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Editing gene: ENGASE (CAeditome ID:64772)

Gene summary for ENGASE

Gene summary

Gene information	Gene symbol	ENGASE
	Gene ID	64772
	Gene name	endo-beta-N-acetylglucosaminidase
	Synonyms	-
	Cytomap	17q25.3
	Type of gene	protein-coding
	Description	cytosolic endo-beta-N-acetylglucosaminidaseDi-N-acetylchitobiosyl beta-N-acetylglucosaminidaseMannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
	Modification date	20210518
	UniProtAcc	Q8NFI3
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for ENGASE

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000167280.15

RNA A-to-I editing events in Cancer.

CAediting_1243739(79076289, +), CAediting_1243740(79076312, +), CAediting_1243741(79076327, +), CAediting_1243742(79076417, +), CAediting_1243743(79076443, +), CAediting_1243744(79076892, +), CAediting_1243745(79076966, +), CAediting_1243746(79076973, +), CAediting_1243747(79077000, +), CAediting_1243748(79077013, +), CAediting_1243749(79077054, +), CAediting_1243750(79077056, +), CAediting_1243751(79077080, +), CAediting_1243752(79077145, +), CAediting_1243753(79078178, +), CAediting_1243754(79078180, +), CAediting_1243755(79078181, +), CAediting_1243756(79078184, +), CAediting_1243757(79078242, +), CAediting_1243758(79078246, +), CAediting_1243759(79078252, +), CAediting_1243760(79079203, +), CAediting_1243761(79079217, +), CAediting_1243762(79079267, +), CAediting_1243763(79079276, +), CAediting_1243764(79079281, +), CAediting_1243765(79079390, +), CAediting_1243766(79079403, +), CAediting_1243767(79079443, +), CAediting_1243768(79079448, +), CAediting_1243769(79085656, +),

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RNA editing positional annotations for ENGASE using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1243739	chr17_79076289_+	intronic
CAediting_1243740	chr17_79076312_+	intronic
CAediting_1243741	chr17_79076327_+	intronic
CAediting_1243742	chr17_79076417_+	intronic
CAediting_1243743	chr17_79076443_+	intronic
CAediting_1243744	chr17_79076892_+	intronic
CAediting_1243745	chr17_79076966_+	intronic
CAediting_1243746	chr17_79076973_+	intronic
CAediting_1243747	chr17_79077000_+	intronic
CAediting_1243748	chr17_79077013_+	intronic
CAediting_1243749	chr17_79077054_+	intronic
CAediting_1243750	chr17_79077056_+	intronic
CAediting_1243751	chr17_79077080_+	intronic
CAediting_1243752	chr17_79077145_+	intronic
CAediting_1243753	chr17_79078178_+	intronic
CAediting_1243754	chr17_79078180_+	intronic
CAediting_1243755	chr17_79078181_+	intronic
CAediting_1243756	chr17_79078184_+	intronic
CAediting_1243757	chr17_79078242_+	intronic
CAediting_1243758	chr17_79078246_+	intronic
CAediting_1243759	chr17_79078252_+	intronic
CAediting_1243760	chr17_79079203_+	intronic
CAediting_1243761	chr17_79079217_+	intronic
CAediting_1243762	chr17_79079267_+	intronic
CAediting_1243763	chr17_79079276_+	intronic
CAediting_1243764	chr17_79079281_+	intronic
CAediting_1243765	chr17_79079390_+	intronic
CAediting_1243766	chr17_79079403_+	intronic
CAediting_1243767	chr17_79079443_+	intronic
CAediting_1243768	chr17_79079448_+	intronic
CAediting_1243769	chr17_79085656_+	exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1243739	chr17_79076289_+	SINE	Alu	AluSx1
CAediting_1243740	chr17_79076312_+	SINE	Alu	AluSx1
CAediting_1243741	chr17_79076327_+	SINE	Alu	AluSx1
CAediting_1243742	chr17_79076417_+	SINE	Alu	AluSx1
CAediting_1243743	chr17_79076443_+	SINE	Alu	AluSx1
CAediting_1243744	chr17_79076892_+	SINE	Alu	AluSx
CAediting_1243745	chr17_79076966_+	SINE	Alu	AluSx
CAediting_1243746	chr17_79076973_+	SINE	Alu	AluSx
CAediting_1243747	chr17_79077000_+	SINE	Alu	AluSx
CAediting_1243748	chr17_79077013_+	SINE	Alu	AluSx
CAediting_1243749	chr17_79077054_+	SINE	Alu	AluSx
CAediting_1243750	chr17_79077056_+	SINE	Alu	AluSx
CAediting_1243751	chr17_79077080_+	SINE	Alu	AluSx
CAediting_1243752	chr17_79077145_+	SINE	Alu	AluSx
CAediting_1243753	chr17_79078178_+	SINE	Alu	AluSx1
CAediting_1243754	chr17_79078180_+	SINE	Alu	AluSx1
CAediting_1243755	chr17_79078181_+	SINE	Alu	AluSx1
CAediting_1243756	chr17_79078184_+	SINE	Alu	AluSx1
CAediting_1243757	chr17_79078242_+	SINE	Alu	AluSx1
CAediting_1243758	chr17_79078246_+	SINE	Alu	AluSx1
CAediting_1243759	chr17_79078252_+	SINE	Alu	AluSx1
CAediting_1243760	chr17_79079203_+	SINE	Alu	AluJb
CAediting_1243761	chr17_79079217_+	SINE	Alu	AluJb
CAediting_1243762	chr17_79079267_+	SINE	Alu	AluJb
CAediting_1243763	chr17_79079276_+	SINE	Alu	AluJb
CAediting_1243764	chr17_79079281_+	SINE	Alu	AluJb
CAediting_1243765	chr17_79079390_+	SINE	Alu	AluJb
CAediting_1243766	chr17_79079403_+	SINE	Alu	AluJb
CAediting_1243767	chr17_79079443_+	SINE	Alu	AluJb
CAediting_1243768	chr17_79079448_+	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for ENGASE

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
ES	CAediting_1243768	chr17_79079448_+	79079445:79079467	3SS	0+17i	GGCATGAGCTGCCGTGGCCAGCC	-17.08	GGCGTGAGCTGCCGTGGCCAGCC	-16.07

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000167280.15.ENGASE.

Correlation between RNA A-to-I editing and PSI for ENSG00000167280.15.ENGASE.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ENGASE

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for ENGASE

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for ENGASE

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1243769	chr17_79085656_+	ENSG00000167280.15	ENST00000300682	hsa-miR-4530	79085650	79085657	8mer-1a	79085641	79085657	145.00	-18.22

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1243769	chr17_79085656_+	ENSG00000167280.15	ENST00000300682	hsa-miR-4524b-5p	79085649	79085655	7mer-m8	79085636	79085656	150	-16.44
CAediting_1243769	chr17_79085656_+	ENSG00000167280.15	ENST00000300682	hsa-miR-601	79085653	79085659	7mer-m8	79085639	79085660	142	-15.7

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000167280.15	ENST00000311595	hsa-miR-200b-3p	79082500	79082505	6mer	79082485	79082506	148	-21.23
CAediting_393	chr1_1167164_+	ENSG00000167280.15	ENST00000578419	hsa-miR-200b-3p	79082500	79082505	6mer	79082485	79082506	148	-21.23
CAediting_393	chr1_1167164_+	ENSG00000167280.15	ENST00000300682	hsa-miR-200b-3p	79082500	79082505	6mer	79082485	79082506	148	-21.23
CAediting_846604	chr11_93733708_-	ENSG00000167280.15	ENST00000300682	hsa-miR-1304-3p	79087131	79087138	8mer-1a	79087117	79087138	140	-16.11
CAediting_846604	chr11_93733708_-	ENSG00000167280.15	ENST00000300682	hsa-miR-1304-3p	79086448	79086454	7mer-m8	79086434	79086455	144	-16.48
CAediting_1306324	chr19_13836464_-	ENSG00000167280.15	ENST00000300682	hsa-miR-27a-3p	79086561	79086567	7mer-m8	79086547	79086568	166	-28.69
CAediting_77128	chr1_85133844_+	ENSG00000167280.15	ENST00000311595	hsa-miR-4423-3p	79082460	79082466	7mer-m8	79082447	79082467	145	-16.53
CAediting_524911	chr7_5495852_-	ENSG00000167280.15	ENST00000578419	hsa-miR-589-3p	79081003	79081009	7mer-m8	79080990	79081010	149	-28.35
CAediting_1229415	chr17_67471547_+	ENSG00000167280.15	ENST00000578419	hsa-miR-548aa	79082071	79082077	7mer-m8	79082053	79082078	161	-19.22
CAediting_77128	chr1_85133844_+	ENSG00000167280.15	ENST00000578419	hsa-miR-4423-3p	79082460	79082466	7mer-m8	79082447	79082467	145	-16.53
CAediting_77128	chr1_85133844_+	ENSG00000167280.15	ENST00000300682	hsa-miR-4423-3p	79082460	79082466	7mer-m8	79082447	79082467	145	-16.53
CAediting_1229415	chr17_67471547_+	ENSG00000167280.15	ENST00000300682	hsa-miR-548aa	79083053	79083059	7mer-m8	79083035	79083060	148	-13.81
CAediting_1054808	chr15_66496985_-	ENSG00000167280.15	ENST00000300682	hsa-miR-4512	79084551	79084558	8mer-1a	79084537	79084558	142	-15.92
CAediting_604450	chr7_133034877_-	ENSG00000167280.15	ENST00000300682	hsa-miR-3654	79085334	79085341	8mer-1a	79085322	79085341	144	-18.5
CAediting_1229415	chr17_67471547_+	ENSG00000167280.15	ENST00000300682	hsa-miR-548aa	79086182	79086188	7mer-m8	79086161	79086189	141	-14.84
CAediting_1229415	chr17_67471547_+	ENSG00000167280.15	ENST00000300682	hsa-miR-548aa	79086500	79086506	7mer-m8	79086484	79086507	155	-20.78
CAediting_1368054	chr19_46709310_-	ENSG00000167280.15	ENST00000300682	hsa-miR-320e	79086045	79086052	8mer-1a	79086034	79086052	151	-21.26
CAediting_77128	chr1_85133844_+	ENSG00000167280.15	ENST00000300682	hsa-miR-4423-3p	79086435	79086441	7mer-m8	79086422	79086442	143	-14.36
CAediting_580943	chr7_100356700_+	ENSG00000167280.15	ENST00000300682	hsa-miR-6840-3p	79088188	79088195	8mer-1a	79088174	79088195	146	-21.45
CAediting_580943	chr7_100356700_+	ENSG00000167280.15	ENST00000300682	hsa-miR-6840-3p	79086462	79086468	7mer-m8	79086448	79086469	146	-27.03
CAediting_524911	chr7_5495852_-	ENSG00000167280.15	ENST00000300682	hsa-miR-589-3p	79086036	79086042	7mer-m8	79086020	79086043	153	-23.49
CAediting_524911	chr7_5495852_-	ENSG00000167280.15	ENST00000300682	hsa-miR-589-3p	79087686	79087692	7mer-m8	79087672	79087693	159	-27.33
CAediting_468389	chr6_31355314_-	ENSG00000167280.15	ENST00000300682	hsa-miR-6891-5p	79085658	79085664	7mer-m8	79085647	79085665	140	-19.37
CAediting_468389	chr6_31355314_-	ENSG00000167280.15	ENST00000300682	hsa-miR-6891-5p	79086075	79086081	7mer-m8	79086063	79086082	155	-24.34

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1054808	chr15_66496985_-	ENSG00000167280.15	ENST00000300682	hsa-miR-4512	79086894	79086900	7mer-m8	79086881	79086901	144	-18.93
CAediting_580943	chr7_100356700_+	ENSG00000167280.15	ENST00000300682	hsa-miR-6840-3p	79088111	79088117	7mer-m8	79088097	79088118	154	-26.04
CAediting_580943	chr7_100356700_+	ENSG00000167280.15	ENST00000300682	hsa-miR-6840-3p	79086173	79086179	7mer-m8	79086159	79086180	153	-19.12
CAediting_580943	chr7_100356700_+	ENSG00000167280.15	ENST00000300682	hsa-miR-6840-3p	79086826	79086832	7mer-m8	79086812	79086833	150	-20.42

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ENGASE

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for ENGASE

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for ENGASE

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for ENGASE

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for ENGASE

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ENGASE

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene