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Editing gene: SMN2 (CAeditome ID:6607)

Gene summary for SMN2

Gene summary

Gene information	Gene symbol	SMN2
	Gene ID	6607
	Gene name	survival of motor neuron 2, centromeric
	Synonyms	BCD541\|C-BCD541\|GEMIN1\|SMNC\|TDRD16B
	Cytomap	5q13.2
	Type of gene	protein-coding
	Description	survival motor neuron proteincomponent of gems 1gemin-1tudor domain containing 16B
	Modification date	20210531
	UniProtAcc	Q16637
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for SMN2

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000205571.11

RNA A-to-I editing events in Cancer.

CAediting_413615(70071222, +), CAediting_413616(70071300, +), CAediting_413617(70071766, +), CAediting_413618(70072894, +), CAediting_413619(70072935, +), CAediting_413620(70074523, +), CAediting_413621(70074532, +), CAediting_413622(70074536, +), CAediting_413623(70074563, +), CAediting_413624(70074564, +), CAediting_413625(70074598, +), CAediting_413626(70074622, +), CAediting_413627(70074721, +), CAediting_413628(70074729, +), CAediting_413629(70074738, +), CAediting_413630(70074759, +), CAediting_413631(70074760, +), CAediting_413632(70074807, +), CAediting_413633(70074845, +), CAediting_413634(70074871, +), CAediting_413635(70074881, +), CAediting_413636(70074894, +), CAediting_413637(70074913, +), CAediting_413638(70074942, +), CAediting_413639(70074971, +), CAediting_413640(70075047, +), CAediting_413641(70075092, +), CAediting_413642(70075128, +), CAediting_413643(70075129, +), CAediting_413644(70075168, +), CAediting_413645(70075176, +), CAediting_413646(70075523, +), CAediting_413647(70075532, +), CAediting_413648(70075534, +), CAediting_413649(70075558, +), CAediting_413650(70075570, +), CAediting_413651(70075582, +), CAediting_413652(70075608, +), CAediting_413653(70075610, +), CAediting_413654(70075616, +), CAediting_413655(70075628, +), CAediting_413656(70075630, +), CAediting_413657(70075637, +), CAediting_413658(70075698, +), CAediting_413659(70075705, +), CAediting_413660(70075730, +), CAediting_413661(70075743, +), CAediting_413662(70075774, +), CAediting_413663(70075777, +), CAediting_413664(70075786, +), CAediting_413665(70075791, +), CAediting_413666(70075874, +), CAediting_413667(70075923, +), CAediting_413668(70075953, +), CAediting_413669(70075954, +), CAediting_413670(70075958, +), CAediting_413671(70075979, +), CAediting_413672(70075980, +), CAediting_413673(70075983, +), CAediting_413674(70075993, +), CAediting_413675(70076003, +), CAediting_413676(70076019, +), CAediting_413677(70076020, +), CAediting_413678(70076029, +), CAediting_413679(70076035, +), CAediting_413680(70076038, +), CAediting_413681(70076041, +), CAediting_413682(70076042, +), CAediting_413683(70076064, +), CAediting_413684(70076077, +), CAediting_413685(70076084, +), CAediting_413686(70076089, +), CAediting_413687(70076115, +), CAediting_413688(70076116, +), CAediting_413689(70076117, +), CAediting_413690(70076129, +), CAediting_413691(70076229, +), CAediting_413692(70076244, +), CAediting_413693(70076256, +), CAediting_413694(70076270, +), CAediting_413695(70076271, +),

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RNA editing positional annotations for SMN2 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_413615	chr5_70071222_+	ncRNA_intronic
CAediting_413616	chr5_70071300_+	exonic
CAediting_413617	chr5_70071766_+	ncRNA_intronic
CAediting_413618	chr5_70072894_+	ncRNA_intronic
CAediting_413619	chr5_70072935_+	ncRNA_intronic
CAediting_413620	chr5_70074523_+	ncRNA_intronic
CAediting_413621	chr5_70074532_+	ncRNA_intronic
CAediting_413622	chr5_70074536_+	ncRNA_intronic
CAediting_413623	chr5_70074563_+	ncRNA_intronic
CAediting_413624	chr5_70074564_+	ncRNA_intronic
CAediting_413625	chr5_70074598_+	ncRNA_intronic
CAediting_413626	chr5_70074622_+	ncRNA_intronic
CAediting_413627	chr5_70074721_+	ncRNA_intronic
CAediting_413628	chr5_70074729_+	ncRNA_intronic
CAediting_413629	chr5_70074738_+	ncRNA_intronic
CAediting_413630	chr5_70074759_+	ncRNA_intronic
CAediting_413631	chr5_70074760_+	ncRNA_intronic
CAediting_413632	chr5_70074807_+	ncRNA_intronic
CAediting_413633	chr5_70074845_+	ncRNA_intronic
CAediting_413634	chr5_70074871_+	ncRNA_intronic
CAediting_413635	chr5_70074881_+	ncRNA_intronic
CAediting_413636	chr5_70074894_+	ncRNA_intronic
CAediting_413637	chr5_70074913_+	ncRNA_intronic
CAediting_413638	chr5_70074942_+	ncRNA_intronic
CAediting_413639	chr5_70074971_+	ncRNA_intronic
CAediting_413640	chr5_70075047_+	ncRNA_intronic
CAediting_413641	chr5_70075092_+	ncRNA_intronic
CAediting_413642	chr5_70075128_+	ncRNA_intronic
CAediting_413643	chr5_70075129_+	ncRNA_intronic
CAediting_413644	chr5_70075168_+	ncRNA_intronic
CAediting_413645	chr5_70075176_+	ncRNA_intronic
CAediting_413646	chr5_70075523_+	ncRNA_intronic
CAediting_413647	chr5_70075532_+	ncRNA_intronic
CAediting_413648	chr5_70075534_+	ncRNA_intronic
CAediting_413649	chr5_70075558_+	ncRNA_intronic
CAediting_413650	chr5_70075570_+	ncRNA_intronic
CAediting_413651	chr5_70075582_+	ncRNA_intronic
CAediting_413652	chr5_70075608_+	ncRNA_intronic
CAediting_413653	chr5_70075610_+	ncRNA_intronic
CAediting_413654	chr5_70075616_+	ncRNA_intronic
CAediting_413655	chr5_70075628_+	ncRNA_intronic
CAediting_413656	chr5_70075630_+	ncRNA_intronic
CAediting_413657	chr5_70075637_+	ncRNA_intronic
CAediting_413658	chr5_70075698_+	ncRNA_intronic
CAediting_413659	chr5_70075705_+	ncRNA_intronic
CAediting_413660	chr5_70075730_+	ncRNA_intronic
CAediting_413661	chr5_70075743_+	ncRNA_intronic
CAediting_413662	chr5_70075774_+	ncRNA_intronic
CAediting_413663	chr5_70075777_+	ncRNA_intronic
CAediting_413664	chr5_70075786_+	ncRNA_intronic
CAediting_413665	chr5_70075791_+	ncRNA_intronic
CAediting_413666	chr5_70075874_+	ncRNA_intronic
CAediting_413667	chr5_70075923_+	ncRNA_intronic
CAediting_413668	chr5_70075953_+	ncRNA_intronic
CAediting_413669	chr5_70075954_+	ncRNA_intronic
CAediting_413670	chr5_70075958_+	ncRNA_intronic
CAediting_413671	chr5_70075979_+	ncRNA_intronic
CAediting_413672	chr5_70075980_+	ncRNA_intronic
CAediting_413673	chr5_70075983_+	ncRNA_intronic
CAediting_413674	chr5_70075993_+	ncRNA_intronic
CAediting_413675	chr5_70076003_+	ncRNA_intronic
CAediting_413676	chr5_70076019_+	ncRNA_intronic
CAediting_413677	chr5_70076020_+	ncRNA_intronic
CAediting_413678	chr5_70076029_+	ncRNA_intronic
CAediting_413679	chr5_70076035_+	ncRNA_intronic
CAediting_413680	chr5_70076038_+	ncRNA_intronic
CAediting_413681	chr5_70076041_+	ncRNA_intronic
CAediting_413682	chr5_70076042_+	ncRNA_intronic
CAediting_413683	chr5_70076064_+	ncRNA_intronic
CAediting_413684	chr5_70076077_+	ncRNA_intronic
CAediting_413685	chr5_70076084_+	ncRNA_intronic
CAediting_413686	chr5_70076089_+	ncRNA_intronic
CAediting_413687	chr5_70076115_+	ncRNA_intronic
CAediting_413688	chr5_70076116_+	ncRNA_intronic
CAediting_413689	chr5_70076117_+	ncRNA_intronic
CAediting_413690	chr5_70076129_+	ncRNA_intronic
CAediting_413691	chr5_70076229_+	ncRNA_intronic
CAediting_413692	chr5_70076244_+	ncRNA_intronic
CAediting_413693	chr5_70076256_+	ncRNA_intronic
CAediting_413694	chr5_70076270_+	ncRNA_intronic
CAediting_413695	chr5_70076271_+	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_413615	chr5_70071222_+	SINE	Alu	AluY
CAediting_413616	chr5_70071300_+	SINE	Alu	AluY
CAediting_413617	chr5_70071766_+	SINE	Alu	AluYc3
CAediting_413618	chr5_70072894_+	SINE	Alu	AluYj4
CAediting_413619	chr5_70072935_+	SINE	Alu	AluYj4
CAediting_413620	chr5_70074523_+	SINE	Alu	AluSp
CAediting_413621	chr5_70074532_+	SINE	Alu	AluSp
CAediting_413622	chr5_70074536_+	SINE	Alu	AluSp
CAediting_413623	chr5_70074563_+	SINE	Alu	AluSp
CAediting_413624	chr5_70074564_+	SINE	Alu	AluSp
CAediting_413625	chr5_70074598_+	SINE	Alu	AluSp
CAediting_413626	chr5_70074622_+	SINE	Alu	AluSp
CAediting_413627	chr5_70074721_+	SINE	Alu	AluSp
CAediting_413628	chr5_70074729_+	SINE	Alu	AluSp
CAediting_413629	chr5_70074738_+	SINE	Alu	AluSp
CAediting_413630	chr5_70074759_+	SINE	Alu	AluSp
CAediting_413631	chr5_70074760_+	SINE	Alu	AluSp
CAediting_413632	chr5_70074807_+	SINE	Alu	AluSp
CAediting_413633	chr5_70074845_+	SINE	Alu	AluSp
CAediting_413634	chr5_70074871_+	SINE	Alu	AluSp
CAediting_413635	chr5_70074881_+	SINE	Alu	AluSp
CAediting_413636	chr5_70074894_+	SINE	Alu	AluSp
CAediting_413637	chr5_70074913_+	SINE	Alu	AluSp
CAediting_413638	chr5_70074942_+	SINE	Alu	AluSp
CAediting_413639	chr5_70074971_+	SINE	Alu	AluSp
CAediting_413640	chr5_70075047_+	SINE	Alu	AluSp
CAediting_413641	chr5_70075092_+	SINE	Alu	AluSp
CAediting_413642	chr5_70075128_+	SINE	Alu	AluSp
CAediting_413643	chr5_70075129_+	SINE	Alu	AluSp
CAediting_413644	chr5_70075168_+	SINE	Alu	AluSp
CAediting_413645	chr5_70075176_+	SINE	Alu	AluSp
CAediting_413646	chr5_70075523_+	SINE	Alu	AluSp
CAediting_413647	chr5_70075532_+	SINE	Alu	AluSp
CAediting_413648	chr5_70075534_+	SINE	Alu	AluSp
CAediting_413649	chr5_70075558_+	SINE	Alu	AluSp
CAediting_413650	chr5_70075570_+	SINE	Alu	AluSp
CAediting_413651	chr5_70075582_+	SINE	Alu	AluSp
CAediting_413652	chr5_70075608_+	SINE	Alu	AluSp
CAediting_413653	chr5_70075610_+	SINE	Alu	AluSp
CAediting_413654	chr5_70075616_+	SINE	Alu	AluSp
CAediting_413655	chr5_70075628_+	SINE	Alu	AluSp
CAediting_413656	chr5_70075630_+	SINE	Alu	AluSp
CAediting_413657	chr5_70075637_+	SINE	Alu	AluSp
CAediting_413658	chr5_70075698_+	SINE	Alu	AluJr
CAediting_413659	chr5_70075705_+	SINE	Alu	AluJr
CAediting_413660	chr5_70075730_+	SINE	Alu	AluJr
CAediting_413661	chr5_70075743_+	SINE	Alu	AluJr
CAediting_413662	chr5_70075774_+	SINE	Alu	AluJr
CAediting_413663	chr5_70075777_+	SINE	Alu	AluJr
CAediting_413664	chr5_70075786_+	SINE	Alu	AluJr
CAediting_413665	chr5_70075791_+	SINE	Alu	AluJr
CAediting_413666	chr5_70075874_+	SINE	Alu	AluSx1
CAediting_413667	chr5_70075923_+	SINE	Alu	AluSx1
CAediting_413668	chr5_70075953_+	SINE	Alu	AluSx1
CAediting_413669	chr5_70075954_+	SINE	Alu	AluSx1
CAediting_413670	chr5_70075958_+	SINE	Alu	AluSx1
CAediting_413671	chr5_70075979_+	SINE	Alu	AluSx1
CAediting_413672	chr5_70075980_+	SINE	Alu	AluSx1
CAediting_413673	chr5_70075983_+	SINE	Alu	AluSx1
CAediting_413674	chr5_70075993_+	SINE	Alu	AluSx1
CAediting_413675	chr5_70076003_+	SINE	Alu	AluSx1
CAediting_413676	chr5_70076019_+	SINE	Alu	AluSx1
CAediting_413677	chr5_70076020_+	SINE	Alu	AluSx1
CAediting_413678	chr5_70076029_+	SINE	Alu	AluSx1
CAediting_413679	chr5_70076035_+	SINE	Alu	AluSx1
CAediting_413680	chr5_70076038_+	SINE	Alu	AluSx1
CAediting_413681	chr5_70076041_+	SINE	Alu	AluSx1
CAediting_413682	chr5_70076042_+	SINE	Alu	AluSx1
CAediting_413683	chr5_70076064_+	SINE	Alu	AluSx1
CAediting_413684	chr5_70076077_+	SINE	Alu	AluSx1
CAediting_413685	chr5_70076084_+	SINE	Alu	AluSx1
CAediting_413686	chr5_70076089_+	SINE	Alu	AluSx1
CAediting_413687	chr5_70076115_+	SINE	Alu	AluSx1
CAediting_413688	chr5_70076116_+	SINE	Alu	AluSx1
CAediting_413689	chr5_70076117_+	SINE	Alu	AluSx1
CAediting_413690	chr5_70076129_+	SINE	Alu	AluSx1
CAediting_413691	chr5_70076229_+	SINE	Alu	AluJr
CAediting_413692	chr5_70076244_+	SINE	Alu	AluJr
CAediting_413693	chr5_70076256_+	SINE	Alu	AluJr
CAediting_413694	chr5_70076270_+	SINE	Alu	AluJr
CAediting_413695	chr5_70076271_+	SINE	Alu	AluJr

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RNA A-to-I editing events in the alternative splicing sites for SMN2

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000205571.11.SMN2.

Correlation between RNA A-to-I editing and PSI for ENSG00000205571.11.SMN2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SMN2

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

THCA.CAediting_413680.ENSG00000205571.SMN2.png
Soverview

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Protein coding region RNA A-to-I editings for SMN2

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for SMN2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000205571.11	ENST00000511812	hsa-miR-200b-3p	70076585	70076591	7mer-1a	70076571	70076591	146	-12.11
CAediting_748296	chr10_51299626_+	ENSG00000205571.11	ENST00000507458	hsa-miR-605-3p	70077963	70077970	8mer-1a	70077946	70077970	149	-20.98
CAediting_396018	chr5_1062918_-	ENSG00000205571.11	ENST00000507458	hsa-miR-4635	70077966	70077972	7mer-m8	70077953	70077973	154	-16.09
CAediting_414656	chr5_72878640_+	ENSG00000205571.11	ENST00000507458	hsa-miR-4804-3p	70078175	70078181	7mer-m8	70078162	70078182	143	-13.6

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SMN2

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000506734.4	nonsense_mediated_decay
ENST00000628696.1	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_413616	ENST00000506734.4	chr5_70071300_+	-408.67	-409.57	-408.67
CAediting_413616	ENST00000628696.1	chr5_70071300_+	-239.17	-239.47	-239.17

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Relation with ADAR for SMN2

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for SMN2

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for SMN2

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for SMN2

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SMN2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
SMN2	C0026847	Spinal Muscular Atrophy	1	CTD_human;GENOMICS_ENGLAND
SMN2	C0270765	Myelopathic Muscular Atrophy	1	CTD_human
SMN2	C0393541	Distal Spinal Muscular Atrophy	1	CTD_human
SMN2	C0393546	Oculopharyngeal Spinal Muscular Atrophy	1	CTD_human
SMN2	C0393547	Bulbospinal Neuronopathy	1	CTD_human
SMN2	C0751334	Progressive Proximal Myelopathic Muscular Atrophy	1	CTD_human
SMN2	C0751335	Scapuloperoneal Form of Spinal Muscular Atrophy	1	CTD_human
SMN2	C0917981	Progressive Muscular Atrophy	1	CTD_human
SMN2	C3661519	Hereditary Motor Neuronopathy	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene