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Editing gene: TMEM168 (CAeditome ID:64418)

Gene summary for TMEM168

Gene summary

Gene information	Gene symbol	TMEM168
	Gene ID	64418
	Gene name	transmembrane protein 168
	Synonyms	-
	Cytomap	7q31.1
	Type of gene	protein-coding
	Description	transmembrane protein 168
	Modification date	20210518
	UniProtAcc	Q9H0V1
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
TMEM168	GO:0030133	Transmembrane protein 168	0000054

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RNA A-to-I events for TMEM168

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000146802.11

RNA A-to-I editing events in Cancer.

CAediting_595667(112764506, -), CAediting_595668(112764597, -), CAediting_595669(112764606, -), CAediting_595670(112764612, -), CAediting_595671(112764639, -), CAediting_595672(112764665, -), CAediting_595673(112764683, -), CAediting_595674(112764696, -), CAediting_595675(112764818, -), CAediting_595676(112764974, -), CAediting_595677(112774657, -), CAediting_595678(112778926, -), CAediting_595679(112778936, -), CAediting_595680(112778951, -), CAediting_595681(112778973, -), CAediting_595682(112779155, -), CAediting_595683(112779163, -), CAediting_595684(112780677, -), CAediting_595685(112780678, -), CAediting_595686(112780685, -), CAediting_595687(112780688, -), CAediting_595688(112785946, -), CAediting_595689(112785963, -), CAediting_595690(112785990, -), CAediting_595691(112785991, -), CAediting_595692(112786003, -), CAediting_595693(112786016, -), CAediting_595694(112786036, -), CAediting_595695(112786042, -), CAediting_595696(112786045, -), CAediting_595697(112786051, -), CAediting_595698(112786059, -), CAediting_595699(112786068, -), CAediting_595700(112786073, -), CAediting_595701(112786086, -), CAediting_595702(112786115, -), CAediting_595703(112786119, -), CAediting_595704(112786120, -), CAediting_595705(112786139, -), CAediting_595706(112786155, -), CAediting_595707(112786196, -), CAediting_595708(112787418, -), CAediting_595709(112787445, -), CAediting_595710(112787448, -), CAediting_595711(112787452, -), CAediting_595712(112787456, -), CAediting_595713(112787471, -), CAediting_595714(112787476, -), CAediting_595715(112787477, -), CAediting_595716(112787512, -), CAediting_595717(112787517, -), CAediting_595718(112787536, -), CAediting_595719(112787547, -), CAediting_595720(112787552, -), CAediting_595721(112787553, -), CAediting_595722(112787565, -), CAediting_595723(112787571, -), CAediting_595724(112787578, -), CAediting_595725(112787579, -), CAediting_595726(112787582, -), CAediting_595727(112787583, -), CAediting_595728(112787584, -), CAediting_595729(112787585, -), CAediting_595730(112787597, -), CAediting_595731(112787608, -), CAediting_595732(112787628, -), CAediting_595733(112787639, -), CAediting_595734(112787642, -), CAediting_595735(112787678, -), CAediting_595736(112787695, -), CAediting_595737(112787703, -), CAediting_595738(112787800, -), CAediting_595739(112787805, -), CAediting_595740(112787818, -), CAediting_595741(112787829, -), CAediting_595742(112787830, -), CAediting_595743(112787838, -), CAediting_595744(112787848, -), CAediting_595745(112787889, -), CAediting_595746(112787897, -), CAediting_595747(112787900, -), CAediting_595748(112787901, -), CAediting_595749(112787902, -), CAediting_595750(112787905, -), CAediting_595751(112787908, -), CAediting_595752(112787910, -), CAediting_595753(112787914, -), CAediting_595754(112787925, -), CAediting_595755(112787935, -), CAediting_595756(112787945, -), CAediting_595757(112787950, -), CAediting_595758(112787956, -), CAediting_595759(112787964, -), CAediting_595760(112788011, -), CAediting_595761(112788013, -),

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RNA editing positional annotations for TMEM168 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_595667	chr7_112764506_-	UTR3
CAediting_595668	chr7_112764597_-	UTR3
CAediting_595669	chr7_112764606_-	UTR3
CAediting_595670	chr7_112764612_-	UTR3
CAediting_595671	chr7_112764639_-	UTR3
CAediting_595672	chr7_112764665_-	UTR3
CAediting_595673	chr7_112764683_-	UTR3
CAediting_595674	chr7_112764696_-	UTR3
CAediting_595675	chr7_112764818_-	UTR3
CAediting_595676	chr7_112764974_-	UTR3
CAediting_595677	chr7_112774657_-	ncRNA_intronic
CAediting_595678	chr7_112778926_-	intronic
CAediting_595679	chr7_112778936_-	intronic
CAediting_595680	chr7_112778951_-	intronic
CAediting_595681	chr7_112778973_-	intronic
CAediting_595682	chr7_112779155_-	intronic
CAediting_595683	chr7_112779163_-	intronic
CAediting_595684	chr7_112780677_-	intronic
CAediting_595685	chr7_112780678_-	intronic
CAediting_595686	chr7_112780685_-	intronic
CAediting_595687	chr7_112780688_-	intronic
CAediting_595688	chr7_112785946_-	intronic
CAediting_595689	chr7_112785963_-	intronic
CAediting_595690	chr7_112785990_-	intronic
CAediting_595691	chr7_112785991_-	intronic
CAediting_595692	chr7_112786003_-	intronic
CAediting_595693	chr7_112786016_-	intronic
CAediting_595694	chr7_112786036_-	intronic
CAediting_595695	chr7_112786042_-	intronic
CAediting_595696	chr7_112786045_-	intronic
CAediting_595697	chr7_112786051_-	intronic
CAediting_595698	chr7_112786059_-	intronic
CAediting_595699	chr7_112786068_-	intronic
CAediting_595700	chr7_112786073_-	intronic
CAediting_595701	chr7_112786086_-	intronic
CAediting_595702	chr7_112786115_-	intronic
CAediting_595703	chr7_112786119_-	intronic
CAediting_595704	chr7_112786120_-	intronic
CAediting_595705	chr7_112786139_-	intronic
CAediting_595706	chr7_112786155_-	intronic
CAediting_595707	chr7_112786196_-	intronic
CAediting_595708	chr7_112787418_-	intronic
CAediting_595709	chr7_112787445_-	intronic
CAediting_595710	chr7_112787448_-	intronic
CAediting_595711	chr7_112787452_-	intronic
CAediting_595712	chr7_112787456_-	intronic
CAediting_595713	chr7_112787471_-	intronic
CAediting_595714	chr7_112787476_-	intronic
CAediting_595715	chr7_112787477_-	intronic
CAediting_595716	chr7_112787512_-	intronic
CAediting_595717	chr7_112787517_-	intronic
CAediting_595718	chr7_112787536_-	intronic
CAediting_595719	chr7_112787547_-	intronic
CAediting_595720	chr7_112787552_-	intronic
CAediting_595721	chr7_112787553_-	intronic
CAediting_595722	chr7_112787565_-	intronic
CAediting_595723	chr7_112787571_-	intronic
CAediting_595724	chr7_112787578_-	intronic
CAediting_595725	chr7_112787579_-	intronic
CAediting_595726	chr7_112787582_-	intronic
CAediting_595727	chr7_112787583_-	intronic
CAediting_595728	chr7_112787584_-	intronic
CAediting_595729	chr7_112787585_-	intronic
CAediting_595730	chr7_112787597_-	intronic
CAediting_595731	chr7_112787608_-	intronic
CAediting_595732	chr7_112787628_-	intronic
CAediting_595733	chr7_112787639_-	intronic
CAediting_595734	chr7_112787642_-	intronic
CAediting_595735	chr7_112787678_-	intronic
CAediting_595736	chr7_112787695_-	intronic
CAediting_595737	chr7_112787703_-	intronic
CAediting_595738	chr7_112787800_-	intronic
CAediting_595739	chr7_112787805_-	intronic
CAediting_595740	chr7_112787818_-	intronic
CAediting_595741	chr7_112787829_-	intronic
CAediting_595742	chr7_112787830_-	intronic
CAediting_595743	chr7_112787838_-	intronic
CAediting_595744	chr7_112787848_-	intronic
CAediting_595745	chr7_112787889_-	intronic
CAediting_595746	chr7_112787897_-	intronic
CAediting_595747	chr7_112787900_-	intronic
CAediting_595748	chr7_112787901_-	intronic
CAediting_595749	chr7_112787902_-	intronic
CAediting_595750	chr7_112787905_-	intronic
CAediting_595751	chr7_112787908_-	intronic
CAediting_595752	chr7_112787910_-	intronic
CAediting_595753	chr7_112787914_-	intronic
CAediting_595754	chr7_112787925_-	intronic
CAediting_595755	chr7_112787935_-	intronic
CAediting_595756	chr7_112787945_-	intronic
CAediting_595757	chr7_112787950_-	intronic
CAediting_595758	chr7_112787956_-	intronic
CAediting_595759	chr7_112787964_-	intronic
CAediting_595760	chr7_112788011_-	intronic
CAediting_595761	chr7_112788013_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_595667	chr7_112764506_-	SINE	Alu	AluSc
CAediting_595668	chr7_112764597_-	SINE	Alu	AluSc
CAediting_595669	chr7_112764606_-	SINE	Alu	AluSc
CAediting_595670	chr7_112764612_-	SINE	Alu	AluSc
CAediting_595671	chr7_112764639_-	SINE	Alu	AluSc
CAediting_595672	chr7_112764665_-	SINE	Alu	AluSc
CAediting_595673	chr7_112764683_-	SINE	Alu	AluSc
CAediting_595674	chr7_112764696_-	SINE	Alu	AluSc
CAediting_595675	chr7_112764818_-	SINE	Alu	AluSz6
CAediting_595676	chr7_112764974_-	SINE	Alu	AluSz6
CAediting_595677	chr7_112774657_-	SINE	Alu	AluSq2
CAediting_595678	chr7_112778926_-	SINE	Alu	AluJb
CAediting_595679	chr7_112778936_-	SINE	Alu	AluJb
CAediting_595680	chr7_112778951_-	SINE	Alu	AluJb
CAediting_595681	chr7_112778973_-	SINE	Alu	AluJb
CAediting_595682	chr7_112779155_-	SINE	Alu	AluJb
CAediting_595683	chr7_112779163_-	SINE	Alu	AluJb
CAediting_595684	chr7_112780677_-	SINE	Alu	AluJb
CAediting_595685	chr7_112780678_-	SINE	Alu	AluJb
CAediting_595686	chr7_112780685_-	SINE	Alu	AluJb
CAediting_595687	chr7_112780688_-	SINE	Alu	AluJb
CAediting_595688	chr7_112785946_-	SINE	Alu	AluSx1
CAediting_595689	chr7_112785963_-	SINE	Alu	AluSx1
CAediting_595690	chr7_112785990_-	SINE	Alu	AluSx1
CAediting_595691	chr7_112785991_-	SINE	Alu	AluSx1
CAediting_595692	chr7_112786003_-	SINE	Alu	AluSx1
CAediting_595693	chr7_112786016_-	SINE	Alu	AluSx1
CAediting_595694	chr7_112786036_-	SINE	Alu	AluSx1
CAediting_595695	chr7_112786042_-	SINE	Alu	AluSx1
CAediting_595696	chr7_112786045_-	SINE	Alu	AluSx1
CAediting_595697	chr7_112786051_-	SINE	Alu	AluSx1
CAediting_595698	chr7_112786059_-	SINE	Alu	AluSx1
CAediting_595699	chr7_112786068_-	SINE	Alu	AluSx1
CAediting_595700	chr7_112786073_-	SINE	Alu	AluSx1
CAediting_595701	chr7_112786086_-	SINE	Alu	AluSx1
CAediting_595702	chr7_112786115_-	SINE	Alu	AluSx1
CAediting_595703	chr7_112786119_-	SINE	Alu	AluSx1
CAediting_595704	chr7_112786120_-	SINE	Alu	AluSx1
CAediting_595705	chr7_112786139_-	SINE	Alu	AluSx1
CAediting_595706	chr7_112786155_-	SINE	Alu	AluSx1
CAediting_595707	chr7_112786196_-	SINE	Alu	AluSx1
CAediting_595708	chr7_112787418_-	SINE	Alu	AluSx1
CAediting_595709	chr7_112787445_-	SINE	Alu	AluSx1
CAediting_595710	chr7_112787448_-	SINE	Alu	AluSx1
CAediting_595711	chr7_112787452_-	SINE	Alu	AluSx1
CAediting_595712	chr7_112787456_-	SINE	Alu	AluSx1
CAediting_595713	chr7_112787471_-	SINE	Alu	AluSx1
CAediting_595714	chr7_112787476_-	SINE	Alu	AluSx1
CAediting_595715	chr7_112787477_-	SINE	Alu	AluSx1
CAediting_595716	chr7_112787512_-	SINE	Alu	AluSx1
CAediting_595717	chr7_112787517_-	SINE	Alu	AluSx1
CAediting_595718	chr7_112787536_-	SINE	Alu	AluSx1
CAediting_595719	chr7_112787547_-	SINE	Alu	AluSx1
CAediting_595720	chr7_112787552_-	SINE	Alu	AluSx1
CAediting_595721	chr7_112787553_-	SINE	Alu	AluSx1
CAediting_595722	chr7_112787565_-	SINE	Alu	AluSx1
CAediting_595723	chr7_112787571_-	SINE	Alu	AluSx1
CAediting_595724	chr7_112787578_-	SINE	Alu	AluSx1
CAediting_595725	chr7_112787579_-	SINE	Alu	AluSx1
CAediting_595726	chr7_112787582_-	SINE	Alu	AluSx1
CAediting_595727	chr7_112787583_-	SINE	Alu	AluSx1
CAediting_595728	chr7_112787584_-	SINE	Alu	AluSx1
CAediting_595729	chr7_112787585_-	SINE	Alu	AluSx1
CAediting_595730	chr7_112787597_-	SINE	Alu	AluSx1
CAediting_595731	chr7_112787608_-	SINE	Alu	AluSx1
CAediting_595732	chr7_112787628_-	SINE	Alu	AluSx1
CAediting_595733	chr7_112787639_-	SINE	Alu	AluSx1
CAediting_595734	chr7_112787642_-	SINE	Alu	AluSx1
CAediting_595735	chr7_112787678_-	SINE	Alu	AluSx1
CAediting_595736	chr7_112787695_-	SINE	Alu	AluSx1
CAediting_595737	chr7_112787703_-	SINE	Alu	AluSx1
CAediting_595738	chr7_112787800_-	SINE	Alu	AluSp
CAediting_595739	chr7_112787805_-	SINE	Alu	AluSp
CAediting_595740	chr7_112787818_-	SINE	Alu	AluSp
CAediting_595741	chr7_112787829_-	SINE	Alu	AluSp
CAediting_595742	chr7_112787830_-	SINE	Alu	AluSp
CAediting_595743	chr7_112787838_-	SINE	Alu	AluSp
CAediting_595744	chr7_112787848_-	SINE	Alu	AluSp
CAediting_595745	chr7_112787889_-	SINE	Alu	AluSp
CAediting_595746	chr7_112787897_-	SINE	Alu	AluSp
CAediting_595747	chr7_112787900_-	SINE	Alu	AluSp
CAediting_595748	chr7_112787901_-	SINE	Alu	AluSp
CAediting_595749	chr7_112787902_-	SINE	Alu	AluSp
CAediting_595750	chr7_112787905_-	SINE	Alu	AluSp
CAediting_595751	chr7_112787908_-	SINE	Alu	AluSp
CAediting_595752	chr7_112787910_-	SINE	Alu	AluSp
CAediting_595753	chr7_112787914_-	SINE	Alu	AluSp
CAediting_595754	chr7_112787925_-	SINE	Alu	AluSp
CAediting_595755	chr7_112787935_-	SINE	Alu	AluSp
CAediting_595756	chr7_112787945_-	SINE	Alu	AluSp
CAediting_595757	chr7_112787950_-	SINE	Alu	AluSp
CAediting_595758	chr7_112787956_-	SINE	Alu	AluSp
CAediting_595759	chr7_112787964_-	SINE	Alu	AluSp
CAediting_595760	chr7_112788011_-	SINE	Alu	AluSp
CAediting_595761	chr7_112788013_-	SINE	Alu	AluSp

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RNA A-to-I editing events in the alternative splicing sites for TMEM168

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000146802.11.TMEM168.

Correlation between RNA A-to-I editing and PSI for ENSG00000146802.11.TMEM168.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TMEM168

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for TMEM168

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for TMEM168

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TMEM168

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000312814.9	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_595667	ENST00000312814.9	chr7_112764506_-	-1967.80	-1966.80	-1986.10
CAediting_595668	ENST00000312814.9	chr7_112764597_-	-1970.50	-1966.80	-1986.10
CAediting_595669	ENST00000312814.9	chr7_112764606_-	-1967.30	-1966.80	-1986.10
CAediting_595670	ENST00000312814.9	chr7_112764612_-	-1967.90	-1966.80	-1986.10
CAediting_595671	ENST00000312814.9	chr7_112764639_-	-1969.30	-1966.80	-1986.10
CAediting_595672	ENST00000312814.9	chr7_112764665_-	-1968.20	-1966.80	-1986.10
CAediting_595673	ENST00000312814.9	chr7_112764683_-	-1968.10	-1966.80	-1986.10
CAediting_595674	ENST00000312814.9	chr7_112764696_-	-1970.40	-1966.80	-1986.10
CAediting_595675	ENST00000312814.9	chr7_112764818_-	-1970.00	-1966.80	-1986.10
CAediting_595676	ENST00000312814.9	chr7_112764974_-	-1973.10	-1966.80	-1986.10

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Relation with ADAR for TMEM168

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
STAD	CAediting_595759	chr7_112787964_-	.	.	0.0337783788281057	0.242251518826082	.	.

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Relation with cancer stages for TMEM168

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for TMEM168

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
STAD	CAediting_595740	chr7_112787818_-	0.0327399829580934	0.0376681	11.3891

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RelatedDrugs for TMEM168

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for TMEM168

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene