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Editing gene: SP3 (CAeditome ID:6670)

Gene summary for SP3

Gene summary

Gene information	Gene symbol	SP3
	Gene ID	6670
	Gene name	Sp3 transcription factor
	Synonyms	SPR2
	Cytomap	2q31.1
	Type of gene	protein-coding
	Description	transcription factor Sp3GC-binding transcription factor Sp3specificity protein 3
	Modification date	20210518
	UniProtAcc	Q02447
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
SP3	GO:0000977	Transcription factor Sp3	14979875
SP3	GO:1990837	Transcription factor Sp3	28473536
SP3	GO:0006355	Transcription factor Sp3	12560508
SP3	GO:0045893	Transcription factor Sp3	12771217

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RNA A-to-I events for SP3

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000172845.12

RNA A-to-I editing events in Cancer.

CAediting_225783(173920729, -), CAediting_225784(173921445, -), CAediting_225785(173921591, -), CAediting_225786(173921621, -), CAediting_225787(173921659, -), CAediting_225788(173921967, -), CAediting_225789(173921989, -), CAediting_225790(173922038, -), CAediting_225791(173926596, -), CAediting_225792(173927103, -), CAediting_225793(173927196, -), CAediting_225794(173927240, -), CAediting_225795(173927241, -), CAediting_225796(173931262, -), CAediting_225797(173931272, -), CAediting_225798(173931285, -), CAediting_225799(173931508, -), CAediting_225800(173931615, -), CAediting_225801(173931621, -), CAediting_225802(173931623, -), CAediting_225803(173932221, -), CAediting_225804(173932329, -), CAediting_225805(173932340, -), CAediting_225806(173932362, -), CAediting_225807(173932482, -), CAediting_225808(173932825, -), CAediting_225809(173932834, -), CAediting_225810(173932910, -), CAediting_225811(173934014, -), CAediting_225812(173934052, -), CAediting_225813(173934131, -), CAediting_225814(173934140, -), CAediting_225815(173934183, -), CAediting_225816(173935199, -), CAediting_225817(173935229, -), CAediting_225818(173936104, -), CAediting_225819(173936124, -), CAediting_225820(173936125, -), CAediting_225821(173936136, -), CAediting_225822(173936146, -), CAediting_225823(173936149, -), CAediting_225824(173936157, -), CAediting_225825(173936163, -), CAediting_225826(173936185, -), CAediting_225827(173936189, -), CAediting_225828(173936209, -), CAediting_225829(173936220, -), CAediting_225830(173936283, -), CAediting_225831(173936298, -), CAediting_225832(173938412, -), CAediting_225833(173940038, -), CAediting_225834(173940108, -), CAediting_225835(173941440, -), CAediting_225836(173941445, -), CAediting_225837(173943532, -), CAediting_225838(173943563, -), CAediting_225839(173943564, -), CAediting_225840(173943580, -), CAediting_225841(173943620, -), CAediting_225842(173944289, -), CAediting_225843(173944461, -), CAediting_225844(173944872, -), CAediting_225845(173945882, -), CAediting_225846(173946003, -), CAediting_225847(173946027, -), CAediting_225848(173946417, -), CAediting_225849(173946752, -), CAediting_225850(173946794, -), CAediting_225851(173946800, -), CAediting_225852(173946805, -), CAediting_225853(173946811, -), CAediting_225854(173946819, -), CAediting_225855(173946837, -), CAediting_225856(173946838, -), CAediting_225857(173946860, -), CAediting_225858(173946866, -), CAediting_225859(173946870, -), CAediting_225860(173946882, -), CAediting_225861(173946914, -), CAediting_225862(173946915, -), CAediting_225863(173946918, -), CAediting_225864(173946920, -), CAediting_225865(173946928, -), CAediting_225866(173946960, -), CAediting_225867(173946978, -), CAediting_225868(173946982, -), CAediting_225869(173946995, -), CAediting_225870(173946996, -), CAediting_225871(173947018, -), CAediting_225872(173965296, -), CAediting_225873(173965305, -), CAediting_225874(173965307, -),

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RNA editing positional annotations for SP3 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_225783	chr2_173920729_-	intronic
CAediting_225784	chr2_173921445_-	intronic
CAediting_225785	chr2_173921591_-	intronic
CAediting_225786	chr2_173921621_-	intronic
CAediting_225787	chr2_173921659_-	intronic
CAediting_225788	chr2_173921967_-	intronic
CAediting_225789	chr2_173921989_-	intronic
CAediting_225790	chr2_173922038_-	intronic
CAediting_225791	chr2_173926596_-	intronic
CAediting_225792	chr2_173927103_-	intronic
CAediting_225793	chr2_173927196_-	intronic
CAediting_225794	chr2_173927240_-	intronic
CAediting_225795	chr2_173927241_-	intronic
CAediting_225796	chr2_173931262_-	intronic
CAediting_225797	chr2_173931272_-	intronic
CAediting_225798	chr2_173931285_-	intronic
CAediting_225799	chr2_173931508_-	intronic
CAediting_225800	chr2_173931615_-	intronic
CAediting_225801	chr2_173931621_-	intronic
CAediting_225802	chr2_173931623_-	intronic
CAediting_225803	chr2_173932221_-	intronic
CAediting_225804	chr2_173932329_-	intronic
CAediting_225805	chr2_173932340_-	intronic
CAediting_225806	chr2_173932362_-	intronic
CAediting_225807	chr2_173932482_-	intronic
CAediting_225808	chr2_173932825_-	intronic
CAediting_225809	chr2_173932834_-	intronic
CAediting_225810	chr2_173932910_-	intronic
CAediting_225811	chr2_173934014_-	intronic
CAediting_225812	chr2_173934052_-	intronic
CAediting_225813	chr2_173934131_-	intronic
CAediting_225814	chr2_173934140_-	intronic
CAediting_225815	chr2_173934183_-	intronic
CAediting_225816	chr2_173935199_-	intronic
CAediting_225817	chr2_173935229_-	intronic
CAediting_225818	chr2_173936104_-	intronic
CAediting_225819	chr2_173936124_-	intronic
CAediting_225820	chr2_173936125_-	intronic
CAediting_225821	chr2_173936136_-	intronic
CAediting_225822	chr2_173936146_-	intronic
CAediting_225823	chr2_173936149_-	intronic
CAediting_225824	chr2_173936157_-	intronic
CAediting_225825	chr2_173936163_-	intronic
CAediting_225826	chr2_173936185_-	intronic
CAediting_225827	chr2_173936189_-	intronic
CAediting_225828	chr2_173936209_-	intronic
CAediting_225829	chr2_173936220_-	intronic
CAediting_225830	chr2_173936283_-	intronic
CAediting_225831	chr2_173936298_-	intronic
CAediting_225832	chr2_173938412_-	intronic
CAediting_225833	chr2_173940038_-	intronic
CAediting_225834	chr2_173940108_-	intronic
CAediting_225835	chr2_173941440_-	intronic
CAediting_225836	chr2_173941445_-	intronic
CAediting_225837	chr2_173943532_-	intronic
CAediting_225838	chr2_173943563_-	intronic
CAediting_225839	chr2_173943564_-	intronic
CAediting_225840	chr2_173943580_-	intronic
CAediting_225841	chr2_173943620_-	intronic
CAediting_225842	chr2_173944289_-	intronic
CAediting_225843	chr2_173944461_-	intronic
CAediting_225844	chr2_173944872_-	intronic
CAediting_225845	chr2_173945882_-	intronic
CAediting_225846	chr2_173946003_-	intronic
CAediting_225847	chr2_173946027_-	intronic
CAediting_225848	chr2_173946417_-	intronic
CAediting_225849	chr2_173946752_-	intronic
CAediting_225850	chr2_173946794_-	intronic
CAediting_225851	chr2_173946800_-	intronic
CAediting_225852	chr2_173946805_-	intronic
CAediting_225853	chr2_173946811_-	intronic
CAediting_225854	chr2_173946819_-	intronic
CAediting_225855	chr2_173946837_-	intronic
CAediting_225856	chr2_173946838_-	intronic
CAediting_225857	chr2_173946860_-	intronic
CAediting_225858	chr2_173946866_-	intronic
CAediting_225859	chr2_173946870_-	intronic
CAediting_225860	chr2_173946882_-	intronic
CAediting_225861	chr2_173946914_-	intronic
CAediting_225862	chr2_173946915_-	intronic
CAediting_225863	chr2_173946918_-	intronic
CAediting_225864	chr2_173946920_-	intronic
CAediting_225865	chr2_173946928_-	intronic
CAediting_225866	chr2_173946960_-	intronic
CAediting_225867	chr2_173946978_-	intronic
CAediting_225868	chr2_173946982_-	intronic
CAediting_225869	chr2_173946995_-	intronic
CAediting_225870	chr2_173946996_-	intronic
CAediting_225871	chr2_173947018_-	intronic
CAediting_225872	chr2_173965296_-	ncRNA_exonic
CAediting_225873	chr2_173965305_-	ncRNA_exonic
CAediting_225874	chr2_173965307_-	ncRNA_exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_225783	chr2_173920729_-	SINE	Alu	AluSx1
CAediting_225784	chr2_173921445_-	SINE	Alu	AluJo
CAediting_225785	chr2_173921591_-	SINE	Alu	AluJo
CAediting_225786	chr2_173921621_-	SINE	Alu	AluJo
CAediting_225787	chr2_173921659_-	SINE	Alu	AluJo
CAediting_225788	chr2_173921967_-	LTR	ERVL-MaLR	MSTA
CAediting_225789	chr2_173921989_-	LTR	ERVL-MaLR	MSTA
CAediting_225790	chr2_173922038_-	LTR	ERVL-MaLR	MSTA
CAediting_225791	chr2_173926596_-	SINE	Alu	AluJo
CAediting_225792	chr2_173927103_-	LTR	ERVL-MaLR	MSTA
CAediting_225793	chr2_173927196_-	LTR	ERVL-MaLR	MSTA
CAediting_225794	chr2_173927240_-	LTR	ERVL-MaLR	MSTA
CAediting_225795	chr2_173927241_-	LTR	ERVL-MaLR	MSTA
CAediting_225796	chr2_173931262_-	SINE	Alu	AluSz
CAediting_225797	chr2_173931272_-	SINE	Alu	AluSz
CAediting_225798	chr2_173931285_-	SINE	Alu	AluSz
CAediting_225799	chr2_173931508_-	SINE	Alu	AluSx4
CAediting_225800	chr2_173931615_-	SINE	Alu	AluSx4
CAediting_225801	chr2_173931621_-	SINE	Alu	AluSx4
CAediting_225802	chr2_173931623_-	SINE	Alu	AluSx4
CAediting_225803	chr2_173932221_-	SINE	Alu	AluSq2
CAediting_225804	chr2_173932329_-	SINE	Alu	AluSq2
CAediting_225805	chr2_173932340_-	SINE	Alu	AluSq2
CAediting_225806	chr2_173932362_-	SINE	Alu	AluSq2
CAediting_225807	chr2_173932482_-	SINE	Alu	AluSq2
CAediting_225808	chr2_173932825_-	SINE	Alu	AluY
CAediting_225809	chr2_173932834_-	SINE	Alu	AluY
CAediting_225810	chr2_173932910_-	SINE	Alu	AluY
CAediting_225811	chr2_173934014_-	SINE	Alu	AluJo
CAediting_225812	chr2_173934052_-	SINE	Alu	AluJo
CAediting_225813	chr2_173934131_-	SINE	Alu	AluJo
CAediting_225814	chr2_173934140_-	SINE	Alu	AluJo
CAediting_225815	chr2_173934183_-	SINE	Alu	AluJo
CAediting_225816	chr2_173935199_-	SINE	Alu	FRAM
CAediting_225817	chr2_173935229_-	SINE	Alu	FRAM
CAediting_225818	chr2_173936104_-	SINE	Alu	AluSx
CAediting_225819	chr2_173936124_-	SINE	Alu	AluSx
CAediting_225820	chr2_173936125_-	SINE	Alu	AluSx
CAediting_225821	chr2_173936136_-	SINE	Alu	AluSx
CAediting_225822	chr2_173936146_-	SINE	Alu	AluSx
CAediting_225823	chr2_173936149_-	SINE	Alu	AluSx
CAediting_225824	chr2_173936157_-	SINE	Alu	AluSx
CAediting_225825	chr2_173936163_-	SINE	Alu	AluSx
CAediting_225826	chr2_173936185_-	SINE	Alu	AluSx
CAediting_225827	chr2_173936189_-	SINE	Alu	AluSx
CAediting_225828	chr2_173936209_-	SINE	Alu	AluSx
CAediting_225829	chr2_173936220_-	SINE	Alu	AluSx
CAediting_225830	chr2_173936283_-	SINE	Alu	AluSx
CAediting_225831	chr2_173936298_-	SINE	Alu	AluSx
CAediting_225832	chr2_173938412_-	SINE	Alu	AluSq2
CAediting_225833	chr2_173940038_-	SINE	Alu	AluSz6
CAediting_225834	chr2_173940108_-	SINE	Alu	AluSz6
CAediting_225835	chr2_173941440_-	SINE	Alu	AluJb
CAediting_225836	chr2_173941445_-	SINE	Alu	AluJb
CAediting_225837	chr2_173943532_-	SINE	Alu	FLAM_C
CAediting_225838	chr2_173943563_-	SINE	Alu	FLAM_C
CAediting_225839	chr2_173943564_-	SINE	Alu	FLAM_C
CAediting_225840	chr2_173943580_-	SINE	Alu	FLAM_C
CAediting_225841	chr2_173943620_-	SINE	Alu	FLAM_C
CAediting_225842	chr2_173944289_-	SINE	Alu	AluJb
CAediting_225843	chr2_173944461_-	SINE	Alu	AluJb
CAediting_225844	chr2_173944872_-	SINE	Alu	AluSz
CAediting_225845	chr2_173945882_-	SINE	Alu	AluSx1
CAediting_225846	chr2_173946003_-	SINE	Alu	AluSx1
CAediting_225847	chr2_173946027_-	SINE	Alu	AluSx1
CAediting_225848	chr2_173946417_-	SINE	Alu	FLAM_A
CAediting_225849	chr2_173946752_-	SINE	Alu	AluJb
CAediting_225850	chr2_173946794_-	SINE	Alu	AluJb
CAediting_225851	chr2_173946800_-	SINE	Alu	AluJb
CAediting_225852	chr2_173946805_-	SINE	Alu	AluJb
CAediting_225853	chr2_173946811_-	SINE	Alu	AluJb
CAediting_225854	chr2_173946819_-	SINE	Alu	AluJb
CAediting_225855	chr2_173946837_-	SINE	Alu	AluJb
CAediting_225856	chr2_173946838_-	SINE	Alu	AluJb
CAediting_225857	chr2_173946860_-	SINE	Alu	AluJb
CAediting_225858	chr2_173946866_-	SINE	Alu	AluJb
CAediting_225859	chr2_173946870_-	SINE	Alu	AluJb
CAediting_225860	chr2_173946882_-	SINE	Alu	AluJb
CAediting_225861	chr2_173946914_-	SINE	Alu	AluJb
CAediting_225862	chr2_173946915_-	SINE	Alu	AluJb
CAediting_225863	chr2_173946918_-	SINE	Alu	AluJb
CAediting_225864	chr2_173946920_-	SINE	Alu	AluJb
CAediting_225865	chr2_173946928_-	SINE	Alu	AluJb
CAediting_225866	chr2_173946960_-	SINE	Alu	AluJb
CAediting_225867	chr2_173946978_-	SINE	Alu	AluJb
CAediting_225868	chr2_173946982_-	SINE	Alu	AluJb
CAediting_225869	chr2_173946995_-	SINE	Alu	AluJb
CAediting_225870	chr2_173946996_-	SINE	Alu	AluJb
CAediting_225871	chr2_173947018_-	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for SP3

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000172845.12.SP3.

Correlation between RNA A-to-I editing and PSI for ENSG00000172845.12.SP3.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SP3

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for SP3

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for SP3

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1229414	chr17_67471546_+	ENSG00000172845.12	ENST00000418194	hsa-miR-548aa	173908717	173908723	7mer-m8	173908716	173908742	166	-15.85
CAediting_1351755	chr19_40282625_-	ENSG00000172845.12	ENST00000418194	hsa-miR-641	173909068	173909074	7mer-m8	173909067	173909092	143	-14.61
CAediting_117844	chr1_162342605_+	ENSG00000172845.12	ENST00000418194	hsa-miR-556-3p	173909236	173909242	7mer-m8	173909235	173909254	144	-12.66
CAediting_1229414	chr17_67471546_+	ENSG00000172845.12	ENST00000416195	hsa-miR-548aa	173908717	173908723	7mer-m8	173908716	173908742	166	-15.85
CAediting_1351755	chr19_40282625_-	ENSG00000172845.12	ENST00000416195	hsa-miR-641	173909068	173909074	7mer-m8	173909067	173909092	143	-14.61
CAediting_117844	chr1_162342605_+	ENSG00000172845.12	ENST00000416195	hsa-miR-556-3p	173909236	173909242	7mer-m8	173909235	173909254	144	-12.66

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1160181	chr17_7017644_-	ENSG00000172845.12	ENST00000418194	hsa-miR-195-3p	173909882	173909888	7mer-m8	173909881	173909902	152	-11.03
CAediting_1351755	chr19_40282625_-	ENSG00000172845.12	ENST00000418194	hsa-miR-641	173909270	173909276	7mer-m8	173909269	173909292	140	-8.51
CAediting_1160181	chr17_7017644_-	ENSG00000172845.12	ENST00000416195	hsa-miR-195-3p	173909882	173909888	7mer-m8	173909881	173909902	152	-11.03
CAediting_1351755	chr19_40282625_-	ENSG00000172845.12	ENST00000416195	hsa-miR-641	173909270	173909276	7mer-m8	173909269	173909292	140	-8.51

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SP3

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000310015.9	protein_coding
ENST00000462904.1	processed_transcript

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_225872	ENST00000310015.9	chr2_173965296_-	-1731.77	-1731.77	-1737.87
CAediting_225873	ENST00000310015.9	chr2_173965305_-	-1734.07	-1731.77	-1737.87
CAediting_225874	ENST00000310015.9	chr2_173965307_-	-1732.17	-1731.77	-1737.87
CAediting_225872	ENST00000462904.1	chr2_173965296_-	-139.30	-139.30	-142.80
CAediting_225873	ENST00000462904.1	chr2_173965305_-	-140.30	-139.30	-142.80
CAediting_225874	ENST00000462904.1	chr2_173965307_-	-139.30	-139.30	-142.80

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Relation with ADAR for SP3

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for SP3

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
STAD	pathologic_stage	CAediting_225851	chr2_173946800_-	0.0360618080411093	0.206832841902945

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Relation with survival for SP3

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for SP3

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SP3

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene