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Editing gene: SLC6A6 (CAeditome ID:6533)

Gene summary for SLC6A6

Gene summary

Gene information	Gene symbol	SLC6A6
	Gene ID	6533
	Gene name	solute carrier family 6 member 6
	Synonyms	TAUT
	Cytomap	3p25.1
	Type of gene	protein-coding
	Description	sodium- and chloride-dependent taurine transportersolute carrier family 6 (neurotransmitter transporter, taurine), member 6
	Modification date	20210518
	UniProtAcc	P31641
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
SLC6A6	GO:0010940	Sodium- and chloride-dependent taurine transporter	24842606
SLC6A6	GO:0071705	Sodium- and chloride-dependent taurine transporter	24842606
SLC6A6	GO:0005368	Sodium- and chloride-dependent taurine transporter	19074966
SLC6A6	GO:0005368	Sodium- and chloride-dependent taurine transporter	31903486
SLC6A6	GO:0015171	Sodium- and chloride-dependent taurine transporter	24842606
SLC6A6	GO:0022858	Sodium- and chloride-dependent taurine transporter	19074966
SLC6A6	GO:0015734	Sodium- and chloride-dependent taurine transporter	19074966
SLC6A6	GO:0015734	Sodium- and chloride-dependent taurine transporter	31903486
SLC6A6	GO:0032328	Sodium- and chloride-dependent taurine transporter	19074966
SLC6A6	GO:0089718	Sodium- and chloride-dependent taurine transporter	19074966
SLC6A6	GO:0089718	Sodium- and chloride-dependent taurine transporter	24842606
SLC6A6	GO:0005886	Sodium- and chloride-dependent taurine transporter	31903486
SLC6A6	GO:0005886	Sodium- and chloride-dependent taurine transporter	28112518
SLC6A6	GO:0016323	Sodium- and chloride-dependent taurine transporter	31791063
SLC6A6	GO:0016324	Sodium- and chloride-dependent taurine transporter	31791063
SLC6A6	GO:0031528	Sodium- and chloride-dependent taurine transporter	15166008

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RNA A-to-I events for SLC6A6

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000131389.15

RNA A-to-I editing events in Cancer.

CAediting_259910(14406202, +), CAediting_259911(14407189, +), CAediting_259912(14410015, +), CAediting_259913(14410021, +), CAediting_259914(14410049, +), CAediting_259915(14410065, +), CAediting_259916(14410066, +), CAediting_259917(14410092, +), CAediting_259918(14410118, +), CAediting_259919(14410152, +), CAediting_259920(14410172, +), CAediting_259921(14414671, +), CAediting_259922(14416867, +), CAediting_259923(14416873, +), CAediting_259924(14416938, +), CAediting_259925(14416944, +), CAediting_259926(14417104, +), CAediting_259927(14417621, +), CAediting_259928(14417638, +), CAediting_259929(14420704, +), CAediting_259930(14420746, +), CAediting_259931(14433677, +), CAediting_259932(14433683, +), CAediting_259933(14433697, +), CAediting_259934(14433729, +), CAediting_259935(14462578, +), CAediting_259936(14466004, +), CAediting_259937(14466141, +), CAediting_259938(14466142, +), CAediting_259939(14466177, +), CAediting_259940(14477282, +),

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RNA editing positional annotations for SLC6A6 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_259910	chr3_14406202_+	ncRNA_intronic
CAediting_259911	chr3_14407189_+	ncRNA_intronic
CAediting_259912	chr3_14410015_+	ncRNA_intronic
CAediting_259913	chr3_14410021_+	ncRNA_intronic
CAediting_259914	chr3_14410049_+	ncRNA_intronic
CAediting_259915	chr3_14410065_+	ncRNA_intronic
CAediting_259916	chr3_14410066_+	ncRNA_intronic
CAediting_259917	chr3_14410092_+	ncRNA_intronic
CAediting_259918	chr3_14410118_+	ncRNA_intronic
CAediting_259919	chr3_14410152_+	ncRNA_intronic
CAediting_259920	chr3_14410172_+	ncRNA_intronic
CAediting_259921	chr3_14414671_+	ncRNA_intronic
CAediting_259922	chr3_14416867_+	ncRNA_intronic
CAediting_259923	chr3_14416873_+	ncRNA_intronic
CAediting_259924	chr3_14416938_+	ncRNA_intronic
CAediting_259925	chr3_14416944_+	ncRNA_intronic
CAediting_259926	chr3_14417104_+	ncRNA_intronic
CAediting_259927	chr3_14417621_+	ncRNA_intronic
CAediting_259928	chr3_14417638_+	ncRNA_intronic
CAediting_259929	chr3_14420704_+	ncRNA_intronic
CAediting_259930	chr3_14420746_+	ncRNA_intronic
CAediting_259931	chr3_14433677_+	ncRNA_intronic
CAediting_259932	chr3_14433683_+	ncRNA_intronic
CAediting_259933	chr3_14433697_+	ncRNA_intronic
CAediting_259934	chr3_14433729_+	ncRNA_intronic
CAediting_259935	chr3_14462578_+	intronic
CAediting_259936	chr3_14466004_+	intronic
CAediting_259937	chr3_14466141_+	intronic
CAediting_259938	chr3_14466142_+	intronic
CAediting_259939	chr3_14466177_+	intronic
CAediting_259940	chr3_14477282_+	exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_259910	chr3_14406202_+	SINE	Alu	AluJo
CAediting_259911	chr3_14407189_+	SINE	Alu	AluJb
CAediting_259912	chr3_14410015_+	SINE	Alu	AluSg4
CAediting_259913	chr3_14410021_+	SINE	Alu	AluSg4
CAediting_259914	chr3_14410049_+	SINE	Alu	AluSg4
CAediting_259915	chr3_14410065_+	SINE	Alu	AluSg4
CAediting_259916	chr3_14410066_+	SINE	Alu	AluSg4
CAediting_259917	chr3_14410092_+	SINE	Alu	AluSg4
CAediting_259918	chr3_14410118_+	SINE	Alu	AluSg4
CAediting_259919	chr3_14410152_+	SINE	Alu	AluSg4
CAediting_259920	chr3_14410172_+	SINE	Alu	AluSg4
CAediting_259921	chr3_14414671_+	SINE	Alu	AluJr
CAediting_259922	chr3_14416867_+	SINE	Alu	AluJb
CAediting_259923	chr3_14416873_+	SINE	Alu	AluJb
CAediting_259924	chr3_14416938_+	SINE	Alu	AluJb
CAediting_259925	chr3_14416944_+	SINE	Alu	AluJb
CAediting_259926	chr3_14417104_+	SINE	Alu	AluJr4
CAediting_259927	chr3_14417621_+	SINE	Alu	AluY
CAediting_259928	chr3_14417638_+	SINE	Alu	AluY
CAediting_259929	chr3_14420704_+	SINE	Alu	AluJb
CAediting_259930	chr3_14420746_+	SINE	Alu	AluJb
CAediting_259931	chr3_14433677_+	SINE	Alu	AluSx1
CAediting_259932	chr3_14433683_+	SINE	Alu	AluSx1
CAediting_259933	chr3_14433697_+	SINE	Alu	AluSx1
CAediting_259934	chr3_14433729_+	SINE	Alu	AluSx1
CAediting_259935	chr3_14462578_+	SINE	Alu	AluJb
CAediting_259936	chr3_14466004_+	SINE	Alu	AluSx1
CAediting_259937	chr3_14466141_+	SINE	Alu	AluSx1
CAediting_259938	chr3_14466142_+	SINE	Alu	AluSx1
CAediting_259939	chr3_14466177_+	SINE	Alu	AluSx1

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RNA A-to-I editing events in the alternative splicing sites for SLC6A6

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000131389.15.SLC6A6.

Correlation between RNA A-to-I editing and PSI for ENSG00000131389.15.SLC6A6.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SLC6A6

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for SLC6A6

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for SLC6A6

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_259940	chr3_14477282_+	ENSG00000131389.15	ENST00000610642	hsa-miR-3156-5p	14477280	14477286	7mer-m8	14477266	14477287	140.00	-10.47
CAediting_259940	chr3_14477282_+	ENSG00000131389.15	ENST00000610642	hsa-miR-3156-5p	14477280	14477286	7mer-m8	14477266	14477287	140.00	-10.47
CAediting_259940	chr3_14477282_+	ENSG00000131389.15	ENST00000610642	hsa-miR-3156-5p	14477280	14477286	7mer-m8	14477266	14477287	140.00	-10.47
CAediting_259940	chr3_14477282_+	ENSG00000131389.15	ENST00000610642	hsa-miR-7161-3p	14477280	14477285	6mer	14477259	14477286	142.00	-19.29
CAediting_259940	chr3_14477282_+	ENSG00000131389.15	ENST00000618278	hsa-miR-3156-5p	14477280	14477286	7mer-m8	14477266	14477287	140.00	-10.47
CAediting_259940	chr3_14477282_+	ENSG00000131389.15	ENST00000618278	hsa-miR-3156-5p	14477280	14477286	7mer-m8	14477266	14477287	140.00	-10.47
CAediting_259940	chr3_14477282_+	ENSG00000131389.15	ENST00000618278	hsa-miR-3156-5p	14477280	14477286	7mer-m8	14477266	14477287	140.00	-10.47
CAediting_259940	chr3_14477282_+	ENSG00000131389.15	ENST00000618278	hsa-miR-7161-3p	14477280	14477285	6mer	14477259	14477286	142.00	-19.29

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000131389.15	ENST00000622186	hsa-miR-200b-3p	14486999	14487004	6mer	14486985	14487005	142	-12.71
CAediting_688080	chr9_63819626_+	ENSG00000131389.15	ENST00000622186	hsa-miR-4477b	14487315	14487321	7mer-m8	14487299	14487322	143	-11.9
CAediting_688080	chr9_63819626_+	ENSG00000131389.15	ENST00000622186	hsa-miR-4477b	14487861	14487867	7mer-m8	14487847	14487868	152	-13.21
CAediting_393	chr1_1167164_+	ENSG00000131389.15	ENST00000613060	hsa-miR-200b-3p	14486999	14487004	6mer	14486985	14487005	142	-12.71
CAediting_688080	chr9_63819626_+	ENSG00000131389.15	ENST00000613060	hsa-miR-4477b	14487315	14487321	7mer-m8	14487299	14487322	143	-11.9
CAediting_688080	chr9_63819626_+	ENSG00000131389.15	ENST00000613060	hsa-miR-4477b	14487861	14487867	7mer-m8	14487847	14487868	152	-13.21
CAediting_393	chr1_1167164_+	ENSG00000131389.15	ENST00000618278	hsa-miR-200b-3p	14486999	14487004	6mer	14486985	14487005	142	-12.71
CAediting_688080	chr9_63819626_+	ENSG00000131389.15	ENST00000618278	hsa-miR-4477b	14487315	14487321	7mer-m8	14487299	14487322	143	-11.9
CAediting_688080	chr9_63819626_+	ENSG00000131389.15	ENST00000618278	hsa-miR-4477b	14487861	14487867	7mer-m8	14487847	14487868	152	-13.21
CAediting_980496	chr14_31014685_-	ENSG00000131389.15	ENST00000621751	hsa-miR-624-3p	14448087	14448093	7mer-m8	14448073	14448094	160	-19.05
CAediting_1399425	chr20_1392958_-	ENSG00000131389.15	ENST00000610642	hsa-miR-6869-5p	14472226	14472233	8mer-1a	14472212	14472233	140	-20.57
CAediting_1054808	chr15_66496985_-	ENSG00000131389.15	ENST00000622186	hsa-miR-4512	14486134	14486141	8mer-1a	14486120	14486141	140	-17.46
CAediting_1054808	chr15_66496985_-	ENSG00000131389.15	ENST00000622186	hsa-miR-4512	14487291	14487297	7mer-m8	14487273	14487298	142	-27.19
CAediting_1351755	chr19_40282625_-	ENSG00000131389.15	ENST00000622186	hsa-miR-641	14487430	14487436	7mer-m8	14487413	14487437	157	-15.98
CAediting_86358	chr1_109598906_+	ENSG00000131389.15	ENST00000622186	hsa-miR-197-5p	14488512	14488517	6mer	14488501	14488523	148	-31.41
CAediting_86358	chr1_109598906_+	ENSG00000131389.15	ENST00000622186	hsa-miR-197-5p	14488517	14488523	7mer-1a	14488501	14488523	148	-31.41
CAediting_228905	chr2_188297554_+	ENSG00000131389.15	ENST00000622186	hsa-miR-561-3p	14486898	14486904	7mer-m8	14486884	14486905	145	-6.76
CAediting_396018	chr5_1062918_-	ENSG00000131389.15	ENST00000622186	hsa-miR-4635	14487862	14487868	7mer-m8	14487849	14487869	140	-12.87
CAediting_524911	chr7_5495852_-	ENSG00000131389.15	ENST00000622186	hsa-miR-589-3p	14488461	14488467	7mer-m8	14488445	14488468	146	-22.65
CAediting_1054808	chr15_66496985_-	ENSG00000131389.15	ENST00000613060	hsa-miR-4512	14486134	14486141	8mer-1a	14486120	14486141	140	-17.46
CAediting_1054808	chr15_66496985_-	ENSG00000131389.15	ENST00000613060	hsa-miR-4512	14487291	14487297	7mer-m8	14487273	14487298	142	-27.19
CAediting_1351755	chr19_40282625_-	ENSG00000131389.15	ENST00000613060	hsa-miR-641	14487430	14487436	7mer-m8	14487413	14487437	157	-15.98
CAediting_86358	chr1_109598906_+	ENSG00000131389.15	ENST00000613060	hsa-miR-197-5p	14488512	14488517	6mer	14488501	14488523	148	-31.41
CAediting_86358	chr1_109598906_+	ENSG00000131389.15	ENST00000613060	hsa-miR-197-5p	14488517	14488523	7mer-1a	14488501	14488523	148	-31.41
CAediting_228905	chr2_188297554_+	ENSG00000131389.15	ENST00000613060	hsa-miR-561-3p	14486898	14486904	7mer-m8	14486884	14486905	145	-6.76
CAediting_396018	chr5_1062918_-	ENSG00000131389.15	ENST00000613060	hsa-miR-4635	14487862	14487868	7mer-m8	14487849	14487869	140	-12.87
CAediting_524911	chr7_5495852_-	ENSG00000131389.15	ENST00000613060	hsa-miR-589-3p	14488461	14488467	7mer-m8	14488445	14488468	146	-22.65
CAediting_524911	chr7_5495852_-	ENSG00000131389.15	ENST00000618278	hsa-miR-589-3p	14481779	14481785	7mer-m8	14481765	14481786	141	-12.54
CAediting_1054808	chr15_66496985_-	ENSG00000131389.15	ENST00000618278	hsa-miR-4512	14486134	14486141	8mer-1a	14486120	14486141	140	-17.46
CAediting_1054808	chr15_66496985_-	ENSG00000131389.15	ENST00000618278	hsa-miR-4512	14487291	14487297	7mer-m8	14487273	14487298	142	-27.19
CAediting_1351755	chr19_40282625_-	ENSG00000131389.15	ENST00000618278	hsa-miR-641	14487430	14487436	7mer-m8	14487413	14487437	157	-15.98
CAediting_86358	chr1_109598906_+	ENSG00000131389.15	ENST00000618278	hsa-miR-197-5p	14488512	14488517	6mer	14488501	14488523	148	-31.41
CAediting_86358	chr1_109598906_+	ENSG00000131389.15	ENST00000618278	hsa-miR-197-5p	14488517	14488523	7mer-1a	14488501	14488523	148	-31.41
CAediting_228905	chr2_188297554_+	ENSG00000131389.15	ENST00000618278	hsa-miR-561-3p	14486898	14486904	7mer-m8	14486884	14486905	145	-6.76
CAediting_396018	chr5_1062918_-	ENSG00000131389.15	ENST00000618278	hsa-miR-4635	14487862	14487868	7mer-m8	14487849	14487869	140	-12.87
CAediting_524911	chr7_5495852_-	ENSG00000131389.15	ENST00000618278	hsa-miR-589-3p	14488461	14488467	7mer-m8	14488445	14488468	146	-22.65
CAediting_1524209	chrX_134546392_-	ENSG00000131389.15	ENST00000610642	hsa-miR-503-5p	14466579	14466585	7mer-m8	14466567	14466586	147	-25.99
CAediting_1524209	chrX_134546392_-	ENSG00000131389.15	ENST00000610642	hsa-miR-503-5p	14472252	14472258	7mer-m8	14472237	14472259	157	-23.52

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000131389.15	ENST00000622186	hsa-miR-200b-3p	14487174	14487180	7mer-m8	14487162	14487181	143	-10.88
CAediting_1306324	chr19_13836464_-	ENSG00000131389.15	ENST00000622186	hsa-miR-27a-3p	14487757	14487763	7mer-m8	14487744	14487764	152	-19.81
CAediting_1306323	chr19_13836462_-	ENSG00000131389.15	ENST00000622186	hsa-miR-27a-3p	14487757	14487763	7mer-m8	14487744	14487764	152	-19.81
CAediting_604450	chr7_133034877_-	ENSG00000131389.15	ENST00000622186	hsa-miR-3654	14485453	14485460	8mer-1a	14485441	14485460	152	-16.86
CAediting_1054808	chr15_66496985_-	ENSG00000131389.15	ENST00000622186	hsa-miR-4512	14485697	14485704	8mer-1a	14485683	14485704	151	-20.18
CAediting_396018	chr5_1062918_-	ENSG00000131389.15	ENST00000622186	hsa-miR-4635	14488564	14488570	7mer-m8	14488551	14488571	140	-9.91
CAediting_228905	chr2_188297554_+	ENSG00000131389.15	ENST00000622186	hsa-miR-561-3p	14487447	14487453	7mer-m8	14487433	14487454	140	-6.22
CAediting_524911	chr7_5495852_-	ENSG00000131389.15	ENST00000622186	hsa-miR-589-3p	14488839	14488845	7mer-m8	14488825	14488846	146	-12.2
CAediting_1351755	chr19_40282625_-	ENSG00000131389.15	ENST00000622186	hsa-miR-641	14487021	14487027	7mer-1a	14487002	14487027	143	-21.69
CAediting_580943	chr7_100356700_+	ENSG00000131389.15	ENST00000622186	hsa-miR-6840-3p	14485478	14485485	8mer-1a	14485464	14485485	140	-17.08
CAediting_580943	chr7_100356700_+	ENSG00000131389.15	ENST00000622186	hsa-miR-6840-3p	14485912	14485918	7mer-m8	14485898	14485919	142	-20.29
CAediting_393	chr1_1167164_+	ENSG00000131389.15	ENST00000613060	hsa-miR-200b-3p	14487174	14487180	7mer-m8	14487162	14487181	143	-10.88
CAediting_1306324	chr19_13836464_-	ENSG00000131389.15	ENST00000613060	hsa-miR-27a-3p	14487757	14487763	7mer-m8	14487744	14487764	152	-19.81
CAediting_1306323	chr19_13836462_-	ENSG00000131389.15	ENST00000613060	hsa-miR-27a-3p	14487757	14487763	7mer-m8	14487744	14487764	152	-19.81
CAediting_604450	chr7_133034877_-	ENSG00000131389.15	ENST00000613060	hsa-miR-3654	14485453	14485460	8mer-1a	14485441	14485460	152	-16.86
CAediting_1054808	chr15_66496985_-	ENSG00000131389.15	ENST00000613060	hsa-miR-4512	14485697	14485704	8mer-1a	14485683	14485704	151	-20.18
CAediting_396018	chr5_1062918_-	ENSG00000131389.15	ENST00000613060	hsa-miR-4635	14488564	14488570	7mer-m8	14488551	14488571	140	-9.91
CAediting_228905	chr2_188297554_+	ENSG00000131389.15	ENST00000613060	hsa-miR-561-3p	14487447	14487453	7mer-m8	14487433	14487454	140	-6.22
CAediting_524911	chr7_5495852_-	ENSG00000131389.15	ENST00000613060	hsa-miR-589-3p	14488839	14488845	7mer-m8	14488825	14488846	146	-12.2
CAediting_1351755	chr19_40282625_-	ENSG00000131389.15	ENST00000613060	hsa-miR-641	14487021	14487027	7mer-1a	14487002	14487027	143	-21.69
CAediting_580943	chr7_100356700_+	ENSG00000131389.15	ENST00000613060	hsa-miR-6840-3p	14485478	14485485	8mer-1a	14485464	14485485	140	-17.08
CAediting_580943	chr7_100356700_+	ENSG00000131389.15	ENST00000613060	hsa-miR-6840-3p	14485912	14485918	7mer-m8	14485898	14485919	142	-20.29
CAediting_393	chr1_1167164_+	ENSG00000131389.15	ENST00000618278	hsa-miR-200b-3p	14487174	14487180	7mer-m8	14487162	14487181	143	-10.88
CAediting_1306324	chr19_13836464_-	ENSG00000131389.15	ENST00000618278	hsa-miR-27a-3p	14487757	14487763	7mer-m8	14487744	14487764	152	-19.81
CAediting_1306323	chr19_13836462_-	ENSG00000131389.15	ENST00000618278	hsa-miR-27a-3p	14487757	14487763	7mer-m8	14487744	14487764	152	-19.81
CAediting_604450	chr7_133034877_-	ENSG00000131389.15	ENST00000618278	hsa-miR-3654	14485453	14485460	8mer-1a	14485441	14485460	152	-16.86
CAediting_1054808	chr15_66496985_-	ENSG00000131389.15	ENST00000618278	hsa-miR-4512	14485697	14485704	8mer-1a	14485683	14485704	151	-20.18
CAediting_396018	chr5_1062918_-	ENSG00000131389.15	ENST00000618278	hsa-miR-4635	14488564	14488570	7mer-m8	14488551	14488571	140	-9.91
CAediting_228905	chr2_188297554_+	ENSG00000131389.15	ENST00000618278	hsa-miR-561-3p	14487447	14487453	7mer-m8	14487433	14487454	140	-6.22
CAediting_524911	chr7_5495852_-	ENSG00000131389.15	ENST00000618278	hsa-miR-589-3p	14488839	14488845	7mer-m8	14488825	14488846	146	-12.2
CAediting_1351755	chr19_40282625_-	ENSG00000131389.15	ENST00000618278	hsa-miR-641	14487021	14487027	7mer-1a	14487002	14487027	143	-21.69
CAediting_580943	chr7_100356700_+	ENSG00000131389.15	ENST00000618278	hsa-miR-6840-3p	14485912	14485918	7mer-m8	14485898	14485919	142	-20.29
CAediting_580943	chr7_100356700_+	ENSG00000131389.15	ENST00000618278	hsa-miR-6840-3p	14485478	14485485	8mer-1a	14485464	14485485	140	-17.08

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SLC6A6

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000610642.3	nonsense_mediated_decay
ENST00000613060.3	protein_coding
ENST00000618278.3	nonsense_mediated_decay
ENST00000622186.3	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_259940	ENST00000610642.3	chr3_14477282_+	-705.70	-705.70	-705.70
CAediting_259940	ENST00000613060.3	chr3_14477282_+	-2288.00	-2287.00	-2288.00
CAediting_259940	ENST00000618278.3	chr3_14477282_+	-2238.70	-2236.60	-2238.70
CAediting_259940	ENST00000622186.3	chr3_14477282_+	-2286.50	-2285.50	-2286.50

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Relation with ADAR for SLC6A6

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for SLC6A6

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for SLC6A6

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for SLC6A6

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SLC6A6

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
SLC6A6	C0151744	Myocardial Ischemia	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene