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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: PARP12 (CAeditome ID:64761)

Gene summary for PARP12

check button Gene summary
Gene informationGene symbol

PARP12

Gene ID

64761

Gene namepoly(ADP-ribose) polymerase family member 12
SynonymsARTD12|MST109|MSTP109|ZC3H1|ZC3HDC1
Cytomap

7q34

Type of geneprotein-coding
Descriptionprotein mono-ADP-ribosyltransferase PARP12ADP-ribosyltransferase diphtheria toxin-like 12poly [ADP-ribose] polymerase 12zinc finger CCCH type domain containing 1
Modification date20210518
UniProtAcc

Q9H0J9

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
PARP12

GO:1990404

Protein mono-ADP-ribosyltransferase PARP12

25043379

PARP12

GO:0070213

Protein mono-ADP-ribosyltransferase PARP12

25043379

PARP12

GO:0140289

Protein mono-ADP-ribosyltransferase PARP12

25043379


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RNA A-to-I events for PARP12

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000059378.11

check button RNA A-to-I editing events in Cancer.
CAediting_607943(140030380, -), CAediting_607944(140030381, -), CAediting_607945(140030415, -), CAediting_607946(140030418, -), CAediting_607947(140030441, -), CAediting_607948(140030476, -), CAediting_607949(140030498, -), CAediting_607950(140030515, -), CAediting_607951(140030560, -), CAediting_607952(140030565, -), CAediting_607953(140030567, -), CAediting_607954(140030572, -), CAediting_607955(140030594, -), CAediting_607956(140031249, -), CAediting_607957(140031273, -), CAediting_607958(140031278, -), CAediting_607959(140031287, -), CAediting_607960(140031290, -), CAediting_607961(140031339, -), CAediting_607962(140031347, -), CAediting_607963(140031367, -), CAediting_607964(140031369, -), CAediting_607965(140031371, -), CAediting_607966(140031374, -), CAediting_607967(140032425, -), CAediting_607968(140032427, -), CAediting_607969(140032428, -), CAediting_607970(140032450, -), CAediting_607971(140032452, -), CAediting_607972(140032456, -), CAediting_607973(140032999, -), CAediting_607974(140033009, -), CAediting_607975(140033012, -), CAediting_607976(140033019, -), CAediting_607977(140033020, -), CAediting_607978(140033035, -), CAediting_607979(140033050, -), CAediting_607980(140033055, -), CAediting_607981(140033068, -), CAediting_607982(140033074, -), CAediting_607983(140033077, -), CAediting_607984(140033091, -), CAediting_607985(140033135, -), CAediting_607986(140033143, -), CAediting_607987(140033151, -), CAediting_607988(140033172, -), CAediting_607989(140033178, -), CAediting_607990(140033182, -), CAediting_607991(140035048, -), CAediting_607992(140037097, -), CAediting_607993(140037105, -), CAediting_607994(140037193, -), CAediting_607995(140037216, -), CAediting_607996(140037267, -), CAediting_607997(140040824, -), CAediting_607998(140040849, -), CAediting_607999(140040914, -), CAediting_608000(140040986, -), CAediting_608001(140043641, -), CAediting_608002(140043745, -), CAediting_608003(140043750, -), CAediting_608004(140043804, -), CAediting_608005(140043813, -), CAediting_608006(140043821, -), CAediting_608007(140051497, -), CAediting_608008(140051502, -), CAediting_608009(140051528, -),

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RNA editing positional annotations for PARP12 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_607943chr7_140030380_-ncRNA_intronic
CAediting_607944chr7_140030381_-ncRNA_intronic
CAediting_607945chr7_140030415_-ncRNA_intronic
CAediting_607946chr7_140030418_-ncRNA_intronic
CAediting_607947chr7_140030441_-ncRNA_intronic
CAediting_607948chr7_140030476_-ncRNA_intronic
CAediting_607949chr7_140030498_-ncRNA_intronic
CAediting_607950chr7_140030515_-ncRNA_intronic
CAediting_607951chr7_140030560_-ncRNA_intronic
CAediting_607952chr7_140030565_-ncRNA_intronic
CAediting_607953chr7_140030567_-ncRNA_intronic
CAediting_607954chr7_140030572_-ncRNA_intronic
CAediting_607955chr7_140030594_-ncRNA_intronic
CAediting_607956chr7_140031249_-ncRNA_intronic
CAediting_607957chr7_140031273_-ncRNA_intronic
CAediting_607958chr7_140031278_-ncRNA_intronic
CAediting_607959chr7_140031287_-ncRNA_intronic
CAediting_607960chr7_140031290_-ncRNA_intronic
CAediting_607961chr7_140031339_-ncRNA_intronic
CAediting_607962chr7_140031347_-ncRNA_intronic
CAediting_607963chr7_140031367_-ncRNA_intronic
CAediting_607964chr7_140031369_-ncRNA_intronic
CAediting_607965chr7_140031371_-ncRNA_intronic
CAediting_607966chr7_140031374_-ncRNA_intronic
CAediting_607967chr7_140032425_-ncRNA_intronic
CAediting_607968chr7_140032427_-ncRNA_intronic
CAediting_607969chr7_140032428_-ncRNA_intronic
CAediting_607970chr7_140032450_-ncRNA_intronic
CAediting_607971chr7_140032452_-ncRNA_intronic
CAediting_607972chr7_140032456_-ncRNA_intronic
CAediting_607973chr7_140032999_-ncRNA_intronic
CAediting_607974chr7_140033009_-ncRNA_intronic
CAediting_607975chr7_140033012_-ncRNA_intronic
CAediting_607976chr7_140033019_-ncRNA_intronic
CAediting_607977chr7_140033020_-ncRNA_intronic
CAediting_607978chr7_140033035_-ncRNA_intronic
CAediting_607979chr7_140033050_-ncRNA_intronic
CAediting_607980chr7_140033055_-ncRNA_intronic
CAediting_607981chr7_140033068_-ncRNA_intronic
CAediting_607982chr7_140033074_-ncRNA_intronic
CAediting_607983chr7_140033077_-ncRNA_intronic
CAediting_607984chr7_140033091_-ncRNA_intronic
CAediting_607985chr7_140033135_-ncRNA_intronic
CAediting_607986chr7_140033143_-ncRNA_intronic
CAediting_607987chr7_140033151_-ncRNA_intronic
CAediting_607988chr7_140033172_-ncRNA_intronic
CAediting_607989chr7_140033178_-ncRNA_intronic
CAediting_607990chr7_140033182_-ncRNA_intronic
CAediting_607991chr7_140035048_-ncRNA_intronic
CAediting_607992chr7_140037097_-ncRNA_intronic
CAediting_607993chr7_140037105_-ncRNA_intronic
CAediting_607994chr7_140037193_-ncRNA_intronic
CAediting_607995chr7_140037216_-ncRNA_intronic
CAediting_607996chr7_140037267_-ncRNA_intronic
CAediting_607997chr7_140040824_-ncRNA_intronic
CAediting_607998chr7_140040849_-ncRNA_intronic
CAediting_607999chr7_140040914_-ncRNA_intronic
CAediting_608000chr7_140040986_-ncRNA_intronic
CAediting_608001chr7_140043641_-ncRNA_intronic
CAediting_608002chr7_140043745_-ncRNA_intronic
CAediting_608003chr7_140043750_-ncRNA_intronic
CAediting_608004chr7_140043804_-ncRNA_intronic
CAediting_608005chr7_140043813_-ncRNA_intronic
CAediting_608006chr7_140043821_-ncRNA_intronic
CAediting_608007chr7_140051497_-ncRNA_intronic
CAediting_608008chr7_140051502_-ncRNA_intronic
CAediting_608009chr7_140051528_-ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_607943chr7_140030380_-SINEAluAluSz
CAediting_607944chr7_140030381_-SINEAluAluSz
CAediting_607945chr7_140030415_-SINEAluAluSz
CAediting_607946chr7_140030418_-SINEAluAluSz
CAediting_607947chr7_140030441_-SINEAluAluSz
CAediting_607948chr7_140030476_-SINEAluAluSz
CAediting_607949chr7_140030498_-SINEAluAluSz
CAediting_607950chr7_140030515_-SINEAluAluSz
CAediting_607951chr7_140030560_-SINEAluAluSz
CAediting_607952chr7_140030565_-SINEAluAluSz
CAediting_607953chr7_140030567_-SINEAluAluSz
CAediting_607954chr7_140030572_-SINEAluAluSz
CAediting_607955chr7_140030594_-SINEAluAluSz
CAediting_607956chr7_140031249_-SINEAluAluJb
CAediting_607957chr7_140031273_-SINEAluAluJb
CAediting_607958chr7_140031278_-SINEAluAluJb
CAediting_607959chr7_140031287_-SINEAluAluJb
CAediting_607960chr7_140031290_-SINEAluAluJb
CAediting_607961chr7_140031339_-SINEAluAluJb
CAediting_607962chr7_140031347_-SINEAluAluJb
CAediting_607963chr7_140031367_-SINEAluAluJb
CAediting_607964chr7_140031369_-SINEAluAluJb
CAediting_607965chr7_140031371_-SINEAluAluJb
CAediting_607966chr7_140031374_-Simple_repeatSimple_repeat(ATAA)n
CAediting_607967chr7_140032425_-SINEAluAluJo
CAediting_607968chr7_140032427_-SINEAluAluJo
CAediting_607969chr7_140032428_-SINEAluAluJo
CAediting_607970chr7_140032450_-SINEAluAluJo
CAediting_607971chr7_140032452_-SINEAluAluJo
CAediting_607972chr7_140032456_-SINEAluAluJo
CAediting_607973chr7_140032999_-SINEAluAluJb
CAediting_607974chr7_140033009_-SINEAluAluJb
CAediting_607975chr7_140033012_-SINEAluAluJb
CAediting_607976chr7_140033019_-SINEAluAluJb
CAediting_607977chr7_140033020_-SINEAluAluJb
CAediting_607978chr7_140033035_-SINEAluAluJb
CAediting_607979chr7_140033050_-SINEAluAluJb
CAediting_607980chr7_140033055_-SINEAluAluJb
CAediting_607981chr7_140033068_-SINEAluAluJb
CAediting_607982chr7_140033074_-SINEAluAluJb
CAediting_607983chr7_140033077_-SINEAluAluJb
CAediting_607984chr7_140033091_-SINEAluAluJb
CAediting_607985chr7_140033135_-SINEAluAluJb
CAediting_607986chr7_140033143_-SINEAluAluJb
CAediting_607987chr7_140033151_-SINEAluAluJb
CAediting_607988chr7_140033172_-SINEAluAluJb
CAediting_607989chr7_140033178_-SINEAluAluJb
CAediting_607990chr7_140033182_-SINEAluAluJb
CAediting_607991chr7_140035048_-RetroposonSVASVA_E
CAediting_607992chr7_140037097_-SINEAluAluSz
CAediting_607993chr7_140037105_-SINEAluAluSz
CAediting_607994chr7_140037193_-SINEAluAluSz
CAediting_607995chr7_140037216_-SINEAluAluSz
CAediting_607996chr7_140037267_-SINEAluAluSz
CAediting_607997chr7_140040824_-SINEAluAluSz
CAediting_607998chr7_140040849_-SINEAluAluSz
CAediting_607999chr7_140040914_-SINEAluAluSz
CAediting_608000chr7_140040986_-SINEAluAluSz
CAediting_608001chr7_140043641_-SINEAluAluSz
CAediting_608002chr7_140043745_-SINEAluAluSz
CAediting_608003chr7_140043750_-SINEAluAluSz
CAediting_608004chr7_140043804_-SINEAluAluSz
CAediting_608005chr7_140043813_-SINEAluAluSz
CAediting_608006chr7_140043821_-SINEAluAluSz
CAediting_608007chr7_140051497_-SINEAluAluSz
CAediting_608008chr7_140051502_-SINEAluAluSz
CAediting_608009chr7_140051528_-SINEAluAluSz

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RNA A-to-I editing events in the alternative splicing sites for PARP12

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESCAediting_607988chr7_140033172_-140033153:1400331753SS0+17iCACACCTGTAATCCCAACAGTTC7.19CACGCCTGTAATCCCAACAGTTC7.46
MEX_1CAediting_607988chr7_140033172_-140033153:1400331753SS0+17iCACACCTGTAATCCCAACAGTTC7.19CACGCCTGTAATCCCAACAGTTC7.46

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000059378.11.PARP12.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000059378.11.PARP12.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PARP12

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for PARP12

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for PARP12

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1160181chr17_7017644_-ENSG00000059378.11ENST00000473341hsa-miR-195-3p1400244491400244568mer-1a140024449140024470148-10.17
CAediting_1399425chr20_1392958_-ENSG00000059378.11ENST00000473341hsa-miR-6869-5p1400246531400246597mer-m8140024652140024673140-15.17
CAediting_524911chr7_5495852_-ENSG00000059378.11ENST00000473341hsa-miR-589-3p1400245241400245307mer-m8140024523140024546147-16.14
CAediting_524911chr7_5495852_-ENSG00000059378.11ENST00000473341hsa-miR-589-3p1400240951400241028mer-1a140024095140024118152-17.69
CAediting_1399425chr20_1392958_-ENSG00000059378.11ENST00000489809hsa-miR-6869-5p1400246531400246597mer-m8140024652140024673140-15.17
CAediting_1399425chr20_1392958_-ENSG00000059378.11ENST00000491598hsa-miR-6869-5p1400246531400246597mer-m8140024652140024673140-15.17
CAediting_1524209chrX_134546392_-ENSG00000059378.11ENST00000473341hsa-miR-503-5p1400273391400273457mer-m8140027338140027358146-15.45
CAediting_468389chr6_31355314_-ENSG00000059378.11ENST00000473341hsa-miR-6891-5p1400246241400246307mer-m8140024623140024640148-18.36
CAediting_468389chr6_31355314_-ENSG00000059378.11ENST00000489809hsa-miR-6891-5p1400246241400246307mer-m8140024623140024640148-18.36
CAediting_468389chr6_31355314_-ENSG00000059378.11ENST00000491598hsa-miR-6891-5p1400246241400246307mer-m8140024623140024640148-18.36

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_573000chr7_92204081_-ENSG00000059378.11ENST00000473341hsa-miR-1285-5p1400238091400238157mer-m8140023808140023828143-13.09
CAediting_1229413chr17_67471544_+ENSG00000059378.11ENST00000473341hsa-miR-548aa1400242301400242378mer-1a140024230140024256145-8.62
CAediting_580943chr7_100356700_+ENSG00000059378.11ENST00000473341hsa-miR-6840-3p1400240581400240647mer-m8140024057140024078140-21.26
CAediting_580943chr7_100356700_+ENSG00000059378.11ENST00000473341hsa-miR-6840-3p1400239671400239748mer-1a140023967140023988145-24.3
CAediting_468389chr6_31355314_-ENSG00000059378.11ENST00000473341hsa-miR-6891-5p1400247651400247717mer-m8140024764140024782140-13.21
CAediting_468389chr6_31355314_-ENSG00000059378.11ENST00000489809hsa-miR-6891-5p1400247651400247717mer-m8140024764140024782140-13.21
CAediting_468389chr6_31355314_-ENSG00000059378.11ENST00000491598hsa-miR-6891-5p1400247651400247717mer-m8140024764140024782140-13.21

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for PARP12

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for PARP12

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for PARP12

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for PARP12

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for PARP12

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PARP12

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
PARP12C0021400Influenza1CTD_human
PARP12C0242383Age related macular degeneration1CTD_human