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| Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: BCL11B (CAeditome ID:64919) |
Gene summary for BCL11B |
 Gene summary |
| Gene information | Gene symbol | BCL11B | Gene ID | 64919 |
| Gene name | BAF chromatin remodeling complex subunit BCL11B | |
| Synonyms | ATL1|ATL1-alpha|ATL1-beta|ATL1-delta|ATL1-gamma|CTIP-2|CTIP2|IDDFSTA|IMD49|RIT1|ZNF856B|hRIT1-alpha | |
| Cytomap | 14q32.2 | |
| Type of gene | protein-coding | |
| Description | B-cell lymphoma/leukemia 11BB cell CLL/lymphoma 11BB-cell CLL/lymphoma 11B (zinc finger protein)B-cell CLL/lymphoma 11B/T-cell receptor delta constant region fusion proteinB-cell lymphoma/leukaemia 11BBCL-11BBCL11B, BAF complex componentBCL11B/TRDC | |
| Modification date | 20210518 | |
| UniProtAcc | Q9C0K0 | |
| Context | - 33663588(Inhibition of BCL11B induces downregulation of PTK7 and results in growth retardation and apoptosis in T-cell acute lymphoblastic leukemia) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| BCL11B | GO:1990837 | B-cell lymphoma/leukemia 11B | 28473536 |
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RNA A-to-I events for BCL11B |
| RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure. |
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| RNA editing frequencies across 33 cancers of gene: ENSG00000127152.16 |
| RNA A-to-I editing events in Cancer. |
| CAediting_1015462(99218177, -), CAediting_1015463(99249853, -), CAediting_1015464(99249871, -), CAediting_1015465(99249884, -), CAediting_1015466(99249964, -), CAediting_1015467(99250160, -), CAediting_1015468(99250174, -), CAediting_1015469(99250210, -), CAediting_1015470(99250230, -), CAediting_1015471(99250302, -), CAediting_1015472(99250307, -), CAediting_1015473(99250308, -), |
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RNA editing positional annotations for BCL11B using Annovar |
| Protein coding RNA editing(s). |
| CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| CAeditome ID | Position | Variant type |
| CAediting_1015462 | chr14_99218177_- | intronic |
| CAediting_1015463 | chr14_99249853_- | intronic |
| CAediting_1015464 | chr14_99249871_- | intronic |
| CAediting_1015465 | chr14_99249884_- | intronic |
| CAediting_1015466 | chr14_99249964_- | intronic |
| CAediting_1015467 | chr14_99250160_- | intronic |
| CAediting_1015468 | chr14_99250174_- | intronic |
| CAediting_1015469 | chr14_99250210_- | intronic |
| CAediting_1015470 | chr14_99250230_- | intronic |
| CAediting_1015471 | chr14_99250302_- | intronic |
| CAediting_1015472 | chr14_99250307_- | intronic |
| CAediting_1015473 | chr14_99250308_- | intronic |
| Repat-regional RNA editing(s). |
| CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| CAediting_1015462 | chr14_99218177_- | SINE | Alu | AluY |
| CAediting_1015463 | chr14_99249853_- | SINE | Alu | AluSx1 |
| CAediting_1015464 | chr14_99249871_- | SINE | Alu | AluSx1 |
| CAediting_1015465 | chr14_99249884_- | SINE | Alu | AluSx1 |
| CAediting_1015466 | chr14_99249964_- | SINE | Alu | AluSx1 |
| CAediting_1015467 | chr14_99250160_- | SINE | Alu | AluY |
| CAediting_1015468 | chr14_99250174_- | SINE | Alu | AluY |
| CAediting_1015469 | chr14_99250210_- | SINE | Alu | AluY |
| CAediting_1015470 | chr14_99250230_- | SINE | Alu | AluY |
| CAediting_1015471 | chr14_99250302_- | SINE | Alu | AluY |
| CAediting_1015472 | chr14_99250307_- | SINE | Alu | AluY |
| CAediting_1015473 | chr14_99250308_- | SINE | Alu | AluY |
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RNA A-to-I editing events in the alternative splicing sites for BCL11B |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000127152.16.BCL11B. |
| Correlation between RNA A-to-I editing and PSI for ENSG00000127152.16.BCL11B. |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for BCL11B |
| Differential gene expressions between RNA A-to-I edited and non-edited tumor samples. * The grey color means N/A. |
| Correlation between RNA A-to-I editing and gene expression. |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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Protein coding region RNA A-to-I editings for BCL11B |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for BCL11B |
| **If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| CAediting_393 | chr1_1167164_+ | ENSG00000127152.16 | ENST00000345514 | hsa-miR-200b-3p | 99173295 | 99173301 | 7mer-m8 | 99173294 | 99173315 | 157 | -13.01 |
| CAediting_393 | chr1_1167164_+ | ENSG00000127152.16 | ENST00000357195 | hsa-miR-200b-3p | 99173295 | 99173301 | 7mer-m8 | 99173294 | 99173315 | 157 | -13.01 |
| CAediting_1229414 | chr17_67471546_+ | ENSG00000127152.16 | ENST00000345514 | hsa-miR-548aa | 99170466 | 99170472 | 7mer-m8 | 99170465 | 99170490 | 161 | -17.3 |
| CAediting_1229414 | chr17_67471546_+ | ENSG00000127152.16 | ENST00000345514 | hsa-miR-548aa | 99170134 | 99170140 | 7mer-m8 | 99170133 | 99170162 | 150 | -21.75 |
| CAediting_77128 | chr1_85133844_+ | ENSG00000127152.16 | ENST00000345514 | hsa-miR-4423-3p | 99172877 | 99172883 | 7mer-m8 | 99172876 | 99172896 | 145 | -16.53 |
| CAediting_442554 | chr5_154685830_+ | ENSG00000127152.16 | ENST00000345514 | hsa-miR-1303 | 99169287 | 99169294 | 8mer-1a | 99169287 | 99169308 | 146 | -17.05 |
| CAediting_414656 | chr5_72878640_+ | ENSG00000127152.16 | ENST00000345514 | hsa-miR-4804-3p | 99173437 | 99173443 | 7mer-m8 | 99173436 | 99173455 | 142 | -17.76 |
| CAediting_524911 | chr7_5495852_- | ENSG00000127152.16 | ENST00000345514 | hsa-miR-589-3p | 99169538 | 99169544 | 7mer-m8 | 99169537 | 99169562 | 155 | -20.51 |
| CAediting_1229414 | chr17_67471546_+ | ENSG00000127152.16 | ENST00000357195 | hsa-miR-548aa | 99170466 | 99170472 | 7mer-m8 | 99170465 | 99170490 | 161 | -17.3 |
| CAediting_1229414 | chr17_67471546_+ | ENSG00000127152.16 | ENST00000357195 | hsa-miR-548aa | 99170134 | 99170140 | 7mer-m8 | 99170133 | 99170162 | 150 | -21.75 |
| CAediting_77128 | chr1_85133844_+ | ENSG00000127152.16 | ENST00000357195 | hsa-miR-4423-3p | 99172877 | 99172883 | 7mer-m8 | 99172876 | 99172896 | 145 | -16.53 |
| CAediting_442554 | chr5_154685830_+ | ENSG00000127152.16 | ENST00000357195 | hsa-miR-1303 | 99169287 | 99169294 | 8mer-1a | 99169287 | 99169308 | 146 | -17.05 |
| CAediting_414656 | chr5_72878640_+ | ENSG00000127152.16 | ENST00000357195 | hsa-miR-4804-3p | 99173437 | 99173443 | 7mer-m8 | 99173436 | 99173455 | 142 | -17.76 |
| CAediting_524911 | chr7_5495852_- | ENSG00000127152.16 | ENST00000357195 | hsa-miR-589-3p | 99169538 | 99169544 | 7mer-m8 | 99169537 | 99169562 | 155 | -20.51 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| CAediting_393 | chr1_1167164_+ | ENSG00000127152.16 | ENST00000345514 | hsa-miR-200b-3p | 99172650 | 99172656 | 7mer-m8 | 99172649 | 99172670 | 149 | -10.98 |
| CAediting_393 | chr1_1167164_+ | ENSG00000127152.16 | ENST00000345514 | hsa-miR-200b-3p | 99172103 | 99172109 | 7mer-m8 | 99172102 | 99172123 | 140 | -10.44 |
| CAediting_393 | chr1_1167164_+ | ENSG00000127152.16 | ENST00000345514 | hsa-miR-200b-3p | 99171910 | 99171916 | 7mer-m8 | 99171909 | 99171930 | 140 | -7.51 |
| CAediting_688081 | chr9_63819627_+ | ENSG00000127152.16 | ENST00000345514 | hsa-miR-4477b | 99169404 | 99169410 | 7mer-m8 | 99169403 | 99169424 | 142 | -7.67 |
| CAediting_396018 | chr5_1062918_- | ENSG00000127152.16 | ENST00000345514 | hsa-miR-4635 | 99169325 | 99169330 | 6mer | 99169324 | 99169344 | 155 | -22.51 |
| CAediting_1524209 | chrX_134546392_- | ENSG00000127152.16 | ENST00000345514 | hsa-miR-503-5p | 99172271 | 99172277 | 7mer-m8 | 99172270 | 99172292 | 140 | -16.67 |
| CAediting_1229413 | chr17_67471544_+ | ENSG00000127152.16 | ENST00000345514 | hsa-miR-548aa | 99173549 | 99173555 | 7mer-m8 | 99173548 | 99173572 | 150 | -6.79 |
| CAediting_1229414 | chr17_67471546_+ | ENSG00000127152.16 | ENST00000345514 | hsa-miR-548aa | 99173549 | 99173555 | 7mer-m8 | 99173548 | 99173572 | 150 | -6.79 |
| CAediting_1229415 | chr17_67471547_+ | ENSG00000127152.16 | ENST00000345514 | hsa-miR-548aa | 99173549 | 99173555 | 7mer-m8 | 99173548 | 99173572 | 150 | -6.79 |
| CAediting_468389 | chr6_31355314_- | ENSG00000127152.16 | ENST00000345514 | hsa-miR-6891-5p | 99170625 | 99170630 | 6mer | 99170624 | 99170643 | 148 | -24.72 |
| CAediting_468389 | chr6_31355314_- | ENSG00000127152.16 | ENST00000345514 | hsa-miR-6891-5p | 99170291 | 99170297 | 7mer-m8 | 99170290 | 99170306 | 145 | -19.49 |
| CAediting_393 | chr1_1167164_+ | ENSG00000127152.16 | ENST00000357195 | hsa-miR-200b-3p | 99172650 | 99172656 | 7mer-m8 | 99172649 | 99172670 | 149 | -10.98 |
| CAediting_393 | chr1_1167164_+ | ENSG00000127152.16 | ENST00000357195 | hsa-miR-200b-3p | 99172103 | 99172109 | 7mer-m8 | 99172102 | 99172123 | 140 | -10.44 |
| CAediting_393 | chr1_1167164_+ | ENSG00000127152.16 | ENST00000357195 | hsa-miR-200b-3p | 99171910 | 99171916 | 7mer-m8 | 99171909 | 99171930 | 140 | -7.51 |
| CAediting_688081 | chr9_63819627_+ | ENSG00000127152.16 | ENST00000357195 | hsa-miR-4477b | 99169404 | 99169410 | 7mer-m8 | 99169403 | 99169424 | 142 | -7.67 |
| CAediting_396018 | chr5_1062918_- | ENSG00000127152.16 | ENST00000357195 | hsa-miR-4635 | 99169325 | 99169330 | 6mer | 99169324 | 99169344 | 155 | -22.51 |
| CAediting_1524209 | chrX_134546392_- | ENSG00000127152.16 | ENST00000357195 | hsa-miR-503-5p | 99172271 | 99172277 | 7mer-m8 | 99172270 | 99172292 | 140 | -16.67 |
| CAediting_1229413 | chr17_67471544_+ | ENSG00000127152.16 | ENST00000357195 | hsa-miR-548aa | 99173549 | 99173555 | 7mer-m8 | 99173548 | 99173572 | 150 | -6.79 |
| CAediting_1229414 | chr17_67471546_+ | ENSG00000127152.16 | ENST00000357195 | hsa-miR-548aa | 99173549 | 99173555 | 7mer-m8 | 99173548 | 99173572 | 150 | -6.79 |
| CAediting_1229415 | chr17_67471547_+ | ENSG00000127152.16 | ENST00000357195 | hsa-miR-548aa | 99173549 | 99173555 | 7mer-m8 | 99173548 | 99173572 | 150 | -6.79 |
| CAediting_468389 | chr6_31355314_- | ENSG00000127152.16 | ENST00000357195 | hsa-miR-6891-5p | 99170625 | 99170630 | 6mer | 99170624 | 99170643 | 148 | -24.72 |
| CAediting_468389 | chr6_31355314_- | ENSG00000127152.16 | ENST00000357195 | hsa-miR-6891-5p | 99170291 | 99170297 | 7mer-m8 | 99170290 | 99170306 | 145 | -19.49 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for BCL11B |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in RNA structures for Minimum free energy (MFE). |
| CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for BCL11B |
| Correlation between ADAR gene expression and RNA editing frequency |
| Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for BCL11B |
| Correlation between Cancer stages and RNA editing frequency |
| Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for BCL11B |
| Correlation between RNA editing and survival |
| Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
| STAD | CAediting_1015466 | chr14_99249964_- | 0.00149349998109782 | 0.00461763 | 20.9444 |
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RelatedDrugs for BCL11B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.8 2021-01-03) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BCL11B |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| BCL11B | C4310656 | IMMUNODEFICIENCY 49 | 2 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| BCL11B | C0024299 | Lymphoma | 1 | CTD_human |
| BCL11B | C1961099 | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 1 | CTD_human |
| BCL11B | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |
| BCL11B | C4748152 | INTELLECTUAL DEVELOPMENTAL DISORDER WITH SPEECH DELAY, DYSMORPHIC FACIES, AND T-CELL ABNORMALITIES | 1 | GENOMICS_ENGLAND |
