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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: SLC2A5 (CAeditome ID:6518)

Gene summary for SLC2A5

check button Gene summary
Gene informationGene symbol

SLC2A5

Gene ID

6518

Gene namesolute carrier family 2 member 5
SynonymsGLUT-5|GLUT5
Cytomap

1p36.23

Type of geneprotein-coding
Descriptionsolute carrier family 2, facilitated glucose transporter member 5glucose transporter type 5, small intestineglucose transporter-like protein 5solute carrier family 2 (facilitated glucose/fructose transporter), member 5testicular tissue protein Li 81
Modification date20210518
UniProtAcc

P22732

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
SLC2A5

GO:0005353

Solute carrier family 2, facilitated glucose transporter member 5

28083649

SLC2A5

GO:0005353

Solute carrier family 2, facilitated glucose transporter member 5

8333543

SLC2A5

GO:0015755

Solute carrier family 2, facilitated glucose transporter member 5

28083649

SLC2A5

GO:1990539

Solute carrier family 2, facilitated glucose transporter member 5

8333543

SLC2A5

GO:0005886

Solute carrier family 2, facilitated glucose transporter member 5

28083649

SLC2A5

GO:0005887

Solute carrier family 2, facilitated glucose transporter member 5

8333543


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RNA A-to-I events for SLC2A5

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000142583.16
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_8080(9036246, -), CAediting_8081(9036287, -), CAediting_8082(9036288, -), CAediting_8083(9036295, -), CAediting_8084(9036306, -), CAediting_8085(9036324, -), CAediting_8086(9036330, -), CAediting_8087(9036373, -), CAediting_8088(9036400, -), CAediting_8089(9036401, -), CAediting_8090(9036407, -), CAediting_8091(9036411, -), CAediting_8092(9036420, -), CAediting_8093(9036423, -), CAediting_8094(9036424, -), CAediting_8095(9036432, -), CAediting_8096(9036433, -), CAediting_8097(9036596, -), CAediting_8098(9036611, -), CAediting_8099(9036676, -), CAediting_8100(9036741, -), CAediting_8101(9036754, -), CAediting_8102(9036759, -), CAediting_8103(9036778, -), CAediting_8104(9036837, -), CAediting_8105(9036839, -), CAediting_8106(9036840, -), CAediting_8107(9037279, -), CAediting_8108(9043915, -), CAediting_8109(9043959, -), CAediting_8110(9045673, -), CAediting_8111(9045677, -), CAediting_8112(9048758, -), CAediting_8113(9048845, -), CAediting_8114(9049695, -), CAediting_8115(9054707, -), CAediting_8116(9054753, -), CAediting_8117(9055454, -), CAediting_8118(9055930, -), CAediting_8119(9056451, -), CAediting_8120(9057166, -), CAediting_8121(9059281, -), CAediting_8122(9059596, -), CAediting_8123(9059602, -), CAediting_8124(9059733, -), CAediting_8125(9059823, -), CAediting_8126(9061027, -), CAediting_8127(9064027, -), CAediting_8128(9064967, -), CAediting_8129(9064970, -), CAediting_8130(9065014, -), CAediting_8131(9066312, -), CAediting_8132(9066333, -), CAediting_8133(9066429, -), CAediting_8134(9066480, -), CAediting_8135(9066746, -), CAediting_8136(9066764, -), CAediting_8137(9066789, -), CAediting_8138(9066823, -), CAediting_8139(9066866, -), CAediting_8140(9066892, -), CAediting_8141(9068514, -),

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RNA editing positional annotations for SLC2A5 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_8080chr1_9036246_-UTR3
CAediting_8081chr1_9036287_-UTR3
CAediting_8082chr1_9036288_-UTR3
CAediting_8083chr1_9036295_-UTR3
CAediting_8084chr1_9036306_-UTR3
CAediting_8085chr1_9036324_-UTR3
CAediting_8086chr1_9036330_-UTR3
CAediting_8087chr1_9036373_-UTR3
CAediting_8088chr1_9036400_-UTR3
CAediting_8089chr1_9036401_-UTR3
CAediting_8090chr1_9036407_-UTR3
CAediting_8091chr1_9036411_-UTR3
CAediting_8092chr1_9036420_-UTR3
CAediting_8093chr1_9036423_-UTR3
CAediting_8094chr1_9036424_-UTR3
CAediting_8095chr1_9036432_-UTR3
CAediting_8096chr1_9036433_-UTR3
CAediting_8097chr1_9036596_-UTR3
CAediting_8098chr1_9036611_-UTR3
CAediting_8099chr1_9036676_-UTR3
CAediting_8100chr1_9036741_-UTR3
CAediting_8101chr1_9036754_-UTR3
CAediting_8102chr1_9036759_-UTR3
CAediting_8103chr1_9036778_-UTR3
CAediting_8104chr1_9036837_-UTR3
CAediting_8105chr1_9036839_-UTR3
CAediting_8106chr1_9036840_-UTR3
CAediting_8107chr1_9037279_-UTR3
CAediting_8108chr1_9043915_-intronic
CAediting_8109chr1_9043959_-intronic
CAediting_8110chr1_9045673_-intronic
CAediting_8111chr1_9045677_-intronic
CAediting_8112chr1_9048758_-intronic
CAediting_8113chr1_9048845_-intronic
CAediting_8114chr1_9049695_-intronic
CAediting_8115chr1_9054707_-intronic
CAediting_8116chr1_9054753_-intronic
CAediting_8117chr1_9055454_-intronic
CAediting_8118chr1_9055930_-intronic
CAediting_8119chr1_9056451_-intronic
CAediting_8120chr1_9057166_-intronic
CAediting_8121chr1_9059281_-intronic
CAediting_8122chr1_9059596_-intronic
CAediting_8123chr1_9059602_-intronic
CAediting_8124chr1_9059733_-intronic
CAediting_8125chr1_9059823_-intronic
CAediting_8126chr1_9061027_-intronic
CAediting_8127chr1_9064027_-intronic
CAediting_8128chr1_9064967_-intronic
CAediting_8129chr1_9064970_-intronic
CAediting_8130chr1_9065014_-intronic
CAediting_8131chr1_9066312_-intronic
CAediting_8132chr1_9066333_-intronic
CAediting_8133chr1_9066429_-intronic
CAediting_8134chr1_9066480_-intronic
CAediting_8135chr1_9066746_-intronic
CAediting_8136chr1_9066764_-intronic
CAediting_8137chr1_9066789_-intronic
CAediting_8138chr1_9066823_-intronic
CAediting_8139chr1_9066866_-intronic
CAediting_8140chr1_9066892_-intronic
CAediting_8141chr1_9068514_-intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_8080chr1_9036246_-SINEAluAluJb
CAediting_8081chr1_9036287_-SINEAluAluJb
CAediting_8082chr1_9036288_-SINEAluAluJb
CAediting_8083chr1_9036295_-SINEAluAluJb
CAediting_8084chr1_9036306_-SINEAluAluJb
CAediting_8085chr1_9036324_-SINEAluAluJb
CAediting_8086chr1_9036330_-SINEAluAluJb
CAediting_8087chr1_9036373_-SINEAluAluJb
CAediting_8088chr1_9036400_-SINEAluAluJb
CAediting_8089chr1_9036401_-SINEAluAluJb
CAediting_8090chr1_9036407_-SINEAluAluJb
CAediting_8091chr1_9036411_-SINEAluAluJb
CAediting_8092chr1_9036420_-SINEAluAluJb
CAediting_8093chr1_9036423_-SINEAluAluJb
CAediting_8094chr1_9036424_-SINEAluAluJb
CAediting_8095chr1_9036432_-SINEAluAluJb
CAediting_8096chr1_9036433_-SINEAluAluJb
CAediting_8097chr1_9036596_-SINEAluAluY
CAediting_8098chr1_9036611_-SINEAluAluY
CAediting_8099chr1_9036676_-SINEAluAluY
CAediting_8100chr1_9036741_-SINEAluAluY
CAediting_8101chr1_9036754_-SINEAluAluY
CAediting_8102chr1_9036759_-SINEAluAluY
CAediting_8103chr1_9036778_-SINEAluAluY
CAediting_8104chr1_9036837_-SINEAluAluY
CAediting_8105chr1_9036839_-SINEAluAluY
CAediting_8106chr1_9036840_-SINEAluAluY
CAediting_8108chr1_9043915_-SINEAluAluSq2
CAediting_8109chr1_9043959_-SINEAluAluSq2
CAediting_8110chr1_9045673_-SINEAluAluSq2
CAediting_8111chr1_9045677_-SINEAluAluSq2
CAediting_8112chr1_9048758_-SINEAluAluSz6
CAediting_8113chr1_9048845_-SINEAluAluSz6
CAediting_8114chr1_9049695_-SINEAluAluSx
CAediting_8115chr1_9054707_-SINEAluAluJo
CAediting_8116chr1_9054753_-SINEAluAluJo
CAediting_8117chr1_9055454_-SINEAluAluSx3
CAediting_8118chr1_9055930_-SINEAluAluSx1
CAediting_8119chr1_9056451_-SINEAluAluSq2
CAediting_8120chr1_9057166_-SINEAluAluSx
CAediting_8121chr1_9059281_-SINEAluAluY
CAediting_8122chr1_9059596_-SINEAluAluJr4
CAediting_8123chr1_9059602_-SINEAluAluJr4
CAediting_8124chr1_9059733_-SINEAluAluJr4
CAediting_8125chr1_9059823_-SINEAluAluJr4
CAediting_8126chr1_9061027_-SINEAluAluJb
CAediting_8127chr1_9064027_-SINEAluAluJr4
CAediting_8128chr1_9064967_-SINEAluAluSg
CAediting_8129chr1_9064970_-SINEAluAluSg
CAediting_8130chr1_9065014_-SINEAluAluSg
CAediting_8131chr1_9066312_-SINEAluAluJb
CAediting_8132chr1_9066333_-SINEAluAluJb
CAediting_8133chr1_9066429_-SINEAluAluJb
CAediting_8134chr1_9066480_-SINEAluAluJb
CAediting_8135chr1_9066746_-SINEAluAluJr
CAediting_8136chr1_9066764_-SINEAluAluJr
CAediting_8137chr1_9066789_-SINEAluAluJr
CAediting_8138chr1_9066823_-SINEAluAluJr
CAediting_8139chr1_9066866_-SINEAluAluJr
CAediting_8140chr1_9066892_-SINEAluAluJr
CAediting_8141chr1_9068514_-SINEAluAluSq2

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RNA A-to-I editing events in the alternative splicing sites for SLC2A5

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESCAediting_8114chr1_9049695_-9049695:90497173SS3+0iTTTTTTTTTTTTTTCTTTAGACA10.4TTTTTTTTTTTTTTCTTTAGACG10.16
MEX_2CAediting_8114chr1_9049695_-9049695:90497173SS3+0iTTTTTTTTTTTTTTCTTTAGACA10.4TTTTTTTTTTTTTTCTTTAGACG10.16

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000142583.16.SLC2A5.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000142583.16.SLC2A5.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SLC2A5

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for SLC2A5

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for SLC2A5

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_748296chr10_51299626_+ENSG00000142583.16ENST00000377414hsa-miR-605-3p904029890403047mer-m890402979040314146-15.69
CAediting_1229415chr17_67471547_+ENSG00000142583.16ENST00000377414hsa-miR-548aa904154090415467mer-m890415399041564148-16.03
CAediting_1306323chr19_13836462_-ENSG00000142583.16ENST00000377414hsa-miR-27a-3p904057890405836mer90405779040598142-17.73
CAediting_1306323chr19_13836462_-ENSG00000142583.16ENST00000377414hsa-miR-27a-3p904106690410727mer-m890410659041085154-19.33
CAediting_1368054chr19_46709310_-ENSG00000142583.16ENST00000377414hsa-miR-320e904048990404957mer-m890404889040505146-18.6
CAediting_1368054chr19_46709310_-ENSG00000142583.16ENST00000377414hsa-miR-320e904020690402127mer-m890402059040222142-16.66
CAediting_1524209chrX_134546392_-ENSG00000142583.16ENST00000377414hsa-miR-503-5p904020090402067mer-m890401999040221146-21.96
CAediting_1524209chrX_134546392_-ENSG00000142583.16ENST00000377414hsa-miR-503-5p904012990401346mer90401289040151148-28.44

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1524209chrX_134546392_-ENSG00000142583.16ENST00000377414hsa-miR-503-5p904037490403807mer-m890403739040394155-27.87
CAediting_748296chr10_51299626_+ENSG00000142583.16ENST00000377414hsa-miR-605-3p904019790402037mer-m890401969040215142-15.86
CAediting_468389chr6_31355314_-ENSG00000142583.16ENST00000377414hsa-miR-6891-5p904086690408716mer90408659040883148-22.13

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SLC2A5

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000377424.7protein_codingSoverviewSoverview

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
CAediting_8080ENST00000377424.7chr1_9036246_--1592.60-1593.50-1631.30
CAediting_8081ENST00000377424.7chr1_9036287_--1597.70-1593.50-1631.30
CAediting_8082ENST00000377424.7chr1_9036288_--1597.30-1593.50-1631.30
CAediting_8083ENST00000377424.7chr1_9036295_--1592.60-1593.50-1631.30
CAediting_8084ENST00000377424.7chr1_9036306_--1592.80-1593.50-1631.30
CAediting_8085ENST00000377424.7chr1_9036324_--1600.70-1593.50-1631.30
CAediting_8086ENST00000377424.7chr1_9036330_--1599.30-1593.50-1631.30
CAediting_8087ENST00000377424.7chr1_9036373_--1593.50-1593.50-1631.30
CAediting_8088ENST00000377424.7chr1_9036400_--1590.20-1593.50-1631.30
CAediting_8089ENST00000377424.7chr1_9036401_--1593.50-1593.50-1631.30
CAediting_8090ENST00000377424.7chr1_9036407_--1593.50-1593.50-1631.30
CAediting_8091ENST00000377424.7chr1_9036411_--1592.70-1593.50-1631.30
CAediting_8092ENST00000377424.7chr1_9036420_--1593.20-1593.50-1631.30
CAediting_8093ENST00000377424.7chr1_9036423_--1593.60-1593.50-1631.30
CAediting_8094ENST00000377424.7chr1_9036424_--1596.70-1593.50-1631.30
CAediting_8095ENST00000377424.7chr1_9036432_--1596.40-1593.50-1631.30
CAediting_8096ENST00000377424.7chr1_9036433_--1594.80-1593.50-1631.30
CAediting_8097ENST00000377424.7chr1_9036596_--1598.60-1593.50-1631.30
CAediting_8098ENST00000377424.7chr1_9036611_--1593.40-1593.50-1631.30
CAediting_8099ENST00000377424.7chr1_9036676_--1593.80-1593.50-1631.30
CAediting_8100ENST00000377424.7chr1_9036741_--1592.80-1593.50-1631.30
CAediting_8101ENST00000377424.7chr1_9036754_--1593.30-1593.50-1631.30
CAediting_8102ENST00000377424.7chr1_9036759_--1592.30-1593.50-1631.30
CAediting_8103ENST00000377424.7chr1_9036778_--1595.10-1593.50-1631.30
CAediting_8104ENST00000377424.7chr1_9036837_--1592.90-1593.50-1631.30
CAediting_8105ENST00000377424.7chr1_9036839_--1593.50-1593.50-1631.30
CAediting_8106ENST00000377424.7chr1_9036840_--1599.90-1593.50-1631.30
CAediting_8107ENST00000377424.7chr1_9037279_--1594.60-1593.50-1631.30

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Relation with ADAR for SLC2A5

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
LGGCAediting_8089chr1_9036401_-..0.02490855210893620.208207544426171..
GBMCAediting_8089chr1_9036401_-0.03932477476236980.24013068226128....
KIRCCAediting_8089chr1_9036401_-0.004695837854949580.166733701260045....
GBMCAediting_8092chr1_9036420_-0.02399280512469310.260501658521894....
KIRCCAediting_8092chr1_9036420_-....0.03120911435848130.124836881391665
GBMCAediting_8093chr1_9036423_-0.004187660652833330.376949561868913....
KIRCCAediting_8093chr1_9036423_-0.03123852874554680.146961175743629....
LGGCAediting_8096chr1_9036433_-....0.02826542993598430.192446488975281
GBMCAediting_8096chr1_9036433_-0.003276863804717790.339723997639397....
KIRCCAediting_8096chr1_9036433_-0.0006399892114771190.185601338267835....

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Relation with cancer stages for SLC2A5

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
KIRCpathologic_stageCAediting_8089chr1_9036401_-0.02972751518885210.128788327140838
KIRCpathologic_stageCAediting_8093chr1_9036423_-0.02959111660265970.148758363573937
KIRCpathologic_stageCAediting_8095chr1_9036432_-0.03009816982931640.144630904071438
KIRCpathologic_stageCAediting_8096chr1_9036433_-0.0006358776703303590.186246289584199

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Relation with survival for SLC2A5

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for SLC2A5

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC2A5

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
SLC2A5C0006142Malignant neoplasm of breast1CTD_human
SLC2A5C0678222Breast Carcinoma1CTD_human
SLC2A5C1257931Mammary Neoplasms, Human1CTD_human
SLC2A5C1458155Mammary Neoplasms1CTD_human
SLC2A5C4704874Mammary Carcinoma, Human1CTD_human