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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: SRC (CAeditome ID:6714)

Gene summary for SRC

check button Gene summary
Gene informationGene symbol

SRC

Gene ID

6714

Gene nameSRC proto-oncogene, non-receptor tyrosine kinase
SynonymsASV|SRC1|THC6|c-SRC|p60-Src
Cytomap

20q11.23

Type of geneprotein-coding
Descriptionproto-oncogene tyrosine-protein kinase Srcproto-oncogene c-Srcprotooncogene SRC, Rous sarcomatyrosine kinase pp60c-srctyrosine-protein kinase SRC-1v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Modification date20210518
UniProtAcc

P12931

Context- 32209481(c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
SRC

GO:0018108

Proto-oncogene tyrosine-protein kinase Src

22732588

SRC

GO:0004672

Proto-oncogene tyrosine-protein kinase Src

18616680

SRC

GO:0004713

Proto-oncogene tyrosine-protein kinase Src

16441665

SRC

GO:0004713

Proto-oncogene tyrosine-protein kinase Src

19059439

SRC

GO:0004713

Proto-oncogene tyrosine-protein kinase Src

19307596

SRC

GO:0004715

Proto-oncogene tyrosine-protein kinase Src

11606584

SRC

GO:0016004

Proto-oncogene tyrosine-protein kinase Src

11606584

SRC

GO:0020037

Proto-oncogene tyrosine-protein kinase Src

21036157

SRC

GO:0018108

Proto-oncogene tyrosine-protein kinase Src

12051764

SRC

GO:0035306

Proto-oncogene tyrosine-protein kinase Src

23159740

SRC

GO:0035556

Proto-oncogene tyrosine-protein kinase Src

11606584

SRC

GO:0035556

Proto-oncogene tyrosine-protein kinase Src

15248232

SRC

GO:0045747

Proto-oncogene tyrosine-protein kinase Src

25731159

SRC

GO:0046777

Proto-oncogene tyrosine-protein kinase Src

16441665

SRC

GO:0060576

Proto-oncogene tyrosine-protein kinase Src

25731159

SRC

GO:0070102

Proto-oncogene tyrosine-protein kinase Src

25731159

SRC

GO:0071902

Proto-oncogene tyrosine-protein kinase Src

19059439

SRC

GO:0005654

Proto-oncogene tyrosine-protein kinase Src

0000052

SRC

GO:0005737

Proto-oncogene tyrosine-protein kinase Src

16441665

SRC

GO:0005739

Proto-oncogene tyrosine-protein kinase Src

19767770

SRC

GO:0005743

Proto-oncogene tyrosine-protein kinase Src

12615910

SRC

GO:0005764

Proto-oncogene tyrosine-protein kinase Src

20605918

SRC

GO:0005770

Proto-oncogene tyrosine-protein kinase Src

20605918

SRC

GO:0005829

Proto-oncogene tyrosine-protein kinase Src

0000052

SRC

GO:0005829

Proto-oncogene tyrosine-protein kinase Src

19767770

SRC

GO:0005886

Proto-oncogene tyrosine-protein kinase Src

0000052

SRC

GO:0005886

Proto-oncogene tyrosine-protein kinase Src

20605918

SRC

GO:0005901

Proto-oncogene tyrosine-protein kinase Src

17848177

SRC

GO:0030054

Proto-oncogene tyrosine-protein kinase Src

0000052

SRC

GO:0048471

Proto-oncogene tyrosine-protein kinase Src

19307596


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RNA A-to-I events for SRC

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000197122.10

check button RNA A-to-I editing events in Cancer.
CAediting_1426742(37365685, +), CAediting_1426743(37365697, +), CAediting_1426744(37367121, +), CAediting_1426745(37367780, +), CAediting_1426746(37367880, +), CAediting_1426747(37368311, +), CAediting_1426748(37368346, +), CAediting_1426749(37368397, +), CAediting_1426750(37369817, +), CAediting_1426751(37369818, +), CAediting_1426752(37369939, +), CAediting_1426753(37369983, +), CAediting_1426754(37370034, +), CAediting_1426755(37370428, +), CAediting_1426756(37371771, +), CAediting_1426757(37371886, +), CAediting_1426758(37374173, +), CAediting_1426759(37374209, +), CAediting_1426760(37374213, +), CAediting_1426761(37378232, +), CAediting_1426762(37378237, +), CAediting_1426763(37378262, +), CAediting_1426764(37378263, +), CAediting_1426765(37378267, +), CAediting_1426766(37378275, +), CAediting_1426767(37378509, +), CAediting_1426768(37379528, +), CAediting_1426769(37379533, +), CAediting_1426770(37379559, +), CAediting_1426771(37379562, +), CAediting_1426772(37379563, +), CAediting_1426773(37379568, +), CAediting_1426774(37379577, +), CAediting_1426775(37379597, +), CAediting_1426776(37379603, +), CAediting_1426777(37379604, +), CAediting_1426778(37379609, +), CAediting_1426779(37379613, +), CAediting_1426780(37379617, +), CAediting_1426781(37379626, +), CAediting_1426782(37379630, +), CAediting_1426783(37379633, +), CAediting_1426784(37379636, +), CAediting_1426785(37379644, +), CAediting_1426786(37379645, +), CAediting_1426787(37379679, +), CAediting_1426788(37379681, +), CAediting_1426789(37379706, +), CAediting_1426790(37379708, +), CAediting_1426791(37379762, +), CAediting_1426792(37379781, +), CAediting_1426793(37379785, +), CAediting_1426794(37379802, +), CAediting_1426795(37379805, +), CAediting_1426796(37379816, +), CAediting_1426797(37379817, +), CAediting_1426798(37380048, +), CAediting_1426799(37380049, +), CAediting_1426800(37380051, +), CAediting_1426801(37380067, +), CAediting_1426802(37380070, +), CAediting_1426803(37380088, +), CAediting_1426804(37383760, +), CAediting_1426805(37383775, +), CAediting_1426806(37383787, +), CAediting_1426807(37383801, +), CAediting_1426808(37387918, +), CAediting_1426809(37387925, +), CAediting_1426810(37387958, +), CAediting_1426811(37387962, +), CAediting_1426812(37387963, +), CAediting_1426813(37387985, +), CAediting_1426814(37388064, +), CAediting_1426815(37388469, +), CAediting_1426816(37388482, +), CAediting_1426817(37388490, +), CAediting_1426818(37388550, +), CAediting_1426819(37388564, +), CAediting_1426820(37388605, +), CAediting_1426821(37388619, +), CAediting_1426822(37388672, +), CAediting_1426823(37388735, +), CAediting_1426824(37389098, +), CAediting_1426825(37390497, +), CAediting_1426826(37390540, +), CAediting_1426827(37390545, +), CAediting_1426828(37390551, +), CAediting_1426829(37390555, +), CAediting_1426830(37390578, +), CAediting_1426831(37390580, +), CAediting_1426832(37390606, +), CAediting_1426833(37390639, +), CAediting_1426834(37390644, +), CAediting_1426835(37390679, +), CAediting_1426836(37391348, +), CAediting_1426837(37391508, +), CAediting_1426838(37391519, +), CAediting_1426839(37391590, +), CAediting_1426840(37391598, +), CAediting_1426841(37391599, +), CAediting_1426842(37391678, +), CAediting_1426843(37391698, +), CAediting_1426844(37391700, +), CAediting_1426845(37391701, +), CAediting_1426846(37391707, +), CAediting_1426847(37391740, +), CAediting_1426848(37391774, +), CAediting_1426849(37391775, +), CAediting_1426850(37391788, +), CAediting_1426851(37391799, +), CAediting_1426852(37391806, +), CAediting_1426853(37399678, +),

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RNA editing positional annotations for SRC using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1426742chr20_37365685_+ncRNA_intronic
CAediting_1426743chr20_37365697_+ncRNA_intronic
CAediting_1426744chr20_37367121_+ncRNA_intronic
CAediting_1426745chr20_37367780_+ncRNA_intronic
CAediting_1426746chr20_37367880_+ncRNA_intronic
CAediting_1426747chr20_37368311_+ncRNA_intronic
CAediting_1426748chr20_37368346_+ncRNA_intronic
CAediting_1426749chr20_37368397_+ncRNA_intronic
CAediting_1426750chr20_37369817_+ncRNA_intronic
CAediting_1426751chr20_37369818_+ncRNA_intronic
CAediting_1426752chr20_37369939_+ncRNA_intronic
CAediting_1426753chr20_37369983_+ncRNA_intronic
CAediting_1426754chr20_37370034_+ncRNA_intronic
CAediting_1426755chr20_37370428_+ncRNA_intronic
CAediting_1426756chr20_37371771_+ncRNA_intronic
CAediting_1426757chr20_37371886_+ncRNA_intronic
CAediting_1426758chr20_37374173_+ncRNA_intronic
CAediting_1426759chr20_37374209_+ncRNA_intronic
CAediting_1426760chr20_37374213_+ncRNA_intronic
CAediting_1426761chr20_37378232_+ncRNA_intronic
CAediting_1426762chr20_37378237_+ncRNA_intronic
CAediting_1426763chr20_37378262_+ncRNA_intronic
CAediting_1426764chr20_37378263_+ncRNA_intronic
CAediting_1426765chr20_37378267_+ncRNA_intronic
CAediting_1426766chr20_37378275_+ncRNA_intronic
CAediting_1426767chr20_37378509_+ncRNA_intronic
CAediting_1426768chr20_37379528_+ncRNA_intronic
CAediting_1426769chr20_37379533_+ncRNA_intronic
CAediting_1426770chr20_37379559_+ncRNA_intronic
CAediting_1426771chr20_37379562_+ncRNA_intronic
CAediting_1426772chr20_37379563_+ncRNA_intronic
CAediting_1426773chr20_37379568_+ncRNA_intronic
CAediting_1426774chr20_37379577_+ncRNA_intronic
CAediting_1426775chr20_37379597_+ncRNA_intronic
CAediting_1426776chr20_37379603_+ncRNA_intronic
CAediting_1426777chr20_37379604_+ncRNA_intronic
CAediting_1426778chr20_37379609_+ncRNA_intronic
CAediting_1426779chr20_37379613_+ncRNA_intronic
CAediting_1426780chr20_37379617_+ncRNA_intronic
CAediting_1426781chr20_37379626_+ncRNA_intronic
CAediting_1426782chr20_37379630_+ncRNA_intronic
CAediting_1426783chr20_37379633_+ncRNA_intronic
CAediting_1426784chr20_37379636_+ncRNA_intronic
CAediting_1426785chr20_37379644_+ncRNA_intronic
CAediting_1426786chr20_37379645_+ncRNA_intronic
CAediting_1426787chr20_37379679_+ncRNA_intronic
CAediting_1426788chr20_37379681_+ncRNA_intronic
CAediting_1426789chr20_37379706_+ncRNA_intronic
CAediting_1426790chr20_37379708_+ncRNA_intronic
CAediting_1426791chr20_37379762_+ncRNA_intronic
CAediting_1426792chr20_37379781_+ncRNA_intronic
CAediting_1426793chr20_37379785_+ncRNA_intronic
CAediting_1426794chr20_37379802_+ncRNA_intronic
CAediting_1426795chr20_37379805_+ncRNA_intronic
CAediting_1426796chr20_37379816_+ncRNA_intronic
CAediting_1426797chr20_37379817_+ncRNA_intronic
CAediting_1426798chr20_37380048_+ncRNA_intronic
CAediting_1426799chr20_37380049_+ncRNA_intronic
CAediting_1426800chr20_37380051_+ncRNA_intronic
CAediting_1426801chr20_37380067_+ncRNA_intronic
CAediting_1426802chr20_37380070_+ncRNA_intronic
CAediting_1426803chr20_37380088_+ncRNA_intronic
CAediting_1426804chr20_37383760_+intronic
CAediting_1426805chr20_37383775_+intronic
CAediting_1426806chr20_37383787_+intronic
CAediting_1426807chr20_37383801_+intronic
CAediting_1426808chr20_37387918_+ncRNA_intronic
CAediting_1426809chr20_37387925_+ncRNA_intronic
CAediting_1426810chr20_37387958_+ncRNA_intronic
CAediting_1426811chr20_37387962_+ncRNA_intronic
CAediting_1426812chr20_37387963_+ncRNA_intronic
CAediting_1426813chr20_37387985_+ncRNA_intronic
CAediting_1426814chr20_37388064_+ncRNA_intronic
CAediting_1426815chr20_37388469_+ncRNA_intronic
CAediting_1426816chr20_37388482_+ncRNA_intronic
CAediting_1426817chr20_37388490_+ncRNA_intronic
CAediting_1426818chr20_37388550_+ncRNA_intronic
CAediting_1426819chr20_37388564_+ncRNA_intronic
CAediting_1426820chr20_37388605_+ncRNA_intronic
CAediting_1426821chr20_37388619_+ncRNA_intronic
CAediting_1426822chr20_37388672_+ncRNA_intronic
CAediting_1426823chr20_37388735_+ncRNA_intronic
CAediting_1426824chr20_37389098_+ncRNA_intronic
CAediting_1426825chr20_37390497_+ncRNA_intronic
CAediting_1426826chr20_37390540_+ncRNA_intronic
CAediting_1426827chr20_37390545_+ncRNA_intronic
CAediting_1426828chr20_37390551_+ncRNA_intronic
CAediting_1426829chr20_37390555_+ncRNA_intronic
CAediting_1426830chr20_37390578_+ncRNA_intronic
CAediting_1426831chr20_37390580_+ncRNA_intronic
CAediting_1426832chr20_37390606_+ncRNA_intronic
CAediting_1426833chr20_37390639_+ncRNA_intronic
CAediting_1426834chr20_37390644_+ncRNA_intronic
CAediting_1426835chr20_37390679_+ncRNA_intronic
CAediting_1426836chr20_37391348_+ncRNA_intronic
CAediting_1426837chr20_37391508_+ncRNA_intronic
CAediting_1426838chr20_37391519_+ncRNA_intronic
CAediting_1426839chr20_37391590_+ncRNA_intronic
CAediting_1426840chr20_37391598_+ncRNA_intronic
CAediting_1426841chr20_37391599_+ncRNA_intronic
CAediting_1426842chr20_37391678_+ncRNA_intronic
CAediting_1426843chr20_37391698_+ncRNA_intronic
CAediting_1426844chr20_37391700_+ncRNA_intronic
CAediting_1426845chr20_37391701_+ncRNA_intronic
CAediting_1426846chr20_37391707_+ncRNA_intronic
CAediting_1426847chr20_37391740_+ncRNA_intronic
CAediting_1426848chr20_37391774_+ncRNA_intronic
CAediting_1426849chr20_37391775_+ncRNA_intronic
CAediting_1426850chr20_37391788_+ncRNA_intronic
CAediting_1426851chr20_37391799_+ncRNA_intronic
CAediting_1426852chr20_37391806_+ncRNA_intronic
CAediting_1426853chr20_37399678_+ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1426742chr20_37365685_+SINEAluAluJr
CAediting_1426743chr20_37365697_+SINEAluAluJr
CAediting_1426744chr20_37367121_+SINEAluAluJo
CAediting_1426745chr20_37367780_+SINEAluAluJr4
CAediting_1426746chr20_37367880_+SINEAluAluJr4
CAediting_1426747chr20_37368311_+SINEAluAluSx1
CAediting_1426748chr20_37368346_+SINEAluAluSx1
CAediting_1426749chr20_37368397_+SINEAluAluSx1
CAediting_1426750chr20_37369817_+SINEAluAluSx1
CAediting_1426751chr20_37369818_+SINEAluAluSx1
CAediting_1426752chr20_37369939_+SINEAluAluSx1
CAediting_1426753chr20_37369983_+SINEAluAluSx1
CAediting_1426754chr20_37370034_+SINEAluAluSx1
CAediting_1426755chr20_37370428_+SINEAluAluSx1
CAediting_1426756chr20_37371771_+SINEAluAluSq2
CAediting_1426757chr20_37371886_+SINEAluAluSq2
CAediting_1426758chr20_37374173_+SINEAluAluSx4
CAediting_1426759chr20_37374209_+SINEAluAluSx4
CAediting_1426760chr20_37374213_+SINEAluAluSx4
CAediting_1426761chr20_37378232_+SINEAluAluJr
CAediting_1426762chr20_37378237_+SINEAluAluJr
CAediting_1426763chr20_37378262_+SINEAluAluJr
CAediting_1426764chr20_37378263_+SINEAluAluJr
CAediting_1426765chr20_37378267_+SINEAluAluJr
CAediting_1426766chr20_37378275_+SINEAluAluJr
CAediting_1426768chr20_37379528_+SINEAluAluSx
CAediting_1426769chr20_37379533_+SINEAluAluSx
CAediting_1426770chr20_37379559_+SINEAluAluSx
CAediting_1426771chr20_37379562_+SINEAluAluSx
CAediting_1426772chr20_37379563_+SINEAluAluSx
CAediting_1426773chr20_37379568_+SINEAluAluSx
CAediting_1426774chr20_37379577_+SINEAluAluSx
CAediting_1426775chr20_37379597_+SINEAluAluSx
CAediting_1426776chr20_37379603_+SINEAluAluSx
CAediting_1426777chr20_37379604_+SINEAluAluSx
CAediting_1426778chr20_37379609_+SINEAluAluSx
CAediting_1426779chr20_37379613_+SINEAluAluSx
CAediting_1426780chr20_37379617_+SINEAluAluSx
CAediting_1426781chr20_37379626_+SINEAluAluSx
CAediting_1426782chr20_37379630_+SINEAluAluSx
CAediting_1426783chr20_37379633_+SINEAluAluSx
CAediting_1426784chr20_37379636_+SINEAluAluSx
CAediting_1426785chr20_37379644_+SINEAluAluSx
CAediting_1426786chr20_37379645_+SINEAluAluSx
CAediting_1426787chr20_37379679_+SINEAluAluSx
CAediting_1426788chr20_37379681_+SINEAluAluSx
CAediting_1426789chr20_37379706_+SINEAluAluSx
CAediting_1426790chr20_37379708_+SINEAluAluSx
CAediting_1426791chr20_37379762_+SINEAluAluSx1
CAediting_1426792chr20_37379781_+SINEAluAluSx1
CAediting_1426793chr20_37379785_+SINEAluAluSx1
CAediting_1426794chr20_37379802_+SINEAluAluSx1
CAediting_1426795chr20_37379805_+SINEAluAluSx1
CAediting_1426796chr20_37379816_+SINEAluAluSx1
CAediting_1426797chr20_37379817_+SINEAluAluSx1
CAediting_1426803chr20_37380088_+SINEMIRMIRb
CAediting_1426804chr20_37383760_+SINEAluAluSz
CAediting_1426805chr20_37383775_+SINEAluAluSz
CAediting_1426806chr20_37383787_+SINEAluAluSz
CAediting_1426807chr20_37383801_+SINEAluAluSz
CAediting_1426808chr20_37387918_+SINEMIRMIRb
CAediting_1426809chr20_37387925_+SINEMIRMIRb
CAediting_1426810chr20_37387958_+SINEMIRMIRb
CAediting_1426811chr20_37387962_+SINEMIRMIRb
CAediting_1426812chr20_37387963_+SINEMIRMIRb
CAediting_1426813chr20_37387985_+SINEMIRMIRb
CAediting_1426815chr20_37388469_+SINEAluAluJo
CAediting_1426816chr20_37388482_+SINEAluAluJo
CAediting_1426817chr20_37388490_+SINEAluAluJo
CAediting_1426818chr20_37388550_+SINEAluAluJo
CAediting_1426819chr20_37388564_+SINEAluAluJo
CAediting_1426820chr20_37388605_+SINEAluAluJo
CAediting_1426821chr20_37388619_+SINEAluAluJo
CAediting_1426822chr20_37388672_+SINEAluAluJo
CAediting_1426823chr20_37388735_+SINEAluAluJo
CAediting_1426825chr20_37390497_+SINEAluAluSz
CAediting_1426826chr20_37390540_+SINEAluAluSz
CAediting_1426827chr20_37390545_+SINEAluAluSz
CAediting_1426828chr20_37390551_+SINEAluAluSz
CAediting_1426829chr20_37390555_+SINEAluAluSz
CAediting_1426830chr20_37390578_+SINEAluAluSz
CAediting_1426831chr20_37390580_+SINEAluAluSz
CAediting_1426832chr20_37390606_+SINEAluAluSz
CAediting_1426833chr20_37390639_+SINEAluAluSz
CAediting_1426834chr20_37390644_+SINEAluAluSz
CAediting_1426835chr20_37390679_+SINEAluAluSz
CAediting_1426836chr20_37391348_+SINEMIRMIR3
CAediting_1426837chr20_37391508_+SINEMIRMIR1_Amn
CAediting_1426838chr20_37391519_+SINEMIRMIR1_Amn
CAediting_1426839chr20_37391590_+SINEAluAluSz
CAediting_1426840chr20_37391598_+SINEAluAluSz
CAediting_1426841chr20_37391599_+SINEAluAluSz
CAediting_1426842chr20_37391678_+SINEAluAluSz
CAediting_1426843chr20_37391698_+SINEAluAluSz
CAediting_1426844chr20_37391700_+SINEAluAluSz
CAediting_1426845chr20_37391701_+SINEAluAluSz
CAediting_1426846chr20_37391707_+SINEAluAluSz
CAediting_1426847chr20_37391740_+SINEAluAluSz
CAediting_1426848chr20_37391774_+SINEAluAluSz
CAediting_1426849chr20_37391775_+SINEAluAluSz
CAediting_1426850chr20_37391788_+SINEAluAluSz
CAediting_1426851chr20_37391799_+SINEAluAluSz
CAediting_1426852chr20_37391806_+SINEAluAluSz
CAediting_1426853chr20_37399678_+SINEAluAluSz

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RNA A-to-I editing events in the alternative splicing sites for SRC

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000197122.10.SRC.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000197122.10.SRC.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SRC

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for SRC

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for SRC

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_748296chr10_51299626_+ENSG00000197122.10ENST00000373578hsa-miR-605-3p37403984374039907mer-m83740396837403991146-16.38
CAediting_846604chr11_93733708_-ENSG00000197122.10ENST00000373578hsa-miR-1304-3p37405164374051707mer-m83740515037405171140-16.85
CAediting_748296chr10_51299626_+ENSG00000197122.10ENST00000358208hsa-miR-605-3p37403984374039907mer-m83740396837403991146-16.38
CAediting_846604chr11_93733708_-ENSG00000197122.10ENST00000358208hsa-miR-1304-3p37405164374051707mer-m83740515037405171140-16.85
CAediting_748296chr10_51299626_+ENSG00000197122.10ENST00000373567hsa-miR-605-3p37403984374039907mer-m83740396837403991146-16.38
CAediting_846604chr11_93733708_-ENSG00000197122.10ENST00000373567hsa-miR-1304-3p37405164374051707mer-m83740515037405171140-16.85
CAediting_748296chr10_51299626_+ENSG00000197122.10ENST00000373558hsa-miR-605-3p37403984374039907mer-m83740396837403991146-16.38
CAediting_846604chr11_93733708_-ENSG00000197122.10ENST00000373558hsa-miR-1304-3p37405164374051707mer-m83740515037405171140-16.85
CAediting_1368054chr19_46709310_-ENSG00000197122.10ENST00000373578hsa-miR-320e37403598374036047mer-m83740358837403605154-19.69
CAediting_77128chr1_85133844_+ENSG00000197122.10ENST00000373578hsa-miR-4423-3p37404820374048267mer-m83740480737404827140-15.96
CAediting_442554chr5_154685830_+ENSG00000197122.10ENST00000373578hsa-miR-130337405183374051897mer-m83740517137405190158-19.76
CAediting_414656chr5_72878640_+ENSG00000197122.10ENST00000373578hsa-miR-4804-3p37405732374057387mer-m83740571637405739148-19.15
CAediting_604450chr7_133034877_-ENSG00000197122.10ENST00000373578hsa-miR-365437403596374036027mer-m83740358537403603147-18.43
CAediting_573000chr7_92204081_-ENSG00000197122.10ENST00000373578hsa-miR-1285-5p37405459374054657mer-m83740544637405466167-19.72
CAediting_1368054chr19_46709310_-ENSG00000197122.10ENST00000358208hsa-miR-320e37403598374036047mer-m83740358837403605154-19.69
CAediting_77128chr1_85133844_+ENSG00000197122.10ENST00000358208hsa-miR-4423-3p37404820374048267mer-m83740480737404827140-15.96
CAediting_442554chr5_154685830_+ENSG00000197122.10ENST00000358208hsa-miR-130337405183374051897mer-m83740517137405190158-19.76
CAediting_604450chr7_133034877_-ENSG00000197122.10ENST00000358208hsa-miR-365437403596374036027mer-m83740358537403603147-18.43
CAediting_1368054chr19_46709310_-ENSG00000197122.10ENST00000373567hsa-miR-320e37403598374036047mer-m83740358837403605154-19.69
CAediting_77128chr1_85133844_+ENSG00000197122.10ENST00000373567hsa-miR-4423-3p37404820374048267mer-m83740480737404827140-15.96
CAediting_442554chr5_154685830_+ENSG00000197122.10ENST00000373567hsa-miR-130337405183374051897mer-m83740517137405190158-19.76
CAediting_414656chr5_72878640_+ENSG00000197122.10ENST00000373567hsa-miR-4804-3p37405732374057387mer-m83740571637405739148-19.15
CAediting_604450chr7_133034877_-ENSG00000197122.10ENST00000373567hsa-miR-365437403596374036027mer-m83740358537403603147-18.43
CAediting_573000chr7_92204081_-ENSG00000197122.10ENST00000373567hsa-miR-1285-5p37405459374054657mer-m83740544637405466167-19.72
CAediting_1368054chr19_46709310_-ENSG00000197122.10ENST00000373558hsa-miR-320e37403598374036047mer-m83740358837403605154-19.69
CAediting_77128chr1_85133844_+ENSG00000197122.10ENST00000373558hsa-miR-4423-3p37404820374048267mer-m83740480737404827140-15.96
CAediting_442554chr5_154685830_+ENSG00000197122.10ENST00000373558hsa-miR-130337405183374051897mer-m83740517137405190158-19.76
CAediting_414656chr5_72878640_+ENSG00000197122.10ENST00000373558hsa-miR-4804-3p37405732374057387mer-m83740571637405739148-19.15
CAediting_604450chr7_133034877_-ENSG00000197122.10ENST00000373558hsa-miR-365437403596374036027mer-m83740358537403603147-18.43
CAediting_573000chr7_92204081_-ENSG00000197122.10ENST00000373558hsa-miR-1285-5p37405459374054657mer-m83740544637405466167-19.72
CAediting_1524209chrX_134546392_-ENSG00000197122.10ENST00000373578hsa-miR-503-5p37404241374042477mer-m83740422437404248152-26.82
CAediting_1524209chrX_134546392_-ENSG00000197122.10ENST00000358208hsa-miR-503-5p37404241374042477mer-m83740422437404248152-26.82
CAediting_1524209chrX_134546392_-ENSG00000197122.10ENST00000373567hsa-miR-503-5p37404241374042477mer-m83740422437404248152-26.82
CAediting_1524209chrX_134546392_-ENSG00000197122.10ENST00000373558hsa-miR-503-5p37404241374042477mer-m83740422437404248152-26.82

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_77128chr1_85133844_+ENSG00000197122.10ENST00000373578hsa-miR-4423-3p37404561374045688mer-1a3740454837404568140-10.59
CAediting_1054808chr15_66496985_-ENSG00000197122.10ENST00000373578hsa-miR-451237404452374044587mer-m83740443937404459154-26.1
CAediting_1054808chr15_66496985_-ENSG00000197122.10ENST00000373578hsa-miR-451237403505374035117mer-m83740349237403512149-22.5
CAediting_1054808chr15_66496985_-ENSG00000197122.10ENST00000373578hsa-miR-451237404710374047167mer-m83740469537404717144-17.92
CAediting_1054808chr15_66496985_-ENSG00000197122.10ENST00000373578hsa-miR-451237405038374050447mer-m83740502437405045154-23.37
CAediting_1054808chr15_66496985_-ENSG00000197122.10ENST00000373578hsa-miR-451237405197374052037mer-m83740518337405204142-12.78
CAediting_580943chr7_100356700_+ENSG00000197122.10ENST00000373578hsa-miR-6840-3p37403414374034207mer-m83740340137403421154-26.46
CAediting_468389chr6_31355314_-ENSG00000197122.10ENST00000373578hsa-miR-6891-5p37403987374039948mer-1a3740397237403994151-31.06
CAediting_77128chr1_85133844_+ENSG00000197122.10ENST00000358208hsa-miR-4423-3p37404561374045688mer-1a3740454837404568140-10.59
CAediting_1054808chr15_66496985_-ENSG00000197122.10ENST00000358208hsa-miR-451237404452374044587mer-m83740443937404459154-26.1
CAediting_1054808chr15_66496985_-ENSG00000197122.10ENST00000358208hsa-miR-451237403505374035117mer-m83740349237403512149-22.5
CAediting_1054808chr15_66496985_-ENSG00000197122.10ENST00000358208hsa-miR-451237404710374047167mer-m83740469537404717144-17.92
CAediting_1054808chr15_66496985_-ENSG00000197122.10ENST00000358208hsa-miR-451237405038374050447mer-m83740502437405045154-23.37
CAediting_1054808chr15_66496985_-ENSG00000197122.10ENST00000358208hsa-miR-451237405197374052037mer-m83740518337405204142-12.78
CAediting_580943chr7_100356700_+ENSG00000197122.10ENST00000358208hsa-miR-6840-3p37403414374034207mer-m83740340137403421154-26.46
CAediting_468389chr6_31355314_-ENSG00000197122.10ENST00000358208hsa-miR-6891-5p37403987374039948mer-1a3740397237403994151-31.06
CAediting_77128chr1_85133844_+ENSG00000197122.10ENST00000373567hsa-miR-4423-3p37404561374045688mer-1a3740454837404568140-10.59
CAediting_1054808chr15_66496985_-ENSG00000197122.10ENST00000373567hsa-miR-451237404452374044587mer-m83740443937404459154-26.1
CAediting_1054808chr15_66496985_-ENSG00000197122.10ENST00000373567hsa-miR-451237403505374035117mer-m83740349237403512149-22.5
CAediting_1054808chr15_66496985_-ENSG00000197122.10ENST00000373567hsa-miR-451237404710374047167mer-m83740469537404717144-17.92
CAediting_1054808chr15_66496985_-ENSG00000197122.10ENST00000373567hsa-miR-451237405038374050447mer-m83740502437405045154-23.37
CAediting_1054808chr15_66496985_-ENSG00000197122.10ENST00000373567hsa-miR-451237405197374052037mer-m83740518337405204142-12.78
CAediting_580943chr7_100356700_+ENSG00000197122.10ENST00000373567hsa-miR-6840-3p37403414374034207mer-m83740340137403421154-26.46
CAediting_468389chr6_31355314_-ENSG00000197122.10ENST00000373567hsa-miR-6891-5p37403987374039948mer-1a3740397237403994151-31.06
CAediting_77128chr1_85133844_+ENSG00000197122.10ENST00000373558hsa-miR-4423-3p37404561374045688mer-1a3740454837404568140-10.59
CAediting_1054808chr15_66496985_-ENSG00000197122.10ENST00000373558hsa-miR-451237404452374044587mer-m83740443937404459154-26.1
CAediting_1054808chr15_66496985_-ENSG00000197122.10ENST00000373558hsa-miR-451237403505374035117mer-m83740349237403512149-22.5
CAediting_1054808chr15_66496985_-ENSG00000197122.10ENST00000373558hsa-miR-451237404710374047167mer-m83740469537404717144-17.92
CAediting_1054808chr15_66496985_-ENSG00000197122.10ENST00000373558hsa-miR-451237405038374050447mer-m83740502437405045154-23.37
CAediting_1054808chr15_66496985_-ENSG00000197122.10ENST00000373558hsa-miR-451237405197374052037mer-m83740518337405204142-12.78
CAediting_580943chr7_100356700_+ENSG00000197122.10ENST00000373558hsa-miR-6840-3p37403414374034207mer-m83740340137403421154-26.46
CAediting_468389chr6_31355314_-ENSG00000197122.10ENST00000373558hsa-miR-6891-5p37403987374039948mer-1a3740397237403994151-31.06

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SRC

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for SRC

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
STADCAediting_1426798chr20_37380048_+....0.001877502038932650.36030909023748
STADCAediting_1426799chr20_37380049_+....0.001786218666540810.366844271688843

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Relation with cancer stages for SRC

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
STADpathologic_stageCAediting_1426797chr20_37379817_+0.008807202095086810.349997067445769

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Relation with survival for SRC

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for SRC

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
SRCP12931DB06616BosutinibProto-oncogene tyrosine-protein kinase Src SmallMoleculeDrugapproved
SRCP12931DB09079NintedanibProto-oncogene tyrosine-protein kinase Src SmallMoleculeDrugapproved
SRCP12931DB01254DasatinibProto-oncogene tyrosine-protein kinase Src SmallMoleculeDrugapproved|investigational
SRCP12931DB06137TirbanibulinProto-oncogene tyrosine-protein kinase Src SmallMoleculeDrugapproved|investigational
SRCP12931DB08901PonatinibProto-oncogene tyrosine-protein kinase Src SmallMoleculeDrugapproved|investigational
SRCP12931DB12010FostamatinibProto-oncogene tyrosine-protein kinase Src SmallMoleculeDrugapproved|investigational
SRCP12931DB04272Citric acidProto-oncogene tyrosine-protein kinase Src SmallMoleculeDrugapproved|nutraceutical|vet_approved

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RelatedDiseases for SRC

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
SRCC0005684Malignant neoplasm of urinary bladder2CTD_human
SRCC0005695Bladder Neoplasm2CTD_human
SRCC0027626Neoplasm Invasiveness2CTD_human
SRCC0005818Blood Platelet Disorders1GENOMICS_ENGLAND
SRCC0006142Malignant neoplasm of breast1CTD_human
SRCC0007102Malignant tumor of colon1CTD_human
SRCC0009319Colitis1CTD_human
SRCC0009375Colonic Neoplasms1CTD_human
SRCC0018800Cardiomegaly1CTD_human
SRCC0038220Status Epilepticus1CTD_human
SRCC0085548Autosomal Recessive Polycystic Kidney Disease1CTD_human
SRCC0270823Petit mal status1CTD_human
SRCC0311335Grand Mal Status Epilepticus1CTD_human
SRCC0393734Complex Partial Status Epilepticus1CTD_human
SRCC0678222Breast Carcinoma1CTD_human
SRCC0751522Status Epilepticus, Subclinical1CTD_human
SRCC0751523Non-Convulsive Status Epilepticus1CTD_human
SRCC0751524Simple Partial Status Epilepticus1CTD_human
SRCC1257931Mammary Neoplasms, Human1CTD_human
SRCC1383860Cardiac Hypertrophy1CTD_human
SRCC1458155Mammary Neoplasms1CTD_human
SRCC4310789THROMBOCYTOPENIA 61CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
SRCC4704874Mammary Carcinoma, Human1CTD_human