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Editing gene: MICAL1 (CAeditome ID:64780)

Gene summary for MICAL1

Gene summary

Gene information	Gene symbol	MICAL1
	Gene ID	64780
	Gene name	microtubule associated monooxygenase, calponin and LIM domain containing 1
	Synonyms	MICAL\|MICAL-1\|NICAL
	Cytomap	6q21
	Type of gene	protein-coding
	Description	[F-actin]-monooxygenase MICAL1NEDD9-interacting protein with calponin homology and LIM domains[F-actin]-methionine sulfoxide oxidase MICAL1molecule interacting with CasL protein 1protein-methionine sulfoxide oxidase MICAL1
	Modification date	20210518
	UniProtAcc	Q8TDZ2
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
MICAL1	GO:0003779	[F-actin]-monooxygenase MICAL1	21864500
MICAL1	GO:0016174	[F-actin]-monooxygenase MICAL1	21864500
MICAL1	GO:0016174	[F-actin]-monooxygenase MICAL1	26845023
MICAL1	GO:0016709	[F-actin]-monooxygenase MICAL1	21864500
MICAL1	GO:0016709	[F-actin]-monooxygenase MICAL1	26845023
MICAL1	GO:0071949	[F-actin]-monooxygenase MICAL1	21864500
MICAL1	GO:0030042	[F-actin]-monooxygenase MICAL1	21864500
MICAL1	GO:0030042	[F-actin]-monooxygenase MICAL1	28230050
MICAL1	GO:0005737	[F-actin]-monooxygenase MICAL1	11827972
MICAL1	GO:0005737	[F-actin]-monooxygenase MICAL1	24440334
MICAL1	GO:0030496	[F-actin]-monooxygenase MICAL1	28230050
MICAL1	GO:0045171	[F-actin]-monooxygenase MICAL1	28230050

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RNA A-to-I events for MICAL1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000135596.16

RNA A-to-I editing events in Cancer.

CAediting_499482(109445931, -), CAediting_499483(109445934, -), CAediting_499484(109446724, -), CAediting_499485(109450786, -), CAediting_499486(109451219, -), CAediting_499487(109451222, -), CAediting_499488(109451236, -), CAediting_499489(109452914, -), CAediting_499490(109452939, -), CAediting_499491(109460369, -), CAediting_499492(109460385, -), CAediting_499493(109461483, -), CAediting_499494(109461557, -), CAediting_499495(109463017, -), CAediting_499496(109463021, -), CAediting_499497(109463023, -), CAediting_499498(109463034, -), CAediting_499499(109463044, -), CAediting_499500(109463054, -), CAediting_499501(109463059, -), CAediting_499502(109463063, -), CAediting_499503(109463070, -), CAediting_499504(109463079, -), CAediting_499505(109463083, -), CAediting_499506(109463084, -), CAediting_499507(109463089, -), CAediting_499508(109463092, -), CAediting_499509(109463098, -), CAediting_499510(109463102, -), CAediting_499511(109463108, -), CAediting_499512(109463115, -), CAediting_499513(109463124, -), CAediting_499514(109463125, -), CAediting_499515(109463151, -), CAediting_499516(109463186, -), CAediting_499517(109463188, -), CAediting_499518(109463190, -), CAediting_499519(109463205, -), CAediting_499520(109463214, -), CAediting_499521(109463235, -), CAediting_499522(109463241, -), CAediting_499523(109463252, -), CAediting_499524(109463257, -), CAediting_499525(109463258, -), CAediting_499526(109464641, -), CAediting_499527(109464666, -), CAediting_499528(109464668, -), CAediting_499529(109464671, -), CAediting_499530(109464682, -), CAediting_499531(109464684, -), CAediting_499532(109464694, -), CAediting_499533(109464706, -), CAediting_499534(109464711, -), CAediting_499535(109464719, -), CAediting_499536(109464720, -), CAediting_499537(109464723, -), CAediting_499538(109464724, -), CAediting_499539(109464737, -), CAediting_499540(109464744, -), CAediting_499541(109464749, -), CAediting_499542(109464756, -), CAediting_499543(109464773, -), CAediting_499544(109464780, -), CAediting_499545(109464787, -), CAediting_499546(109464792, -), CAediting_499547(109464804, -), CAediting_499548(109464831, -),

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RNA editing positional annotations for MICAL1 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_499484	chr6_109446724_-	nonsynonymous SNV	ENST00000358577.6	c.A2018G	p.E673G	D	B	N
CAediting_499484	chr6_109446724_-	nonsynonymous SNV	ENST00000358807.6	c.A2276G	p.E759G	D	B	N
CAediting_499484	chr6_109446724_-	nonsynonymous SNV	ENST00000630715.1	c.A2333G	p.E778G	D	B	N

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_499482	chr6_109445931_-	ncRNA_intronic
CAediting_499483	chr6_109445934_-	ncRNA_intronic
CAediting_499484	chr6_109446724_-	exonic
CAediting_499485	chr6_109450786_-	ncRNA_intronic
CAediting_499486	chr6_109451219_-	ncRNA_intronic
CAediting_499487	chr6_109451222_-	ncRNA_intronic
CAediting_499488	chr6_109451236_-	ncRNA_intronic
CAediting_499489	chr6_109452914_-	ncRNA_intronic
CAediting_499490	chr6_109452939_-	ncRNA_intronic
CAediting_499491	chr6_109460369_-	intronic
CAediting_499492	chr6_109460385_-	intronic
CAediting_499493	chr6_109461483_-	intronic
CAediting_499494	chr6_109461557_-	intronic
CAediting_499495	chr6_109463017_-	UTR3
CAediting_499496	chr6_109463021_-	UTR3
CAediting_499497	chr6_109463023_-	UTR3
CAediting_499498	chr6_109463034_-	UTR3
CAediting_499499	chr6_109463044_-	UTR3
CAediting_499500	chr6_109463054_-	UTR3
CAediting_499501	chr6_109463059_-	UTR3
CAediting_499502	chr6_109463063_-	UTR3
CAediting_499503	chr6_109463070_-	UTR3
CAediting_499504	chr6_109463079_-	UTR3
CAediting_499505	chr6_109463083_-	UTR3
CAediting_499506	chr6_109463084_-	UTR3
CAediting_499507	chr6_109463089_-	UTR3
CAediting_499508	chr6_109463092_-	UTR3
CAediting_499509	chr6_109463098_-	UTR3
CAediting_499510	chr6_109463102_-	UTR3
CAediting_499511	chr6_109463108_-	UTR3
CAediting_499512	chr6_109463115_-	UTR3
CAediting_499513	chr6_109463124_-	UTR3
CAediting_499514	chr6_109463125_-	UTR3
CAediting_499515	chr6_109463151_-	UTR3
CAediting_499516	chr6_109463186_-	UTR3
CAediting_499517	chr6_109463188_-	UTR3
CAediting_499518	chr6_109463190_-	UTR3
CAediting_499519	chr6_109463205_-	UTR3
CAediting_499520	chr6_109463214_-	UTR3
CAediting_499521	chr6_109463235_-	UTR3
CAediting_499522	chr6_109463241_-	UTR3
CAediting_499523	chr6_109463252_-	UTR3
CAediting_499524	chr6_109463257_-	UTR3
CAediting_499525	chr6_109463258_-	UTR3
CAediting_499526	chr6_109464641_-	UTR3
CAediting_499527	chr6_109464666_-	UTR3
CAediting_499528	chr6_109464668_-	UTR3
CAediting_499529	chr6_109464671_-	UTR3
CAediting_499530	chr6_109464682_-	UTR3
CAediting_499531	chr6_109464684_-	UTR3
CAediting_499532	chr6_109464694_-	UTR3
CAediting_499533	chr6_109464706_-	UTR3
CAediting_499534	chr6_109464711_-	UTR3
CAediting_499535	chr6_109464719_-	UTR3
CAediting_499536	chr6_109464720_-	UTR3
CAediting_499537	chr6_109464723_-	UTR3
CAediting_499538	chr6_109464724_-	UTR3
CAediting_499539	chr6_109464737_-	UTR3
CAediting_499540	chr6_109464744_-	UTR3
CAediting_499541	chr6_109464749_-	UTR3
CAediting_499542	chr6_109464756_-	UTR3
CAediting_499543	chr6_109464773_-	UTR3
CAediting_499544	chr6_109464780_-	UTR3
CAediting_499545	chr6_109464787_-	UTR3
CAediting_499546	chr6_109464792_-	UTR3
CAediting_499547	chr6_109464804_-	UTR3
CAediting_499548	chr6_109464831_-	UTR3

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_499486	chr6_109451219_-	SINE	Alu	AluSq
CAediting_499487	chr6_109451222_-	SINE	Alu	AluSq
CAediting_499488	chr6_109451236_-	SINE	Alu	AluSq
CAediting_499489	chr6_109452914_-	SINE	Alu	AluSz
CAediting_499490	chr6_109452939_-	SINE	Alu	AluSz
CAediting_499491	chr6_109460369_-	SINE	Alu	AluJo
CAediting_499492	chr6_109460385_-	SINE	Alu	AluJo
CAediting_499493	chr6_109461483_-	SINE	Alu	FLAM_C
CAediting_499494	chr6_109461557_-	SINE	Alu	FLAM_C
CAediting_499495	chr6_109463017_-	SINE	Alu	AluSg
CAediting_499496	chr6_109463021_-	SINE	Alu	AluSg
CAediting_499497	chr6_109463023_-	SINE	Alu	AluSg
CAediting_499498	chr6_109463034_-	SINE	Alu	AluSg
CAediting_499499	chr6_109463044_-	SINE	Alu	AluSg
CAediting_499500	chr6_109463054_-	SINE	Alu	AluSg
CAediting_499501	chr6_109463059_-	SINE	Alu	AluSg
CAediting_499502	chr6_109463063_-	SINE	Alu	AluSg
CAediting_499503	chr6_109463070_-	SINE	Alu	AluSg
CAediting_499504	chr6_109463079_-	SINE	Alu	AluSg
CAediting_499505	chr6_109463083_-	SINE	Alu	AluSg
CAediting_499506	chr6_109463084_-	SINE	Alu	AluSg
CAediting_499507	chr6_109463089_-	SINE	Alu	AluSg
CAediting_499508	chr6_109463092_-	SINE	Alu	AluSg
CAediting_499509	chr6_109463098_-	SINE	Alu	AluSg
CAediting_499510	chr6_109463102_-	SINE	Alu	AluSg
CAediting_499511	chr6_109463108_-	SINE	Alu	AluSg
CAediting_499512	chr6_109463115_-	SINE	Alu	AluSg
CAediting_499513	chr6_109463124_-	SINE	Alu	AluSg
CAediting_499514	chr6_109463125_-	SINE	Alu	AluSg
CAediting_499515	chr6_109463151_-	SINE	Alu	AluSg
CAediting_499516	chr6_109463186_-	SINE	Alu	AluSg
CAediting_499517	chr6_109463188_-	SINE	Alu	AluSg
CAediting_499518	chr6_109463190_-	SINE	Alu	AluSg
CAediting_499519	chr6_109463205_-	SINE	Alu	AluSg
CAediting_499520	chr6_109463214_-	SINE	Alu	AluSg
CAediting_499521	chr6_109463235_-	SINE	Alu	AluSg
CAediting_499522	chr6_109463241_-	SINE	Alu	AluSg
CAediting_499523	chr6_109463252_-	SINE	Alu	AluSg
CAediting_499524	chr6_109463257_-	SINE	Alu	AluSg
CAediting_499525	chr6_109463258_-	SINE	Alu	AluSg
CAediting_499527	chr6_109464666_-	SINE	Alu	AluJr
CAediting_499528	chr6_109464668_-	SINE	Alu	AluJr
CAediting_499529	chr6_109464671_-	SINE	Alu	AluJr
CAediting_499530	chr6_109464682_-	SINE	Alu	AluJr
CAediting_499531	chr6_109464684_-	SINE	Alu	AluJr
CAediting_499532	chr6_109464694_-	SINE	Alu	AluJr
CAediting_499533	chr6_109464706_-	SINE	Alu	AluJr
CAediting_499534	chr6_109464711_-	SINE	Alu	AluJr
CAediting_499535	chr6_109464719_-	SINE	Alu	AluJr
CAediting_499536	chr6_109464720_-	SINE	Alu	AluJr
CAediting_499537	chr6_109464723_-	SINE	Alu	AluJr
CAediting_499538	chr6_109464724_-	SINE	Alu	AluJr
CAediting_499539	chr6_109464737_-	SINE	Alu	AluJr
CAediting_499540	chr6_109464744_-	SINE	Alu	AluJr
CAediting_499541	chr6_109464749_-	SINE	Alu	AluJr
CAediting_499542	chr6_109464756_-	SINE	Alu	AluJr
CAediting_499543	chr6_109464773_-	SINE	Alu	AluJr
CAediting_499544	chr6_109464780_-	SINE	Alu	AluJr
CAediting_499545	chr6_109464787_-	SINE	Alu	AluJr
CAediting_499546	chr6_109464792_-	SINE	Alu	AluJr
CAediting_499547	chr6_109464804_-	SINE	Alu	AluJr

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RNA A-to-I editing events in the alternative splicing sites for MICAL1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000135596.16.MICAL1.

Correlation between RNA A-to-I editing and PSI for ENSG00000135596.16.MICAL1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for MICAL1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

TGCT.CAediting_499514.ENSG00000135596.MICAL1.png
Soverview

TGCT.CAediting_499524.ENSG00000135596.MICAL1.png
Soverview

TGCT.CAediting_499533.ENSG00000135596.MICAL1.png
Soverview

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Protein coding region RNA A-to-I editings for MICAL1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for MICAL1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for MICAL1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000358577.6	protein_coding
ENST00000358807.6	protein_coding
ENST00000456101.5	retained_intron
ENST00000465904.1	retained_intron
ENST00000630715.1	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_499484	ENST00000358577.6	chr6_109446724_-	-1309.00	-1306.50	-1309.00
CAediting_499484	ENST00000358807.6	chr6_109446724_-	-1553.90	-1552.10	-1553.90
CAediting_499484	ENST00000456101.5	chr6_109446724_-	-1715.50	-1713.90	-1715.50
CAediting_499484	ENST00000465904.1	chr6_109446724_-	-1802.40	-1801.00	-1802.40
CAediting_499484	ENST00000630715.1	chr6_109446724_-	-1529.80	-1527.60	-1529.80

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Relation with ADAR for MICAL1

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
BLCA	CAediting_499505	chr6_109463083_-	0.0010626223575302	0.32577393260523	.	.	.	.
LGG	CAediting_499505	chr6_109463083_-	0.000557494256739994	0.271563713883417	.	.	.	.
BRCA	CAediting_499505	chr6_109463083_-	2.65129668285528e-19	0.362852661094119	.	.	.	.
CESC	CAediting_499505	chr6_109463083_-	0.00117215041973837	0.358643002364916	.	.	.	.
LUAD	CAediting_499505	chr6_109463083_-	0.0036053926436733	0.270498245739704	.	.	.	.
LUSC	CAediting_499505	chr6_109463083_-	0.0140210642275718	0.211799325660428	.	.	.	.
HNSC	CAediting_499505	chr6_109463083_-	0.0479506069378173	0.196341220464412	.	.	.	.
STAD	CAediting_499505	chr6_109463083_-	0.0107803724161572	0.163982360393285	.	.	.	.
THCA	CAediting_499505	chr6_109463083_-	0.00433743624361738	0.212259300100025	.	.	.	.
UCEC	CAediting_499505	chr6_109463083_-	.	.	0.0475043163702144	0.132867267017613	.	.
ESCA	CAediting_499505	chr6_109463083_-	0.00633108512531347	0.227302839191178	.	.	.	.
OV	CAediting_499505	chr6_109463083_-	0.0180040443204147	0.153557439047135	.	.	.	.
SKCM	CAediting_499505	chr6_109463083_-	0.0306742996724537	0.184078913785588	.	.	.	.
SARC	CAediting_499505	chr6_109463083_-	7.16790296937586e-06	0.470522819013534	.	.	.	.
TGCT	CAediting_499505	chr6_109463083_-	1.29866033779933e-06	0.548278036988217	.	.	.	.
BRCA	CAediting_499506	chr6_109463084_-	0.00448791365463575	0.257707775007634	.	.	.	.
BRCA	CAediting_499509	chr6_109463098_-	0.000530333813988147	0.222939636619831	.	.	.	.
LUSC	CAediting_499509	chr6_109463098_-	0.0229135585788922	0.30095884647595	.	.	.	.
THCA	CAediting_499509	chr6_109463098_-	0.0393213831156422	0.262456647320996	.	.	.	.
ESCA	CAediting_499509	chr6_109463098_-	.	.	0.00174992633909913	0.423667833036868	.	.
BLCA	CAediting_499513	chr6_109463124_-	7.59999500856323e-10	0.32575098324357	0.00243345976705224	0.163896360310196	.	.
LGG	CAediting_499513	chr6_109463124_-	4.75764452588606e-06	0.21238714390484	8.03639725795638e-05	0.183594446490318	.	.
BRCA	CAediting_499513	chr6_109463124_-	1.13113823118001e-31	0.350444541995676	.	.	.	.
LIHC	CAediting_499513	chr6_109463124_-	0.0174638493719348	0.168766530470365	.	.	.	.
CESC	CAediting_499513	chr6_109463124_-	2.6632805599276e-06	0.278769258489571	.	.	.	.
LUAD	CAediting_499513	chr6_109463124_-	3.31703518156518e-08	0.27794617348697	.	.	.	.
COAD	CAediting_499513	chr6_109463124_-	6.43102556386277e-06	0.278299460892189	.	.	.	.
LUSC	CAediting_499513	chr6_109463124_-	3.13222710990143e-09	0.284615117114996	.	.	.	.
PRAD	CAediting_499513	chr6_109463124_-	1.91991213718835e-07	0.244320041236784	.	.	.	.
HNSC	CAediting_499513	chr6_109463124_-	1.37885220810045e-09	0.292777506463709	.	.	.	.
STAD	CAediting_499513	chr6_109463124_-	0.00034154462301769	0.205092502659578	.	.	.	.
THCA	CAediting_499513	chr6_109463124_-	4.80173311654656e-06	0.209607103872078	.	.	.	.
UCEC	CAediting_499513	chr6_109463124_-	3.4189585226767e-10	0.323969463442021	.	.	.	.
ACC	CAediting_499513	chr6_109463124_-	0.00149487196838185	0.421675050693596	.	.	.	.
ESCA	CAediting_499513	chr6_109463124_-	0.00856571087656584	0.209821009455548	.	.	.	.
OV	CAediting_499513	chr6_109463124_-	1.63676024139176e-05	0.233754524633706	.	.	.	.
PCPG	CAediting_499513	chr6_109463124_-	0.000510400007313514	0.27420976057866	.	.	.	.
SKCM	CAediting_499513	chr6_109463124_-	8.81691110247942e-10	0.305483975495795	0.0373914300132868	0.105988904256211	.	.
UCS	CAediting_499513	chr6_109463124_-	0.000574001040662573	0.465679087850373	.	.	.	.
MESO	CAediting_499513	chr6_109463124_-	0.0454129863655387	0.224367677177737	.	.	.	.
SARC	CAediting_499513	chr6_109463124_-	1.04504692767041e-07	0.345524007636096	.	.	.	.
TGCT	CAediting_499513	chr6_109463124_-	1.8705950134793e-08	0.446108415772166	.	.	.	.
THYM	CAediting_499513	chr6_109463124_-	2.17066082983009e-06	0.425208626662782	.	.	0.00839650049196143	0.244704619274139
BLCA	CAediting_499514	chr6_109463125_-	0.00130403189699	0.250501272655516	.	.	.	.
BRCA	CAediting_499514	chr6_109463125_-	6.88861530595063e-13	0.255416984831921	.	.	.	.
LIHC	CAediting_499514	chr6_109463125_-	0.00955226776625951	0.242839154879665	.	.	.	.
CESC	CAediting_499514	chr6_109463125_-	0.00666926217111709	0.211066107317244	.	.	.	.
LUAD	CAediting_499514	chr6_109463125_-	1.47569910423349e-06	0.322904411445103	.	.	.	.
COAD	CAediting_499514	chr6_109463125_-	0.000931563342706333	0.319905143244083	.	.	.	.
PRAD	CAediting_499514	chr6_109463125_-	0.00648480657858612	0.194825547759148	.	.	.	.
HNSC	CAediting_499514	chr6_109463125_-	0.0367560986203629	0.142867973401565	.	.	.	.
KIRC	CAediting_499514	chr6_109463125_-	0.0387105953491088	0.140448922749211	.	.	.	.
UCEC	CAediting_499514	chr6_109463125_-	0.000599240298324345	0.254772915737602	.	.	.	.
ESCA	CAediting_499514	chr6_109463125_-	0.0473650497253651	0.209630353791583	.	.	.	.
OV	CAediting_499514	chr6_109463125_-	0.00404694095608397	0.206023511957551	.	.	.	.
PCPG	CAediting_499514	chr6_109463125_-	0.0118315697231381	0.244826738358176	.	.	.	.
SKCM	CAediting_499514	chr6_109463125_-	0.00010257036751305	0.256615580527442	.	.	.	.
SARC	CAediting_499514	chr6_109463125_-	0.00125740425029161	0.289914965637322	.	.	.	.
TGCT	CAediting_499514	chr6_109463125_-	9.4601798773892e-08	0.507780601074742	.	.	.	.
THYM	CAediting_499514	chr6_109463125_-	0.000167864081597547	0.463627186302207	.	.	.	.
BLCA	CAediting_499524	chr6_109463257_-	0.0253182919514196	0.193191186456759	.	.	.	.
LGG	CAediting_499524	chr6_109463257_-	0.00155203807608625	0.194211948295109	0.000256191787726845	0.223641224343116	.	.
BRCA	CAediting_499524	chr6_109463257_-	1.43859939384754e-19	0.313135852386166	.	.	.	.
CESC	CAediting_499524	chr6_109463257_-	0.000395821275743999	0.296396046616195	.	.	.	.
COAD	CAediting_499524	chr6_109463257_-	0.015807838997205	0.26905647427924	.	.	.	.
LUSC	CAediting_499524	chr6_109463257_-	0.0429331724639394	0.126139790538277	.	.	.	.
GBM	CAediting_499524	chr6_109463257_-	0.0400283197846493	0.200754951988928	.	.	.	.
THCA	CAediting_499524	chr6_109463257_-	0.000234541486588298	0.219318913834472	.	.	.	.
UCEC	CAediting_499524	chr6_109463257_-	0.000175126678881165	0.279194170144828	.	.	.	.
OV	CAediting_499524	chr6_109463257_-	0.00172474274010173	0.187812125626702	.	.	.	.
SKCM	CAediting_499524	chr6_109463257_-	9.14038351385511e-05	0.267285477397542	.	.	.	.
SARC	CAediting_499524	chr6_109463257_-	0.0192142831997174	0.210035329387017	.	.	.	.
TGCT	CAediting_499524	chr6_109463257_-	1.37754118000817e-09	0.550803660240669	.	.	.	.
THYM	CAediting_499524	chr6_109463257_-	4.18068735994373e-06	0.54720649865687	.	.	.	.
BRCA	CAediting_499531	chr6_109464684_-	1.55361493025996e-12	0.360266104540822	.	.	.	.
LUAD	CAediting_499531	chr6_109464684_-	0.0310099195444013	0.293884105909418	.	.	.	.
LUSC	CAediting_499531	chr6_109464684_-	0.045900898648299	0.231262416642021	.	.	.	.
HNSC	CAediting_499531	chr6_109464684_-	0.0404073748276395	0.261074364092085	.	.	.	.
STAD	CAediting_499531	chr6_109464684_-	0.000275235849287725	0.29979179259871	.	.	.	.
OV	CAediting_499531	chr6_109464684_-	0.0125684962886859	0.197531608913546	.	.	0.0496778413042287	0.155931282773274
SKCM	CAediting_499531	chr6_109464684_-	1.17365716585181e-05	0.494426390186622	.	.	.	.
BRCA	CAediting_499533	chr6_109464706_-	1.16903626185743e-15	0.289134186864519	.	.	.	.
CESC	CAediting_499533	chr6_109464706_-	0.00117340134029334	0.363064739740109	.	.	.	.
COAD	CAediting_499533	chr6_109464706_-	0.0132874324007162	0.284738024405417	.	.	.	.
PRAD	CAediting_499533	chr6_109464706_-	0.018530656247617	0.187168532307268	.	.	.	.
STAD	CAediting_499533	chr6_109464706_-	0.000122797807303736	0.246897834370367	.	.	.	.
OV	CAediting_499533	chr6_109464706_-	9.95411423876403e-05	0.250087112698502	.	.	.	.
SKCM	CAediting_499533	chr6_109464706_-	1.12232803542831e-05	0.302150813851053	.	.	.	.
TGCT	CAediting_499533	chr6_109464706_-	5.40823299820779e-08	0.527870594815928	.	.	.	.
SKCM	CAediting_499541	chr6_109464749_-	.	.	.	.	0.0498911484335003	0.20395117018472

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Relation with cancer stages for MICAL1

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
BLCA	pathologic_stage	CAediting_499513	chr6_109463124_-	0.00690991370296104	0.146455684134932
BRCA	pathologic_stage	CAediting_499541	chr6_109464749_-	0.0281567570861039	0.117012990661381
HNSC	clinical_stage	CAediting_499533	chr6_109464706_-	0.0160000392477795	0.198398422060149
HNSC	pathologic_stage	CAediting_499533	chr6_109464706_-	0.00279615699148576	0.267342093233938
KIRC	pathologic_stage	CAediting_499513	chr6_109463124_-	0.0194312710520839	0.112415358652191
KIRC	pathologic_stage	CAediting_499514	chr6_109463125_-	0.0215055782221388	0.156733152160922
KIRC	pathologic_stage	CAediting_499546	chr6_109464792_-	0.0234481321203454	0.31693895001918
KIRP	pathologic_stage	CAediting_499513	chr6_109463124_-	0.0316153363803327	0.164925529291494
LUAD	pathologic_stage	CAediting_499514	chr6_109463125_-	0.0486139848711209	0.13658268010919
LUSC	pathologic_stage	CAediting_499513	chr6_109463124_-	0.00264105447466363	0.147231761645307
TGCT	clinical_stage	CAediting_499514	chr6_109463125_-	0.00640843614059744	-0.369898300926333
TGCT	pathologic_stage	CAediting_499513	chr6_109463124_-	0.0372528184574855	-0.239415512274752
TGCT	pathologic_stage	CAediting_499514	chr6_109463125_-	0.00276456733919749	-0.399506186339577
THCA	pathologic_stage	CAediting_499513	chr6_109463124_-	0.000150553314011617	0.175252119504817

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Relation with survival for MICAL1

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
LIHC	CAediting_499513	chr6_109463124_-	0.0261481740568525	0.000301173	40.3694
MESO	CAediting_499513	chr6_109463124_-	0.00355931339434401	0.00415209	32.3042

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RelatedDrugs for MICAL1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for MICAL1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene