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Editing gene: SHC1 (CAeditome ID:6464)

Gene summary for SHC1

Gene summary

Gene information	Gene symbol	SHC1
	Gene ID	6464
	Gene name	SHC adaptor protein 1
	Synonyms	SHC\|SHCA
	Cytomap	1q21.3
	Type of gene	protein-coding
	Description	SHC-transforming protein 1SH2 domain protein C1SHC (Src homology 2 domain containing) transforming protein 1SHC-transforming protein 3SHC-transforming protein A
	Modification date	20210518
	UniProtAcc	P29353
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
SHC1	GO:0000165	SHC-transforming protein 1	14676841
SHC1	GO:0000187	SHC-transforming protein 1	14676841
SHC1	GO:0071363	SHC-transforming protein 1	20010870
SHC1	GO:0005886	SHC-transforming protein 1	14676841

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RNA A-to-I events for SHC1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000160691.17

RNA A-to-I editing events in Cancer.

CAediting_107068(154962796, -), CAediting_107069(154964277, -), CAediting_107070(154964279, -), CAediting_107071(154964291, -), CAediting_107072(154964318, -), CAediting_107073(154964319, -), CAediting_107074(154964331, -), CAediting_107075(154964332, -), CAediting_107076(154964343, -), CAediting_107077(154964344, -), CAediting_107078(154964366, -), CAediting_107079(154964368, -), CAediting_107080(154964370, -), CAediting_107081(154964425, -), CAediting_107082(154964441, -), CAediting_107083(154964443, -), CAediting_107084(154964445, -), CAediting_107085(154964556, -), CAediting_107086(154964560, -), CAediting_107087(154964567, -), CAediting_107088(154964576, -), CAediting_107089(154964592, -), CAediting_107090(154964599, -), CAediting_107091(154964605, -), CAediting_107092(154964622, -), CAediting_107093(154964665, -), CAediting_107094(154964669, -), CAediting_107095(154964684, -), CAediting_107096(154964685, -), CAediting_107097(154964693, -), CAediting_107098(154964698, -), CAediting_107099(154964721, -), CAediting_107100(154964732, -), CAediting_107101(154964738, -), CAediting_107102(154964739, -), CAediting_107103(154964747, -), CAediting_107104(154964761, -), CAediting_107105(154965089, -), CAediting_107106(154965097, -), CAediting_107107(154965099, -), CAediting_107108(154965112, -), CAediting_107109(154965169, -), CAediting_107110(154965175, -), CAediting_107111(154965244, -), CAediting_107112(154965264, -), CAediting_107113(154965278, -), CAediting_107114(154965304, -), CAediting_107115(154965309, -), CAediting_107116(154965310, -), CAediting_107117(154965316, -), CAediting_107118(154965332, -), CAediting_107119(154966930, -), CAediting_107120(154966931, -), CAediting_107121(154972158, -), CAediting_107122(154973314, -), CAediting_107123(154973319, -), CAediting_107124(154973379, -), CAediting_107125(154973387, -), CAediting_107126(154973399, -), CAediting_107127(154973402, -), CAediting_107128(154973424, -), CAediting_107129(154973428, -),

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RNA editing positional annotations for SHC1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_107068	chr1_154962796_-	ncRNA_intronic
CAediting_107069	chr1_154964277_-	exonic
CAediting_107070	chr1_154964279_-	exonic
CAediting_107071	chr1_154964291_-	exonic
CAediting_107072	chr1_154964318_-	exonic
CAediting_107073	chr1_154964319_-	exonic
CAediting_107074	chr1_154964331_-	exonic
CAediting_107075	chr1_154964332_-	exonic
CAediting_107076	chr1_154964343_-	exonic
CAediting_107077	chr1_154964344_-	exonic
CAediting_107078	chr1_154964366_-	exonic
CAediting_107079	chr1_154964368_-	exonic
CAediting_107080	chr1_154964370_-	splicing
CAediting_107081	chr1_154964425_-	ncRNA_intronic
CAediting_107082	chr1_154964441_-	ncRNA_intronic
CAediting_107083	chr1_154964443_-	ncRNA_intronic
CAediting_107084	chr1_154964445_-	ncRNA_intronic
CAediting_107085	chr1_154964556_-	ncRNA_intronic
CAediting_107086	chr1_154964560_-	ncRNA_intronic
CAediting_107087	chr1_154964567_-	ncRNA_intronic
CAediting_107088	chr1_154964576_-	ncRNA_intronic
CAediting_107089	chr1_154964592_-	ncRNA_intronic
CAediting_107090	chr1_154964599_-	ncRNA_intronic
CAediting_107091	chr1_154964605_-	ncRNA_intronic
CAediting_107092	chr1_154964622_-	ncRNA_intronic
CAediting_107093	chr1_154964665_-	ncRNA_intronic
CAediting_107094	chr1_154964669_-	ncRNA_intronic
CAediting_107095	chr1_154964684_-	ncRNA_intronic
CAediting_107096	chr1_154964685_-	ncRNA_intronic
CAediting_107097	chr1_154964693_-	ncRNA_intronic
CAediting_107098	chr1_154964698_-	ncRNA_intronic
CAediting_107099	chr1_154964721_-	ncRNA_intronic
CAediting_107100	chr1_154964732_-	ncRNA_intronic
CAediting_107101	chr1_154964738_-	ncRNA_intronic
CAediting_107102	chr1_154964739_-	ncRNA_intronic
CAediting_107103	chr1_154964747_-	ncRNA_intronic
CAediting_107104	chr1_154964761_-	ncRNA_intronic
CAediting_107105	chr1_154965089_-	ncRNA_intronic
CAediting_107106	chr1_154965097_-	ncRNA_intronic
CAediting_107107	chr1_154965099_-	ncRNA_intronic
CAediting_107108	chr1_154965112_-	ncRNA_intronic
CAediting_107109	chr1_154965169_-	ncRNA_intronic
CAediting_107110	chr1_154965175_-	ncRNA_intronic
CAediting_107111	chr1_154965244_-	ncRNA_intronic
CAediting_107112	chr1_154965264_-	ncRNA_intronic
CAediting_107113	chr1_154965278_-	ncRNA_intronic
CAediting_107114	chr1_154965304_-	ncRNA_intronic
CAediting_107115	chr1_154965309_-	ncRNA_intronic
CAediting_107116	chr1_154965310_-	ncRNA_intronic
CAediting_107117	chr1_154965316_-	ncRNA_intronic
CAediting_107118	chr1_154965332_-	ncRNA_intronic
CAediting_107119	chr1_154966930_-	intronic
CAediting_107120	chr1_154966931_-	intronic
CAediting_107121	chr1_154972158_-	intronic
CAediting_107122	chr1_154973314_-	UTR5
CAediting_107123	chr1_154973319_-	UTR5
CAediting_107124	chr1_154973379_-	UTR5
CAediting_107125	chr1_154973387_-	UTR5
CAediting_107126	chr1_154973399_-	UTR5
CAediting_107127	chr1_154973402_-	UTR5
CAediting_107128	chr1_154973424_-	UTR5
CAediting_107129	chr1_154973428_-	UTR5

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_107069	chr1_154964277_-	SINE	Alu	AluJb
CAediting_107070	chr1_154964279_-	SINE	Alu	AluJb
CAediting_107071	chr1_154964291_-	SINE	Alu	AluJb
CAediting_107072	chr1_154964318_-	SINE	Alu	AluJb
CAediting_107073	chr1_154964319_-	SINE	Alu	AluJb
CAediting_107074	chr1_154964331_-	SINE	Alu	AluJb
CAediting_107075	chr1_154964332_-	SINE	Alu	AluJb
CAediting_107076	chr1_154964343_-	SINE	Alu	AluJb
CAediting_107077	chr1_154964344_-	SINE	Alu	AluJb
CAediting_107078	chr1_154964366_-	SINE	Alu	AluJb
CAediting_107079	chr1_154964368_-	SINE	Alu	AluJb
CAediting_107080	chr1_154964370_-	SINE	Alu	AluJb
CAediting_107081	chr1_154964425_-	SINE	Alu	AluJb
CAediting_107082	chr1_154964441_-	SINE	Alu	AluJb
CAediting_107083	chr1_154964443_-	SINE	Alu	AluJb
CAediting_107084	chr1_154964445_-	SINE	Alu	AluJb
CAediting_107085	chr1_154964556_-	SINE	Alu	AluJr4
CAediting_107086	chr1_154964560_-	SINE	Alu	AluJr4
CAediting_107087	chr1_154964567_-	SINE	Alu	AluJr4
CAediting_107088	chr1_154964576_-	SINE	Alu	AluJr4
CAediting_107089	chr1_154964592_-	SINE	Alu	AluJr4
CAediting_107090	chr1_154964599_-	SINE	Alu	AluJr4
CAediting_107091	chr1_154964605_-	SINE	Alu	AluJr4
CAediting_107092	chr1_154964622_-	SINE	Alu	AluJr4
CAediting_107093	chr1_154964665_-	SINE	Alu	AluJr4
CAediting_107094	chr1_154964669_-	SINE	Alu	AluJr4
CAediting_107095	chr1_154964684_-	SINE	Alu	AluJr4
CAediting_107096	chr1_154964685_-	SINE	Alu	AluJr4
CAediting_107097	chr1_154964693_-	SINE	Alu	AluJr4
CAediting_107098	chr1_154964698_-	SINE	Alu	AluJr4
CAediting_107099	chr1_154964721_-	SINE	Alu	AluJr4
CAediting_107100	chr1_154964732_-	SINE	Alu	AluJr4
CAediting_107101	chr1_154964738_-	SINE	Alu	AluJr4
CAediting_107102	chr1_154964739_-	SINE	Alu	AluJr4
CAediting_107103	chr1_154964747_-	SINE	Alu	AluJr4
CAediting_107104	chr1_154964761_-	SINE	Alu	AluJr4
CAediting_107105	chr1_154965089_-	SINE	Alu	AluSx1
CAediting_107106	chr1_154965097_-	SINE	Alu	AluSx1
CAediting_107107	chr1_154965099_-	SINE	Alu	AluSx1
CAediting_107108	chr1_154965112_-	SINE	Alu	AluSx1
CAediting_107109	chr1_154965169_-	SINE	Alu	AluSx1
CAediting_107110	chr1_154965175_-	SINE	Alu	AluSx1
CAediting_107111	chr1_154965244_-	SINE	Alu	AluSx1
CAediting_107112	chr1_154965264_-	SINE	Alu	AluSx1
CAediting_107113	chr1_154965278_-	SINE	Alu	AluSx1
CAediting_107114	chr1_154965304_-	SINE	Alu	AluSx1
CAediting_107115	chr1_154965309_-	SINE	Alu	AluSx1
CAediting_107116	chr1_154965310_-	SINE	Alu	AluSx1
CAediting_107117	chr1_154965316_-	SINE	Alu	AluSx1
CAediting_107118	chr1_154965332_-	SINE	Alu	AluSx1
CAediting_107119	chr1_154966930_-	SINE	Alu	AluJo
CAediting_107120	chr1_154966931_-	SINE	Alu	AluJo
CAediting_107121	chr1_154972158_-	SINE	Alu	AluSq2
CAediting_107122	chr1_154973314_-	SINE	Alu	AluSq2
CAediting_107123	chr1_154973319_-	SINE	Alu	AluSq2
CAediting_107124	chr1_154973379_-	SINE	Alu	AluSq2
CAediting_107125	chr1_154973387_-	SINE	Alu	AluSq2
CAediting_107126	chr1_154973399_-	SINE	Alu	AluSq2
CAediting_107127	chr1_154973402_-	SINE	Alu	AluSq2
CAediting_107128	chr1_154973424_-	SINE	Alu	AluSq2
CAediting_107129	chr1_154973428_-	SINE	Alu	AluSq2

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RNA A-to-I editing events in the alternative splicing sites for SHC1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
IR	CAediting_107078	chr1_154964366_-	154964366:154964388	3SS	3+0i	TTGTATTTTTTTTTTGGTAGAGA	5.9	TTGTATTTTTTTTTTGGTAGAGG	5.61
IR	CAediting_107079	chr1_154964368_-	154964366:154964388	3SS	1+0i	TTGTATTTTTTTTTTGGTAGAGA	5.9	TTGTATTTTTTTTTTGGTAGGGA	7.04
IR	CAediting_107080	chr1_154964370_-	154964366:154964388	3SS	0+2i	TTGTATTTTTTTTTTGGTAGAGA	5.9	TTGTATTTTTTTTTTGGTGGAGA	-2.06
ES	CAediting_107128	chr1_154973424_-	154973421:154973429	5SS	0+3i	AAGTGATTC	-9.35	AAGTGGTTC	-15.01
MEX_1	CAediting_107128	chr1_154973424_-	154973421:154973429	5SS	0+3i	AAGTGATTC	-9.35	AAGTGGTTC	-15.01
ES	CAediting_107129	chr1_154973428_-	154973421:154973429	5SS	2+0i	AAGTGATTC	-9.35	AGGTGATTC	-13.08
MEX_1	CAediting_107129	chr1_154973428_-	154973421:154973429	5SS	2+0i	AAGTGATTC	-9.35	AGGTGATTC	-13.08

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000160691.17.SHC1.

Correlation between RNA A-to-I editing and PSI for ENSG00000160691.17.SHC1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SHC1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

KIRC.CAediting_107097.ENSG00000160691.SHC1.png
Soverview

LUAD.CAediting_107103.ENSG00000160691.SHC1.png
Soverview

LUSC.CAediting_107097.ENSG00000160691.SHC1.png
Soverview

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Protein coding region RNA A-to-I editings for SHC1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for SHC1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_107068	chr1_154962796_-	ENSG00000160691.17	ENST00000368445	hsa-miR-3618	154962793	154962799	7mer-m8	154962792	154962813	153	-11.44
CAediting_107068	chr1_154962796_-	ENSG00000160691.17	ENST00000448116	hsa-miR-3618	154962793	154962799	7mer-m8	154962792	154962813	153	-11.44
CAediting_107068	chr1_154962796_-	ENSG00000160691.17	ENST00000368449	hsa-miR-3618	154962793	154962799	7mer-m8	154962792	154962813	153	-11.44
CAediting_107068	chr1_154962796_-	ENSG00000160691.17	ENST00000368453	hsa-miR-3618	154962793	154962799	7mer-m8	154962792	154962813	153	-11.44
CAediting_107068	chr1_154962796_-	ENSG00000160691.17	ENST00000368450	hsa-miR-3618	154962793	154962799	7mer-m8	154962792	154962813	153	-11.44

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_748296	chr10_51299626_+	ENSG00000160691.17	ENST00000368445	hsa-miR-605-3p	154963769	154963775	7mer-m8	154963768	154963790	143	-16.99
CAediting_748296	chr10_51299626_+	ENSG00000160691.17	ENST00000368445	hsa-miR-605-3p	154963054	154963060	7mer-m8	154963053	154963078	162	-18.96
CAediting_688081	chr9_63819627_+	ENSG00000160691.17	ENST00000368445	hsa-miR-4477b	154963744	154963750	7mer-m8	154963743	154963763	141	-11.23
CAediting_748296	chr10_51299626_+	ENSG00000160691.17	ENST00000448116	hsa-miR-605-3p	154963769	154963775	7mer-m8	154963768	154963790	143	-16.99
CAediting_748296	chr10_51299626_+	ENSG00000160691.17	ENST00000448116	hsa-miR-605-3p	154963054	154963060	7mer-m8	154963053	154963078	162	-18.96
CAediting_688081	chr9_63819627_+	ENSG00000160691.17	ENST00000448116	hsa-miR-4477b	154963744	154963750	7mer-m8	154963743	154963763	141	-11.23
CAediting_748296	chr10_51299626_+	ENSG00000160691.17	ENST00000368449	hsa-miR-605-3p	154963769	154963775	7mer-m8	154963768	154963790	143	-16.99
CAediting_748296	chr10_51299626_+	ENSG00000160691.17	ENST00000368449	hsa-miR-605-3p	154963054	154963060	7mer-m8	154963053	154963078	162	-18.96
CAediting_688081	chr9_63819627_+	ENSG00000160691.17	ENST00000368449	hsa-miR-4477b	154963744	154963750	7mer-m8	154963743	154963763	141	-11.23
CAediting_748296	chr10_51299626_+	ENSG00000160691.17	ENST00000368453	hsa-miR-605-3p	154963769	154963775	7mer-m8	154963768	154963790	143	-16.99
CAediting_748296	chr10_51299626_+	ENSG00000160691.17	ENST00000368453	hsa-miR-605-3p	154963054	154963060	7mer-m8	154963053	154963078	162	-18.96
CAediting_688081	chr9_63819627_+	ENSG00000160691.17	ENST00000368453	hsa-miR-4477b	154963744	154963750	7mer-m8	154963743	154963763	141	-11.23
CAediting_748296	chr10_51299626_+	ENSG00000160691.17	ENST00000368450	hsa-miR-605-3p	154963769	154963775	7mer-m8	154963768	154963790	143	-16.99
CAediting_748296	chr10_51299626_+	ENSG00000160691.17	ENST00000368450	hsa-miR-605-3p	154963054	154963060	7mer-m8	154963053	154963078	162	-18.96
CAediting_688081	chr9_63819627_+	ENSG00000160691.17	ENST00000368450	hsa-miR-4477b	154963744	154963750	7mer-m8	154963743	154963763	141	-11.23
CAediting_748296	chr10_51299626_+	ENSG00000160691.17	ENST00000444664	hsa-miR-605-3p	154963769	154963775	7mer-m8	154963768	154963790	143	-16.99
CAediting_688081	chr9_63819627_+	ENSG00000160691.17	ENST00000444664	hsa-miR-4477b	154963744	154963750	7mer-m8	154963743	154963763	141	-11.23
CAediting_86358	chr1_109598906_+	ENSG00000160691.17	ENST00000368445	hsa-miR-197-5p	154963754	154963760	7mer-m8	154963753	154963775	164	-33.08
CAediting_228905	chr2_188297554_+	ENSG00000160691.17	ENST00000368445	hsa-miR-561-3p	154962322	154962328	7mer-m8	154962321	154962339	141	-11.94
CAediting_86358	chr1_109598906_+	ENSG00000160691.17	ENST00000448116	hsa-miR-197-5p	154963754	154963760	7mer-m8	154963753	154963775	164	-33.08
CAediting_228905	chr2_188297554_+	ENSG00000160691.17	ENST00000448116	hsa-miR-561-3p	154962322	154962328	7mer-m8	154962321	154962339	141	-11.94
CAediting_86358	chr1_109598906_+	ENSG00000160691.17	ENST00000368449	hsa-miR-197-5p	154963754	154963760	7mer-m8	154963753	154963775	164	-33.08
CAediting_228905	chr2_188297554_+	ENSG00000160691.17	ENST00000368449	hsa-miR-561-3p	154962322	154962328	7mer-m8	154962321	154962339	141	-11.94
CAediting_86358	chr1_109598906_+	ENSG00000160691.17	ENST00000368453	hsa-miR-197-5p	154963754	154963760	7mer-m8	154963753	154963775	164	-33.08
CAediting_228905	chr2_188297554_+	ENSG00000160691.17	ENST00000368453	hsa-miR-561-3p	154962322	154962328	7mer-m8	154962321	154962339	141	-11.94
CAediting_86358	chr1_109598906_+	ENSG00000160691.17	ENST00000368450	hsa-miR-197-5p	154963754	154963760	7mer-m8	154963753	154963775	164	-33.08
CAediting_228905	chr2_188297554_+	ENSG00000160691.17	ENST00000368450	hsa-miR-561-3p	154962322	154962328	7mer-m8	154962321	154962339	141	-11.94
CAediting_86358	chr1_109598906_+	ENSG00000160691.17	ENST00000444664	hsa-miR-197-5p	154963754	154963760	7mer-m8	154963753	154963775	164	-33.08

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_228905	chr2_188297554_+	ENSG00000160691.17	ENST00000368445	hsa-miR-561-3p	154963374	154963380	7mer-m8	154963373	154963395	152	-11.88
CAediting_228905	chr2_188297554_+	ENSG00000160691.17	ENST00000448116	hsa-miR-561-3p	154963374	154963380	7mer-m8	154963373	154963395	152	-11.88
CAediting_228905	chr2_188297554_+	ENSG00000160691.17	ENST00000368449	hsa-miR-561-3p	154963374	154963380	7mer-m8	154963373	154963395	152	-11.88
CAediting_228905	chr2_188297554_+	ENSG00000160691.17	ENST00000368453	hsa-miR-561-3p	154963374	154963380	7mer-m8	154963373	154963395	152	-11.88
CAediting_228905	chr2_188297554_+	ENSG00000160691.17	ENST00000368450	hsa-miR-561-3p	154963374	154963380	7mer-m8	154963373	154963395	152	-11.88

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SHC1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000368445.8	protein_coding
ENST00000368449.7	protein_coding
ENST00000368450.4	protein_coding
ENST00000368453.7	protein_coding
ENST00000448116.5	protein_coding
ENST00000444664.4	protein_coding
ENST00000366442.2	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_107068	ENST00000368445.8	chr1_154962796_-	-1384.10	-1383.00	-1384.10
CAediting_107068	ENST00000368449.7	chr1_154962796_-	-1082.30	-1081.30	-1082.30
CAediting_107068	ENST00000368450.4	chr1_154962796_-	-1152.50	-1151.40	-1152.50
CAediting_107068	ENST00000368453.7	chr1_154962796_-	-1154.60	-1153.50	-1154.60
CAediting_107068	ENST00000448116.5	chr1_154962796_-	-1393.70	-1392.00	-1393.70
CAediting_107069	ENST00000444664.4	chr1_154964277_-	-467.20	-464.50	-487.90
CAediting_107070	ENST00000444664.4	chr1_154964279_-	-465.40	-464.50	-487.90
CAediting_107071	ENST00000444664.4	chr1_154964291_-	-466.30	-464.50	-487.90
CAediting_107072	ENST00000444664.4	chr1_154964318_-	-468.20	-464.50	-487.90
CAediting_107073	ENST00000444664.4	chr1_154964319_-	-467.50	-464.50	-487.90
CAediting_107074	ENST00000444664.4	chr1_154964331_-	-468.00	-464.50	-487.90
CAediting_107075	ENST00000444664.4	chr1_154964332_-	-464.80	-464.50	-487.90
CAediting_107076	ENST00000444664.4	chr1_154964343_-	-467.10	-464.50	-487.90
CAediting_107077	ENST00000444664.4	chr1_154964344_-	-467.10	-464.50	-487.90
CAediting_107078	ENST00000444664.4	chr1_154964366_-	-466.90	-464.50	-487.90
CAediting_107079	ENST00000444664.4	chr1_154964368_-	-467.40	-464.50	-487.90
CAediting_107122	ENST00000366442.2	chr1_154973314_-	-323.10	-323.90	-332.60
CAediting_107123	ENST00000366442.2	chr1_154973319_-	-326.60	-323.90	-332.60
CAediting_107124	ENST00000366442.2	chr1_154973379_-	-329.30	-323.90	-332.60
CAediting_107125	ENST00000366442.2	chr1_154973387_-	-323.80	-323.90	-332.60
CAediting_107126	ENST00000366442.2	chr1_154973399_-	-323.40	-323.90	-332.60
CAediting_107127	ENST00000366442.2	chr1_154973402_-	-326.00	-323.90	-332.60
CAediting_107128	ENST00000366442.2	chr1_154973424_-	-323.40	-323.90	-332.60
CAediting_107129	ENST00000366442.2	chr1_154973428_-	-323.80	-323.90	-332.60

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Relation with ADAR for SHC1

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
BRCA	CAediting_107070	chr1_154964279_-	0.00718322370755084	0.217939862491568	.	.	0.0206288915187969	0.188245304889969
LUAD	CAediting_107070	chr1_154964279_-	0.0237128200344029	0.207265216994596	.	.	.	.
LUSC	CAediting_107070	chr1_154964279_-	0.0409334459356609	0.219654322130659	.	.	.	.
SKCM	CAediting_107070	chr1_154964279_-	0.0367667300733681	0.207082121627362	.	.	.	.
BRCA	CAediting_107076	chr1_154964343_-	0.000179011233931501	0.27651549724153	.	.	.	.
LUAD	CAediting_107076	chr1_154964343_-	.	.	.	.	0.00780383710596492	0.235082328867683
LUSC	CAediting_107076	chr1_154964343_-	0.000140251697551476	0.303050375871856	.	.	.	.
ESCA	CAediting_107076	chr1_154964343_-	0.0253796105964687	0.22353107478436	.	.	.	.
SKCM	CAediting_107076	chr1_154964343_-	.	.	0.00247055347047471	0.311929910046909	.	.
BRCA	CAediting_107093	chr1_154964665_-	0.0188698252412724	0.218692383177619	.	.	0.0158282022565488	0.224571177900534
LUAD	CAediting_107093	chr1_154964665_-	8.02430499254926e-08	0.492824613129625	.	.	.	.
LUSC	CAediting_107093	chr1_154964665_-	0.0043355947415384	0.277561948304594	.	.	.	.
PCPG	CAediting_107093	chr1_154964665_-	.	.	0.0123847456245123	0.25570001877211	.	.
BLCA	CAediting_107097	chr1_154964693_-	0.00925088843748372	0.325439980824413	.	.	.	.
BRCA	CAediting_107097	chr1_154964693_-	0.0162532882057915	0.19215701049493	.	.	0.0192593511541983	0.187233317047026
LUAD	CAediting_107097	chr1_154964693_-	0.0056138210619623	0.242551534754857	.	.	.	.
LUSC	CAediting_107097	chr1_154964693_-	0.000148041710100862	0.27911582989595	.	.	.	.
KIRC	CAediting_107097	chr1_154964693_-	0.000169049476777251	0.273832085334364	.	.	.	.
OV	CAediting_107097	chr1_154964693_-	0.000595918016150434	0.356926651182384	.	.	.	.
LUAD	CAediting_107099	chr1_154964721_-	0.00659764351094763	0.250890205046368	.	.	.	.
LUSC	CAediting_107099	chr1_154964721_-	0.00788064059582554	0.281524097931479	.	.	.	.
KIRC	CAediting_107099	chr1_154964721_-	.	.	0.00271360852423157	0.208895742885558	.	.
PCPG	CAediting_107099	chr1_154964721_-	.	.	0.0357911308383111	0.22162303928791	.	.
BRCA	CAediting_107103	chr1_154964747_-	0.00316054745560893	0.227120782929305	.	.	.	.
LUAD	CAediting_107103	chr1_154964747_-	0.00153895907161937	0.268080655549371	.	.	.	.
LUAD	CAediting_107104	chr1_154964761_-	.	.	0.0450554683183709	0.242090482888291	.	.

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Relation with cancer stages for SHC1

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
ESCA	clinical_stage	CAediting_107076	chr1_154964343_-	0.0189435983037833	-0.440601221551583
ESCA	pathologic_stage	CAediting_107076	chr1_154964343_-	0.0126735943311911	0.253570388591901
LUAD	pathologic_stage	CAediting_107103	chr1_154964747_-	0.00016759429862073	0.317262396009574

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Relation with survival for SHC1

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
ESCA	CAediting_107076	chr1_154964343_-	0.000619928879993847	0.00178898	166.076

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RelatedDrugs for SHC1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SHC1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
SHC1	C0018800	Cardiomegaly	1	CTD_human
SHC1	C0019193	Hepatitis, Toxic	1	CTD_human
SHC1	C0860207	Drug-Induced Liver Disease	1	CTD_human
SHC1	C1262760	Hepatitis, Drug-Induced	1	CTD_human
SHC1	C1383860	Cardiac Hypertrophy	1	CTD_human
SHC1	C1862939	AMYOTROPHIC LATERAL SCLEROSIS 1	1	CTD_human
SHC1	C1862941	Amyotrophic Lateral Sclerosis, Sporadic	1	CTD_human
SHC1	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
SHC1	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
SHC1	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human
SHC1	C4551993	Amyotrophic Lateral Sclerosis, Familial	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene