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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: CAPN15 (CAeditome ID:6650)

Gene summary for CAPN15

check button Gene summary
Gene informationGene symbol

CAPN15

Gene ID

6650

Gene namecalpain 15
SynonymsOGIN|SOLH
Cytomap

16p13.3

Type of geneprotein-coding
Descriptioncalpain-15small optic lobes homolog
Modification date20210518
UniProtAcc

O75808

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for CAPN15

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000103326.9
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_1077384(531224, +), CAediting_1077385(531278, +), CAediting_1077386(531298, +), CAediting_1077387(531299, +), CAediting_1077388(531316, +), CAediting_1077389(531326, +), CAediting_1077390(531337, +), CAediting_1077391(531985, +), CAediting_1077392(532119, +), CAediting_1077393(532160, +), CAediting_1077394(532161, +), CAediting_1077395(532185, +), CAediting_1077396(532197, +), CAediting_1077397(532435, +), CAediting_1077398(532475, +), CAediting_1077399(533142, +), CAediting_1077400(536518, +), CAediting_1077401(536522, +), CAediting_1077402(536527, +), CAediting_1077403(536540, +), CAediting_1077404(536548, +), CAediting_1077405(536549, +), CAediting_1077406(536552, +), CAediting_1077407(536562, +), CAediting_1077408(536615, +), CAediting_1077409(536635, +), CAediting_1077410(536640, +), CAediting_1077411(536671, +), CAediting_1077412(536684, +), CAediting_1077413(536716, +), CAediting_1077414(537389, +), CAediting_1077415(539011, +), CAediting_1077416(539016, +), CAediting_1077417(539028, +), CAediting_1077418(539032, +), CAediting_1077419(539040, +), CAediting_1077420(539118, +), CAediting_1077421(542601, +), CAediting_1077422(542605, +), CAediting_1077423(542607, +), CAediting_1077424(542611, +), CAediting_1077425(542627, +), CAediting_1077426(542638, +), CAediting_1077427(542641, +), CAediting_1077428(542643, +), CAediting_1077429(542657, +), CAediting_1077430(542662, +), CAediting_1077431(542667, +), CAediting_1077432(542674, +), CAediting_1077433(542690, +), CAediting_1077434(542705, +), CAediting_1077435(542717, +), CAediting_1077436(542729, +), CAediting_1077437(542785, +), CAediting_1077438(542799, +), CAediting_1077439(542821, +), CAediting_1077440(542852, +), CAediting_1077441(542855, +), CAediting_1077442(542904, +), CAediting_1077443(542930, +), CAediting_1077444(542943, +), CAediting_1077445(542953, +), CAediting_1077446(542957, +), CAediting_1077447(542971, +), CAediting_1077448(542972, +), CAediting_1077449(543016, +), CAediting_1077450(543033, +), CAediting_1077451(543035, +), CAediting_1077452(543095, +), CAediting_1077453(543098, +), CAediting_1077454(543350, +), CAediting_1077455(544586, +), CAediting_1077456(545128, +), CAediting_1077457(545139, +), CAediting_1077458(545589, +), CAediting_1077459(545710, +), CAediting_1077460(545711, +),

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RNA editing positional annotations for CAPN15 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1077384chr16_531224_+ncRNA_intronic
CAediting_1077385chr16_531278_+ncRNA_intronic
CAediting_1077386chr16_531298_+ncRNA_intronic
CAediting_1077387chr16_531299_+ncRNA_intronic
CAediting_1077388chr16_531316_+ncRNA_intronic
CAediting_1077389chr16_531326_+ncRNA_intronic
CAediting_1077390chr16_531337_+ncRNA_intronic
CAediting_1077391chr16_531985_+ncRNA_intronic
CAediting_1077392chr16_532119_+ncRNA_intronic
CAediting_1077393chr16_532160_+ncRNA_intronic
CAediting_1077394chr16_532161_+ncRNA_intronic
CAediting_1077395chr16_532185_+ncRNA_intronic
CAediting_1077396chr16_532197_+ncRNA_intronic
CAediting_1077397chr16_532435_+ncRNA_intronic
CAediting_1077398chr16_532475_+ncRNA_intronic
CAediting_1077399chr16_533142_+ncRNA_intronic
CAediting_1077400chr16_536518_+ncRNA_intronic
CAediting_1077401chr16_536522_+ncRNA_intronic
CAediting_1077402chr16_536527_+ncRNA_intronic
CAediting_1077403chr16_536540_+ncRNA_intronic
CAediting_1077404chr16_536548_+ncRNA_intronic
CAediting_1077405chr16_536549_+ncRNA_intronic
CAediting_1077406chr16_536552_+ncRNA_intronic
CAediting_1077407chr16_536562_+ncRNA_intronic
CAediting_1077408chr16_536615_+ncRNA_intronic
CAediting_1077409chr16_536635_+ncRNA_intronic
CAediting_1077410chr16_536640_+ncRNA_intronic
CAediting_1077411chr16_536671_+ncRNA_intronic
CAediting_1077412chr16_536684_+ncRNA_intronic
CAediting_1077413chr16_536716_+ncRNA_intronic
CAediting_1077414chr16_537389_+ncRNA_exonic
CAediting_1077415chr16_539011_+ncRNA_exonic
CAediting_1077416chr16_539016_+ncRNA_exonic
CAediting_1077417chr16_539028_+ncRNA_exonic
CAediting_1077418chr16_539032_+ncRNA_exonic
CAediting_1077419chr16_539040_+ncRNA_exonic
CAediting_1077420chr16_539118_+ncRNA_exonic
CAediting_1077421chr16_542601_+intronic
CAediting_1077422chr16_542605_+intronic
CAediting_1077423chr16_542607_+intronic
CAediting_1077424chr16_542611_+intronic
CAediting_1077425chr16_542627_+intronic
CAediting_1077426chr16_542638_+intronic
CAediting_1077427chr16_542641_+intronic
CAediting_1077428chr16_542643_+intronic
CAediting_1077429chr16_542657_+intronic
CAediting_1077430chr16_542662_+intronic
CAediting_1077431chr16_542667_+intronic
CAediting_1077432chr16_542674_+intronic
CAediting_1077433chr16_542690_+intronic
CAediting_1077434chr16_542705_+intronic
CAediting_1077435chr16_542717_+intronic
CAediting_1077436chr16_542729_+intronic
CAediting_1077437chr16_542785_+intronic
CAediting_1077438chr16_542799_+intronic
CAediting_1077439chr16_542821_+intronic
CAediting_1077440chr16_542852_+intronic
CAediting_1077441chr16_542855_+intronic
CAediting_1077442chr16_542904_+intronic
CAediting_1077443chr16_542930_+intronic
CAediting_1077444chr16_542943_+intronic
CAediting_1077445chr16_542953_+intronic
CAediting_1077446chr16_542957_+intronic
CAediting_1077447chr16_542971_+intronic
CAediting_1077448chr16_542972_+intronic
CAediting_1077449chr16_543016_+intronic
CAediting_1077450chr16_543033_+intronic
CAediting_1077451chr16_543035_+intronic
CAediting_1077452chr16_543095_+intronic
CAediting_1077453chr16_543098_+intronic
CAediting_1077454chr16_543350_+ncRNA_exonic
CAediting_1077455chr16_544586_+intronic
CAediting_1077456chr16_545128_+intronic
CAediting_1077457chr16_545139_+intronic
CAediting_1077458chr16_545589_+intronic
CAediting_1077459chr16_545710_+intronic
CAediting_1077460chr16_545711_+intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1077384chr16_531224_+SINEAluAluJo
CAediting_1077385chr16_531278_+SINEAluAluJo
CAediting_1077386chr16_531298_+SINEAluAluJo
CAediting_1077387chr16_531299_+SINEAluAluJo
CAediting_1077388chr16_531316_+SINEAluAluJo
CAediting_1077389chr16_531326_+SINEAluAluJo
CAediting_1077390chr16_531337_+SINEAluAluJo
CAediting_1077391chr16_531985_+SINEAluAluSx
CAediting_1077392chr16_532119_+SINEAluAluSx
CAediting_1077393chr16_532160_+SINEAluAluSx
CAediting_1077394chr16_532161_+SINEAluAluSx
CAediting_1077395chr16_532185_+SINEAluAluSx
CAediting_1077396chr16_532197_+SINEAluAluSx
CAediting_1077397chr16_532435_+SINEAluAluSz6
CAediting_1077398chr16_532475_+SINEAluAluSz6
CAediting_1077399chr16_533142_+SINEAluAluSx1
CAediting_1077400chr16_536518_+SINEAluAluSg4
CAediting_1077401chr16_536522_+SINEAluAluSg4
CAediting_1077402chr16_536527_+SINEAluAluSg4
CAediting_1077403chr16_536540_+SINEAluAluSg4
CAediting_1077404chr16_536548_+SINEAluAluSg4
CAediting_1077405chr16_536549_+SINEAluAluSg4
CAediting_1077406chr16_536552_+SINEAluAluSg4
CAediting_1077407chr16_536562_+SINEAluAluSg4
CAediting_1077408chr16_536615_+SINEAluAluSg4
CAediting_1077409chr16_536635_+SINEAluAluSg4
CAediting_1077410chr16_536640_+SINEAluAluSg4
CAediting_1077411chr16_536671_+SINEAluAluSg4
CAediting_1077412chr16_536684_+SINEAluAluSg4
CAediting_1077413chr16_536716_+SINEAluAluSg4
CAediting_1077415chr16_539011_+SINEAluAluJr4
CAediting_1077416chr16_539016_+SINEAluAluJr4
CAediting_1077417chr16_539028_+SINEAluAluJr4
CAediting_1077418chr16_539032_+SINEAluAluJr4
CAediting_1077419chr16_539040_+SINEAluAluJr4
CAediting_1077420chr16_539118_+SINEAluAluJr4
CAediting_1077421chr16_542601_+SINEAluAluJb
CAediting_1077422chr16_542605_+SINEAluAluJb
CAediting_1077423chr16_542607_+SINEAluAluJb
CAediting_1077424chr16_542611_+SINEAluAluJb
CAediting_1077425chr16_542627_+SINEAluAluJb
CAediting_1077426chr16_542638_+SINEAluAluJb
CAediting_1077427chr16_542641_+SINEAluAluJb
CAediting_1077428chr16_542643_+SINEAluAluJb
CAediting_1077429chr16_542657_+SINEAluAluJb
CAediting_1077430chr16_542662_+SINEAluAluJb
CAediting_1077431chr16_542667_+SINEAluAluJb
CAediting_1077432chr16_542674_+SINEAluAluJb
CAediting_1077433chr16_542690_+SINEAluAluJb
CAediting_1077434chr16_542705_+SINEAluAluJb
CAediting_1077435chr16_542717_+SINEAluAluJb
CAediting_1077436chr16_542729_+SINEAluAluJb
CAediting_1077437chr16_542785_+SINEAluAluSx1
CAediting_1077438chr16_542799_+SINEAluAluSx1
CAediting_1077439chr16_542821_+SINEAluAluSx1
CAediting_1077440chr16_542852_+SINEAluAluSx1
CAediting_1077441chr16_542855_+SINEAluAluSx1
CAediting_1077442chr16_542904_+SINEAluAluSx1
CAediting_1077443chr16_542930_+SINEAluAluSx1
CAediting_1077444chr16_542943_+SINEAluAluSx1
CAediting_1077445chr16_542953_+SINEAluAluSx1
CAediting_1077446chr16_542957_+SINEAluAluSx1
CAediting_1077447chr16_542971_+SINEAluAluSx1
CAediting_1077448chr16_542972_+SINEAluAluSx1
CAediting_1077449chr16_543016_+SINEAluAluSx1
CAediting_1077450chr16_543033_+SINEAluAluSx1
CAediting_1077451chr16_543035_+SINEAluAluSx1
CAediting_1077452chr16_543095_+SINEAluAluJb
CAediting_1077453chr16_543098_+SINEAluAluJb
CAediting_1077456chr16_545128_+SINEAluAluJb
CAediting_1077457chr16_545139_+SINEAluAluJb

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RNA A-to-I editing events in the alternative splicing sites for CAPN15

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESCAediting_1077409chr16_536635_+536616:5366383SS0+1iGGGTTTCTCCATCTTGCGCAGGC-20.43GGGTTTCTCCATCTTGCGCGGGC-11.68
ESCAediting_1077414chr16_537389_+537384:5373925SS0+3iCTGGTAGGA6.77CTGGTGGGA3.33
MEX_1CAediting_1077414chr16_537389_+537384:5373925SS0+3iCTGGTAGGA6.77CTGGTGGGA3.33

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000103326.9.CAPN15.
boxplot

check button Correlation between RNA A-to-I editing and PSI for ENSG00000103326.9.CAPN15.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CAPN15

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CAPN15

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for CAPN15

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_748296chr10_51299626_+ENSG00000103326.9ENST00000219611hsa-miR-605-3p5543495543557mer-m8554335554356155-18.34
CAediting_980496chr14_31014685_-ENSG00000103326.9ENST00000219611hsa-miR-624-3p5542205542267mer-m8554209554227143-15
CAediting_980496chr14_31014685_-ENSG00000103326.9ENST00000219611hsa-miR-624-3p5544985545058mer-1a554483554505153-13.81
CAediting_1368054chr19_46709310_-ENSG00000103326.9ENST00000219611hsa-miR-320e5545135545197mer-m8554503554520140-16.61
CAediting_580943chr7_100356700_+ENSG00000103326.9ENST00000219611hsa-miR-6840-3p5540245540307mer-m8554010554031156-25.79
CAediting_1524209chrX_134546392_-ENSG00000103326.9ENST00000219611hsa-miR-503-5p5541825541876mer554165554188151-24.92

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CAPN15

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for CAPN15

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
STADCAediting_1077414chr16_537389_+0.04458124916744690.211095885356096....
ESCACAediting_1077422chr16_542605_+....0.02925426248168240.279322932210932
LAMLCAediting_1077422chr16_542605_+0.0188209215140470.3076225543077340.03371632611888260.2793269001291120.0467177624281320.262267012913627
STADCAediting_1077428chr16_542643_+0.03248902541589510.212976379620866....
STADCAediting_1077431chr16_542667_+0.01100842803948410.235283118000929....

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Relation with cancer stages for CAPN15

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for CAPN15

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for CAPN15

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CAPN15

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource