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Editing gene: SRD5A1 (CAeditome ID:6715)

Gene summary for SRD5A1

Gene summary

Gene information	Gene symbol	SRD5A1
	Gene ID	6715
	Gene name	steroid 5 alpha-reductase 1
	Synonyms	S5AR 1
	Cytomap	5p15.31
	Type of gene	protein-coding
	Description	3-oxo-5-alpha-steroid 4-dehydrogenase 1SR type 1steroid 5-alpha-reductase type Isteroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
	Modification date	20210518
	UniProtAcc	P18405
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
SRD5A1	GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase 1	17986282

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RNA A-to-I events for SRD5A1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000145545.10

RNA A-to-I editing events in Cancer.

CAediting_396215(6643430, +), CAediting_396216(6652647, +), CAediting_396217(6652665, +), CAediting_396218(6654630, +), CAediting_396219(6658047, +), CAediting_396220(6658084, +), CAediting_396221(6658204, +), CAediting_396222(6658210, +), CAediting_396223(6658840, +), CAediting_396224(6658850, +), CAediting_396225(6658857, +), CAediting_396226(6658883, +), CAediting_396227(6658921, +), CAediting_396228(6658926, +), CAediting_396229(6658930, +), CAediting_396230(6658974, +), CAediting_396231(6658996, +), CAediting_396232(6659010, +), CAediting_396233(6659014, +), CAediting_396234(6659062, +), CAediting_396235(6661277, +), CAediting_396236(6661279, +), CAediting_396237(6661308, +), CAediting_396238(6661350, +), CAediting_396239(6663605, +), CAediting_396240(6663610, +), CAediting_396241(6663626, +), CAediting_396242(6663627, +), CAediting_396243(6663658, +), CAediting_396244(6663659, +), CAediting_396245(6663673, +), CAediting_396246(6663674, +), CAediting_396247(6663676, +), CAediting_396248(6663683, +), CAediting_396249(6663695, +), CAediting_396250(6663698, +), CAediting_396251(6663699, +), CAediting_396252(6663700, +), CAediting_396253(6663713, +), CAediting_396254(6663739, +), CAediting_396255(6663740, +), CAediting_396256(6663745, +), CAediting_396257(6663762, +), CAediting_396258(6663772, +), CAediting_396259(6663781, +), CAediting_396260(6663788, +), CAediting_396261(6663805, +), CAediting_396262(6663817, +), CAediting_396263(6663848, +), CAediting_396264(6664423, +), CAediting_396265(6664474, +), CAediting_396266(6664479, +), CAediting_396267(6664544, +), CAediting_396268(6664608, +), CAediting_396269(6664615, +), CAediting_396270(6664616, +), CAediting_396271(6664626, +), CAediting_396272(6664644, +), CAediting_396273(6666212, +), CAediting_396274(6670940, +), CAediting_396275(6670948, +), CAediting_396276(6671110, +), CAediting_396277(6671210, +), CAediting_396278(6671211, +), CAediting_396279(6671223, +), CAediting_396280(6672295, +), CAediting_396281(6672301, +), CAediting_396282(6672315, +), CAediting_396283(6672375, +), CAediting_396284(6672376, +), CAediting_396285(6672415, +), CAediting_396286(6672437, +), CAediting_396287(6672472, +), CAediting_396288(6672475, +), CAediting_396289(6672557, +), CAediting_396290(6673342, +), CAediting_396291(6673358, +), CAediting_396292(6673381, +), CAediting_396293(6673384, +), CAediting_396294(6673392, +), CAediting_396295(6673398, +), CAediting_396296(6673459, +), CAediting_396297(6673463, +), CAediting_396298(6673490, +), CAediting_396299(6673491, +), CAediting_396300(6673492, +), CAediting_396301(6673504, +), CAediting_396302(6673512, +), CAediting_396303(6673579, +), CAediting_396304(6673627, +), CAediting_396305(6673639, +), CAediting_396306(6673641, +), CAediting_396307(6673644, +), CAediting_396308(6673654, +), CAediting_396309(6673655, +), CAediting_396310(6673656, +), CAediting_396311(6673663, +), CAediting_396312(6673664, +), CAediting_396313(6673666, +), CAediting_396314(6673673, +), CAediting_396315(6673758, +),

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RNA editing positional annotations for SRD5A1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_396215	chr5_6643430_+	ncRNA_intronic
CAediting_396216	chr5_6652647_+	ncRNA_intronic
CAediting_396217	chr5_6652665_+	ncRNA_intronic
CAediting_396218	chr5_6654630_+	intronic
CAediting_396219	chr5_6658047_+	intronic
CAediting_396220	chr5_6658084_+	intronic
CAediting_396221	chr5_6658204_+	intronic
CAediting_396222	chr5_6658210_+	intronic
CAediting_396223	chr5_6658840_+	intronic
CAediting_396224	chr5_6658850_+	intronic
CAediting_396225	chr5_6658857_+	intronic
CAediting_396226	chr5_6658883_+	intronic
CAediting_396227	chr5_6658921_+	intronic
CAediting_396228	chr5_6658926_+	intronic
CAediting_396229	chr5_6658930_+	intronic
CAediting_396230	chr5_6658974_+	intronic
CAediting_396231	chr5_6658996_+	intronic
CAediting_396232	chr5_6659010_+	intronic
CAediting_396233	chr5_6659014_+	intronic
CAediting_396234	chr5_6659062_+	intronic
CAediting_396235	chr5_6661277_+	intronic
CAediting_396236	chr5_6661279_+	intronic
CAediting_396237	chr5_6661308_+	intronic
CAediting_396238	chr5_6661350_+	intronic
CAediting_396239	chr5_6663605_+	intronic
CAediting_396240	chr5_6663610_+	intronic
CAediting_396241	chr5_6663626_+	intronic
CAediting_396242	chr5_6663627_+	intronic
CAediting_396243	chr5_6663658_+	intronic
CAediting_396244	chr5_6663659_+	intronic
CAediting_396245	chr5_6663673_+	intronic
CAediting_396246	chr5_6663674_+	intronic
CAediting_396247	chr5_6663676_+	intronic
CAediting_396248	chr5_6663683_+	intronic
CAediting_396249	chr5_6663695_+	intronic
CAediting_396250	chr5_6663698_+	intronic
CAediting_396251	chr5_6663699_+	intronic
CAediting_396252	chr5_6663700_+	intronic
CAediting_396253	chr5_6663713_+	intronic
CAediting_396254	chr5_6663739_+	intronic
CAediting_396255	chr5_6663740_+	intronic
CAediting_396256	chr5_6663745_+	intronic
CAediting_396257	chr5_6663762_+	intronic
CAediting_396258	chr5_6663772_+	intronic
CAediting_396259	chr5_6663781_+	intronic
CAediting_396260	chr5_6663788_+	intronic
CAediting_396261	chr5_6663805_+	intronic
CAediting_396262	chr5_6663817_+	intronic
CAediting_396263	chr5_6663848_+	intronic
CAediting_396264	chr5_6664423_+	intronic
CAediting_396265	chr5_6664474_+	intronic
CAediting_396266	chr5_6664479_+	intronic
CAediting_396267	chr5_6664544_+	intronic
CAediting_396268	chr5_6664608_+	intronic
CAediting_396269	chr5_6664615_+	intronic
CAediting_396270	chr5_6664616_+	intronic
CAediting_396271	chr5_6664626_+	intronic
CAediting_396272	chr5_6664644_+	intronic
CAediting_396273	chr5_6666212_+	intronic
CAediting_396274	chr5_6670940_+	UTR3
CAediting_396275	chr5_6670948_+	UTR3
CAediting_396276	chr5_6671110_+	UTR3
CAediting_396277	chr5_6671210_+	UTR3
CAediting_396278	chr5_6671211_+	UTR3
CAediting_396279	chr5_6671223_+	UTR3
CAediting_396280	chr5_6672295_+	UTR3
CAediting_396281	chr5_6672301_+	UTR3
CAediting_396282	chr5_6672315_+	UTR3
CAediting_396283	chr5_6672375_+	UTR3
CAediting_396284	chr5_6672376_+	UTR3
CAediting_396285	chr5_6672415_+	UTR3
CAediting_396286	chr5_6672437_+	UTR3
CAediting_396287	chr5_6672472_+	UTR3
CAediting_396288	chr5_6672475_+	UTR3
CAediting_396289	chr5_6672557_+	UTR3
CAediting_396290	chr5_6673342_+	UTR3
CAediting_396291	chr5_6673358_+	UTR3
CAediting_396292	chr5_6673381_+	UTR3
CAediting_396293	chr5_6673384_+	UTR3
CAediting_396294	chr5_6673392_+	UTR3
CAediting_396295	chr5_6673398_+	UTR3
CAediting_396296	chr5_6673459_+	UTR3
CAediting_396297	chr5_6673463_+	UTR3
CAediting_396298	chr5_6673490_+	UTR3
CAediting_396299	chr5_6673491_+	UTR3
CAediting_396300	chr5_6673492_+	UTR3
CAediting_396301	chr5_6673504_+	UTR3
CAediting_396302	chr5_6673512_+	UTR3
CAediting_396303	chr5_6673579_+	UTR3
CAediting_396304	chr5_6673627_+	UTR3
CAediting_396305	chr5_6673639_+	UTR3
CAediting_396306	chr5_6673641_+	UTR3
CAediting_396307	chr5_6673644_+	UTR3
CAediting_396308	chr5_6673654_+	UTR3
CAediting_396309	chr5_6673655_+	UTR3
CAediting_396310	chr5_6673656_+	UTR3
CAediting_396311	chr5_6673663_+	UTR3
CAediting_396312	chr5_6673664_+	UTR3
CAediting_396313	chr5_6673666_+	UTR3
CAediting_396314	chr5_6673673_+	UTR3
CAediting_396315	chr5_6673758_+	UTR3

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_396215	chr5_6643430_+	SINE	Alu	AluJr
CAediting_396216	chr5_6652647_+	SINE	Alu	AluJb
CAediting_396217	chr5_6652665_+	SINE	Alu	AluJb
CAediting_396218	chr5_6654630_+	SINE	Alu	AluSz6
CAediting_396219	chr5_6658047_+	SINE	Alu	AluSz6
CAediting_396220	chr5_6658084_+	SINE	Alu	AluSz6
CAediting_396221	chr5_6658204_+	SINE	Alu	AluSz6
CAediting_396222	chr5_6658210_+	SINE	Alu	AluSz6
CAediting_396223	chr5_6658840_+	SINE	Alu	AluJr
CAediting_396224	chr5_6658850_+	SINE	Alu	AluJr
CAediting_396225	chr5_6658857_+	SINE	Alu	AluJr
CAediting_396226	chr5_6658883_+	SINE	Alu	AluJr
CAediting_396227	chr5_6658921_+	SINE	Alu	AluJr
CAediting_396228	chr5_6658926_+	SINE	Alu	AluJr
CAediting_396229	chr5_6658930_+	SINE	Alu	AluJr
CAediting_396230	chr5_6658974_+	SINE	Alu	AluJr
CAediting_396231	chr5_6658996_+	SINE	Alu	AluJr
CAediting_396232	chr5_6659010_+	SINE	Alu	AluJr
CAediting_396233	chr5_6659014_+	SINE	Alu	AluJr
CAediting_396234	chr5_6659062_+	SINE	Alu	AluJr
CAediting_396235	chr5_6661277_+	SINE	Alu	AluSq10
CAediting_396236	chr5_6661279_+	SINE	Alu	AluSq10
CAediting_396237	chr5_6661308_+	SINE	Alu	AluSq10
CAediting_396238	chr5_6661350_+	SINE	Alu	AluSq10
CAediting_396239	chr5_6663605_+	SINE	Alu	AluSx1
CAediting_396240	chr5_6663610_+	SINE	Alu	AluSx1
CAediting_396241	chr5_6663626_+	SINE	Alu	AluSx1
CAediting_396242	chr5_6663627_+	SINE	Alu	AluSx1
CAediting_396243	chr5_6663658_+	SINE	Alu	AluSx1
CAediting_396244	chr5_6663659_+	SINE	Alu	AluSx1
CAediting_396245	chr5_6663673_+	SINE	Alu	AluSx1
CAediting_396246	chr5_6663674_+	SINE	Alu	AluSx1
CAediting_396247	chr5_6663676_+	SINE	Alu	AluSx1
CAediting_396248	chr5_6663683_+	SINE	Alu	AluSx1
CAediting_396249	chr5_6663695_+	SINE	Alu	AluSx1
CAediting_396250	chr5_6663698_+	SINE	Alu	AluSx1
CAediting_396251	chr5_6663699_+	SINE	Alu	AluSx1
CAediting_396252	chr5_6663700_+	SINE	Alu	AluSx1
CAediting_396253	chr5_6663713_+	SINE	Alu	AluSx1
CAediting_396254	chr5_6663739_+	SINE	Alu	AluSx1
CAediting_396255	chr5_6663740_+	SINE	Alu	AluSx1
CAediting_396256	chr5_6663745_+	SINE	Alu	AluSx1
CAediting_396257	chr5_6663762_+	SINE	Alu	AluSx1
CAediting_396258	chr5_6663772_+	SINE	Alu	AluSx1
CAediting_396259	chr5_6663781_+	SINE	Alu	AluSx1
CAediting_396260	chr5_6663788_+	SINE	Alu	AluSx1
CAediting_396261	chr5_6663805_+	SINE	Alu	AluSx1
CAediting_396262	chr5_6663817_+	SINE	Alu	AluSx1
CAediting_396263	chr5_6663848_+	SINE	Alu	AluSx1
CAediting_396264	chr5_6664423_+	SINE	Alu	AluJb
CAediting_396265	chr5_6664474_+	SINE	Alu	AluJb
CAediting_396266	chr5_6664479_+	SINE	Alu	AluJb
CAediting_396267	chr5_6664544_+	SINE	Alu	AluJb
CAediting_396268	chr5_6664608_+	SINE	Alu	AluJb
CAediting_396269	chr5_6664615_+	SINE	Alu	AluJb
CAediting_396270	chr5_6664616_+	SINE	Alu	AluJb
CAediting_396271	chr5_6664626_+	SINE	Alu	AluJb
CAediting_396272	chr5_6664644_+	SINE	Alu	AluJb
CAediting_396273	chr5_6666212_+	SINE	Alu	AluY
CAediting_396274	chr5_6670940_+	LINE	L1	L1PB1
CAediting_396275	chr5_6670948_+	LINE	L1	L1PB1
CAediting_396276	chr5_6671110_+	LINE	L1	L1PB1
CAediting_396277	chr5_6671210_+	LINE	L1	L1PB1
CAediting_396278	chr5_6671211_+	LINE	L1	L1PB1
CAediting_396279	chr5_6671223_+	LINE	L1	L1PB1
CAediting_396280	chr5_6672295_+	SINE	Alu	AluSz
CAediting_396281	chr5_6672301_+	SINE	Alu	AluSz
CAediting_396282	chr5_6672315_+	SINE	Alu	AluSz
CAediting_396283	chr5_6672375_+	SINE	Alu	AluSz
CAediting_396284	chr5_6672376_+	SINE	Alu	AluSz
CAediting_396285	chr5_6672415_+	SINE	Alu	AluSz
CAediting_396286	chr5_6672437_+	SINE	Alu	AluSz
CAediting_396287	chr5_6672472_+	SINE	Alu	AluSz
CAediting_396288	chr5_6672475_+	SINE	Alu	AluSz
CAediting_396289	chr5_6672557_+	SINE	Alu	AluSz
CAediting_396290	chr5_6673342_+	LINE	L1	L1MC2
CAediting_396291	chr5_6673358_+	LINE	L1	L1MC2
CAediting_396292	chr5_6673381_+	LINE	L1	L1MC2
CAediting_396293	chr5_6673384_+	LINE	L1	L1MC2
CAediting_396294	chr5_6673392_+	LINE	L1	L1MC2
CAediting_396295	chr5_6673398_+	LINE	L1	L1MC2
CAediting_396296	chr5_6673459_+	LINE	L1	L1MC2
CAediting_396297	chr5_6673463_+	LINE	L1	L1MC2
CAediting_396298	chr5_6673490_+	LINE	L1	L1MC2
CAediting_396299	chr5_6673491_+	LINE	L1	L1MC2
CAediting_396300	chr5_6673492_+	LINE	L1	L1MC2
CAediting_396301	chr5_6673504_+	LINE	L1	L1MC2
CAediting_396302	chr5_6673512_+	LINE	L1	L1MC2
CAediting_396303	chr5_6673579_+	LINE	L1	L1MC2
CAediting_396304	chr5_6673627_+	LINE	L1	L1MC2
CAediting_396305	chr5_6673639_+	LINE	L1	L1MC2
CAediting_396306	chr5_6673641_+	LINE	L1	L1MC2
CAediting_396307	chr5_6673644_+	LINE	L1	L1MC2
CAediting_396308	chr5_6673654_+	LINE	L1	L1MC2
CAediting_396309	chr5_6673655_+	LINE	L1	L1MC2
CAediting_396310	chr5_6673656_+	LINE	L1	L1MC2
CAediting_396311	chr5_6673663_+	LINE	L1	L1MC2
CAediting_396312	chr5_6673664_+	LINE	L1	L1MC2
CAediting_396313	chr5_6673666_+	LINE	L1	L1MC2
CAediting_396314	chr5_6673673_+	LINE	L1	L1MC2
CAediting_396315	chr5_6673758_+	LINE	L1	L1MC2

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RNA A-to-I editing events in the alternative splicing sites for SRD5A1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000145545.10.SRD5A1.

Correlation between RNA A-to-I editing and PSI for ENSG00000145545.10.SRD5A1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SRD5A1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for SRD5A1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for SRD5A1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_396275	chr5_6670948_+	ENSG00000145545.10	ENST00000274192	hsa-miR-6750-3p	6670943	6670949	7mer-m8	6670931	6670950	145.00	-14.12
CAediting_396277	chr5_6671210_+	ENSG00000145545.10	ENST00000274192	hsa-miR-483-3p	6671203	6671210	8mer-1a	6671190	6671210	140.00	-15.06
CAediting_396277	chr5_6671210_+	ENSG00000145545.10	ENST00000274192	hsa-miR-6795-3p	6671209	6671214	6mer	6671195	6671215	143.00	-20.79
CAediting_396293	chr5_6673384_+	ENSG00000145545.10	ENST00000274192	hsa-miR-1208	6673377	6673383	7mer-m8	6673365	6673384	140.00	-11.56
CAediting_396293	chr5_6673384_+	ENSG00000145545.10	ENST00000274192	hsa-miR-891a-3p	6673381	6673387	7mer-m8	6673369	6673388	157.00	-18.15
CAediting_396299	chr5_6673491_+	ENSG00000145545.10	ENST00000274192	hsa-miR-6777-3p	6673489	6673495	7mer-m8	6673478	6673496	151.00	-22.72
CAediting_396303	chr5_6673579_+	ENSG00000145545.10	ENST00000274192	hsa-miR-500b-3p	6673576	6673582	7mer-m8	6673564	6673583	149.00	-21.36
CAediting_396303	chr5_6673579_+	ENSG00000145545.10	ENST00000274192	hsa-miR-665	6673573	6673579	7mer-m8	6673561	6673580	140.00	-14.76
CAediting_396303	chr5_6673579_+	ENSG00000145545.10	ENST00000274192	hsa-miR-6840-3p	6673574	6673580	7mer-m8	6673560	6673581	140.00	-17.76
CAediting_396305	chr5_6673639_+	ENSG00000145545.10	ENST00000274192	hsa-miR-1283	6673635	6673641	7mer-m8	6673621	6673642	140.00	-7.84
CAediting_396305	chr5_6673639_+	ENSG00000145545.10	ENST00000274192	hsa-miR-1283	6673635	6673641	7mer-m8	6673621	6673642	140.00	-7.84
CAediting_396305	chr5_6673639_+	ENSG00000145545.10	ENST00000274192	hsa-miR-187-5p	6673636	6673643	8mer-1a	6673619	6673643	146.00	-17.00
CAediting_396310	chr5_6673656_+	ENSG00000145545.10	ENST00000274192	hsa-miR-526b-5p	6673650	6673656	7mer-m8	6673635	6673657	158.00	-14.95
CAediting_396281	chr5_6672301_+	ENSG00000145545.10	ENST00000274192	hsa-miR-3667-5p	6672299	6672305	7mer-m8	6672283	6672306	147.00	-16.66
CAediting_396282	chr5_6672315_+	ENSG00000145545.10	ENST00000274192	hsa-miR-1273c	6672310	6672315	6mer	6672295	6672316	144.00	-29.32
CAediting_396282	chr5_6672315_+	ENSG00000145545.10	ENST00000274192	hsa-miR-1285-3p	6672314	6672319	6mer	6672299	6672320	152.00	-26.10
CAediting_396282	chr5_6672315_+	ENSG00000145545.10	ENST00000274192	hsa-miR-1285-3p	6672314	6672319	6mer	6672299	6672320	152.00	-26.10
CAediting_396282	chr5_6672315_+	ENSG00000145545.10	ENST00000274192	hsa-miR-4486	6672313	6672319	7mer-m8	6672304	6672320	145.00	-19.61
CAediting_396283	chr5_6672375_+	ENSG00000145545.10	ENST00000274192	hsa-miR-375-3p	6672373	6672379	7mer-m8	6672357	6672380	147.00	-18.70
CAediting_396288	chr5_6672475_+	ENSG00000145545.10	ENST00000274192	hsa-miR-433-5p	6672469	6672475	7mer-m8	6672453	6672476	167.00	-28.70
CAediting_396291	chr5_6673358_+	ENSG00000145545.10	ENST00000274192	hsa-miR-361-3p	6673356	6673362	7mer-1a	6673336	6673362	147.00	-26.82
CAediting_396294	chr5_6673392_+	ENSG00000145545.10	ENST00000274192	hsa-miR-6821-5p	6673387	6673393	7mer-m8	6673372	6673394	155.00	-27.06
CAediting_396295	chr5_6673398_+	ENSG00000145545.10	ENST00000274192	hsa-miR-3660	6673395	6673402	8mer-1a	6673382	6673402	149.00	-15.65
CAediting_396295	chr5_6673398_+	ENSG00000145545.10	ENST00000274192	hsa-miR-3934-5p	6673391	6673397	7mer-m8	6673377	6673398	145.00	-19.54
CAediting_396295	chr5_6673398_+	ENSG00000145545.10	ENST00000274192	hsa-miR-4526	6673395	6673402	8mer-1a	6673382	6673402	147.00	-18.40
CAediting_396295	chr5_6673398_+	ENSG00000145545.10	ENST00000274192	hsa-miR-552-3p	6673392	6673398	7mer-m8	6673379	6673399	155.00	-17.82
CAediting_396300	chr5_6673492_+	ENSG00000145545.10	ENST00000274192	hsa-miR-3200-3p	6673487	6673493	7mer-m8	6673472	6673494	151.00	-25.76
CAediting_396300	chr5_6673492_+	ENSG00000145545.10	ENST00000274192	hsa-miR-6841-3p	6673486	6673492	7mer-m8	6673473	6673493	164.00	-27.17
CAediting_396302	chr5_6673512_+	ENSG00000145545.10	ENST00000274192	hsa-miR-150-5p	6673505	6673511	7mer-m8	6673490	6673512	146.00	-21.35
CAediting_396302	chr5_6673512_+	ENSG00000145545.10	ENST00000274192	hsa-miR-6749-3p	6673507	6673513	7mer-m8	6673496	6673514	148.00	-23.49
CAediting_396306	chr5_6673641_+	ENSG00000145545.10	ENST00000274192	hsa-miR-4769-3p	6673638	6673644	7mer-m8	6673624	6673645	140.00	-11.53
CAediting_396306	chr5_6673641_+	ENSG00000145545.10	ENST00000274192	hsa-miR-5590-5p	6673637	6673643	7mer-m8	6673624	6673644	149.00	-12.39
CAediting_396306	chr5_6673641_+	ENSG00000145545.10	ENST00000274192	hsa-miR-6817-5p	6673638	6673644	7mer-m8	6673624	6673645	151.00	-17.82
CAediting_396312	chr5_6673664_+	ENSG00000145545.10	ENST00000274192	hsa-miR-3128	6673657	6673664	8mer-1a	6673642	6673664	142.00	-13.72
CAediting_396314	chr5_6673673_+	ENSG00000145545.10	ENST00000274192	hsa-miR-3152-5p	6673670	6673676	7mer-m8	6673656	6673677	146.00	-10.93
CAediting_396314	chr5_6673673_+	ENSG00000145545.10	ENST00000274192	hsa-miR-4423-5p	6673671	6673677	7mer-m8	6673655	6673678	150.00	-12.27
CAediting_396314	chr5_6673673_+	ENSG00000145545.10	ENST00000274192	hsa-miR-6836-3p	6673669	6673676	8mer-1a	6673656	6673676	140.00	-14.81

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_396282	chr5_6672315_+	ENSG00000145545.10	ENST00000274192	hsa-miR-1262	6672312	6672318	7mer-m8	6672298	6672319	142	-16.42
CAediting_396286	chr5_6672437_+	ENSG00000145545.10	ENST00000274192	hsa-miR-1285-3p	6672431	6672437	7mer-m8	6672417	6672438	140	-16.92
CAediting_396286	chr5_6672437_+	ENSG00000145545.10	ENST00000274192	hsa-miR-1285-3p	6672431	6672437	7mer-m8	6672417	6672438	140	-16.92
CAediting_396294	chr5_6673392_+	ENSG00000145545.10	ENST00000274192	hsa-miR-147a	6673387	6673393	7mer-m8	6673375	6673394	147	-19.44
CAediting_396311	chr5_6673663_+	ENSG00000145545.10	ENST00000274192	hsa-miR-182-5p	6673657	6673664	8mer-1a	6673637	6673664	153	-15.35
CAediting_396312	chr5_6673664_+	ENSG00000145545.10	ENST00000274192	hsa-miR-182-5p	6673657	6673664	8mer-1a	6673637	6673664	153	-15.35
CAediting_396314	chr5_6673673_+	ENSG00000145545.10	ENST00000274192	hsa-miR-2115-5p	6673668	6673675	8mer-1a	6673654	6673675	140	-11.54
CAediting_396286	chr5_6672437_+	ENSG00000145545.10	ENST00000274192	hsa-miR-3187-5p	6672431	6672437	7mer-m8	6672417	6672438	152	-23.77
CAediting_396307	chr5_6673644_+	ENSG00000145545.10	ENST00000274192	hsa-miR-320a-3p	6673642	6673649	8mer-1a	6673628	6673649	143	-11.36
CAediting_396307	chr5_6673644_+	ENSG00000145545.10	ENST00000274192	hsa-miR-320b	6673642	6673649	8mer-1a	6673628	6673649	143	-11
CAediting_396307	chr5_6673644_+	ENSG00000145545.10	ENST00000274192	hsa-miR-320b	6673642	6673649	8mer-1a	6673628	6673649	143	-11
CAediting_396307	chr5_6673644_+	ENSG00000145545.10	ENST00000274192	hsa-miR-320c	6673642	6673649	8mer-1a	6673630	6673649	143	-9.06
CAediting_396307	chr5_6673644_+	ENSG00000145545.10	ENST00000274192	hsa-miR-320c	6673642	6673649	8mer-1a	6673630	6673649	143	-9.06
CAediting_396307	chr5_6673644_+	ENSG00000145545.10	ENST00000274192	hsa-miR-320d	6673642	6673649	8mer-1a	6673631	6673649	143	-9.06
CAediting_396307	chr5_6673644_+	ENSG00000145545.10	ENST00000274192	hsa-miR-320d	6673642	6673649	8mer-1a	6673631	6673649	143	-9.06
CAediting_396280	chr5_6672295_+	ENSG00000145545.10	ENST00000274192	hsa-miR-340-3p	6672293	6672300	8mer-1a	6672279	6672300	146	-20.89
CAediting_396294	chr5_6673392_+	ENSG00000145545.10	ENST00000274192	hsa-miR-3650	6673389	6673395	7mer-m8	6673376	6673396	143	-15.38
CAediting_396296	chr5_6673459_+	ENSG00000145545.10	ENST00000274192	hsa-miR-367-5p	6673453	6673459	7mer-m8	6673437	6673460	154	-17.21
CAediting_396298	chr5_6673490_+	ENSG00000145545.10	ENST00000274192	hsa-miR-3680-3p	6673485	6673491	7mer-m8	6673469	6673492	151	-18.81
CAediting_396299	chr5_6673491_+	ENSG00000145545.10	ENST00000274192	hsa-miR-3680-3p	6673485	6673491	7mer-m8	6673469	6673492	151	-18.81
CAediting_396300	chr5_6673492_+	ENSG00000145545.10	ENST00000274192	hsa-miR-3680-3p	6673485	6673491	7mer-m8	6673469	6673492	151	-18.81
CAediting_396298	chr5_6673490_+	ENSG00000145545.10	ENST00000274192	hsa-miR-3680-3p	6673485	6673491	7mer-m8	6673469	6673492	151	-18.81
CAediting_396299	chr5_6673491_+	ENSG00000145545.10	ENST00000274192	hsa-miR-3680-3p	6673485	6673491	7mer-m8	6673469	6673492	151	-18.81
CAediting_396300	chr5_6673492_+	ENSG00000145545.10	ENST00000274192	hsa-miR-3680-3p	6673485	6673491	7mer-m8	6673469	6673492	151	-18.81
CAediting_396280	chr5_6672295_+	ENSG00000145545.10	ENST00000274192	hsa-miR-371b-5p	6672289	6672296	8mer-1a	6672275	6672296	155	-12.12
CAediting_396280	chr5_6672295_+	ENSG00000145545.10	ENST00000274192	hsa-miR-373-5p	6672289	6672296	8mer-1a	6672275	6672296	145	-9.85
CAediting_396307	chr5_6673644_+	ENSG00000145545.10	ENST00000274192	hsa-miR-4429	6673642	6673649	8mer-1a	6673630	6673649	143	-12.57
CAediting_396281	chr5_6672301_+	ENSG00000145545.10	ENST00000274192	hsa-miR-4432	6672299	6672305	7mer-m8	6672284	6672306	152	-15.61
CAediting_396315	chr5_6673758_+	ENSG00000145545.10	ENST00000274192	hsa-miR-4482-3p	6673754	6673760	7mer-m8	6673739	6673761	153	-9.87
CAediting_396276	chr5_6671110_+	ENSG00000145545.10	ENST00000274192	hsa-miR-4495	6671106	6671112	7mer-m8	6671093	6671113	145	-10.31
CAediting_396290	chr5_6673342_+	ENSG00000145545.10	ENST00000274192	hsa-miR-4663	6673337	6673344	8mer-1a	6673321	6673344	140	-15.18
CAediting_396282	chr5_6672315_+	ENSG00000145545.10	ENST00000274192	hsa-miR-4701-3p	6672312	6672318	7mer-m8	6672299	6672319	149	-19.07
CAediting_396290	chr5_6673342_+	ENSG00000145545.10	ENST00000274192	hsa-miR-4728-3p	6673339	6673345	7mer-m8	6673322	6673346	142	-10.36
CAediting_396274	chr5_6670940_+	ENSG00000145545.10	ENST00000274192	hsa-miR-509-3-5p	6670936	6670941	6mer	6670920	6670942	153	-23.2
CAediting_396280	chr5_6672295_+	ENSG00000145545.10	ENST00000274192	hsa-miR-514b-5p	6672291	6672296	6mer	6672276	6672297	140	-12.23
CAediting_396282	chr5_6672315_+	ENSG00000145545.10	ENST00000274192	hsa-miR-542-3p	6672309	6672315	7mer-m8	6672296	6672316	152	-15.72
CAediting_396274	chr5_6670940_+	ENSG00000145545.10	ENST00000274192	hsa-miR-548aw	6670933	6670939	7mer-m8	6670922	6670940	143	-7.49
CAediting_396289	chr5_6672557_+	ENSG00000145545.10	ENST00000274192	hsa-miR-550b-2-5p	6672550	6672557	8mer-1a	6672536	6672557	145	-16.48
CAediting_396289	chr5_6672557_+	ENSG00000145545.10	ENST00000274192	hsa-miR-550b-2-5p	6672550	6672557	8mer-1a	6672536	6672557	145	-16.48
CAediting_396286	chr5_6672437_+	ENSG00000145545.10	ENST00000274192	hsa-miR-612	6672431	6672437	7mer-m8	6672415	6672438	153	-26.06
CAediting_396280	chr5_6672295_+	ENSG00000145545.10	ENST00000274192	hsa-miR-616-5p	6672289	6672296	8mer-1a	6672276	6672296	146	-11.59
CAediting_396282	chr5_6672315_+	ENSG00000145545.10	ENST00000274192	hsa-miR-6736-5p	6672312	6672318	7mer-m8	6672297	6672319	148	-25.2
CAediting_396282	chr5_6672315_+	ENSG00000145545.10	ENST00000274192	hsa-miR-6776-5p	6672313	6672319	7mer-m8	6672301	6672320	152	-22.73
CAediting_396280	chr5_6672295_+	ENSG00000145545.10	ENST00000274192	hsa-miR-6827-3p	6672293	6672300	8mer-1a	6672280	6672300	140	-14.67
CAediting_396286	chr5_6672437_+	ENSG00000145545.10	ENST00000274192	hsa-miR-6860	6672431	6672437	7mer-m8	6672418	6672438	153	-21.69
CAediting_396294	chr5_6673392_+	ENSG00000145545.10	ENST00000274192	hsa-miR-6867-5p	6673388	6673394	7mer-m8	6673375	6673395	141	-12.39
CAediting_396296	chr5_6673459_+	ENSG00000145545.10	ENST00000274192	hsa-miR-7152-5p	6673456	6673462	7mer-m8	6673441	6673463	153	-16.69
CAediting_396297	chr5_6673463_+	ENSG00000145545.10	ENST00000274192	hsa-miR-7152-5p	6673456	6673462	7mer-m8	6673441	6673463	153	-16.69

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_748296	chr10_51299626_+	ENSG00000145545.10	ENST00000274192	hsa-miR-605-3p	6671902	6671908	7mer-m8	6671888	6671909	144	-14.28
CAediting_980496	chr14_31014685_-	ENSG00000145545.10	ENST00000274192	hsa-miR-624-3p	6670415	6670421	7mer-m8	6670403	6670422	147	-16.36
CAediting_524911	chr7_5495852_-	ENSG00000145545.10	ENST00000513117	hsa-miR-589-3p	6668948	6668954	7mer-m8	6668935	6668955	144	-16.95
CAediting_1229413	chr17_67471544_+	ENSG00000145545.10	ENST00000274192	hsa-miR-548aa	6669042	6669048	7mer-m8	6669024	6669049	142	-16.58
CAediting_1229414	chr17_67471546_+	ENSG00000145545.10	ENST00000274192	hsa-miR-548aa	6672487	6672493	7mer-m8	6672470	6672494	140	-10.6
CAediting_1229415	chr17_67471547_+	ENSG00000145545.10	ENST00000274192	hsa-miR-548aa	6669714	6669720	7mer-m8	6669693	6669721	149	-13.63
CAediting_1160181	chr17_7017644_-	ENSG00000145545.10	ENST00000274192	hsa-miR-195-3p	6669429	6669435	7mer-m8	6669415	6669436	140	-6.31
CAediting_1306323	chr19_13836462_-	ENSG00000145545.10	ENST00000274192	hsa-miR-27a-3p	6669010	6669016	7mer-m8	6668997	6669017	150	-22.68
CAediting_86358	chr1_109598906_+	ENSG00000145545.10	ENST00000274192	hsa-miR-197-5p	6672514	6672521	8mer-1a	6672493	6672521	146	-26.62
CAediting_77128	chr1_85133844_+	ENSG00000145545.10	ENST00000274192	hsa-miR-4423-3p	6670111	6670117	7mer-m8	6670098	6670118	140	-13.89
CAediting_1399425	chr20_1392958_-	ENSG00000145545.10	ENST00000274192	hsa-miR-6869-5p	6672638	6672645	8mer-1a	6672624	6672645	140	-14.84
CAediting_228905	chr2_188297554_+	ENSG00000145545.10	ENST00000274192	hsa-miR-561-3p	6674085	6674091	7mer-m8	6674069	6674092	146	-12.11
CAediting_396018	chr5_1062918_-	ENSG00000145545.10	ENST00000274192	hsa-miR-4635	6670282	6670288	7mer-m8	6670265	6670289	149	-20.21
CAediting_396018	chr5_1062918_-	ENSG00000145545.10	ENST00000274192	hsa-miR-4635	6672504	6672510	7mer-m8	6672491	6672511	162	-21.35
CAediting_442554	chr5_154685830_+	ENSG00000145545.10	ENST00000274192	hsa-miR-1303	6670521	6670527	7mer-m8	6670507	6670528	149	-19.01
CAediting_580943	chr7_100356700_+	ENSG00000145545.10	ENST00000274192	hsa-miR-6840-3p	6672364	6672370	7mer-m8	6672346	6672371	142	-22.88
CAediting_524911	chr7_5495852_-	ENSG00000145545.10	ENST00000274192	hsa-miR-589-3p	6672305	6672311	7mer-m8	6672288	6672312	162	-21.55
CAediting_524911	chr7_5495852_-	ENSG00000145545.10	ENST00000274192	hsa-miR-589-3p	6668948	6668954	7mer-m8	6668935	6668955	144	-16.95
CAediting_524911	chr7_5495852_-	ENSG00000145545.10	ENST00000274192	hsa-miR-589-3p	6669027	6669033	7mer-m8	6669010	6669034	160	-21.23

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1160181	chr17_7017644_-	ENSG00000145545.10	ENST00000274192	hsa-miR-195-3p	6672754	6672760	7mer-m8	6672740	6672761	143	-8.97
CAediting_86358	chr1_109598906_+	ENSG00000145545.10	ENST00000274192	hsa-miR-197-5p	6672637	6672644	8mer-1a	6672624	6672644	146	-16.79
CAediting_393	chr1_1167164_+	ENSG00000145545.10	ENST00000274192	hsa-miR-200b-3p	6670868	6670873	6mer	6670853	6670874	147	-11.55
CAediting_396018	chr5_1062918_-	ENSG00000145545.10	ENST00000274192	hsa-miR-4635	6668651	6668657	7mer-m8	6668640	6668658	146	-13.6
CAediting_1229413	chr17_67471544_+	ENSG00000145545.10	ENST00000274192	hsa-miR-548aa	6669632	6669638	7mer-m8	6669616	6669639	148	-7.03
CAediting_1229414	chr17_67471546_+	ENSG00000145545.10	ENST00000274192	hsa-miR-548aa	6669632	6669638	7mer-m8	6669616	6669639	148	-7.03
CAediting_1229415	chr17_67471547_+	ENSG00000145545.10	ENST00000274192	hsa-miR-548aa	6669632	6669638	7mer-m8	6669616	6669639	148	-7.03
CAediting_524911	chr7_5495852_-	ENSG00000145545.10	ENST00000274192	hsa-miR-589-3p	6673111	6673117	7mer-m8	6673098	6673118	150	-16.09
CAediting_524911	chr7_5495852_-	ENSG00000145545.10	ENST00000274192	hsa-miR-589-3p	6669080	6669086	7mer-m8	6669064	6669087	150	-14.91
CAediting_580943	chr7_100356700_+	ENSG00000145545.10	ENST00000274192	hsa-miR-6840-3p	6668969	6668975	7mer-m8	6668952	6668976	149	-27.59
CAediting_1399425	chr20_1392958_-	ENSG00000145545.10	ENST00000274192	hsa-miR-6869-5p	6671732	6671738	7mer-m8	6671718	6671739	146	-14.91
CAediting_468389	chr6_31355314_-	ENSG00000145545.10	ENST00000274192	hsa-miR-6891-5p	6670401	6670406	6mer	6670389	6670407	148	-23.03

Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for SRD5A1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000274192.6	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_396274	ENST00000274192.6	chr5_6670940_+	-2207.19	-2207.99	-2242.99
CAediting_396275	ENST00000274192.6	chr5_6670948_+	-2213.39	-2207.99	-2242.99
CAediting_396276	ENST00000274192.6	chr5_6671110_+	-2214.69	-2207.99	-2242.99
CAediting_396277	ENST00000274192.6	chr5_6671210_+	-2211.19	-2207.99	-2242.99
CAediting_396278	ENST00000274192.6	chr5_6671211_+	-2208.99	-2207.99	-2242.99
CAediting_396279	ENST00000274192.6	chr5_6671223_+	-2208.29	-2207.99	-2242.99
CAediting_396280	ENST00000274192.6	chr5_6672295_+	-2210.79	-2207.99	-2242.99
CAediting_396281	ENST00000274192.6	chr5_6672301_+	-2207.09	-2207.99	-2242.99
CAediting_396282	ENST00000274192.6	chr5_6672315_+	-2208.19	-2207.99	-2242.99
CAediting_396283	ENST00000274192.6	chr5_6672375_+	-2207.69	-2207.99	-2242.99
CAediting_396284	ENST00000274192.6	chr5_6672376_+	-2208.09	-2207.99	-2242.99
CAediting_396285	ENST00000274192.6	chr5_6672415_+	-2210.39	-2207.99	-2242.99
CAediting_396286	ENST00000274192.6	chr5_6672437_+	-2207.29	-2207.99	-2242.99
CAediting_396287	ENST00000274192.6	chr5_6672472_+	-2208.29	-2207.99	-2242.99
CAediting_396288	ENST00000274192.6	chr5_6672475_+	-2208.79	-2207.99	-2242.99
CAediting_396289	ENST00000274192.6	chr5_6672557_+	-2207.99	-2207.99	-2242.99
CAediting_396290	ENST00000274192.6	chr5_6673342_+	-2207.19	-2207.99	-2242.99
CAediting_396291	ENST00000274192.6	chr5_6673358_+	-2206.69	-2207.99	-2242.99
CAediting_396292	ENST00000274192.6	chr5_6673381_+	-2207.29	-2207.99	-2242.99
CAediting_396293	ENST00000274192.6	chr5_6673384_+	-2210.89	-2207.99	-2242.99
CAediting_396294	ENST00000274192.6	chr5_6673392_+	-2208.29	-2207.99	-2242.99
CAediting_396295	ENST00000274192.6	chr5_6673398_+	-2214.09	-2207.99	-2242.99
CAediting_396296	ENST00000274192.6	chr5_6673459_+	-2207.59	-2207.99	-2242.99
CAediting_396297	ENST00000274192.6	chr5_6673463_+	-2209.09	-2207.99	-2242.99
CAediting_396298	ENST00000274192.6	chr5_6673490_+	-2208.39	-2207.99	-2242.99
CAediting_396299	ENST00000274192.6	chr5_6673491_+	-2208.09	-2207.99	-2242.99
CAediting_396300	ENST00000274192.6	chr5_6673492_+	-2207.69	-2207.99	-2242.99
CAediting_396301	ENST00000274192.6	chr5_6673504_+	-2207.59	-2207.99	-2242.99
CAediting_396302	ENST00000274192.6	chr5_6673512_+	-2207.59	-2207.99	-2242.99
CAediting_396303	ENST00000274192.6	chr5_6673579_+	-2212.69	-2207.99	-2242.99
CAediting_396304	ENST00000274192.6	chr5_6673627_+	-2207.59	-2207.99	-2242.99
CAediting_396305	ENST00000274192.6	chr5_6673639_+	-2207.99	-2207.99	-2242.99
CAediting_396306	ENST00000274192.6	chr5_6673641_+	-2207.69	-2207.99	-2242.99
CAediting_396307	ENST00000274192.6	chr5_6673644_+	-2207.29	-2207.99	-2242.99
CAediting_396308	ENST00000274192.6	chr5_6673654_+	-2207.29	-2207.99	-2242.99
CAediting_396309	ENST00000274192.6	chr5_6673655_+	-2210.59	-2207.99	-2242.99
CAediting_396310	ENST00000274192.6	chr5_6673656_+	-2208.39	-2207.99	-2242.99
CAediting_396311	ENST00000274192.6	chr5_6673663_+	-2208.39	-2207.99	-2242.99
CAediting_396312	ENST00000274192.6	chr5_6673664_+	-2208.09	-2207.99	-2242.99
CAediting_396313	ENST00000274192.6	chr5_6673666_+	-2208.99	-2207.99	-2242.99
CAediting_396314	ENST00000274192.6	chr5_6673673_+	-2207.69	-2207.99	-2242.99
CAediting_396315	ENST00000274192.6	chr5_6673758_+	-2213.19	-2207.99	-2242.99

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Relation with ADAR for SRD5A1

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
LGG	CAediting_396275	chr5_6670948_+	0.00234654560298741	0.212408277802312	.	.	.	.
LGG	CAediting_396276	chr5_6671110_+	1.81124519598312e-05	0.274550601658463	.	.	.	.
BRCA	CAediting_396276	chr5_6671110_+	0.00638253969750471	0.283930240965116	.	.	.	.
GBM	CAediting_396276	chr5_6671110_+	2.64649388451482e-07	0.543950929890919	.	.	.	.
LIHC	CAediting_396277	chr5_6671210_+	0.0164315587331448	0.325169635731799	0.0351320016119793	0.287350309221076	.	.
GBM	CAediting_396277	chr5_6671210_+	0.017524216087684	0.296084183444145	.	.	.	.
BLCA	CAediting_396293	chr5_6673384_+	0.0447408152445548	0.279551542704836	.	.	.	.
LGG	CAediting_396293	chr5_6673384_+	1.71854118906485e-07	0.245524167198293	.	.	.	.
BRCA	CAediting_396293	chr5_6673384_+	1.65964332453431e-05	0.239661655882729	.	.	0.038918780462199	0.116234430408029
LIHC	CAediting_396293	chr5_6673384_+	3.3382709892087e-08	0.343778093168617	.	.	.	.
CESC	CAediting_396293	chr5_6673384_+	.	.	.	.	0.0260430657858872	0.247275001241576
LUAD	CAediting_396293	chr5_6673384_+	0.000220564765202001	0.325944407166073	.	.	.	.
LUSC	CAediting_396293	chr5_6673384_+	4.57001051392843e-07	0.437858300536386	.	.	.	.
GBM	CAediting_396293	chr5_6673384_+	0.000257162325914774	0.322673703145426	.	.	.	.
KIRC	CAediting_396293	chr5_6673384_+	0.0227817066847095	0.119663960349981	.	.	.	.
SKCM	CAediting_396293	chr5_6673384_+	0.00477573982280948	0.310565888013381	.	.	.	.
SARC	CAediting_396293	chr5_6673384_+	0.0153589852503754	0.280846565929703	.	.	.	.
LGG	CAediting_396296	chr5_6673459_+	0.000557837035415073	0.356740833972725	.	.	.	.
LIHC	CAediting_396296	chr5_6673459_+	0.0100883998638874	0.23903615556777	.	.	.	.
LIHC	CAediting_396298	chr5_6673490_+	0.0167300393117421	0.253048583802784	.	.	.	.
LGG	CAediting_396302	chr5_6673512_+	0.0242459131830483	0.31523544488327	.	.	.	.
LGG	CAediting_396303	chr5_6673579_+	5.88202438551395e-06	0.217262914128822	.	.	.	.
BRCA	CAediting_396303	chr5_6673579_+	0.0450263301214302	0.119463624478572	.	.	.	.
LIHC	CAediting_396303	chr5_6673579_+	0.000122409198808674	0.263836868654241	.	.	.	.
LUAD	CAediting_396303	chr5_6673579_+	0.00216755021828562	0.315775429462544	.	.	.	.
LUSC	CAediting_396303	chr5_6673579_+	0.00420177848501411	0.294217201153527	.	.	.	.
GBM	CAediting_396303	chr5_6673579_+	0.00055314787103761	0.318503392592886	.	.	.	.
STAD	CAediting_396303	chr5_6673579_+	.	.	0.0194680683475483	0.247298554710061	.	.
KIRC	CAediting_396303	chr5_6673579_+	0.0121826547293321	0.137032563099406	.	.	.	.
SKCM	CAediting_396303	chr5_6673579_+	0.00345922529287466	0.315535253688503	.	.	.	.
LGG	CAediting_396305	chr5_6673639_+	0.00438245961655467	0.256273260718678	.	.	.	.
LIHC	CAediting_396305	chr5_6673639_+	0.000725217071966993	0.34983133843658	.	.	.	.
LGG	CAediting_396310	chr5_6673656_+	7.44156324379689e-08	0.44002050121411	.	.	.	.
BRCA	CAediting_396310	chr5_6673656_+	0.0335754159177503	0.219447698217981	.	.	.	.
LIHC	CAediting_396310	chr5_6673656_+	0.000349779730592632	0.327725136175841	.	.	.	.
LGG	CAediting_396315	chr5_6673758_+	7.04675865127331e-15	0.451687883098013	.	.	.	.
BRCA	CAediting_396315	chr5_6673758_+	0.00662608753834368	0.259779664200354	.	.	.	.
LIHC	CAediting_396315	chr5_6673758_+	1.77517337003952e-05	0.337272221881576	.	.	0.0150339263685132	0.195007341057463
KIRC	CAediting_396315	chr5_6673758_+	0.00527092171928994	0.293349521880749	.	.	.	.

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Relation with cancer stages for SRD5A1

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
KIRC	pathologic_stage	CAediting_396277	chr5_6671210_+	0.0379590669121592	0.167413995664568
KIRC	pathologic_stage	CAediting_396293	chr5_6673384_+	1.8616380043055e-06	0.248209942722434
LIHC	pathologic_stage	CAediting_396293	chr5_6673384_+	0.0465647308062347	0.133730384933866
LUAD	pathologic_stage	CAediting_396293	chr5_6673384_+	0.0336625075098984	0.191700187201405

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Relation with survival for SRD5A1

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
LUSC	CAediting_396303	chr5_6673579_+	0.0194804316362243	0.0465788	0.0572244

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RelatedDrugs for SRD5A1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
SRD5A1	P18405	DB00421	Spironolactone	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SmallMoleculeDrug	approved
SRD5A1	P18405	DB01216	Finasteride	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SmallMoleculeDrug	approved
SRD5A1	P18405	DB09389	Norgestrel	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SmallMoleculeDrug	approved
SRD5A1	P18405	DB00367	Levonorgestrel	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SmallMoleculeDrug	approved\|investigational
SRD5A1	P18405	DB01126	Dutasteride	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SmallMoleculeDrug	approved\|investigational

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RelatedDiseases for SRD5A1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
SRD5A1	C0001973	Alcoholic Intoxication, Chronic	2	PSYGENET
SRD5A1	C0014175	Endometriosis	2	CTD_human
SRD5A1	C0032460	Polycystic Ovary Syndrome	2	CTD_human
SRD5A1	C0033578	Prostatic Neoplasms	2	CTD_human
SRD5A1	C0269102	Endometrioma	2	CTD_human
SRD5A1	C0376358	Malignant neoplasm of prostate	2	CTD_human
SRD5A1	C1136382	Sclerocystic Ovaries	2	CTD_human
SRD5A1	C0011570	Mental Depression	1	PSYGENET
SRD5A1	C0011581	Depressive disorder	1	PSYGENET
SRD5A1	C0023893	Liver Cirrhosis, Experimental	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene