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Editing gene: VPS33A (CAeditome ID:65082)

Gene summary for VPS33A

Gene summary

Gene information	Gene symbol	VPS33A
	Gene ID	65082
	Gene name	VPS33A core subunit of CORVET and HOPS complexes
	Synonyms	MPSPS
	Cytomap	12q24.31
	Type of gene	protein-coding
	Description	vacuolar protein sorting-associated protein 33AVPS33A, CORVET/HOPS core subunitvacuolar protein sorting 33 homolog Avacuolar protein sorting 33A
	Modification date	20210529
	UniProtAcc	Q96AX1
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
VPS33A	GO:0016192	Vacuolar protein sorting-associated protein 33A	15790593
VPS33A	GO:0032400	Vacuolar protein sorting-associated protein 33A	15790593
VPS33A	GO:0032418	Vacuolar protein sorting-associated protein 33A	15790593
VPS33A	GO:0005769	Vacuolar protein sorting-associated protein 33A	19109425
VPS33A	GO:0005770	Vacuolar protein sorting-associated protein 33A	19109425
VPS33A	GO:0048471	Vacuolar protein sorting-associated protein 33A	19109425
VPS33A	GO:0030897	Vacuolar protein sorting-associated protein 33A	19109425
VPS33A	GO:0030897	Vacuolar protein sorting-associated protein 33A	23901104
VPS33A	GO:0030897	Vacuolar protein sorting-associated protein 33A	25783203

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RNA A-to-I events for VPS33A

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000139719.8

RNA A-to-I editing events in Cancer.

CAediting_941575(122230315, -), CAediting_941576(122230324, -), CAediting_941577(122230338, -), CAediting_941578(122230351, -), CAediting_941579(122230377, -), CAediting_941580(122230396, -), CAediting_941581(122230411, -), CAediting_941582(122230415, -), CAediting_941583(122230418, -), CAediting_941584(122230432, -), CAediting_941585(122230433, -), CAediting_941586(122230446, -), CAediting_941587(122230455, -), CAediting_941588(122230469, -), CAediting_941589(122230481, -), CAediting_941590(122230488, -), CAediting_941591(122230497, -), CAediting_941592(122230499, -), CAediting_941593(122230524, -), CAediting_941594(122230548, -), CAediting_941595(122231877, -), CAediting_941596(122231891, -), CAediting_941597(122231919, -), CAediting_941598(122232000, -), CAediting_941599(122238494, -), CAediting_941600(122240162, -), CAediting_941601(122242761, -), CAediting_941602(122243859, -), CAediting_941603(122243870, -), CAediting_941604(122245724, -), CAediting_941605(122253351, -), CAediting_941606(122253382, -), CAediting_941607(122253390, -), CAediting_941608(122253396, -), CAediting_941609(122253431, -), CAediting_941610(122253470, -), CAediting_941611(122253471, -), CAediting_941612(122253484, -), CAediting_941613(122253787, -), CAediting_941614(122253794, -), CAediting_941615(122253795, -), CAediting_941616(122253803, -), CAediting_941617(122253806, -), CAediting_941618(122253842, -), CAediting_941619(122253912, -), CAediting_941620(122253917, -), CAediting_941621(122254607, -), CAediting_941622(122254610, -), CAediting_941623(122254868, -), CAediting_941624(122254871, -), CAediting_941625(122256488, -), CAediting_941626(122256497, -), CAediting_941627(122256527, -), CAediting_941628(122257315, -), CAediting_941629(122257341, -), CAediting_941630(122257551, -), CAediting_941631(122257560, -), CAediting_941632(122257561, -), CAediting_941633(122257616, -), CAediting_941634(122257621, -), CAediting_941635(122257626, -), CAediting_941636(122258833, -), CAediting_941637(122258856, -), CAediting_941638(122258965, -), CAediting_941639(122259258, -), CAediting_941640(122259921, -), CAediting_941641(122260478, -),

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RNA editing positional annotations for VPS33A using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_941610	chr12_122253470_-	nonsynonymous SNV	ENST00000451053.2	c.A557G	p.K186R	D	B	N
CAediting_941611	chr12_122253471_-	nonsynonymous SNV	ENST00000451053.2	c.A556G	p.K186E	D	B	N

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_941575	chr12_122230315_-	UTR3
CAediting_941576	chr12_122230324_-	UTR3
CAediting_941577	chr12_122230338_-	UTR3
CAediting_941578	chr12_122230351_-	UTR3
CAediting_941579	chr12_122230377_-	UTR3
CAediting_941580	chr12_122230396_-	UTR3
CAediting_941581	chr12_122230411_-	UTR3
CAediting_941582	chr12_122230415_-	UTR3
CAediting_941583	chr12_122230418_-	UTR3
CAediting_941584	chr12_122230432_-	UTR3
CAediting_941585	chr12_122230433_-	UTR3
CAediting_941586	chr12_122230446_-	UTR3
CAediting_941587	chr12_122230455_-	UTR3
CAediting_941588	chr12_122230469_-	UTR3
CAediting_941589	chr12_122230481_-	UTR3
CAediting_941590	chr12_122230488_-	UTR3
CAediting_941591	chr12_122230497_-	UTR3
CAediting_941592	chr12_122230499_-	UTR3
CAediting_941593	chr12_122230524_-	UTR3
CAediting_941594	chr12_122230548_-	UTR3
CAediting_941595	chr12_122231877_-	UTR3
CAediting_941596	chr12_122231891_-	UTR3
CAediting_941597	chr12_122231919_-	UTR3
CAediting_941598	chr12_122232000_-	UTR3
CAediting_941599	chr12_122238494_-	ncRNA_intronic
CAediting_941600	chr12_122240162_-	ncRNA_intronic
CAediting_941601	chr12_122242761_-	ncRNA_intronic
CAediting_941602	chr12_122243859_-	ncRNA_intronic
CAediting_941603	chr12_122243870_-	ncRNA_intronic
CAediting_941604	chr12_122245724_-	ncRNA_intronic
CAediting_941605	chr12_122253351_-	ncRNA_intronic
CAediting_941606	chr12_122253382_-	ncRNA_intronic
CAediting_941607	chr12_122253390_-	ncRNA_intronic
CAediting_941608	chr12_122253396_-	ncRNA_intronic
CAediting_941609	chr12_122253431_-	ncRNA_intronic
CAediting_941610	chr12_122253470_-	exonic
CAediting_941611	chr12_122253471_-	exonic
CAediting_941612	chr12_122253484_-	exonic
CAediting_941613	chr12_122253787_-	ncRNA_intronic
CAediting_941614	chr12_122253794_-	ncRNA_intronic
CAediting_941615	chr12_122253795_-	ncRNA_intronic
CAediting_941616	chr12_122253803_-	ncRNA_intronic
CAediting_941617	chr12_122253806_-	ncRNA_intronic
CAediting_941618	chr12_122253842_-	ncRNA_intronic
CAediting_941619	chr12_122253912_-	ncRNA_intronic
CAediting_941620	chr12_122253917_-	ncRNA_intronic
CAediting_941621	chr12_122254607_-	ncRNA_intronic
CAediting_941622	chr12_122254610_-	ncRNA_intronic
CAediting_941623	chr12_122254868_-	ncRNA_intronic
CAediting_941624	chr12_122254871_-	ncRNA_intronic
CAediting_941625	chr12_122256488_-	ncRNA_intronic
CAediting_941626	chr12_122256497_-	ncRNA_intronic
CAediting_941627	chr12_122256527_-	ncRNA_intronic
CAediting_941628	chr12_122257315_-	ncRNA_intronic
CAediting_941629	chr12_122257341_-	ncRNA_intronic
CAediting_941630	chr12_122257551_-	ncRNA_intronic
CAediting_941631	chr12_122257560_-	ncRNA_intronic
CAediting_941632	chr12_122257561_-	ncRNA_intronic
CAediting_941633	chr12_122257616_-	ncRNA_intronic
CAediting_941634	chr12_122257621_-	ncRNA_intronic
CAediting_941635	chr12_122257626_-	ncRNA_intronic
CAediting_941636	chr12_122258833_-	ncRNA_intronic
CAediting_941637	chr12_122258856_-	ncRNA_intronic
CAediting_941638	chr12_122258965_-	ncRNA_intronic
CAediting_941639	chr12_122259258_-	ncRNA_intronic
CAediting_941640	chr12_122259921_-	ncRNA_intronic
CAediting_941641	chr12_122260478_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_941575	chr12_122230315_-	SINE	Alu	AluSx
CAediting_941576	chr12_122230324_-	SINE	Alu	AluSx
CAediting_941577	chr12_122230338_-	SINE	Alu	AluSx
CAediting_941578	chr12_122230351_-	SINE	Alu	AluSx
CAediting_941579	chr12_122230377_-	SINE	Alu	AluSx
CAediting_941580	chr12_122230396_-	SINE	Alu	AluSx
CAediting_941581	chr12_122230411_-	SINE	Alu	AluSx
CAediting_941582	chr12_122230415_-	SINE	Alu	AluSx
CAediting_941583	chr12_122230418_-	SINE	Alu	AluSx
CAediting_941584	chr12_122230432_-	SINE	Alu	AluSx
CAediting_941585	chr12_122230433_-	SINE	Alu	AluSx
CAediting_941586	chr12_122230446_-	SINE	Alu	AluSx
CAediting_941587	chr12_122230455_-	SINE	Alu	AluSx
CAediting_941588	chr12_122230469_-	SINE	Alu	AluSx
CAediting_941589	chr12_122230481_-	SINE	Alu	AluSx
CAediting_941590	chr12_122230488_-	SINE	Alu	AluSx
CAediting_941591	chr12_122230497_-	SINE	Alu	AluSx
CAediting_941592	chr12_122230499_-	SINE	Alu	AluSx
CAediting_941593	chr12_122230524_-	SINE	Alu	AluSx
CAediting_941594	chr12_122230548_-	SINE	Alu	AluSx
CAediting_941595	chr12_122231877_-	SINE	Alu	AluSx
CAediting_941596	chr12_122231891_-	SINE	Alu	AluSx
CAediting_941597	chr12_122231919_-	SINE	Alu	AluSx
CAediting_941598	chr12_122232000_-	SINE	Alu	AluSx
CAediting_941599	chr12_122238494_-	SINE	Alu	AluSz
CAediting_941600	chr12_122240162_-	SINE	Alu	AluSz6
CAediting_941601	chr12_122242761_-	SINE	Alu	AluSx1
CAediting_941602	chr12_122243859_-	SINE	Alu	AluJb
CAediting_941603	chr12_122243870_-	SINE	Alu	AluJb
CAediting_941604	chr12_122245724_-	SINE	Alu	AluSq2
CAediting_941605	chr12_122253351_-	SINE	Alu	AluSg
CAediting_941606	chr12_122253382_-	SINE	Alu	AluSg
CAediting_941607	chr12_122253390_-	SINE	Alu	AluSg
CAediting_941608	chr12_122253396_-	SINE	Alu	AluSg
CAediting_941609	chr12_122253431_-	SINE	Alu	AluSg
CAediting_941610	chr12_122253470_-	SINE	Alu	AluSg
CAediting_941611	chr12_122253471_-	SINE	Alu	AluSg
CAediting_941612	chr12_122253484_-	SINE	Alu	AluSg
CAediting_941613	chr12_122253787_-	SINE	Alu	AluSx1
CAediting_941614	chr12_122253794_-	SINE	Alu	AluSx1
CAediting_941615	chr12_122253795_-	SINE	Alu	AluSx1
CAediting_941616	chr12_122253803_-	SINE	Alu	AluSx1
CAediting_941617	chr12_122253806_-	SINE	Alu	AluSx1
CAediting_941618	chr12_122253842_-	SINE	Alu	AluSx1
CAediting_941619	chr12_122253912_-	SINE	Alu	AluSx1
CAediting_941620	chr12_122253917_-	SINE	Alu	AluSx1
CAediting_941621	chr12_122254607_-	SINE	Alu	AluSx
CAediting_941622	chr12_122254610_-	SINE	Alu	AluSx
CAediting_941623	chr12_122254868_-	SINE	Alu	AluSx1
CAediting_941624	chr12_122254871_-	SINE	Alu	AluSx1
CAediting_941625	chr12_122256488_-	SINE	Alu	AluSz
CAediting_941626	chr12_122256497_-	SINE	Alu	AluSz
CAediting_941627	chr12_122256527_-	SINE	Alu	AluSz
CAediting_941628	chr12_122257315_-	SINE	Alu	AluSx1
CAediting_941629	chr12_122257341_-	SINE	Alu	AluSx1
CAediting_941630	chr12_122257551_-	SINE	Alu	AluSx
CAediting_941631	chr12_122257560_-	SINE	Alu	AluSx
CAediting_941632	chr12_122257561_-	SINE	Alu	AluSx
CAediting_941633	chr12_122257616_-	SINE	Alu	AluSx
CAediting_941634	chr12_122257621_-	SINE	Alu	AluSx
CAediting_941635	chr12_122257626_-	SINE	Alu	AluSx
CAediting_941636	chr12_122258833_-	SINE	Alu	AluSx
CAediting_941637	chr12_122258856_-	SINE	Alu	AluSx
CAediting_941638	chr12_122258965_-	SINE	Alu	AluSx
CAediting_941639	chr12_122259258_-	SINE	Alu	AluSp
CAediting_941640	chr12_122259921_-	SINE	Alu	AluJr
CAediting_941641	chr12_122260478_-	SINE	Alu	AluSx1

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RNA A-to-I editing events in the alternative splicing sites for VPS33A

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000139719.8.VPS33A.

Correlation between RNA A-to-I editing and PSI for ENSG00000139719.8.VPS33A.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for VPS33A

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for VPS33A

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for VPS33A

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_941576	chr12_122230324_-	ENSG00000139719.8	ENST00000267199	hsa-miR-106a-3p	122230322	122230327	6mer	122230321	122230342	141.00	-21.13
CAediting_941577	chr12_122230338_-	ENSG00000139719.8	ENST00000267199	hsa-miR-6746-5p	122230337	122230343	7mer-1a	122230337	122230358	140.00	-28.51
CAediting_941577	chr12_122230338_-	ENSG00000139719.8	ENST00000267199	hsa-miR-6771-5p	122230336	122230343	8mer-1a	122230336	122230360	166.00	-33.43
CAediting_941579	chr12_122230377_-	ENSG00000139719.8	ENST00000267199	hsa-miR-12119	122230376	122230381	6mer	122230375	122230402	141.00	-17.82
CAediting_941579	chr12_122230377_-	ENSG00000139719.8	ENST00000267199	hsa-miR-4294	122230372	122230378	7mer-m8	122230371	122230388	150.00	-18.29
CAediting_941579	chr12_122230377_-	ENSG00000139719.8	ENST00000267199	hsa-miR-4329	122230376	122230383	8mer-1a	122230376	122230394	145.00	-16.55
CAediting_941584	chr12_122230432_-	ENSG00000139719.8	ENST00000267199	hsa-miR-548ae-3p	122230427	122230433	7mer-m8	122230426	122230447	143.00	-11.52
CAediting_941584	chr12_122230432_-	ENSG00000139719.8	ENST00000267199	hsa-miR-548ae-3p	122230427	122230433	7mer-m8	122230426	122230447	143.00	-11.52
CAediting_941584	chr12_122230432_-	ENSG00000139719.8	ENST00000267199	hsa-miR-548ah-3p	122230427	122230433	7mer-m8	122230426	122230449	145.00	-12.47
CAediting_941584	chr12_122230432_-	ENSG00000139719.8	ENST00000267199	hsa-miR-548aj-3p	122230427	122230433	7mer-m8	122230426	122230447	143.00	-9.41
CAediting_941584	chr12_122230432_-	ENSG00000139719.8	ENST00000267199	hsa-miR-548aj-3p	122230427	122230433	7mer-m8	122230426	122230447	143.00	-9.41
CAediting_941584	chr12_122230432_-	ENSG00000139719.8	ENST00000267199	hsa-miR-548am-3p	122230427	122230433	7mer-m8	122230426	122230449	145.00	-11.74
CAediting_941584	chr12_122230432_-	ENSG00000139719.8	ENST00000267199	hsa-miR-548aq-3p	122230427	122230433	7mer-m8	122230426	122230448	143.00	-11.90
CAediting_941584	chr12_122230432_-	ENSG00000139719.8	ENST00000267199	hsa-miR-548j-3p	122230427	122230433	7mer-m8	122230426	122230446	141.00	-11.52
CAediting_941584	chr12_122230432_-	ENSG00000139719.8	ENST00000267199	hsa-miR-548x-3p	122230427	122230433	7mer-m8	122230426	122230446	143.00	-9.41
CAediting_941584	chr12_122230432_-	ENSG00000139719.8	ENST00000267199	hsa-miR-548x-3p	122230427	122230433	7mer-m8	122230426	122230446	143.00	-9.41
CAediting_941584	chr12_122230432_-	ENSG00000139719.8	ENST00000267199	hsa-miR-7844-5p	122230429	122230435	7mer-m8	122230428	122230449	168.00	-23.16
CAediting_941585	chr12_122230433_-	ENSG00000139719.8	ENST00000267199	hsa-miR-3157-5p	122230432	122230438	7mer-m8	122230431	122230453	155.00	-22.88
CAediting_941585	chr12_122230433_-	ENSG00000139719.8	ENST00000267199	hsa-miR-34a-3p	122230430	122230436	7mer-m8	122230429	122230451	149.00	-8.76
CAediting_941586	chr12_122230446_-	ENSG00000139719.8	ENST00000267199	hsa-miR-4746-3p	122230445	122230451	7mer-m8	122230444	122230466	150.00	-20.03
CAediting_941587	chr12_122230455_-	ENSG00000139719.8	ENST00000267199	hsa-miR-1228-3p	122230451	122230457	7mer-m8	122230450	122230467	147.00	-19.76
CAediting_941588	chr12_122230469_-	ENSG00000139719.8	ENST00000267199	hsa-miR-4691-3p	122230465	122230471	7mer-m8	122230464	122230491	150.00	-28.00
CAediting_941590	chr12_122230488_-	ENSG00000139719.8	ENST00000267199	hsa-miR-3622a-5p	122230483	122230489	7mer-m8	122230482	122230502	154.00	-23.08
CAediting_941591	chr12_122230497_-	ENSG00000139719.8	ENST00000267199	hsa-miR-6078	122230494	122230501	8mer-1a	122230494	122230512	149.00	-20.85
CAediting_941596	chr12_122231891_-	ENSG00000139719.8	ENST00000267199	hsa-miR-4701-5p	122231887	122231893	7mer-m8	122231886	122231907	153.00	-12.71
CAediting_941596	chr12_122231891_-	ENSG00000139719.8	ENST00000267199	hsa-miR-588	122231887	122231893	7mer-m8	122231886	122231907	150.00	-13.81
CAediting_941597	chr12_122231919_-	ENSG00000139719.8	ENST00000267199	hsa-miR-4466	122231915	122231921	7mer-m8	122231914	122231931	140.00	-24.15
CAediting_941597	chr12_122231919_-	ENSG00000139719.8	ENST00000267199	hsa-miR-675-5p	122231915	122231921	7mer-m8	122231914	122231935	145.00	-18.60
CAediting_941598	chr12_122232000_-	ENSG00000139719.8	ENST00000267199	hsa-miR-381-5p	122231999	122232005	7mer-m8	122231998	122232019	146.00	-19.29
CAediting_941581	chr12_122230411_-	ENSG00000139719.8	ENST00000267199	hsa-miR-1224-3p	122230407	122230413	7mer-m8	122230406	122230426	149.00	-22.51

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_941598	chr12_122232000_-	ENSG00000139719.8	ENST00000267199	hsa-miR-1294	122231999	122232005	7mer-m8	122231998	122232018	151	-20.27
CAediting_941575	chr12_122230315_-	ENSG00000139719.8	ENST00000267199	hsa-miR-203a-5p	122230310	122230316	7mer-m8	122230309	122230333	152	-17.58
CAediting_941577	chr12_122230338_-	ENSG00000139719.8	ENST00000267199	hsa-miR-30b-3p	122230337	122230344	8mer-1a	122230337	122230358	155	-18.05
CAediting_941593	chr12_122230524_-	ENSG00000139719.8	ENST00000267199	hsa-miR-3174	122230522	122230527	6mer	122230521	122230543	143	-20.42
CAediting_941590	chr12_122230488_-	ENSG00000139719.8	ENST00000267199	hsa-miR-3622b-5p	122230484	122230489	6mer	122230483	122230504	140	-20.46
CAediting_941581	chr12_122230411_-	ENSG00000139719.8	ENST00000267199	hsa-miR-3675-3p	122230410	122230416	7mer-m8	122230409	122230430	145	-12.58
CAediting_941582	chr12_122230415_-	ENSG00000139719.8	ENST00000267199	hsa-miR-3675-3p	122230410	122230416	7mer-m8	122230409	122230430	145	-12.58
CAediting_941587	chr12_122230455_-	ENSG00000139719.8	ENST00000267199	hsa-miR-3686	122230455	122230461	7mer-m8	122230454	122230475	140	-11.03
CAediting_941577	chr12_122230338_-	ENSG00000139719.8	ENST00000267199	hsa-miR-3689a-3p	122230337	122230344	8mer-1a	122230337	122230357	144	-20.77
CAediting_941577	chr12_122230338_-	ENSG00000139719.8	ENST00000267199	hsa-miR-3689b-3p	122230337	122230344	8mer-1a	122230337	122230357	144	-20.82
CAediting_941577	chr12_122230338_-	ENSG00000139719.8	ENST00000267199	hsa-miR-3689c	122230337	122230344	8mer-1a	122230337	122230357	144	-20.82
CAediting_941594	chr12_122230548_-	ENSG00000139719.8	ENST00000267199	hsa-miR-3925-3p	122230547	122230553	7mer-m8	122230546	122230566	149	-15.74
CAediting_941589	chr12_122230481_-	ENSG00000139719.8	ENST00000267199	hsa-miR-3929	122230477	122230483	7mer-m8	122230476	122230497	152	-19.95
CAediting_941597	chr12_122231919_-	ENSG00000139719.8	ENST00000267199	hsa-miR-4455	122231914	122231920	7mer-m8	122231913	122231928	148	-16.9
CAediting_941589	chr12_122230481_-	ENSG00000139719.8	ENST00000267199	hsa-miR-4478	122230477	122230483	7mer-m8	122230476	122230494	153	-25.39
CAediting_941580	chr12_122230396_-	ENSG00000139719.8	ENST00000267199	hsa-miR-4517	122230394	122230399	6mer	122230393	122230416	152	-19.07
CAediting_941592	chr12_122230499_-	ENSG00000139719.8	ENST00000267199	hsa-miR-4539	122230497	122230503	7mer-1a	122230497	122230516	141	-21.16
CAediting_941589	chr12_122230481_-	ENSG00000139719.8	ENST00000267199	hsa-miR-4649-3p	122230480	122230486	7mer-m8	122230479	122230499	147	-14.24
CAediting_941594	chr12_122230548_-	ENSG00000139719.8	ENST00000267199	hsa-miR-508-5p	122230546	122230552	7mer-m8	122230545	122230576	142	-28.61
CAediting_941578	chr12_122230351_-	ENSG00000139719.8	ENST00000267199	hsa-miR-541-3p	122230349	122230355	7mer-m8	122230348	122230369	147	-23.23
CAediting_941580	chr12_122230396_-	ENSG00000139719.8	ENST00000267199	hsa-miR-5583-3p	122230394	122230400	7mer-m8	122230393	122230414	143	-8.55
CAediting_941580	chr12_122230396_-	ENSG00000139719.8	ENST00000267199	hsa-miR-5583-3p	122230394	122230400	7mer-m8	122230393	122230414	143	-8.55
CAediting_941588	chr12_122230469_-	ENSG00000139719.8	ENST00000267199	hsa-miR-5690	122230465	122230471	7mer-m8	122230464	122230484	145	-17.72
CAediting_941590	chr12_122230488_-	ENSG00000139719.8	ENST00000267199	hsa-miR-580-3p	122230488	122230494	7mer-m8	122230487	122230510	150	-16.56
CAediting_941578	chr12_122230351_-	ENSG00000139719.8	ENST00000267199	hsa-miR-6134	122230347	122230353	7mer-m8	122230346	122230364	142	-16.76
CAediting_941578	chr12_122230351_-	ENSG00000139719.8	ENST00000267199	hsa-miR-654-5p	122230349	122230355	7mer-m8	122230348	122230369	146	-20.58
CAediting_941577	chr12_122230338_-	ENSG00000139719.8	ENST00000267199	hsa-miR-6779-5p	122230337	122230344	8mer-1a	122230337	122230360	148	-24.09
CAediting_941577	chr12_122230338_-	ENSG00000139719.8	ENST00000267199	hsa-miR-6780a-5p	122230337	122230344	8mer-1a	122230337	122230361	143	-19.7
CAediting_941589	chr12_122230481_-	ENSG00000139719.8	ENST00000267199	hsa-miR-6884-5p	122230476	122230482	7mer-m8	122230475	122230499	154	-23.24
CAediting_941589	chr12_122230481_-	ENSG00000139719.8	ENST00000267199	hsa-miR-7160-5p	122230479	122230485	7mer-m8	122230478	122230498	146	-18.59
CAediting_941594	chr12_122230548_-	ENSG00000139719.8	ENST00000267199	hsa-miR-7703	122230543	122230549	7mer-m8	122230542	122230564	154	-18.52
CAediting_941595	chr12_122231877_-	ENSG00000139719.8	ENST00000267199	hsa-miR-7855-5p	122231874	122231879	6mer	122231873	122231894	140	-16.84
CAediting_941577	chr12_122230338_-	ENSG00000139719.8	ENST00000267199	hsa-miR-887-5p	122230336	122230343	8mer-1a	122230336	122230356	147	-13.82
CAediting_941598	chr12_122232000_-	ENSG00000139719.8	ENST00000267199	hsa-miR-9986	122231999	122232005	7mer-m8	122231998	122232019	148	-18.28

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000139719.8	ENST00000543633	hsa-miR-200b-3p	122244573	122244579	7mer-m8	122244572	122244591	157	-15.35
CAediting_1368054	chr19_46709310_-	ENSG00000139719.8	ENST00000267199	hsa-miR-320e	122231613	122231619	7mer-m8	122231612	122231629	140	-16.32
CAediting_86358	chr1_109598906_+	ENSG00000139719.8	ENST00000267199	hsa-miR-197-5p	122230007	122230013	7mer-m8	122230006	122230028	140	-13.47
CAediting_580943	chr7_100356700_+	ENSG00000139719.8	ENST00000267199	hsa-miR-6840-3p	122230503	122230509	7mer-m8	122230502	122230523	143	-28
CAediting_524911	chr7_5495852_-	ENSG00000139719.8	ENST00000267199	hsa-miR-589-3p	122232038	122232044	7mer-m8	122232037	122232061	162	-23.13

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1368054	chr19_46709310_-	ENSG00000139719.8	ENST00000267199	hsa-miR-320e	122232122	122232127	6mer	122232121	122232138	140	-16.12
CAediting_396018	chr5_1062918_-	ENSG00000139719.8	ENST00000267199	hsa-miR-4635	122231523	122231529	7mer-m8	122231522	122231540	144	-14.01
CAediting_1351755	chr19_40282625_-	ENSG00000139719.8	ENST00000267199	hsa-miR-641	122230126	122230133	8mer-1a	122230126	122230149	140	-9.64
CAediting_580943	chr7_100356700_+	ENSG00000139719.8	ENST00000267199	hsa-miR-6840-3p	122229981	122229987	7mer-m8	122229980	122230001	140	-18.27
CAediting_580943	chr7_100356700_+	ENSG00000139719.8	ENST00000267199	hsa-miR-6840-3p	122229930	122229937	8mer-1a	122229930	122229951	145	-21.86

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for VPS33A

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for VPS33A

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for VPS33A

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

Top

Relation with survival for VPS33A

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for VPS33A

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for VPS33A

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
VPS33A	C4310627	MUCOPOLYSACCHARIDOSIS-PLUS SYNDROME	2	CTD_human;ORPHANET;UNIPROT

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene