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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: SPTBN1 (CAeditome ID:6711)

Gene summary for SPTBN1

check button Gene summary
Gene informationGene symbol

SPTBN1

Gene ID

6711

Gene namespectrin beta, non-erythrocytic 1
SynonymsELF|HEL102|SPTB2|betaSpII
Cytomap

2p16.2

Type of geneprotein-coding
Descriptionspectrin beta chain, non-erythrocytic 1beta-G spectrinbeta-II spectrinbeta-fodrinbeta-spectrin 2beta-spectrin IIbeta-spectrin non-erythrocytic 1embryonic liver beta-fodrinepididymis luminal protein 102fodrin beta chainspectrin beta chain, brain
Modification date20210518
UniProtAcc

Q01082

Context- 33754058(SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
SPTBN1

GO:0005730

Spectrin beta chain, non-erythrocytic 1

9537418

SPTBN1

GO:0005737

Spectrin beta chain, non-erythrocytic 1

9537418


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RNA A-to-I events for SPTBN1

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000115306.14

check button RNA A-to-I editing events in Cancer.
CAediting_181578(54464713, +), CAediting_181579(54464751, +), CAediting_181580(54464755, +), CAediting_181581(54464776, +), CAediting_181582(54464789, +), CAediting_181583(54464790, +), CAediting_181584(54464873, +), CAediting_181585(54464875, +), CAediting_181586(54467499, +), CAediting_181587(54468054, +), CAediting_181588(54468125, +), CAediting_181589(54468145, +), CAediting_181590(54468148, +), CAediting_181591(54471150, +), CAediting_181592(54475121, +), CAediting_181593(54475376, +), CAediting_181594(54475377, +), CAediting_181595(54475408, +), CAediting_181596(54475412, +), CAediting_181597(54475418, +), CAediting_181598(54475435, +), CAediting_181599(54475455, +), CAediting_181600(54475468, +), CAediting_181601(54475534, +), CAediting_181602(54475590, +), CAediting_181603(54476126, +), CAediting_181604(54476140, +), CAediting_181605(54476156, +), CAediting_181606(54476224, +), CAediting_181607(54476271, +), CAediting_181608(54476289, +), CAediting_181609(54476309, +), CAediting_181610(54476310, +), CAediting_181611(54476311, +), CAediting_181612(54476312, +), CAediting_181613(54476315, +), CAediting_181614(54476317, +), CAediting_181615(54476364, +), CAediting_181616(54482370, +), CAediting_181617(54484101, +), CAediting_181618(54489095, +), CAediting_181619(54489611, +), CAediting_181620(54561306, +), CAediting_181621(54561317, +), CAediting_181622(54561323, +), CAediting_181623(54561368, +), CAediting_181624(54561369, +), CAediting_181625(54562660, +), CAediting_181626(54566258, +), CAediting_181627(54566288, +), CAediting_181628(54566291, +), CAediting_181629(54566397, +), CAediting_181630(54566431, +), CAediting_181631(54566666, +), CAediting_181632(54567401, +), CAediting_181633(54567414, +), CAediting_181634(54567453, +), CAediting_181635(54567486, +), CAediting_181636(54568125, +), CAediting_181637(54568126, +), CAediting_181638(54568195, +), CAediting_181639(54568204, +), CAediting_181640(54568216, +), CAediting_181641(54568260, +), CAediting_181642(54568261, +), CAediting_181643(54568285, +), CAediting_181644(54568307, +), CAediting_181645(54580902, +), CAediting_181646(54592046, +), CAediting_181647(54592047, +), CAediting_181648(54592514, +), CAediting_181649(54592524, +), CAediting_181650(54592622, +), CAediting_181651(54614700, +), CAediting_181652(54620542, +), CAediting_181653(54640607, +), CAediting_181654(54640621, +),

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RNA editing positional annotations for SPTBN1 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_181578chr2_54464713_+intronic
CAediting_181579chr2_54464751_+intronic
CAediting_181580chr2_54464755_+intronic
CAediting_181581chr2_54464776_+intronic
CAediting_181582chr2_54464789_+intronic
CAediting_181583chr2_54464790_+intronic
CAediting_181584chr2_54464873_+intronic
CAediting_181585chr2_54464875_+intronic
CAediting_181586chr2_54467499_+intronic
CAediting_181587chr2_54468054_+intronic
CAediting_181588chr2_54468125_+intronic
CAediting_181589chr2_54468145_+intronic
CAediting_181590chr2_54468148_+intronic
CAediting_181591chr2_54471150_+intronic
CAediting_181592chr2_54475121_+intronic
CAediting_181593chr2_54475376_+intronic
CAediting_181594chr2_54475377_+intronic
CAediting_181595chr2_54475408_+intronic
CAediting_181596chr2_54475412_+intronic
CAediting_181597chr2_54475418_+intronic
CAediting_181598chr2_54475435_+intronic
CAediting_181599chr2_54475455_+intronic
CAediting_181600chr2_54475468_+intronic
CAediting_181601chr2_54475534_+intronic
CAediting_181602chr2_54475590_+intronic
CAediting_181603chr2_54476126_+intronic
CAediting_181604chr2_54476140_+intronic
CAediting_181605chr2_54476156_+intronic
CAediting_181606chr2_54476224_+intronic
CAediting_181607chr2_54476271_+intronic
CAediting_181608chr2_54476289_+intronic
CAediting_181609chr2_54476309_+intronic
CAediting_181610chr2_54476310_+intronic
CAediting_181611chr2_54476311_+intronic
CAediting_181612chr2_54476312_+intronic
CAediting_181613chr2_54476315_+intronic
CAediting_181614chr2_54476317_+intronic
CAediting_181615chr2_54476364_+intronic
CAediting_181616chr2_54482370_+intronic
CAediting_181617chr2_54484101_+intronic
CAediting_181618chr2_54489095_+intronic
CAediting_181619chr2_54489611_+intronic
CAediting_181620chr2_54561306_+intronic
CAediting_181621chr2_54561317_+intronic
CAediting_181622chr2_54561323_+intronic
CAediting_181623chr2_54561368_+intronic
CAediting_181624chr2_54561369_+intronic
CAediting_181625chr2_54562660_+intronic
CAediting_181626chr2_54566258_+intronic
CAediting_181627chr2_54566288_+intronic
CAediting_181628chr2_54566291_+intronic
CAediting_181629chr2_54566397_+intronic
CAediting_181630chr2_54566431_+intronic
CAediting_181631chr2_54566666_+intronic
CAediting_181632chr2_54567401_+intronic
CAediting_181633chr2_54567414_+intronic
CAediting_181634chr2_54567453_+intronic
CAediting_181635chr2_54567486_+intronic
CAediting_181636chr2_54568125_+intronic
CAediting_181637chr2_54568126_+intronic
CAediting_181638chr2_54568195_+intronic
CAediting_181639chr2_54568204_+intronic
CAediting_181640chr2_54568216_+intronic
CAediting_181641chr2_54568260_+intronic
CAediting_181642chr2_54568261_+intronic
CAediting_181643chr2_54568285_+intronic
CAediting_181644chr2_54568307_+intronic
CAediting_181645chr2_54580902_+intronic
CAediting_181646chr2_54592046_+intronic
CAediting_181647chr2_54592047_+intronic
CAediting_181648chr2_54592514_+intronic
CAediting_181649chr2_54592524_+intronic
CAediting_181650chr2_54592622_+intronic
CAediting_181651chr2_54614700_+intronic
CAediting_181652chr2_54620542_+intronic
CAediting_181653chr2_54640607_+intronic
CAediting_181654chr2_54640621_+intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_181578chr2_54464713_+SINEAluAluJb
CAediting_181579chr2_54464751_+SINEAluAluJb
CAediting_181580chr2_54464755_+SINEAluAluJb
CAediting_181581chr2_54464776_+SINEAluAluJb
CAediting_181582chr2_54464789_+SINEAluAluJb
CAediting_181583chr2_54464790_+SINEAluAluJb
CAediting_181584chr2_54464873_+SINEAluAluJb
CAediting_181585chr2_54464875_+SINEAluAluJb
CAediting_181586chr2_54467499_+SINEAluAluSq10
CAediting_181587chr2_54468054_+SINEAluAluSx1
CAediting_181588chr2_54468125_+SINEAluAluSx1
CAediting_181589chr2_54468145_+SINEAluAluSx1
CAediting_181590chr2_54468148_+SINEAluAluSx1
CAediting_181591chr2_54471150_+SINEAluAluJo
CAediting_181592chr2_54475121_+SINEAluAluSq2
CAediting_181603chr2_54476126_+LTRERVL-MaLRMLT1I
CAediting_181604chr2_54476140_+LTRERVL-MaLRMLT1I
CAediting_181605chr2_54476156_+LTRERVL-MaLRMLT1I
CAediting_181607chr2_54476271_+LTRERVL-MaLRMLT1I
CAediting_181608chr2_54476289_+LTRERVL-MaLRMLT1I
CAediting_181609chr2_54476309_+LTRERVL-MaLRMLT1I
CAediting_181610chr2_54476310_+LTRERVL-MaLRMLT1I
CAediting_181611chr2_54476311_+LTRERVL-MaLRMLT1I
CAediting_181612chr2_54476312_+LTRERVL-MaLRMLT1I
CAediting_181613chr2_54476315_+LTRERVL-MaLRMLT1I
CAediting_181614chr2_54476317_+LTRERVL-MaLRMLT1I
CAediting_181616chr2_54482370_+SINEAluFLAM_C
CAediting_181617chr2_54484101_+SINEAluAluJb
CAediting_181618chr2_54489095_+SINEAluAluJb
CAediting_181619chr2_54489611_+SINEAluAluSz6
CAediting_181620chr2_54561306_+SINEAluAluJb
CAediting_181621chr2_54561317_+SINEAluAluJb
CAediting_181622chr2_54561323_+SINEAluAluJb
CAediting_181623chr2_54561368_+SINEAluAluJb
CAediting_181624chr2_54561369_+SINEAluAluJb
CAediting_181625chr2_54562660_+SINEAluAluJb
CAediting_181626chr2_54566258_+SINEAluAluSx1
CAediting_181627chr2_54566288_+SINEAluAluSx1
CAediting_181628chr2_54566291_+SINEAluAluSx1
CAediting_181629chr2_54566397_+SINEAluAluSx1
CAediting_181630chr2_54566431_+SINEAluAluSx1
CAediting_181631chr2_54566666_+SINEAluAluSx
CAediting_181632chr2_54567401_+SINEAluAluJb
CAediting_181633chr2_54567414_+SINEAluAluJb
CAediting_181634chr2_54567453_+SINEAluAluJb
CAediting_181635chr2_54567486_+SINEAluAluJb
CAediting_181636chr2_54568125_+SINEAluAluSx
CAediting_181637chr2_54568126_+SINEAluAluSx
CAediting_181638chr2_54568195_+SINEAluAluSx
CAediting_181639chr2_54568204_+SINEAluAluSx
CAediting_181640chr2_54568216_+SINEAluAluSx
CAediting_181641chr2_54568260_+SINEAluAluSx
CAediting_181642chr2_54568261_+SINEAluAluSx
CAediting_181643chr2_54568285_+SINEAluAluSx
CAediting_181644chr2_54568307_+SINEAluAluSx
CAediting_181645chr2_54580902_+SINEAluAluSz
CAediting_181646chr2_54592046_+SINEAluAluJr4
CAediting_181647chr2_54592047_+SINEAluAluJr4
CAediting_181648chr2_54592514_+SINEAluAluSp
CAediting_181649chr2_54592524_+SINEAluAluSp
CAediting_181650chr2_54592622_+SINEAluAluSp
CAediting_181651chr2_54614700_+SINEAluAluSx1
CAediting_181652chr2_54620542_+SINEAluFRAM
CAediting_181653chr2_54640607_+SINEAluAluSz
CAediting_181654chr2_54640621_+SINEAluAluSz

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RNA A-to-I editing events in the alternative splicing sites for SPTBN1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000115306.14.SPTBN1.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000115306.14.SPTBN1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SPTBN1

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for SPTBN1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for SPTBN1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_846604chr11_93733708_-ENSG00000115306.14ENST00000615901hsa-miR-1304-3p54670843546708508mer-1a5467083054670850142-20.11
CAediting_688080chr9_63819626_+ENSG00000115306.14ENST00000615901hsa-miR-4477b54668837546688437mer-m85466882254668844153-16.1
CAediting_688080chr9_63819626_+ENSG00000115306.14ENST00000615901hsa-miR-4477b54668664546686707mer-m85466864954668671155-14.52
CAediting_442554chr5_154685830_+ENSG00000115306.14ENST00000615901hsa-miR-130354668746546687527mer-m85466873254668753157-14.75
CAediting_1229413chr17_67471544_+ENSG00000115306.14ENST00000333896hsa-miR-548aa54660197546602048mer-1a5466018054660204140-7.95
CAediting_1229413chr17_67471544_+ENSG00000115306.14ENST00000333896hsa-miR-548aa54661263546612697mer-m85466124954661270145-16.95
CAediting_1351755chr19_40282625_-ENSG00000115306.14ENST00000333896hsa-miR-64154662236546622416mer5466221954662242144-17.01
CAediting_77128chr1_85133844_+ENSG00000115306.14ENST00000333896hsa-miR-4423-3p54662111546621177mer-m85466209854662118140-13.41
CAediting_573001chr7_92204086_-ENSG00000115306.14ENST00000333896hsa-miR-1285-5p54661319546613268mer-1a5466130654661326146-13.91

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393chr1_1167164_+ENSG00000115306.14ENST00000615901hsa-miR-200b-3p54668822546688287mer-m85466880854668829145-9.88
CAediting_604450chr7_133034877_-ENSG00000115306.14ENST00000615901hsa-miR-365454670378546703858mer-1a5467036654670385146-13.24
CAediting_77128chr1_85133844_+ENSG00000115306.14ENST00000615901hsa-miR-4423-3p54668653546686608mer-1a5466864154668660152-10.5
CAediting_396018chr5_1062918_-ENSG00000115306.14ENST00000615901hsa-miR-463554670919546709257mer-m85467090554670926146-13.25
CAediting_524911chr7_5495852_-ENSG00000115306.14ENST00000333896hsa-miR-589-3p54661559546615657mer-m85466154354661566154-12.58
CAediting_1351755chr19_40282625_-ENSG00000115306.14ENST00000333896hsa-miR-64154661434546614407mer-m85466141654661441147-10.77

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SPTBN1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for SPTBN1

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for SPTBN1

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for SPTBN1

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for SPTBN1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SPTBN1

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
SPTBN1C0043094Weight Gain1CTD_human