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Editing gene: AACS (CAeditome ID:65985)

Gene summary for AACS

Gene summary

Gene information	Gene symbol	AACS
	Gene ID	65985
	Gene name	acetoacetyl-CoA synthetase
	Synonyms	ACSF1\|SUR-5
	Cytomap	12q24.31
	Type of gene	protein-coding
	Description	acetoacetyl-CoA synthetaseacetoacetate-CoA ligaseacyl-CoA synthetase family member 1homolog of C. elegans supressor of ras 5 (sur-5)protein sur-5 homolog
	Modification date	20210518
	UniProtAcc	Q86V21
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for AACS

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000081760.15

RNA A-to-I editing events in Cancer.

CAediting_947160(125068219, +), CAediting_947161(125068302, +), CAediting_947162(125074400, +), CAediting_947163(125107736, +), CAediting_947164(125107783, +), CAediting_947165(125107784, +), CAediting_947166(125109257, +), CAediting_947167(125114531, +), CAediting_947168(125117730, +), CAediting_947169(125117731, +), CAediting_947170(125117785, +), CAediting_947171(125117800, +), CAediting_947172(125117803, +), CAediting_947173(125117804, +), CAediting_947174(125117829, +), CAediting_947175(125117869, +), CAediting_947176(125117890, +), CAediting_947177(125117904, +), CAediting_947178(125117909, +), CAediting_947179(125122558, +), CAediting_947180(125124081, +), CAediting_947181(125124111, +), CAediting_947182(125124112, +), CAediting_947183(125124114, +), CAediting_947184(125124130, +), CAediting_947185(125124166, +), CAediting_947186(125124174, +), CAediting_947187(125124205, +), CAediting_947188(125124206, +), CAediting_947189(125124210, +), CAediting_947190(125124220, +), CAediting_947191(125126601, +), CAediting_947192(125126646, +), CAediting_947193(125126661, +), CAediting_947194(125126675, +), CAediting_947195(125126682, +), CAediting_947196(125126715, +), CAediting_947197(125126818, +), CAediting_947198(125127032, +), CAediting_947199(125127046, +), CAediting_947200(125127075, +), CAediting_947201(125127641, +), CAediting_947202(125130961, +), CAediting_947203(125131351, +), CAediting_947204(125132116, +), CAediting_947205(125135804, +), CAediting_947206(125136212, +), CAediting_947207(125137225, +), CAediting_947208(125137243, +), CAediting_947209(125137248, +), CAediting_947210(125137273, +), CAediting_947211(125137334, +), CAediting_947212(125137348, +), CAediting_947213(125137356, +), CAediting_947214(125137366, +), CAediting_947215(125137402, +), CAediting_947216(125137434, +), CAediting_947217(125137444, +), CAediting_947218(125141453, +), CAediting_947219(125141456, +), CAediting_947220(125141470, +), CAediting_947221(125141475, +), CAediting_947222(125141483, +), CAediting_947223(125141499, +), CAediting_947224(125141520, +), CAediting_947225(125141531, +), CAediting_947226(125141535, +), CAediting_947227(125141536, +), CAediting_947228(125141547, +), CAediting_947229(125141550, +), CAediting_947230(125141574, +), CAediting_947231(125141586, +), CAediting_947232(125141590, +), CAediting_947233(125141603, +), CAediting_947234(125141617, +), CAediting_947235(125141618, +), CAediting_947236(125141642, +), CAediting_947237(125141647, +), CAediting_947238(125141654, +), CAediting_947239(125141720, +),

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RNA editing positional annotations for AACS using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_947160	chr12_125068219_+	intronic
CAediting_947161	chr12_125068302_+	intronic
CAediting_947162	chr12_125074400_+	intronic
CAediting_947163	chr12_125107736_+	ncRNA_intronic
CAediting_947164	chr12_125107783_+	ncRNA_intronic
CAediting_947165	chr12_125107784_+	ncRNA_intronic
CAediting_947166	chr12_125109257_+	ncRNA_intronic
CAediting_947167	chr12_125114531_+	exonic
CAediting_947168	chr12_125117730_+	ncRNA_exonic
CAediting_947169	chr12_125117731_+	ncRNA_exonic
CAediting_947170	chr12_125117785_+	ncRNA_exonic
CAediting_947171	chr12_125117800_+	ncRNA_exonic
CAediting_947172	chr12_125117803_+	ncRNA_exonic
CAediting_947173	chr12_125117804_+	ncRNA_exonic
CAediting_947174	chr12_125117829_+	ncRNA_exonic
CAediting_947175	chr12_125117869_+	ncRNA_exonic
CAediting_947176	chr12_125117890_+	ncRNA_exonic
CAediting_947177	chr12_125117904_+	ncRNA_exonic
CAediting_947178	chr12_125117909_+	ncRNA_exonic
CAediting_947179	chr12_125122558_+	ncRNA_exonic
CAediting_947180	chr12_125124081_+	ncRNA_exonic
CAediting_947181	chr12_125124111_+	ncRNA_exonic
CAediting_947182	chr12_125124112_+	ncRNA_exonic
CAediting_947183	chr12_125124114_+	ncRNA_exonic
CAediting_947184	chr12_125124130_+	ncRNA_exonic
CAediting_947185	chr12_125124166_+	ncRNA_exonic
CAediting_947186	chr12_125124174_+	ncRNA_exonic
CAediting_947187	chr12_125124205_+	ncRNA_exonic
CAediting_947188	chr12_125124206_+	ncRNA_exonic
CAediting_947189	chr12_125124210_+	ncRNA_exonic
CAediting_947190	chr12_125124220_+	ncRNA_exonic
CAediting_947191	chr12_125126601_+	ncRNA_exonic
CAediting_947192	chr12_125126646_+	ncRNA_exonic
CAediting_947193	chr12_125126661_+	ncRNA_exonic
CAediting_947194	chr12_125126675_+	ncRNA_exonic
CAediting_947195	chr12_125126682_+	ncRNA_exonic
CAediting_947196	chr12_125126715_+	ncRNA_exonic
CAediting_947197	chr12_125126818_+	ncRNA_exonic
CAediting_947198	chr12_125127032_+	ncRNA_exonic
CAediting_947199	chr12_125127046_+	ncRNA_exonic
CAediting_947200	chr12_125127075_+	ncRNA_exonic
CAediting_947201	chr12_125127641_+	ncRNA_exonic
CAediting_947202	chr12_125130961_+	ncRNA_intronic
CAediting_947203	chr12_125131351_+	ncRNA_intronic
CAediting_947204	chr12_125132116_+	ncRNA_intronic
CAediting_947205	chr12_125135804_+	ncRNA_exonic
CAediting_947206	chr12_125136212_+	ncRNA_intronic
CAediting_947207	chr12_125137225_+	ncRNA_intronic
CAediting_947208	chr12_125137243_+	ncRNA_intronic
CAediting_947209	chr12_125137248_+	ncRNA_intronic
CAediting_947210	chr12_125137273_+	ncRNA_intronic
CAediting_947211	chr12_125137334_+	ncRNA_intronic
CAediting_947212	chr12_125137348_+	ncRNA_intronic
CAediting_947213	chr12_125137356_+	ncRNA_intronic
CAediting_947214	chr12_125137366_+	ncRNA_intronic
CAediting_947215	chr12_125137402_+	ncRNA_intronic
CAediting_947216	chr12_125137434_+	ncRNA_intronic
CAediting_947217	chr12_125137444_+	ncRNA_intronic
CAediting_947218	chr12_125141453_+	ncRNA_exonic
CAediting_947219	chr12_125141456_+	ncRNA_exonic
CAediting_947220	chr12_125141470_+	ncRNA_exonic
CAediting_947221	chr12_125141475_+	ncRNA_exonic
CAediting_947222	chr12_125141483_+	ncRNA_exonic
CAediting_947223	chr12_125141499_+	ncRNA_exonic
CAediting_947224	chr12_125141520_+	ncRNA_exonic
CAediting_947225	chr12_125141531_+	ncRNA_exonic
CAediting_947226	chr12_125141535_+	ncRNA_exonic
CAediting_947227	chr12_125141536_+	ncRNA_exonic
CAediting_947228	chr12_125141547_+	ncRNA_exonic
CAediting_947229	chr12_125141550_+	ncRNA_exonic
CAediting_947230	chr12_125141574_+	ncRNA_exonic
CAediting_947231	chr12_125141586_+	ncRNA_exonic
CAediting_947232	chr12_125141590_+	ncRNA_exonic
CAediting_947233	chr12_125141603_+	ncRNA_exonic
CAediting_947234	chr12_125141617_+	ncRNA_exonic
CAediting_947235	chr12_125141618_+	ncRNA_exonic
CAediting_947236	chr12_125141642_+	ncRNA_exonic
CAediting_947237	chr12_125141647_+	ncRNA_exonic
CAediting_947238	chr12_125141654_+	ncRNA_exonic
CAediting_947239	chr12_125141720_+	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_947160	chr12_125068219_+	SINE	Alu	AluJb
CAediting_947161	chr12_125068302_+	SINE	Alu	AluJb
CAediting_947162	chr12_125074400_+	SINE	Alu	AluJo
CAediting_947163	chr12_125107736_+	SINE	Alu	AluSz6
CAediting_947164	chr12_125107783_+	SINE	Alu	AluSz6
CAediting_947165	chr12_125107784_+	SINE	Alu	AluSz6
CAediting_947166	chr12_125109257_+	SINE	Alu	AluJo
CAediting_947168	chr12_125117730_+	SINE	Alu	AluJr
CAediting_947169	chr12_125117731_+	SINE	Alu	AluJr
CAediting_947170	chr12_125117785_+	SINE	Alu	AluJr
CAediting_947171	chr12_125117800_+	SINE	Alu	AluJr
CAediting_947172	chr12_125117803_+	SINE	Alu	AluJr
CAediting_947173	chr12_125117804_+	SINE	Alu	AluJr
CAediting_947174	chr12_125117829_+	SINE	Alu	AluJr
CAediting_947175	chr12_125117869_+	SINE	Alu	AluJr
CAediting_947176	chr12_125117890_+	SINE	Alu	AluJr
CAediting_947177	chr12_125117904_+	SINE	Alu	AluJr
CAediting_947178	chr12_125117909_+	SINE	Alu	AluJr
CAediting_947179	chr12_125122558_+	SINE	Alu	AluSx3
CAediting_947180	chr12_125124081_+	SINE	Alu	AluJo
CAediting_947181	chr12_125124111_+	SINE	Alu	AluJo
CAediting_947182	chr12_125124112_+	SINE	Alu	AluJo
CAediting_947183	chr12_125124114_+	SINE	Alu	AluJo
CAediting_947184	chr12_125124130_+	SINE	Alu	AluJo
CAediting_947185	chr12_125124166_+	SINE	Alu	AluJo
CAediting_947186	chr12_125124174_+	SINE	Alu	AluJo
CAediting_947187	chr12_125124205_+	SINE	Alu	AluJo
CAediting_947188	chr12_125124206_+	SINE	Alu	AluJo
CAediting_947189	chr12_125124210_+	SINE	Alu	AluJo
CAediting_947190	chr12_125124220_+	SINE	Alu	AluJo
CAediting_947191	chr12_125126601_+	SINE	Alu	AluJb
CAediting_947192	chr12_125126646_+	SINE	Alu	AluJb
CAediting_947193	chr12_125126661_+	SINE	Alu	AluJb
CAediting_947194	chr12_125126675_+	SINE	Alu	AluJb
CAediting_947195	chr12_125126682_+	SINE	Alu	AluJb
CAediting_947196	chr12_125126715_+	SINE	Alu	AluJb
CAediting_947197	chr12_125126818_+	SINE	Alu	AluJb
CAediting_947198	chr12_125127032_+	SINE	Alu	AluSp
CAediting_947199	chr12_125127046_+	SINE	Alu	AluSp
CAediting_947200	chr12_125127075_+	SINE	Alu	AluSp
CAediting_947201	chr12_125127641_+	SINE	Alu	AluSx
CAediting_947203	chr12_125131351_+	SINE	Alu	AluJo
CAediting_947205	chr12_125135804_+	SINE	Alu	AluSz6
CAediting_947206	chr12_125136212_+	SINE	Alu	AluJo
CAediting_947207	chr12_125137225_+	SINE	Alu	AluSz
CAediting_947208	chr12_125137243_+	SINE	Alu	AluSz
CAediting_947209	chr12_125137248_+	SINE	Alu	AluSz
CAediting_947210	chr12_125137273_+	SINE	Alu	AluSz
CAediting_947211	chr12_125137334_+	SINE	Alu	AluSz
CAediting_947212	chr12_125137348_+	SINE	Alu	AluSz
CAediting_947213	chr12_125137356_+	SINE	Alu	AluSz
CAediting_947214	chr12_125137366_+	SINE	Alu	AluSz
CAediting_947215	chr12_125137402_+	SINE	Alu	AluSz
CAediting_947216	chr12_125137434_+	SINE	Alu	AluSz
CAediting_947217	chr12_125137444_+	SINE	Alu	AluSz
CAediting_947218	chr12_125141453_+	SINE	Alu	AluY
CAediting_947219	chr12_125141456_+	SINE	Alu	AluY
CAediting_947220	chr12_125141470_+	SINE	Alu	AluY
CAediting_947221	chr12_125141475_+	SINE	Alu	AluY
CAediting_947222	chr12_125141483_+	SINE	Alu	AluY
CAediting_947223	chr12_125141499_+	SINE	Alu	AluY
CAediting_947224	chr12_125141520_+	SINE	Alu	AluY
CAediting_947225	chr12_125141531_+	SINE	Alu	AluY
CAediting_947226	chr12_125141535_+	SINE	Alu	AluY
CAediting_947227	chr12_125141536_+	SINE	Alu	AluY
CAediting_947228	chr12_125141547_+	SINE	Alu	AluY
CAediting_947229	chr12_125141550_+	SINE	Alu	AluY
CAediting_947230	chr12_125141574_+	SINE	Alu	AluY
CAediting_947231	chr12_125141586_+	SINE	Alu	AluY
CAediting_947232	chr12_125141590_+	SINE	Alu	AluY
CAediting_947233	chr12_125141603_+	SINE	Alu	AluY
CAediting_947234	chr12_125141617_+	SINE	Alu	AluY
CAediting_947235	chr12_125141618_+	SINE	Alu	AluY
CAediting_947236	chr12_125141642_+	SINE	Alu	AluY
CAediting_947237	chr12_125141647_+	SINE	Alu	AluY
CAediting_947238	chr12_125141654_+	SINE	Alu	AluY
CAediting_947239	chr12_125141720_+	SINE	Alu	AluY

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RNA A-to-I editing events in the alternative splicing sites for AACS

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000081760.15.AACS.

Correlation between RNA A-to-I editing and PSI for ENSG00000081760.15.AACS.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for AACS

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for AACS

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for AACS

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1229415	chr17_67471547_+	ENSG00000081760.15	ENST00000418937	hsa-miR-548aa	125086383	125086389	7mer-m8	125086365	125086390	158	-15.79

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for AACS

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for AACS

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for AACS

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for AACS

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for AACS

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for AACS

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene