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Editing gene: PLA2G2F (CAeditome ID:64600)

Gene summary for PLA2G2F

Gene summary

Gene information	Gene symbol	PLA2G2F
	Gene ID	64600
	Gene name	phospholipase A2 group IIF
	Synonyms	GIIFsPLA2\|sPLA2-IIF
	Cytomap	1p36.12
	Type of gene	protein-coding
	Description	group IIF secretory phospholipase A2GIIF sPLA2phosphatidylcholine 2-acylhydrolase 2F
	Modification date	20210518
	UniProtAcc	Q9BZM2
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
PLA2G2F	GO:0047498	Group IIF secretory phospholipase A2	11112443
PLA2G2F	GO:0036148	Group IIF secretory phospholipase A2	11112443
PLA2G2F	GO:0036150	Group IIF secretory phospholipase A2	11112443
PLA2G2F	GO:0036151	Group IIF secretory phospholipase A2	11112443
PLA2G2F	GO:0036152	Group IIF secretory phospholipase A2	11112443

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RNA A-to-I events for PLA2G2F

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000158786.4

RNA A-to-I editing events in Cancer.

CAediting_20909(20144813, +), CAediting_20910(20144821, +), CAediting_20911(20144822, +), CAediting_20912(20144878, +), CAediting_20913(20144900, +), CAediting_20914(20144912, +), CAediting_20915(20144917, +), CAediting_20916(20144918, +), CAediting_20917(20144921, +), CAediting_20918(20144953, +), CAediting_20919(20144956, +), CAediting_20920(20144957, +), CAediting_20921(20144986, +), CAediting_20922(20144992, +), CAediting_20923(20144998, +), CAediting_20924(20144999, +), CAediting_20925(20145006, +), CAediting_20926(20145010, +), CAediting_20927(20145013, +), CAediting_20928(20145019, +), CAediting_20929(20145027, +), CAediting_20930(20145064, +), CAediting_20931(20145308, +), CAediting_20932(20145324, +), CAediting_20933(20145359, +), CAediting_20934(20145421, +), CAediting_20935(20145454, +), CAediting_20936(20145523, +), CAediting_20937(20145527, +), CAediting_20938(20145541, +), CAediting_20939(20145542, +), CAediting_20940(20145554, +), CAediting_20941(20145556, +), CAediting_20942(20145682, +), CAediting_20943(20145710, +), CAediting_20944(20145727, +), CAediting_20945(20145749, +), CAediting_20946(20145808, +), CAediting_20947(20145820, +), CAediting_20948(20145849, +), CAediting_20949(20145870, +), CAediting_20950(20147969, +),

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RNA editing positional annotations for PLA2G2F using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_20909	chr1_20144813_+	intronic
CAediting_20910	chr1_20144821_+	intronic
CAediting_20911	chr1_20144822_+	intronic
CAediting_20912	chr1_20144878_+	intronic
CAediting_20913	chr1_20144900_+	intronic
CAediting_20914	chr1_20144912_+	intronic
CAediting_20915	chr1_20144917_+	intronic
CAediting_20916	chr1_20144918_+	intronic
CAediting_20917	chr1_20144921_+	intronic
CAediting_20918	chr1_20144953_+	intronic
CAediting_20919	chr1_20144956_+	intronic
CAediting_20920	chr1_20144957_+	intronic
CAediting_20921	chr1_20144986_+	intronic
CAediting_20922	chr1_20144992_+	intronic
CAediting_20923	chr1_20144998_+	intronic
CAediting_20924	chr1_20144999_+	intronic
CAediting_20925	chr1_20145006_+	intronic
CAediting_20926	chr1_20145010_+	intronic
CAediting_20927	chr1_20145013_+	intronic
CAediting_20928	chr1_20145019_+	intronic
CAediting_20929	chr1_20145027_+	intronic
CAediting_20930	chr1_20145064_+	intronic
CAediting_20931	chr1_20145308_+	intronic
CAediting_20932	chr1_20145324_+	intronic
CAediting_20933	chr1_20145359_+	intronic
CAediting_20934	chr1_20145421_+	intronic
CAediting_20935	chr1_20145454_+	intronic
CAediting_20936	chr1_20145523_+	intronic
CAediting_20937	chr1_20145527_+	intronic
CAediting_20938	chr1_20145541_+	intronic
CAediting_20939	chr1_20145542_+	intronic
CAediting_20940	chr1_20145554_+	intronic
CAediting_20941	chr1_20145556_+	intronic
CAediting_20942	chr1_20145682_+	intronic
CAediting_20943	chr1_20145710_+	intronic
CAediting_20944	chr1_20145727_+	intronic
CAediting_20945	chr1_20145749_+	intronic
CAediting_20946	chr1_20145808_+	intronic
CAediting_20947	chr1_20145820_+	intronic
CAediting_20948	chr1_20145849_+	intronic
CAediting_20949	chr1_20145870_+	intronic
CAediting_20950	chr1_20147969_+	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_20909	chr1_20144813_+	SINE	Alu	AluSz
CAediting_20910	chr1_20144821_+	SINE	Alu	AluSz
CAediting_20911	chr1_20144822_+	SINE	Alu	AluSz
CAediting_20912	chr1_20144878_+	SINE	Alu	AluSz
CAediting_20913	chr1_20144900_+	SINE	Alu	AluSz
CAediting_20914	chr1_20144912_+	SINE	Alu	AluSz
CAediting_20915	chr1_20144917_+	SINE	Alu	AluSz
CAediting_20916	chr1_20144918_+	SINE	Alu	AluSz
CAediting_20917	chr1_20144921_+	SINE	Alu	AluSz
CAediting_20918	chr1_20144953_+	SINE	Alu	AluSz
CAediting_20919	chr1_20144956_+	SINE	Alu	AluSz
CAediting_20920	chr1_20144957_+	SINE	Alu	AluSz
CAediting_20921	chr1_20144986_+	SINE	Alu	AluSz
CAediting_20922	chr1_20144992_+	SINE	Alu	AluSz
CAediting_20923	chr1_20144998_+	SINE	Alu	AluSz
CAediting_20924	chr1_20144999_+	SINE	Alu	AluSz
CAediting_20925	chr1_20145006_+	SINE	Alu	AluSz
CAediting_20926	chr1_20145010_+	SINE	Alu	AluSz
CAediting_20927	chr1_20145013_+	SINE	Alu	AluSz
CAediting_20928	chr1_20145019_+	SINE	Alu	AluSz
CAediting_20929	chr1_20145027_+	SINE	Alu	AluSz
CAediting_20930	chr1_20145064_+	SINE	Alu	AluSz
CAediting_20931	chr1_20145308_+	SINE	Alu	AluSc
CAediting_20932	chr1_20145324_+	SINE	Alu	AluSc
CAediting_20933	chr1_20145359_+	SINE	Alu	AluSc
CAediting_20934	chr1_20145421_+	SINE	Alu	AluSc
CAediting_20935	chr1_20145454_+	SINE	Alu	AluSc
CAediting_20936	chr1_20145523_+	SINE	Alu	AluSc
CAediting_20937	chr1_20145527_+	SINE	Alu	AluSc
CAediting_20938	chr1_20145541_+	SINE	Alu	AluSc
CAediting_20939	chr1_20145542_+	SINE	Alu	AluSc
CAediting_20940	chr1_20145554_+	SINE	Alu	AluSc
CAediting_20941	chr1_20145556_+	SINE	Alu	AluSc
CAediting_20942	chr1_20145682_+	SINE	Alu	AluJo
CAediting_20943	chr1_20145710_+	SINE	Alu	AluJo
CAediting_20944	chr1_20145727_+	SINE	Alu	AluJo
CAediting_20945	chr1_20145749_+	SINE	Alu	AluJo
CAediting_20946	chr1_20145808_+	SINE	Alu	AluJo
CAediting_20947	chr1_20145820_+	SINE	Alu	AluJo
CAediting_20948	chr1_20145849_+	SINE	Alu	AluJo
CAediting_20949	chr1_20145870_+	SINE	Alu	AluJo
CAediting_20950	chr1_20147969_+	DNA	hAT-Charlie	MER5A

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RNA A-to-I editing events in the alternative splicing sites for PLA2G2F

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000158786.4.PLA2G2F.

Correlation between RNA A-to-I editing and PSI for ENSG00000158786.4.PLA2G2F.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PLA2G2F

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for PLA2G2F

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for PLA2G2F

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for PLA2G2F

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for PLA2G2F

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
BLCA	CAediting_20919	chr1_20144956_+	6.92826936576271e-07	0.543005316581144	.	.	.	.
BLCA	CAediting_20920	chr1_20144957_+	0.00196600697259845	0.368869060876821	.	.	.	.
BLCA	CAediting_20923	chr1_20144998_+	0.0307108885932795	0.260381341867956	.	.	.	.
BLCA	CAediting_20924	chr1_20144999_+	0.0366616501457348	0.277450297730566	.	.	.	.
BLCA	CAediting_20950	chr1_20147969_+	0.00134778644557161	0.414500672992497	.	.	.	.

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Relation with cancer stages for PLA2G2F

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for PLA2G2F

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for PLA2G2F

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for PLA2G2F

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene