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Editing gene: SSR3 (CAeditome ID:6747)

Gene summary for SSR3

Gene summary

Gene information	Gene symbol	SSR3
	Gene ID	6747
	Gene name	signal sequence receptor subunit 3
	Synonyms	TRAPG
	Cytomap	3q25.31
	Type of gene	protein-coding
	Description	translocon-associated protein subunit gammaSSR gammaTRAP-complex gamma subunitTRAP-gammasignal sequence receptor subunit gammasignal sequence receptor, gamma (translocon-associated protein gamma)translocon-associated protein gamma subunit
	Modification date	20210518
	UniProtAcc	Q9UNL2
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for SSR3

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000114850.5

RNA A-to-I editing events in Cancer.

CAediting_318651(156540349, -), CAediting_318652(156540361, -), CAediting_318653(156540412, -), CAediting_318654(156540424, -), CAediting_318655(156540438, -), CAediting_318656(156540447, -), CAediting_318657(156540457, -), CAediting_318658(156540458, -), CAediting_318659(156540466, -), CAediting_318660(156540468, -), CAediting_318661(156540482, -), CAediting_318662(156540487, -), CAediting_318663(156540497, -), CAediting_318664(156540506, -), CAediting_318665(156540524, -), CAediting_318666(156540549, -), CAediting_318667(156540570, -), CAediting_318668(156540602, -), CAediting_318669(156541428, -), CAediting_318670(156541468, -), CAediting_318671(156541519, -), CAediting_318672(156541522, -), CAediting_318673(156541525, -), CAediting_318674(156541535, -), CAediting_318675(156541581, -), CAediting_318676(156541582, -), CAediting_318677(156541587, -), CAediting_318678(156541590, -), CAediting_318679(156541591, -), CAediting_318680(156541592, -), CAediting_318681(156541607, -), CAediting_318682(156541608, -), CAediting_318683(156541661, -), CAediting_318684(156542010, -), CAediting_318685(156552042, -), CAediting_318686(156553113, -),

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RNA editing positional annotations for SSR3 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_318651	chr3_156540349_-	UTR3
CAediting_318652	chr3_156540361_-	UTR3
CAediting_318653	chr3_156540412_-	UTR3
CAediting_318654	chr3_156540424_-	UTR3
CAediting_318655	chr3_156540438_-	UTR3
CAediting_318656	chr3_156540447_-	UTR3
CAediting_318657	chr3_156540457_-	UTR3
CAediting_318658	chr3_156540458_-	UTR3
CAediting_318659	chr3_156540466_-	UTR3
CAediting_318660	chr3_156540468_-	UTR3
CAediting_318661	chr3_156540482_-	UTR3
CAediting_318662	chr3_156540487_-	UTR3
CAediting_318663	chr3_156540497_-	UTR3
CAediting_318664	chr3_156540506_-	UTR3
CAediting_318665	chr3_156540524_-	UTR3
CAediting_318666	chr3_156540549_-	UTR3
CAediting_318667	chr3_156540570_-	UTR3
CAediting_318668	chr3_156540602_-	UTR3
CAediting_318669	chr3_156541428_-	UTR3
CAediting_318670	chr3_156541468_-	UTR3
CAediting_318671	chr3_156541519_-	UTR3
CAediting_318672	chr3_156541522_-	UTR3
CAediting_318673	chr3_156541525_-	UTR3
CAediting_318674	chr3_156541535_-	UTR3
CAediting_318675	chr3_156541581_-	UTR3
CAediting_318676	chr3_156541582_-	UTR3
CAediting_318677	chr3_156541587_-	UTR3
CAediting_318678	chr3_156541590_-	UTR3
CAediting_318679	chr3_156541591_-	UTR3
CAediting_318680	chr3_156541592_-	UTR3
CAediting_318681	chr3_156541607_-	UTR3
CAediting_318682	chr3_156541608_-	UTR3
CAediting_318683	chr3_156541661_-	UTR3
CAediting_318684	chr3_156542010_-	UTR3
CAediting_318685	chr3_156552042_-	ncRNA_intronic
CAediting_318686	chr3_156553113_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_318651	chr3_156540349_-	SINE	Alu	AluY
CAediting_318652	chr3_156540361_-	SINE	Alu	AluY
CAediting_318653	chr3_156540412_-	SINE	Alu	AluY
CAediting_318654	chr3_156540424_-	SINE	Alu	AluY
CAediting_318655	chr3_156540438_-	SINE	Alu	AluY
CAediting_318656	chr3_156540447_-	SINE	Alu	AluY
CAediting_318657	chr3_156540457_-	SINE	Alu	AluY
CAediting_318658	chr3_156540458_-	SINE	Alu	AluY
CAediting_318659	chr3_156540466_-	SINE	Alu	AluY
CAediting_318660	chr3_156540468_-	SINE	Alu	AluY
CAediting_318661	chr3_156540482_-	SINE	Alu	AluY
CAediting_318662	chr3_156540487_-	SINE	Alu	AluY
CAediting_318663	chr3_156540497_-	SINE	Alu	AluY
CAediting_318664	chr3_156540506_-	SINE	Alu	AluY
CAediting_318665	chr3_156540524_-	SINE	Alu	AluY
CAediting_318666	chr3_156540549_-	SINE	Alu	AluY
CAediting_318667	chr3_156540570_-	SINE	Alu	AluY
CAediting_318668	chr3_156540602_-	SINE	Alu	AluY
CAediting_318669	chr3_156541428_-	SINE	Alu	AluSq2
CAediting_318670	chr3_156541468_-	SINE	Alu	AluSq2
CAediting_318671	chr3_156541519_-	SINE	Alu	AluSq2
CAediting_318672	chr3_156541522_-	SINE	Alu	AluSq2
CAediting_318673	chr3_156541525_-	SINE	Alu	AluSq2
CAediting_318674	chr3_156541535_-	SINE	Alu	AluSq2
CAediting_318675	chr3_156541581_-	SINE	Alu	AluSq2
CAediting_318676	chr3_156541582_-	SINE	Alu	AluSq2
CAediting_318677	chr3_156541587_-	SINE	Alu	AluSq2
CAediting_318678	chr3_156541590_-	SINE	Alu	AluSq2
CAediting_318679	chr3_156541591_-	SINE	Alu	AluSq2
CAediting_318680	chr3_156541592_-	SINE	Alu	AluSq2
CAediting_318681	chr3_156541607_-	SINE	Alu	AluSq2
CAediting_318682	chr3_156541608_-	SINE	Alu	AluSq2
CAediting_318685	chr3_156552042_-	SINE	Alu	AluJb
CAediting_318686	chr3_156553113_-	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for SSR3

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000114850.5.SSR3.

Correlation between RNA A-to-I editing and PSI for ENSG00000114850.5.SSR3.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SSR3

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for SSR3

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for SSR3

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1229415	chr17_67471547_+	ENSG00000114850.5	ENST00000467789	hsa-miR-548aa	156543176	156543182	7mer-m8	156543175	156543199	140	-8.39
CAediting_1229415	chr17_67471547_+	ENSG00000114850.5	ENST00000476217	hsa-miR-548aa	156543176	156543182	7mer-m8	156543175	156543199	140	-8.39
CAediting_1229415	chr17_67471547_+	ENSG00000114850.5	ENST00000463503	hsa-miR-548aa	156543176	156543182	7mer-m8	156543175	156543199	140	-8.39

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SSR3

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000265044.5	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_318651	ENST00000265044.5	chr3_156540349_-	-1181.80	-1181.00	-1176.20
CAediting_318652	ENST00000265044.5	chr3_156540361_-	-1184.60	-1181.00	-1176.20
CAediting_318653	ENST00000265044.5	chr3_156540412_-	-1180.30	-1181.00	-1176.20
CAediting_318654	ENST00000265044.5	chr3_156540424_-	-1180.60	-1181.00	-1176.20
CAediting_318655	ENST00000265044.5	chr3_156540438_-	-1180.70	-1181.00	-1176.20
CAediting_318656	ENST00000265044.5	chr3_156540447_-	-1181.00	-1181.00	-1176.20
CAediting_318657	ENST00000265044.5	chr3_156540457_-	-1181.00	-1181.00	-1176.20
CAediting_318658	ENST00000265044.5	chr3_156540458_-	-1181.10	-1181.00	-1176.20
CAediting_318659	ENST00000265044.5	chr3_156540466_-	-1186.40	-1181.00	-1176.20
CAediting_318660	ENST00000265044.5	chr3_156540468_-	-1180.60	-1181.00	-1176.20
CAediting_318661	ENST00000265044.5	chr3_156540482_-	-1180.30	-1181.00	-1176.20
CAediting_318662	ENST00000265044.5	chr3_156540487_-	-1180.10	-1181.00	-1176.20
CAediting_318663	ENST00000265044.5	chr3_156540497_-	-1180.20	-1181.00	-1176.20
CAediting_318664	ENST00000265044.5	chr3_156540506_-	-1180.30	-1181.00	-1176.20
CAediting_318665	ENST00000265044.5	chr3_156540524_-	-1180.30	-1181.00	-1176.20
CAediting_318666	ENST00000265044.5	chr3_156540549_-	-1180.60	-1181.00	-1176.20
CAediting_318667	ENST00000265044.5	chr3_156540570_-	-1181.00	-1181.00	-1176.20
CAediting_318668	ENST00000265044.5	chr3_156540602_-	-1179.60	-1181.00	-1176.20
CAediting_318669	ENST00000265044.5	chr3_156541428_-	-1180.60	-1181.00	-1176.20
CAediting_318670	ENST00000265044.5	chr3_156541468_-	-1182.40	-1181.00	-1176.20
CAediting_318671	ENST00000265044.5	chr3_156541519_-	-1180.10	-1181.00	-1176.20
CAediting_318672	ENST00000265044.5	chr3_156541522_-	-1180.10	-1181.00	-1176.20
CAediting_318673	ENST00000265044.5	chr3_156541525_-	-1180.30	-1181.00	-1176.20
CAediting_318674	ENST00000265044.5	chr3_156541535_-	-1181.00	-1181.00	-1176.20
CAediting_318675	ENST00000265044.5	chr3_156541581_-	-1181.00	-1181.00	-1176.20
CAediting_318676	ENST00000265044.5	chr3_156541582_-	-1181.10	-1181.00	-1176.20
CAediting_318677	ENST00000265044.5	chr3_156541587_-	-1181.00	-1181.00	-1176.20
CAediting_318678	ENST00000265044.5	chr3_156541590_-	-1181.10	-1181.00	-1176.20
CAediting_318679	ENST00000265044.5	chr3_156541591_-	-1181.10	-1181.00	-1176.20
CAediting_318680	ENST00000265044.5	chr3_156541592_-	-1181.10	-1181.00	-1176.20
CAediting_318681	ENST00000265044.5	chr3_156541607_-	-1181.00	-1181.00	-1176.20
CAediting_318682	ENST00000265044.5	chr3_156541608_-	-1181.10	-1181.00	-1176.20
CAediting_318683	ENST00000265044.5	chr3_156541661_-	-1180.60	-1181.00	-1176.20
CAediting_318684	ENST00000265044.5	chr3_156542010_-	-1181.20	-1181.00	-1176.20

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Relation with ADAR for SSR3

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
BRCA	CAediting_318655	chr3_156540438_-	0.0376369813886184	0.17912938508974	.	.	.	.
LIHC	CAediting_318655	chr3_156540438_-	0.00147757054863743	0.246290802280667	.	.	.	.
HNSC	CAediting_318655	chr3_156540438_-	.	.	.	.	0.000384252993239316	0.478382052401596
BRCA	CAediting_318663	chr3_156540497_-	0.018486100869787	0.31959552195701	.	.	.	.
COAD	CAediting_318664	chr3_156540506_-	0.00724251558331742	0.272449314672676	.	.	.	.
GBM	CAediting_318664	chr3_156540506_-	0.000344199892449049	0.33229824842211	.	.	.	.
STAD	CAediting_318664	chr3_156540506_-	0.0207238041545793	0.141502919373072	.	.	.	.
UCEC	CAediting_318664	chr3_156540506_-	2.64890542274849e-07	0.340097358941607	.	.	.	.
ESCA	CAediting_318664	chr3_156540506_-	0.018285709472002	0.19781586728108	.	.	.	.
BRCA	CAediting_318666	chr3_156540549_-	0.0173996386357402	0.243531624090067	.	.	.	.
LIHC	CAediting_318666	chr3_156540549_-	0.0114318107608374	0.206699474159396	.	.	.	.
OV	CAediting_318674	chr3_156541535_-	0.000884111809276819	0.386043708744436	.	.	.	.

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Relation with cancer stages for SSR3

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for SSR3

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
GBM	CAediting_318664	chr3_156540506_-	0.00448420748781686	0.0402598	0.00770456

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RelatedDrugs for SSR3

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SSR3

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene