chr13_32399037_+	SINE	Alu	FLAM_C
CAediting_956583	chr13_32399045_+	SINE	Alu	FLAM_C
CAediting_956584	chr13_32399051_+	SINE	Alu	FLAM_C
CAediting_956585	chr13_32399054_+	SINE	Alu	FLAM_C
CAediting_956586	chr13_32399060_+	SINE	Alu	FLAM_C
CAediting_956587	chr13_32399063_+	SINE	Alu	FLAM_C
CAediting_956588	chr13_32399068_+	SINE	Alu	FLAM_C
CAediting_956589	chr13_32399086_+	SINE	Alu	FLAM_C
CAediting_956590	chr13_32399094_+	SINE	Alu	FLAM_C
CAediting_956591	chr13_32399099_+	SINE	Alu	FLAM_C
CAediting_956592	chr13_32399100_+	SINE	Alu	FLAM_C
CAediting_956593	chr13_32399119_+	SINE	Alu	FLAM_C
CAediting_956594	chr13_32399123_+	SINE	Alu	FLAM_C
CAediting_956595	chr13_32399141_+	SINE	Alu	FLAM_C
CAediting_956596	chr13_32399804_+	SINE	Alu	AluSx
CAediting_956597	chr13_32399806_+	SINE	Alu	AluSx
CAediting_956598	chr13_32399849_+	SINE	Alu	AluSx
CAediting_956599	chr13_32399859_+	SINE	Alu	AluSx
CAediting_956600	chr13_32399864_+	SINE	Alu	AluSx
CAediting_956601	chr13_32399884_+	SINE	Alu	AluSx
CAediting_956602	chr13_32399888_+	SINE	Alu	AluSx
CAediting_956603	chr13_32399912_+	SINE	Alu	AluSx
CAediting_956604	chr13_32399925_+	SINE	Alu	AluSx
CAediting_956605	chr13_32399947_+	SINE	Alu	AluSx
CAediting_956606	chr13_32399969_+	SINE	Alu	AluSx
CAediting_956607	chr13_32399971_+	SINE	Alu	AluSx
CAediting_956608	chr13_32399973_+	SINE	Alu	AluSx
CAediting_956609	chr13_32399983_+	SINE	Alu	AluSx
CAediting_956610	chr13_32399986_+	SINE	Alu	AluSx
CAediting_956611	chr13_32399996_+	SINE	Alu	AluSx
CAediting_956612	chr13_32400006_+	SINE	Alu	AluSx
CAediting_956613	chr13_32400007_+	SINE	Alu	AluSx
CAediting_956614	chr13_32400015_+	SINE	Alu	AluSx
CAediting_956615	chr13_32400020_+	SINE	Alu	AluSx
CAediting_956616	chr13_32400025_+	SINE	Alu	AluSx
CAediting_956617	chr13_32400038_+	SINE	Alu	AluSx
CAediting_956618	chr13_32400046_+	SINE	Alu	AluSx
CAediting_956619	chr13_32400047_+	SINE	Alu	AluSx
CAediting_956620	chr13_32400048_+	SINE	Alu	AluSx
CAediting_956621	chr13_32400060_+	SINE	Alu	AluSx
CAediting_956622	chr13_32400069_+	SINE	Alu	AluSx

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RNA A-to-I editing events in the alternative splicing sites for BRCA2

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000139618.13.BRCA2.

Correlation between RNA A-to-I editing and PSI for ENSG00000139618.13.BRCA2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for BRCA2

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

LUAD.CAediting_956620.ENSG00000139618.BRCA2.png
Soverview

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Protein coding region RNA A-to-I editings for BRCA2

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for BRCA2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_86358	chr1_109598906_+	ENSG00000139618.13	ENST00000470094	hsa-miR-197-5p	32396969	32396975	7mer-m8	32396954	32396976	140	-20.72

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for BRCA2

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for BRCA2

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
BRCA	CAediting_956581	chr13_32399024_+	9.18662125078032e-05	0.201646460899095	.	.	.	.
CESC	CAediting_956581	chr13_32399024_+	0.00150313826684902	0.221913234548499	.	.	.	.
LUAD	CAediting_956581	chr13_32399024_+	0.0092985847827605	0.325231551760941	.	.	.	.
LUSC	CAediting_956581	chr13_32399024_+	5.50996971522322e-06	0.353712327303581	.	.	0.00957864494654482	0.206179984440355
HNSC	CAediting_956581	chr13_32399024_+	0.00956121162428103	0.204297310819753	.	.	.	.
STAD	CAediting_956581	chr13_32399024_+	2.76820915053485e-06	0.274476769148932	.	.	.	.
UCEC	CAediting_956581	chr13_32399024_+	0.01091661133443	0.33476812498382	.	.	.	.
ESCA	CAediting_956581	chr13_32399024_+	0.00355451225341492	0.234312137824178	.	.	.	.
OV	CAediting_956581	chr13_32399024_+	0.0301513515144348	0.147567953404005	.	.	.	.
SARC	CAediting_956581	chr13_32399024_+	0.0224292524919948	0.250385130876706	.	.	.	.
TGCT	CAediting_956581	chr13_32399024_+	0.0300864909227635	0.250645953874934	.	.	.	.
BLCA	CAediting_956587	chr13_32399063_+	0.000406728390730714	0.297914160765876	.	.	.	.
BRCA	CAediting_956587	chr13_32399063_+	1.47716851287658e-05	0.218256818864518	.	.	.	.
CESC	CAediting_956587	chr13_32399063_+	0.00474989085486604	0.214966782678042	.	.	.	.
COAD	CAediting_956587	chr13_32399063_+	9.52899900263708e-05	0.319413344000709	.	.	.	.
LUSC	CAediting_956587	chr13_32399063_+	0.000157603190466804	0.264095405349383	.	.	.	.
HNSC	CAediting_956587	chr13_32399063_+	0.00324873153461571	0.221931279139826	.	.	.	.
STAD	CAediting_956587	chr13_32399063_+	0.000832005897886008	0.196541808631193	.	.	.	.
UCEC	CAediting_956587	chr13_32399063_+	0.0139322655426142	0.310841208591508	.	.	.	.
ESCA	CAediting_956587	chr13_32399063_+	0.00840442945245959	0.212363173793548	.	.	.	.
OV	CAediting_956587	chr13_32399063_+	0.0247105713045576	0.156087838825224	.	.	.	.
SKCM	CAediting_956587	chr13_32399063_+	0.0366005697488423	0.174365675525382	0.00193640633566564	0.256224728771235	.	.
READ	CAediting_956587	chr13_32399063_+	9.07082187104785e-05	0.520373908787957	.	.	.	.
SARC	CAediting_956587	chr13_32399063_+	0.0141045056733904	0.286191049267804	0.000176619739750809	0.425249149413381	.	.
TGCT	CAediting_956587	chr13_32399063_+	0.00354986253082578	0.33929156663652	.	.	.	.
BLCA	CAediting_956604	chr13_32399925_+	8.40620263594487e-05	0.293640504852091	.	.	.	.
BRCA	CAediting_956604	chr13_32399925_+	0.00270118694116595	0.142363685489676	.	.	.	.
CESC	CAediting_956604	chr13_32399925_+	0.0025127914346803	0.246632631199666	.	.	.	.
LUAD	CAediting_956604	chr13_32399925_+	0.000412960287578326	0.32125234690001	.	.	.	.
LUSC	CAediting_956604	chr13_32399925_+	0.000463711140429609	0.26043234891309	0.0490623883835974	0.148159922529713	.	.
STAD	CAediting_956604	chr13_32399925_+	0.000423097912370779	0.280628248066113	.	.	.	.
UCEC	CAediting_956604	chr13_32399925_+	0.0190529589260975	0.186952077465885	.	.	.	.
OV	CAediting_956604	chr13_32399925_+	0.00468617137053672	0.212835858078032	.	.	.	.
SKCM	CAediting_956604	chr13_32399925_+	3.00012526688017e-05	0.331620057003393	.	.	.	.
SARC	CAediting_956604	chr13_32399925_+	0.028646313038216	0.20968445175048	.	.	.	.
TGCT	CAediting_956604	chr13_32399925_+	3.21741520711561e-05	0.444532124712563	.	.	.	.
BLCA	CAediting_956611	chr13_32399996_+	2.62622536713697e-05	0.270529115988114	.	.	.	.
BRCA	CAediting_956611	chr13_32399996_+	5.75303708731652e-21	0.400245621396443	.	.	.	.
LIHC	CAediting_956611	chr13_32399996_+	0.00103055581917932	0.442179168932705	.	.	.	.
CESC	CAediting_956611	chr13_32399996_+	7.56105911646903e-09	0.384646617682726	.	.	0.0228691279027035	0.156622033230793
LUAD	CAediting_956611	chr13_32399996_+	0.000294574238200329	0.322270398852163	.	.	.	.
COAD	CAediting_956611	chr13_32399996_+	0.0478566781654667	0.161842379940168	.	.	.	.
LUSC	CAediting_956611	chr13_32399996_+	1.79820738238605e-07	0.360629743925768	.	.	.	.
STAD	CAediting_956611	chr13_32399996_+	1.91899700737944e-05	0.272090366349592	.	.	.	.
UCEC	CAediting_956611	chr13_32399996_+	0.0301547587107707	0.150377680006954	0.03788072749793	0.144070958291669	.	.
ESCA	CAediting_956611	chr13_32399996_+	3.34424336206093e-05	0.336187492000577	.	.	.	.
OV	CAediting_956611	chr13_32399996_+	8.35288465024034e-09	0.384467407875867	.	.	.	.
SKCM	CAediting_956611	chr13_32399996_+	0.0010850623940426	0.254449709053078	0.00339376244321997	0.228881594693983	.	.
READ	CAediting_956611	chr13_32399996_+	0.0359176348574054	0.278514452948339	.	.	.	.
SARC	CAediting_956611	chr13_32399996_+	5.9303412518003e-06	0.418526005711306	.	.	.	.
TGCT	CAediting_956611	chr13_32399996_+	9.08909886999678e-06	0.455930508972667	.	.	.	.
THYM	CAediting_956611	chr13_32399996_+	9.98291990224388e-06	0.544402926801176	.	.	0.0127291796633574	0.325250769435756
STAD	CAediting_956615	chr13_32400020_+	0.0349536667483073	0.220172099210805	.	.	.	.
ESCA	CAediting_956615	chr13_32400020_+	0.0467573263892463	0.238522523050559	.	.	.	.
BLCA	CAediting_956617	chr13_32400038_+	1.34680575233516e-07	0.352500829568337	0.0416847202723672	0.140015997463918	.	.
BRCA	CAediting_956617	chr13_32400038_+	2.16436657993629e-14	0.350446413817314	.	.	.	.
CESC	CAediting_956617	chr13_32400038_+	1.28668277977207e-09	0.41058553493762	.	.	.	.
COAD	CAediting_956617	chr13_32400038_+	0.000121183655295565	0.342362162778313	0.00893669000501874	0.236747290757664	.	.
LUSC	CAediting_956617	chr13_32400038_+	0.00738588273966628	0.210399603546438	.	.	.	.
STAD	CAediting_956617	chr13_32400038_+	0.011373208748913	0.171927289951645	.	.	.	.
UCEC	CAediting_956617	chr13_32400038_+	0.00216782959410756	0.254410479767599	.	.	.	.
OV	CAediting_956617	chr13_32400038_+	0.00036115774531826	0.265171478554619	.	.	.	.
SKCM	CAediting_956617	chr13_32400038_+	0.000733609521429159	0.280146435477053	.	.	.	.
SARC	CAediting_956617	chr13_32400038_+	0.0289756835413278	0.235608871040523	.	.	.	.
TGCT	CAediting_956617	chr13_32400038_+	0.00425522725806416	0.284937350212655	.	.	.	.
BLCA	CAediting_956619	chr13_32400047_+	0.00383607599138456	0.348638522919629	.	.	.	.
BRCA	CAediting_956619	chr13_32400047_+	0.000235394299977959	0.303972399265936	.	.	.	.
CESC	CAediting_956619	chr13_32400047_+	0.00010129354829535	0.431076873691939	.	.	.	.
STAD	CAediting_956619	chr13_32400047_+	0.000194405758929971	0.366058354902326	.	.	.	.
ESCA	CAediting_956619	chr13_32400047_+	0.011690828922584	0.331791366720819	.	.	.	.
BLCA	CAediting_956620	chr13_32400048_+	4.27595545990298e-13	0.463131726007829	.	.	.	.
BRCA	CAediting_956620	chr13_32400048_+	9.41206644668691e-18	0.417959264118077	.	.	.	.
LIHC	CAediting_956620	chr13_32400048_+	0.0130431825455381	0.348809312850416	.	.	.	.
CESC	CAediting_956620	chr13_32400048_+	4.50358854983341e-08	0.354707450616364	.	.	.	.
LUAD	CAediting_956620	chr13_32400048_+	2.99885815240219e-09	0.630198434068703	.	.	.	.
COAD	CAediting_956620	chr13_32400048_+	3.64543612069527e-08	0.4149447656029	0.0211232058372128	0.180505294106521	.	.
LUSC	CAediting_956620	chr13_32400048_+	0.000181936590850061	0.284066594046648	.	.	.	.
HNSC	CAediting_956620	chr13_32400048_+	1.12805746821931e-05	0.309484184044633	.	.	.	.
STAD	CAediting_956620	chr13_32400048_+	0.000792855046522037	0.219258064283083	.	.	.	.
UCEC	CAediting_956620	chr13_32400048_+	3.29770959539129e-05	0.311835010317735	.	.	.	.
ESCA	CAediting_956620	chr13_32400048_+	0.00657833121594279	0.227861874760257	.	.	.	.
OV	CAediting_956620	chr13_32400048_+	7.82291939385417e-06	0.329810978774654	.	.	.	.
SKCM	CAediting_956620	chr13_32400048_+	0.0350356002241131	0.180930388055138	.	.	.	.
READ	CAediting_956620	chr13_32400048_+	0.000150397715264788	0.489240060441718	.	.	.	.
SARC	CAediting_956620	chr13_32400048_+	0.000851532279932545	0.329977416702465	.	.	.	.
TGCT	CAediting_956620	chr13_32400048_+	2.9153610380181e-05	0.406940171478072	.	.	.	.
THYM	CAediting_956620	chr13_32400048_+	9.25698703136163e-05	0.479435863831219	.	.	0.0411458013860409	0.262288004228227

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Relation with cancer stages for BRCA2

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
BLCA	pathologic_stage	CAediting_956581	chr13_32399024_+	0.0191871412838668	0.192982703420437
CESC	clinical_stage	CAediting_956581	chr13_32399024_+	0.0423829355714765	-0.143679365664575
CESC	clinical_stage	CAediting_956619	chr13_32400047_+	0.0377927526253207	-0.238758572594227
ESCA	clinical_stage	CAediting_956611	chr13_32399996_+	0.0495613669091128	-0.285043122938103
ESCA	clinical_stage	CAediting_956619	chr13_32400047_+	0.0110416005329381	-0.568797238562342
HNSC	pathologic_stage	CAediting_956581	chr13_32399024_+	0.0388543523109338	0.181422023811332
STAD	pathologic_stage	CAediting_956620	chr13_32400048_+	0.0483297526881366	-0.132980042300142
UCEC	clinical_stage	CAediting_956587	chr13_32399063_+	0.048121169133262	-0.252051056911699
UCEC	clinical_stage	CAediting_956611	chr13_32399996_+	0.0256937373765639	0.1546788533295

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Relation with survival for BRCA2

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for BRCA2

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for BRCA2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
BRCA2	C0006142	Malignant neoplasm of breast	30	CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
BRCA2	C1838457	FANCONI ANEMIA, COMPLEMENTATION GROUP D1	14	CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
BRCA2	C2675520	BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 2	13	CLINGEN;CTD_human;GENOMICS_ENGLAND
BRCA2	C2675521	BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 2	10	CLINGEN
BRCA2	C2675522	OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 2	10	CLINGEN
BRCA2	C0376358	Malignant neoplasm of prostate	5	CTD_human;GENOMICS_ENGLAND
BRCA2	C0027708	Nephroblastoma	4	CTD_human;GENOMICS_ENGLAND;ORPHANET
BRCA2	C0677776	Hereditary Breast and Ovarian Cancer Syndrome	4	CTD_human;GENOMICS_ENGLAND;ORPHANET
BRCA2	C0015625	Fanconi Anemia	3	GENOMICS_ENGLAND
BRCA2	C0025149	Medulloblastoma	3	CTD_human;GENOMICS_ENGLAND
BRCA2	C0346153	Breast Cancer, Familial	3	ORPHANET
BRCA2	C0678222	Breast Carcinoma	3	CGI;CTD_human
BRCA2	C1257931	Mammary Neoplasms, Human	3	CTD_human
BRCA2	C1458155	Mammary Neoplasms	3	CTD_human
BRCA2	C4704874	Mammary Carcinoma, Human	3	CTD_human
BRCA2	C0030297	Pancreatic Neoplasm	2	CGI;CTD_human
BRCA2	C0346647	Malignant neoplasm of pancreas	2	CGI;CTD_human;UNIPROT
BRCA2	C2751641	GLIOMA SUSCEPTIBILITY 3	2	GENOMICS_ENGLAND
BRCA2	C3150546	PANCREATIC CANCER, SUSCEPTIBILITY TO, 2	2	GENOMICS_ENGLAND
BRCA2	C0005586	Bipolar Disorder	1	PSYGENET
BRCA2	C0024121	Lung Neoplasms	1	CGI;CTD_human
BRCA2	C0030312	Pancytopenia	1	GENOMICS_ENGLAND
BRCA2	C0033578	Prostatic Neoplasms	1	CTD_human
BRCA2	C0206720	Squamous Cell Neoplasms	1	CTD_human
BRCA2	C0242379	Malignant neoplasm of lung	1	CGI;CTD_human;UNIPROT
BRCA2	C0265219	Miller Dieker syndrome	1	GENOMICS_ENGLAND
BRCA2	C0751688	Malignant Squamous Cell Neoplasm	1	CTD_human
BRCA2	C0919267	ovarian neoplasm	1	CGI;CTD_human
BRCA2	C1140680	Malignant neoplasm of ovary	1	CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
BRCA2	C1855710	Bone marrow hypocellularity	1	GENOMICS_ENGLAND
BRCA2	C2931038	Pancreatic carcinoma, familial	1	ORPHANET
BRCA2	C2931456	Prostate cancer, familial	1	ORPHANET
BRCA2	C3463824	MYELODYSPLASTIC SYNDROME	1	GENOMICS_ENGLAND
BRCA2	C4228778	Abnormality of radial ray	1	GENOMICS_ENGLAND
BRCA2	C4749652	Hereditary site-specific ovarian cancer syndrome	1	ORPHANET

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene