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Editing gene: SLC3A1 (CAeditome ID:6519)

Gene summary for SLC3A1

Gene summary

Gene information	Gene symbol	SLC3A1
	Gene ID	6519
	Gene name	solute carrier family 3 member 1
	Synonyms	ATR1\|CSNU1\|D2H\|NBAT\|RBAT
	Cytomap	2p21
	Type of gene	protein-coding
	Description	neutral and basic amino acid transport protein rBATB(0,+)-type amino acid transport proteinSLC3A1 variant BSLC3A1 variant CSLC3A1 variant DSLC3A1 variant ESLC3A1 variant FSLC3A1 variant Gamino acid transporter 1solute carrier family 3 (amino acid
	Modification date	20210518
	UniProtAcc	Q07837
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
SLC3A1	GO:0031526	Neutral and basic amino acid transport protein rBAT	12167606

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RNA A-to-I events for SLC3A1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000138079.12

RNA A-to-I editing events in Cancer.

CAediting_176368(44284263, +), CAediting_176369(44294255, +), CAediting_176370(44294979, +), CAediting_176371(44295004, +), CAediting_176372(44295006, +), CAediting_176373(44295012, +), CAediting_176374(44295018, +), CAediting_176375(44301467, +), CAediting_176376(44301485, +), CAediting_176377(44301486, +), CAediting_176378(44301487, +), CAediting_176379(44301499, +), CAediting_176380(44301529, +), CAediting_176381(44301659, +), CAediting_176382(44301660, +), CAediting_176383(44301795, +), CAediting_176384(44301814, +), CAediting_176385(44301934, +), CAediting_176386(44301935, +), CAediting_176387(44301937, +), CAediting_176388(44302943, +), CAediting_176389(44302944, +), CAediting_176390(44302989, +), CAediting_176391(44303080, +), CAediting_176392(44303090, +), CAediting_176393(44303308, +), CAediting_176394(44303338, +), CAediting_176395(44303344, +), CAediting_176396(44303370, +), CAediting_176397(44303373, +), CAediting_176398(44303383, +), CAediting_176399(44303498, +), CAediting_176400(44303499, +), CAediting_176401(44303511, +), CAediting_176402(44303513, +), CAediting_176403(44314980, +), CAediting_176404(44314988, +), CAediting_176405(44315006, +), CAediting_176406(44315012, +), CAediting_176407(44315057, +), CAediting_176408(44315140, +), CAediting_176409(44315143, +), CAediting_176410(44315152, +), CAediting_176411(44315164, +), CAediting_176412(44315165, +), CAediting_176413(44315204, +), CAediting_176414(44315205, +), CAediting_176415(44315385, +), CAediting_176416(44315387, +), CAediting_176417(44315393, +), CAediting_176418(44315394, +), CAediting_176419(44315421, +), CAediting_176420(44315423, +), CAediting_176421(44315427, +), CAediting_176422(44315448, +), CAediting_176423(44315458, +), CAediting_176424(44315467, +), CAediting_176425(44315527, +), CAediting_176426(44315567, +), CAediting_176427(44315581, +), CAediting_176428(44315582, +), CAediting_176429(44315589, +), CAediting_176430(44315597, +), CAediting_176431(44315601, +), CAediting_176432(44315616, +), CAediting_176433(44315644, +),

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RNA editing positional annotations for SLC3A1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_176368	chr2_44284263_+	intronic
CAediting_176369	chr2_44294255_+	intronic
CAediting_176370	chr2_44294979_+	intronic
CAediting_176371	chr2_44295004_+	intronic
CAediting_176372	chr2_44295006_+	intronic
CAediting_176373	chr2_44295012_+	intronic
CAediting_176374	chr2_44295018_+	intronic
CAediting_176375	chr2_44301467_+	intronic
CAediting_176376	chr2_44301485_+	intronic
CAediting_176377	chr2_44301486_+	intronic
CAediting_176378	chr2_44301487_+	intronic
CAediting_176379	chr2_44301499_+	intronic
CAediting_176380	chr2_44301529_+	intronic
CAediting_176381	chr2_44301659_+	intronic
CAediting_176382	chr2_44301660_+	intronic
CAediting_176383	chr2_44301795_+	intronic
CAediting_176384	chr2_44301814_+	intronic
CAediting_176385	chr2_44301934_+	intronic
CAediting_176386	chr2_44301935_+	intronic
CAediting_176387	chr2_44301937_+	intronic
CAediting_176388	chr2_44302943_+	intronic
CAediting_176389	chr2_44302944_+	intronic
CAediting_176390	chr2_44302989_+	intronic
CAediting_176391	chr2_44303080_+	intronic
CAediting_176392	chr2_44303090_+	intronic
CAediting_176393	chr2_44303308_+	intronic
CAediting_176394	chr2_44303338_+	intronic
CAediting_176395	chr2_44303344_+	intronic
CAediting_176396	chr2_44303370_+	intronic
CAediting_176397	chr2_44303373_+	intronic
CAediting_176398	chr2_44303383_+	intronic
CAediting_176399	chr2_44303498_+	intronic
CAediting_176400	chr2_44303499_+	intronic
CAediting_176401	chr2_44303511_+	intronic
CAediting_176402	chr2_44303513_+	intronic
CAediting_176403	chr2_44314980_+	UTR3
CAediting_176404	chr2_44314988_+	UTR3
CAediting_176405	chr2_44315006_+	UTR3
CAediting_176406	chr2_44315012_+	UTR3
CAediting_176407	chr2_44315057_+	UTR3
CAediting_176408	chr2_44315140_+	UTR3
CAediting_176409	chr2_44315143_+	UTR3
CAediting_176410	chr2_44315152_+	UTR3
CAediting_176411	chr2_44315164_+	UTR3
CAediting_176412	chr2_44315165_+	UTR3
CAediting_176413	chr2_44315204_+	UTR3
CAediting_176414	chr2_44315205_+	UTR3
CAediting_176415	chr2_44315385_+	intronic
CAediting_176416	chr2_44315387_+	intronic
CAediting_176417	chr2_44315393_+	intronic
CAediting_176418	chr2_44315394_+	intronic
CAediting_176419	chr2_44315421_+	intronic
CAediting_176420	chr2_44315423_+	intronic
CAediting_176421	chr2_44315427_+	intronic
CAediting_176422	chr2_44315448_+	intronic
CAediting_176423	chr2_44315458_+	intronic
CAediting_176424	chr2_44315467_+	intronic
CAediting_176425	chr2_44315527_+	intronic
CAediting_176426	chr2_44315567_+	intronic
CAediting_176427	chr2_44315581_+	intronic
CAediting_176428	chr2_44315582_+	intronic
CAediting_176429	chr2_44315589_+	intronic
CAediting_176430	chr2_44315597_+	intronic
CAediting_176431	chr2_44315601_+	intronic
CAediting_176432	chr2_44315616_+	intronic
CAediting_176433	chr2_44315644_+	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_176368	chr2_44284263_+	SINE	Alu	AluSx4
CAediting_176369	chr2_44294255_+	SINE	Alu	AluSx1
CAediting_176370	chr2_44294979_+	SINE	Alu	AluJo
CAediting_176371	chr2_44295004_+	SINE	Alu	AluJo
CAediting_176372	chr2_44295006_+	SINE	Alu	AluJo
CAediting_176373	chr2_44295012_+	SINE	Alu	AluJo
CAediting_176374	chr2_44295018_+	SINE	Alu	AluJo
CAediting_176375	chr2_44301467_+	SINE	Alu	AluSg
CAediting_176376	chr2_44301485_+	SINE	Alu	AluSg
CAediting_176377	chr2_44301486_+	SINE	Alu	AluSg
CAediting_176378	chr2_44301487_+	SINE	Alu	AluSg
CAediting_176379	chr2_44301499_+	SINE	Alu	AluSg
CAediting_176380	chr2_44301529_+	SINE	Alu	AluSg
CAediting_176381	chr2_44301659_+	SINE	Alu	AluSg
CAediting_176382	chr2_44301660_+	SINE	Alu	AluSg
CAediting_176383	chr2_44301795_+	SINE	Alu	AluSx
CAediting_176384	chr2_44301814_+	SINE	Alu	AluSx
CAediting_176385	chr2_44301934_+	SINE	Alu	AluSx
CAediting_176386	chr2_44301935_+	SINE	Alu	AluSx
CAediting_176387	chr2_44301937_+	SINE	Alu	AluSx
CAediting_176388	chr2_44302943_+	SINE	Alu	AluSq2
CAediting_176389	chr2_44302944_+	SINE	Alu	AluSq2
CAediting_176390	chr2_44302989_+	SINE	Alu	AluSq2
CAediting_176391	chr2_44303080_+	SINE	Alu	AluSq2
CAediting_176392	chr2_44303090_+	SINE	Alu	AluSq2
CAediting_176393	chr2_44303308_+	SINE	Alu	AluSz
CAediting_176394	chr2_44303338_+	SINE	Alu	AluSz
CAediting_176395	chr2_44303344_+	SINE	Alu	AluSz
CAediting_176396	chr2_44303370_+	SINE	Alu	AluSz
CAediting_176397	chr2_44303373_+	SINE	Alu	AluSz
CAediting_176398	chr2_44303383_+	SINE	Alu	AluSz
CAediting_176399	chr2_44303498_+	SINE	Alu	AluSz
CAediting_176400	chr2_44303499_+	SINE	Alu	AluSz
CAediting_176401	chr2_44303511_+	SINE	Alu	AluSz
CAediting_176402	chr2_44303513_+	SINE	Alu	AluSz
CAediting_176403	chr2_44314980_+	SINE	Alu	AluSq2
CAediting_176404	chr2_44314988_+	SINE	Alu	AluSq2
CAediting_176405	chr2_44315006_+	SINE	Alu	AluSq2
CAediting_176406	chr2_44315012_+	SINE	Alu	AluSq2
CAediting_176407	chr2_44315057_+	SINE	Alu	AluSq2
CAediting_176408	chr2_44315140_+	SINE	Alu	AluSq2
CAediting_176409	chr2_44315143_+	SINE	Alu	AluSq2
CAediting_176410	chr2_44315152_+	SINE	Alu	AluSq2
CAediting_176411	chr2_44315164_+	SINE	Alu	AluSq2
CAediting_176412	chr2_44315165_+	SINE	Alu	AluSq2
CAediting_176413	chr2_44315204_+	SINE	Alu	AluSq2
CAediting_176414	chr2_44315205_+	SINE	Alu	AluSq2
CAediting_176415	chr2_44315385_+	SINE	Alu	AluJo
CAediting_176416	chr2_44315387_+	SINE	Alu	AluJo
CAediting_176417	chr2_44315393_+	SINE	Alu	AluJo
CAediting_176418	chr2_44315394_+	SINE	Alu	AluJo
CAediting_176419	chr2_44315421_+	SINE	Alu	AluJo
CAediting_176420	chr2_44315423_+	SINE	Alu	AluJo
CAediting_176421	chr2_44315427_+	SINE	Alu	AluJo
CAediting_176422	chr2_44315448_+	SINE	Alu	AluJo
CAediting_176423	chr2_44315458_+	SINE	Alu	AluJo
CAediting_176424	chr2_44315467_+	SINE	Alu	AluJo
CAediting_176425	chr2_44315527_+	SINE	Alu	AluJo
CAediting_176426	chr2_44315567_+	SINE	Alu	AluJo
CAediting_176427	chr2_44315581_+	SINE	Alu	AluJo
CAediting_176428	chr2_44315582_+	SINE	Alu	AluJo
CAediting_176429	chr2_44315589_+	SINE	Alu	AluJo
CAediting_176430	chr2_44315597_+	SINE	Alu	AluJo
CAediting_176431	chr2_44315601_+	SINE	Alu	AluJo
CAediting_176432	chr2_44315616_+	SINE	Alu	AluJo
CAediting_176433	chr2_44315644_+	SINE	Alu	AluJo

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RNA A-to-I editing events in the alternative splicing sites for SLC3A1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000138079.12.SLC3A1.

Correlation between RNA A-to-I editing and PSI for ENSG00000138079.12.SLC3A1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SLC3A1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

KIRC.CAediting_176403.ENSG00000138079.SLC3A1.png
Soverview

KIRC.CAediting_176416.ENSG00000138079.SLC3A1.png
Soverview

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Protein coding region RNA A-to-I editings for SLC3A1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for SLC3A1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_176403	chr2_44314980_+	ENSG00000138079.12	ENST00000409229	hsa-miR-508-5p	44314977	44314983	7mer-m8	44314960	44314984	152.00	-25.43
CAediting_176403	chr2_44314980_+	ENSG00000138079.12	ENST00000409229	hsa-miR-6512-3p	44314975	44314981	7mer-m8	44314961	44314982	152.00	-21.16
CAediting_176403	chr2_44314980_+	ENSG00000138079.12	ENST00000409229	hsa-miR-6720-5p	44314975	44314981	7mer-m8	44314960	44314982	159.00	-27.03
CAediting_176403	chr2_44314980_+	ENSG00000138079.12	ENST00000409229	hsa-miR-766-3p	44314976	44314982	7mer-m8	44314961	44314983	151.00	-26.14
CAediting_176406	chr2_44315012_+	ENSG00000138079.12	ENST00000409229	hsa-miR-3929	44315009	44315014	6mer	44314991	44315015	148.00	-35.38
CAediting_176406	chr2_44315012_+	ENSG00000138079.12	ENST00000409229	hsa-miR-485-5p	44315009	44315015	7mer-m8	44314996	44315016	153.00	-17.86
CAediting_176406	chr2_44315012_+	ENSG00000138079.12	ENST00000409229	hsa-miR-604	44315007	44315013	7mer-m8	44314995	44315014	152.00	-27.58
CAediting_176406	chr2_44315012_+	ENSG00000138079.12	ENST00000409229	hsa-miR-6884-5p	44315009	44315015	7mer-m8	44314998	44315016	145.00	-22.71
CAediting_176407	chr2_44315057_+	ENSG00000138079.12	ENST00000409229	hsa-miR-6771-5p	44315051	44315057	7mer-m8	44315037	44315058	159.00	-32.37
CAediting_176409	chr2_44315143_+	ENSG00000138079.12	ENST00000409229	hsa-miR-433-5p	44315137	44315143	7mer-m8	44315121	44315144	159.00	-27.80
CAediting_176410	chr2_44315152_+	ENSG00000138079.12	ENST00000409229	hsa-miR-4707-3p	44315148	44315154	7mer-m8	44315136	44315155	152.00	-25.82
CAediting_176410	chr2_44315152_+	ENSG00000138079.12	ENST00000409229	hsa-miR-7108-3p	44315147	44315153	7mer-m8	44315135	44315154	143.00	-18.34
CAediting_176414	chr2_44315205_+	ENSG00000138079.12	ENST00000409229	hsa-miR-3189-3p	44315199	44315205	7mer-m8	44315187	44315206	149.00	-22.73
CAediting_176414	chr2_44315205_+	ENSG00000138079.12	ENST00000409229	hsa-miR-6813-3p	44315200	44315206	7mer-m8	44315187	44315207	140.00	-11.60
CAediting_176404	chr2_44314988_+	ENSG00000138079.12	ENST00000409229	hsa-miR-324-3p	44314984	44314990	7mer-m8	44314968	44314991	146.00	-19.67
CAediting_176404	chr2_44314988_+	ENSG00000138079.12	ENST00000409229	hsa-miR-4793-3p	44314981	44314987	7mer-m8	44314966	44314988	149.00	-20.89
CAediting_176404	chr2_44314988_+	ENSG00000138079.12	ENST00000409229	hsa-miR-6807-3p	44314983	44314988	6mer	44314967	44314989	152.00	-29.09
CAediting_176405	chr2_44315006_+	ENSG00000138079.12	ENST00000409229	hsa-miR-4285	44315002	44315008	7mer-m8	44314991	44315009	150.00	-26.52
CAediting_176411	chr2_44315164_+	ENSG00000138079.12	ENST00000409229	hsa-miR-4294	44315162	44315168	7mer-m8	44315152	44315169	150.00	-18.29
CAediting_176412	chr2_44315165_+	ENSG00000138079.12	ENST00000409229	hsa-miR-28-5p	44315163	44315169	7mer-m8	44315149	44315170	143.00	-18.76
CAediting_176412	chr2_44315165_+	ENSG00000138079.12	ENST00000409229	hsa-miR-3139	44315163	44315169	7mer-m8	44315148	44315170	157.00	-24.37
CAediting_176412	chr2_44315165_+	ENSG00000138079.12	ENST00000409229	hsa-miR-4635	44315159	44315164	6mer	44315147	44315165	144.00	-19.24
CAediting_176412	chr2_44315165_+	ENSG00000138079.12	ENST00000409229	hsa-miR-708-5p	44315163	44315169	7mer-m8	44315149	44315170	162.00	-21.52
CAediting_176413	chr2_44315204_+	ENSG00000138079.12	ENST00000409229	hsa-miR-326	44315199	44315205	7mer-m8	44315187	44315206	140.00	-13.37
CAediting_176413	chr2_44315204_+	ENSG00000138079.12	ENST00000409229	hsa-miR-330-5p	44315199	44315205	7mer-m8	44315185	44315206	140.00	-20.32
CAediting_176413	chr2_44315204_+	ENSG00000138079.12	ENST00000409229	hsa-miR-4314	44315198	44315204	7mer-m8	44315188	44315205	140.00	-21.18
CAediting_176413	chr2_44315204_+	ENSG00000138079.12	ENST00000409229	hsa-miR-514a-5p	44315200	44315206	7mer-m8	44315184	44315207	146.00	-18.76
CAediting_176413	chr2_44315204_+	ENSG00000138079.12	ENST00000409229	hsa-miR-514a-5p	44315200	44315206	7mer-m8	44315184	44315207	146.00	-18.76
CAediting_176413	chr2_44315204_+	ENSG00000138079.12	ENST00000409229	hsa-miR-514a-5p	44315200	44315206	7mer-m8	44315184	44315207	146.00	-18.76

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_176407	chr2_44315057_+	ENSG00000138079.12	ENST00000409229	hsa-miR-12126	44315053	44315060	8mer-1a	44315036	44315060	149	-17.84
CAediting_176403	chr2_44314980_+	ENSG00000138079.12	ENST00000409229	hsa-miR-1251-5p	44314976	44314982	7mer-m8	44314958	44314983	153	-21.65
CAediting_176403	chr2_44314980_+	ENSG00000138079.12	ENST00000409229	hsa-miR-1287-3p	44314975	44314981	7mer-m8	44314955	44314982	145	-20.89
CAediting_176407	chr2_44315057_+	ENSG00000138079.12	ENST00000409229	hsa-miR-30b-3p	44315050	44315057	8mer-1a	44315036	44315057	151	-15.97
CAediting_176404	chr2_44314988_+	ENSG00000138079.12	ENST00000409229	hsa-miR-32-5p	44314982	44314988	7mer-m8	44314968	44314989	148	-12.78
CAediting_176404	chr2_44314988_+	ENSG00000138079.12	ENST00000409229	hsa-miR-363-3p	44314982	44314988	7mer-m8	44314968	44314989	151	-12.2
CAediting_176407	chr2_44315057_+	ENSG00000138079.12	ENST00000409229	hsa-miR-3689a-3p	44315050	44315057	8mer-1a	44315035	44315057	142	-16.82
CAediting_176407	chr2_44315057_+	ENSG00000138079.12	ENST00000409229	hsa-miR-3689b-3p	44315050	44315057	8mer-1a	44315035	44315057	142	-16.94
CAediting_176407	chr2_44315057_+	ENSG00000138079.12	ENST00000409229	hsa-miR-3689c	44315050	44315057	8mer-1a	44315035	44315057	142	-16.94
CAediting_176406	chr2_44315012_+	ENSG00000138079.12	ENST00000409229	hsa-miR-377-5p	44315009	44315015	7mer-m8	44314995	44315016	155	-19.92
CAediting_176411	chr2_44315164_+	ENSG00000138079.12	ENST00000409229	hsa-miR-510-3p	44315157	44315164	8mer-1a	44315144	44315164	145	-10.87
CAediting_176406	chr2_44315012_+	ENSG00000138079.12	ENST00000409229	hsa-miR-6086	44315009	44315015	7mer-m8	44314997	44315016	152	-23.83
CAediting_176407	chr2_44315057_+	ENSG00000138079.12	ENST00000409229	hsa-miR-6779-5p	44315050	44315057	8mer-1a	44315038	44315057	146	-20.38
CAediting_176407	chr2_44315057_+	ENSG00000138079.12	ENST00000409229	hsa-miR-6780a-5p	44315050	44315057	8mer-1a	44315034	44315057	152	-23.27
CAediting_176405	chr2_44315006_+	ENSG00000138079.12	ENST00000409229	hsa-miR-6807-5p	44314999	44315005	7mer-m8	44314985	44315006	141	-16.22
CAediting_176408	chr2_44315140_+	ENSG00000138079.12	ENST00000409229	hsa-miR-7855-5p	44315137	44315142	6mer	44315123	44315143	140	-24.46
CAediting_176409	chr2_44315143_+	ENSG00000138079.12	ENST00000409229	hsa-miR-7855-5p	44315137	44315142	6mer	44315123	44315143	140	-24.46
CAediting_176407	chr2_44315057_+	ENSG00000138079.12	ENST00000409229	hsa-miR-887-5p	44315051	44315057	7mer-m8	44315037	44315058	152	-21.24
CAediting_176413	chr2_44315204_+	ENSG00000138079.12	ENST00000409229	hsa-miR-887-5p	44315197	44315204	8mer-1a	44315184	44315204	147	-13.82

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1229414	chr17_67471546_+	ENSG00000138079.12	ENST00000409387	hsa-miR-548aa	44318304	44318310	7mer-m8	44318287	44318311	140	-12.74
CAediting_1229413	chr17_67471544_+	ENSG00000138079.12	ENST00000409229	hsa-miR-548aa	44315155	44315162	8mer-1a	44315138	44315162	140	-13.69
CAediting_1229414	chr17_67471546_+	ENSG00000138079.12	ENST00000409229	hsa-miR-548aa	44314993	44314999	7mer-m8	44314972	44315000	169	-23.3
CAediting_1229415	chr17_67471547_+	ENSG00000138079.12	ENST00000409229	hsa-miR-548aa	44314439	44314445	7mer-m8	44314422	44314446	154	-8.94
CAediting_396018	chr5_1062918_-	ENSG00000138079.12	ENST00000409229	hsa-miR-4635	44315173	44315178	6mer	44315159	44315179	146	-18.69
CAediting_524911	chr7_5495852_-	ENSG00000138079.12	ENST00000409229	hsa-miR-589-3p	44314415	44314421	7mer-m8	44314399	44314422	149	-17.42
CAediting_468389	chr6_31355314_-	ENSG00000138079.12	ENST00000409229	hsa-miR-6891-5p	44314263	44314269	7mer-m8	44314252	44314270	144	-20.65

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_524911	chr7_5495852_-	ENSG00000138079.12	ENST00000409229	hsa-miR-589-3p	44314373	44314380	8mer-1a	44314355	44314380	149	-13.52
CAediting_580943	chr7_100356700_+	ENSG00000138079.12	ENST00000409229	hsa-miR-6840-3p	44315020	44315026	7mer-m8	44315002	44315027	147	-23.38

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SLC3A1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000409229.6	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_176403	ENST00000409229.6	chr2_44314980_+	-860.30	-855.70	-877.60
CAediting_176404	ENST00000409229.6	chr2_44314988_+	-857.70	-855.70	-877.60
CAediting_176405	ENST00000409229.6	chr2_44315006_+	-856.00	-855.70	-877.60
CAediting_176406	ENST00000409229.6	chr2_44315012_+	-857.40	-855.70	-877.60
CAediting_176407	ENST00000409229.6	chr2_44315057_+	-855.00	-855.70	-877.60
CAediting_176408	ENST00000409229.6	chr2_44315140_+	-856.50	-855.70	-877.60
CAediting_176409	ENST00000409229.6	chr2_44315143_+	-856.40	-855.70	-877.60
CAediting_176410	ENST00000409229.6	chr2_44315152_+	-857.70	-855.70	-877.60
CAediting_176411	ENST00000409229.6	chr2_44315164_+	-856.60	-855.70	-877.60
CAediting_176412	ENST00000409229.6	chr2_44315165_+	-856.00	-855.70	-877.60
CAediting_176413	ENST00000409229.6	chr2_44315204_+	-856.40	-855.70	-877.60
CAediting_176414	ENST00000409229.6	chr2_44315205_+	-860.70	-855.70	-877.60

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Relation with ADAR for SLC3A1

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
KIRC	CAediting_176424	chr2_44315467_+	0.0146117328016678	0.19904310633023	.	.	.	.
KIRP	CAediting_176424	chr2_44315467_+	0.00178462881139998	0.311662812646728	.	.	.	.

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Relation with cancer stages for SLC3A1

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
KIRP	clinical_stage	CAediting_176424	chr2_44315467_+	0.0371414656707778	0.259108518919145
KIRP	pathologic_stage	CAediting_176416	chr2_44315387_+	0.00706506976780566	0.356116650671107
KIRP	pathologic_stage	CAediting_176424	chr2_44315467_+	0.00219478907062607	0.322315106003981
KIRP	pathologic_stage	CAediting_176430	chr2_44315597_+	0.0419988073342426	0.270299830976494

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Relation with survival for SLC3A1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for SLC3A1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SLC3A1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
SLC3A1	C0010691	Cystinuria	20	CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
SLC3A1	C1848030	Hypotonia-Cystinuria Syndrome	2	CTD_human;ORPHANET
SLC3A1	C1857388	Cystinuria, Type A	1	ORPHANET
SLC3A1	C4304537	2p21 microdeletion syndrome	1	ORPHANET

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene