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Editing gene: CYP3A43 (CAeditome ID:64816)

Gene summary for CYP3A43

Gene summary

Gene information	Gene symbol	CYP3A43
	Gene ID	64816
	Gene name	cytochrome P450 family 3 subfamily A member 43
	Synonyms	-
	Cytomap	7q22.1
	Type of gene	protein-coding
	Description	cytochrome P450 3A43cytochrome P450, family 3, subfamily A, polypeptide 43cytochrome P450, subfamily IIIA, polypeptide 43
	Modification date	20210518
	UniProtAcc	Q9HB55
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for CYP3A43

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000021461.15

RNA A-to-I editing events in Cancer.

CAediting_578819(99845584, +), CAediting_578820(99845819, +), CAediting_578821(99847738, +), CAediting_578822(99850037, +), CAediting_578823(99850074, +), CAediting_578824(99861794, +),

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RNA editing positional annotations for CYP3A43 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_578819	chr7_99845584_+	ncRNA_intronic
CAediting_578820	chr7_99845819_+	ncRNA_intronic
CAediting_578821	chr7_99847738_+	ncRNA_exonic
CAediting_578822	chr7_99850037_+	exonic
CAediting_578823	chr7_99850074_+	ncRNA_intronic
CAediting_578824	chr7_99861794_+	exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_578819	chr7_99845584_+	SINE	Alu	AluSz6
CAediting_578820	chr7_99845819_+	SINE	Alu	AluSx
CAediting_578821	chr7_99847738_+	SINE	Alu	AluSq2
CAediting_578822	chr7_99850037_+	SINE	Alu	AluSg
CAediting_578823	chr7_99850074_+	SINE	Alu	AluSg

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RNA A-to-I editing events in the alternative splicing sites for CYP3A43

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000021461.15.CYP3A43.

Correlation between RNA A-to-I editing and PSI for ENSG00000021461.15.CYP3A43.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CYP3A43

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CYP3A43

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for CYP3A43

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_578822	chr7_99850037_+	ENSG00000021461.15	ENST00000436834	hsa-miR-3188	99850034	99850040	7mer-m8	99850018	99850041	149.00	-22.42
CAediting_578822	chr7_99850037_+	ENSG00000021461.15	ENST00000433277	hsa-miR-3188	99850034	99850040	7mer-m8	99850018	99850041	149.00	-22.42
CAediting_578824	chr7_99861794_+	ENSG00000021461.15	ENST00000342499	hsa-miR-433-5p	99861788	99861794	7mer-m8	99861774	99861795	141.00	-15.31
CAediting_578824	chr7_99861794_+	ENSG00000021461.15	ENST00000436834	hsa-miR-433-5p	99861788	99861794	7mer-m8	99861774	99861795	141.00	-15.31
CAediting_578824	chr7_99861794_+	ENSG00000021461.15	ENST00000433277	hsa-miR-433-5p	99861788	99861794	7mer-m8	99861774	99861795	141.00	-15.31
CAediting_578824	chr7_99861794_+	ENSG00000021461.15	ENST00000434806	hsa-miR-433-5p	99861788	99861794	7mer-m8	99861774	99861795	141.00	-15.31

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_578822	chr7_99850037_+	ENSG00000021461.15	ENST00000436834	hsa-miR-30a-3p	99850030	99850036	7mer-m8	99850014	99850037	151	-13.88
CAediting_578822	chr7_99850037_+	ENSG00000021461.15	ENST00000436834	hsa-miR-30d-3p	99850030	99850036	7mer-m8	99850014	99850037	150	-13.07
CAediting_578822	chr7_99850037_+	ENSG00000021461.15	ENST00000436834	hsa-miR-30e-3p	99850030	99850036	7mer-m8	99850016	99850037	143	-10.19
CAediting_578823	chr7_99850074_+	ENSG00000021461.15	ENST00000436834	hsa-miR-4478	99850071	99850077	7mer-m8	99850063	99850078	149	-25.05
CAediting_578823	chr7_99850074_+	ENSG00000021461.15	ENST00000436834	hsa-miR-4649-3p	99850068	99850074	7mer-m8	99850055	99850075	140	-14.3
CAediting_578823	chr7_99850074_+	ENSG00000021461.15	ENST00000436834	hsa-miR-7160-5p	99850069	99850075	7mer-m8	99850056	99850076	146	-17.63
CAediting_578822	chr7_99850037_+	ENSG00000021461.15	ENST00000433277	hsa-miR-30a-3p	99850030	99850036	7mer-m8	99850014	99850037	151	-13.88
CAediting_578822	chr7_99850037_+	ENSG00000021461.15	ENST00000433277	hsa-miR-30d-3p	99850030	99850036	7mer-m8	99850014	99850037	150	-13.07
CAediting_578822	chr7_99850037_+	ENSG00000021461.15	ENST00000433277	hsa-miR-30e-3p	99850030	99850036	7mer-m8	99850016	99850037	143	-10.19
CAediting_578823	chr7_99850074_+	ENSG00000021461.15	ENST00000433277	hsa-miR-4478	99850071	99850077	7mer-m8	99850063	99850078	149	-25.05
CAediting_578823	chr7_99850074_+	ENSG00000021461.15	ENST00000433277	hsa-miR-4649-3p	99850068	99850074	7mer-m8	99850055	99850075	140	-14.3
CAediting_578823	chr7_99850074_+	ENSG00000021461.15	ENST00000433277	hsa-miR-7160-5p	99850069	99850075	7mer-m8	99850056	99850076	146	-17.63

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_688081	chr9_63819627_+	ENSG00000021461.15	ENST00000342499	hsa-miR-4477b	99866004	99866010	7mer-m8	99865990	99866011	151	-9.68
CAediting_688081	chr9_63819627_+	ENSG00000021461.15	ENST00000433277	hsa-miR-4477b	99866004	99866010	7mer-m8	99865990	99866011	151	-9.68
CAediting_688081	chr9_63819627_+	ENSG00000021461.15	ENST00000444905	hsa-miR-4477b	99866004	99866010	7mer-m8	99865990	99866011	151	-9.68
CAediting_604450	chr7_133034877_-	ENSG00000021461.15	ENST00000342499	hsa-miR-3654	99859942	99859949	8mer-1a	99859928	99859949	150	-19.48
CAediting_1160181	chr17_7017644_-	ENSG00000021461.15	ENST00000436834	hsa-miR-195-3p	99847558	99847564	7mer-m8	99847546	99847565	152	-12.65
CAediting_604450	chr7_133034877_-	ENSG00000021461.15	ENST00000436834	hsa-miR-3654	99859942	99859949	8mer-1a	99859928	99859949	150	-19.48
CAediting_604450	chr7_133034877_-	ENSG00000021461.15	ENST00000433277	hsa-miR-3654	99859942	99859949	8mer-1a	99859928	99859949	150	-19.48
CAediting_604450	chr7_133034877_-	ENSG00000021461.15	ENST00000434806	hsa-miR-3654	99859942	99859949	8mer-1a	99859928	99859949	150	-19.48

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CYP3A43

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000222382.5	protein_coding
ENST00000312017.8	protein_coding
ENST00000342499.7	protein_coding
ENST00000354829.5	protein_coding
ENST00000415413.4	protein_coding
ENST00000417625.4	protein_coding
ENST00000433277.4	nonsense_mediated_decay
ENST00000434806.4	nonsense_mediated_decay
ENST00000436834.4	nonsense_mediated_decay
ENST00000444905.4	protein_coding
ENST00000477658.4	processed_transcript
ENST00000481362.4	retained_intron
ENST00000491648.4	processed_transcript
ENST00000495115.4	processed_transcript
ENST00000472352.1	retained_intron

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_578824	ENST00000222382.5	chr7_99861794_+	-392.30	-392.20	-392.30
CAediting_578824	ENST00000312017.8	chr7_99861794_+	-349.30	-349.20	-349.30
CAediting_578824	ENST00000342499.7	chr7_99861794_+	-346.00	-345.90	-346.00
CAediting_578824	ENST00000354829.5	chr7_99861794_+	-439.20	-439.10	-439.20
CAediting_578824	ENST00000415413.4	chr7_99861794_+	-257.30	-257.20	-257.30
CAediting_578824	ENST00000417625.4	chr7_99861794_+	-341.30	-341.20	-341.30
CAediting_578822	ENST00000433277.4	chr7_99850037_+	-360.90	-360.30	-361.30
CAediting_578823	ENST00000433277.4	chr7_99850074_+	-360.60	-360.30	-361.30
CAediting_578824	ENST00000433277.4	chr7_99861794_+	-360.40	-360.30	-361.30
CAediting_578822	ENST00000434806.4	chr7_99850037_+	-446.70	-446.10	-447.80
CAediting_578823	ENST00000434806.4	chr7_99850074_+	-447.10	-446.10	-447.80
CAediting_578824	ENST00000434806.4	chr7_99861794_+	-446.20	-446.10	-447.80
CAediting_578822	ENST00000436834.4	chr7_99850037_+	-344.10	-343.50	-343.80
CAediting_578823	ENST00000436834.4	chr7_99850074_+	-343.60	-343.50	-343.80
CAediting_578824	ENST00000436834.4	chr7_99861794_+	-343.10	-343.50	-343.80
CAediting_578824	ENST00000444905.4	chr7_99861794_+	-185.10	-185.00	-185.10
CAediting_578824	ENST00000477658.4	chr7_99861794_+	-267.90	-267.80	-267.90
CAediting_578821	ENST00000481362.4	chr7_99847738_+	-527.50	-527.20	-527.10
CAediting_578824	ENST00000481362.4	chr7_99861794_+	-526.80	-527.20	-527.10
CAediting_578824	ENST00000491648.4	chr7_99861794_+	-244.90	-244.80	-244.90
CAediting_578824	ENST00000495115.4	chr7_99861794_+	-167.10	-167.00	-167.10
CAediting_578824	ENST00000472352.1	chr7_99861794_+	-157.99	-157.89	-157.99

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Relation with ADAR for CYP3A43

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for CYP3A43

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for CYP3A43

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for CYP3A43

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
CYP3A43	Q9HB55	DB11994	Diacerein	Cytochrome P450 3A43	SmallMoleculeDrug	approved\|investigational

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RelatedDiseases for CYP3A43

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
CYP3A43	C0033578	Prostatic Neoplasms	1	CTD_human
CYP3A43	C0376358	Malignant neoplasm of prostate	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene