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Editing gene: TMEM237 (CAeditome ID:65062)

Gene summary for TMEM237

Gene summary

Gene information	Gene symbol	TMEM237
	Gene ID	65062
	Gene name	transmembrane protein 237
	Synonyms	ALS2CR4\|JBTS14
	Cytomap	2q33.1
	Type of gene	protein-coding
	Description	transmembrane protein 237amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein
	Modification date	20210518
	UniProtAcc	Q96Q45
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
TMEM237	GO:0035869	Transmembrane protein 237	22152675

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RNA A-to-I events for TMEM237

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000155755.17

RNA A-to-I editing events in Cancer.

CAediting_233892(201621818, -),

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RNA editing positional annotations for TMEM237 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_233892	chr2_201621818_-	ncRNA_exonic

Repat-regional RNA editing(s).

CAeditome ID

Position

Repeat family

Repeat sub family

Repeat name

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RNA A-to-I editing events in the alternative splicing sites for TMEM237

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000155755.17.TMEM237.

Correlation between RNA A-to-I editing and PSI for ENSG00000155755.17.TMEM237.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TMEM237

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for TMEM237

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for TMEM237

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_233892	chr2_201621818_-	ENSG00000155755.17	ENST00000409444	hsa-miR-455-3p	201621818	201621824	7mer-m8	201621817	201621837	143.00	-15.26
CAediting_233892	chr2_201621818_-	ENSG00000155755.17	ENST00000409444	hsa-miR-5195-3p	201621816	201621821	6mer	201621815	201621835	145.00	-23.12

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_233892	chr2_201621818_-	ENSG00000155755.17	ENST00000409444	hsa-miR-554	201621816	201621823	8mer-1a	201621816	201621836	145	-15.15

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_688080	chr9_63819626_+	ENSG00000155755.17	ENST00000409444	hsa-miR-4477b	201621188	201621194	7mer-m8	201621187	201621212	151	-17.37
CAediting_1229413	chr17_67471544_+	ENSG00000155755.17	ENST00000409444	hsa-miR-548aa	201621769	201621775	7mer-m8	201621768	201621792	149	-14.41
CAediting_1229413	chr17_67471544_+	ENSG00000155755.17	ENST00000409444	hsa-miR-548aa	201620238	201620244	7mer-m8	201620237	201620257	144	-11.56
CAediting_1229415	chr17_67471547_+	ENSG00000155755.17	ENST00000409444	hsa-miR-548aa	201622573	201622579	7mer-m8	201622572	201622601	158	-23.06
CAediting_1160181	chr17_7017644_-	ENSG00000155755.17	ENST00000409444	hsa-miR-195-3p	201622039	201622046	8mer-1a	201622039	201622061	145	-12.37
CAediting_1351755	chr19_40282625_-	ENSG00000155755.17	ENST00000409444	hsa-miR-641	201622794	201622800	7mer-m8	201622793	201622815	150	-17.57
CAediting_1351755	chr19_40282625_-	ENSG00000155755.17	ENST00000409444	hsa-miR-641	201621975	201621981	7mer-1a	201621975	201621996	147	-22.91
CAediting_1351755	chr19_40282625_-	ENSG00000155755.17	ENST00000409444	hsa-miR-641	201621914	201621920	7mer-m8	201621913	201621937	157	-14.05
CAediting_1368054	chr19_46709310_-	ENSG00000155755.17	ENST00000409444	hsa-miR-320e	201623413	201623419	7mer-m8	201623412	201623430	142	-19.94
CAediting_117844	chr1_162342605_+	ENSG00000155755.17	ENST00000409444	hsa-miR-556-3p	201622953	201622960	8mer-1a	201622953	201622978	147	-10.66
CAediting_228905	chr2_188297554_+	ENSG00000155755.17	ENST00000409444	hsa-miR-561-3p	201621640	201621646	7mer-m8	201621639	201621659	157	-17.76
CAediting_1368054	chr19_46709310_-	ENSG00000155755.17	ENST00000286196	hsa-miR-320e	201624245	201624252	8mer-1a	201624245	201624263	155	-19.97
CAediting_86358	chr1_109598906_+	ENSG00000155755.17	ENST00000432684	hsa-miR-197-5p	201633410	201633417	8mer-1a	201633410	201633431	149	-20.88
CAediting_86358	chr1_109598906_+	ENSG00000155755.17	ENST00000444047	hsa-miR-197-5p	201633410	201633417	8mer-1a	201633410	201633431	149	-20.88

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000155755.17	ENST00000409444	hsa-miR-200b-3p	201624218	201624224	7mer-m8	201624217	201624235	152	-9.33
CAediting_1306323	chr19_13836462_-	ENSG00000155755.17	ENST00000409444	hsa-miR-27a-3p	201622981	201622987	7mer-m8	201622980	201622998	154	-15.81
CAediting_1306323	chr19_13836462_-	ENSG00000155755.17	ENST00000409444	hsa-miR-27a-3p	201621957	201621963	7mer-m8	201621956	201621977	148	-11.93
CAediting_1368054	chr19_46709310_-	ENSG00000155755.17	ENST00000409444	hsa-miR-320e	201622990	201622996	7mer-m8	201622989	201623006	148	-18.99
CAediting_1368054	chr19_46709310_-	ENSG00000155755.17	ENST00000409444	hsa-miR-320e	201621828	201621835	8mer-1a	201621828	201621845	146	-15.89
CAediting_604450	chr7_133034877_-	ENSG00000155755.17	ENST00000409444	hsa-miR-3654	201622659	201622665	7mer-m8	201622658	201622676	140	-17.11
CAediting_1229413	chr17_67471544_+	ENSG00000155755.17	ENST00000409444	hsa-miR-548aa	201622371	201622377	7mer-m8	201622370	201622391	145	-8.65
CAediting_1229415	chr17_67471547_+	ENSG00000155755.17	ENST00000409444	hsa-miR-548aa	201622371	201622377	7mer-m8	201622370	201622391	145	-8.65
CAediting_1229414	chr17_67471546_+	ENSG00000155755.17	ENST00000409444	hsa-miR-548aa	201622371	201622377	7mer-m8	201622370	201622391	145	-8.65
CAediting_393	chr1_1167164_+	ENSG00000155755.17	ENST00000621467	hsa-miR-200b-3p	201624218	201624224	7mer-m8	201624217	201624235	152	-9.33
CAediting_393	chr1_1167164_+	ENSG00000155755.17	ENST00000286196	hsa-miR-200b-3p	201624218	201624224	7mer-m8	201624217	201624235	152	-9.33

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TMEM237

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000409444.5	protein_coding
ENST00000409883.5	protein_coding
ENST00000495329.1	retained_intron

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_233892	ENST00000409444.5	chr2_201621818_-	-1639.20	-1632.60	-1639.20
CAediting_233892	ENST00000409883.5	chr2_201621818_-	-1579.80	-1573.20	-1579.80
CAediting_233892	ENST00000495329.1	chr2_201621818_-	-1243.60	-1237.00	-1243.60

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Relation with ADAR for TMEM237

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
LGG	CAediting_233892	chr2_201621818_-	6.86203723829687e-10	0.320775831667265	.	.	.	.
BRCA	CAediting_233892	chr2_201621818_-	5.40343191657152e-31	0.532167873000776	.	.	.	.
CESC	CAediting_233892	chr2_201621818_-	0.0341113203460182	0.278734038314629	.	.	.	.
LUAD	CAediting_233892	chr2_201621818_-	0.00761197672943567	0.316439975753364	.	.	.	.
LUSC	CAediting_233892	chr2_201621818_-	6.99792224106169e-10	0.585642537881998	.	.	.	.
GBM	CAediting_233892	chr2_201621818_-	0.00034141655676267	0.363525998026569	.	.	.	.
HNSC	CAediting_233892	chr2_201621818_-	.	.	0.0215494794660756	0.289123802614681	.	.
OV	CAediting_233892	chr2_201621818_-	7.65517986838861e-05	0.361774112840448	.	.	.	.
PCPG	CAediting_233892	chr2_201621818_-	1.58809289023993e-06	0.420323751430386	.	.	.	.
SKCM	CAediting_233892	chr2_201621818_-	0.000142702874924237	0.401021787778408	.	.	.	.
SARC	CAediting_233892	chr2_201621818_-	6.56296177516817e-05	0.481129721304893	.	.	.	.

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Relation with cancer stages for TMEM237

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
LUAD	pathologic_stage	CAediting_233892	chr2_201621818_-	0.04922087015598	0.237696881552292
THCA	pathologic_stage	CAediting_233892	chr2_201621818_-	0.000834032485101447	0.302284049662546

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Relation with survival for TMEM237

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for TMEM237

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for TMEM237

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
TMEM237	C0431399	Familial aplasia of the vermis	2	GENOMICS_ENGLAND;ORPHANET
TMEM237	C3280766	JOUBERT SYNDROME 14	2	GENOMICS_ENGLAND
TMEM237	C4551568	Joubert syndrome 1	2	ORPHANET
TMEM237	C1846790	JOUBERT SYNDROME 4 (disorder)	1	ORPHANET
TMEM237	C1855675	Arima syndrome	1	GENOMICS_ENGLAND;ORPHANET

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene