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Editing gene: CDH22 (CAeditome ID:64405)

Gene summary for CDH22

Gene summary

Gene information	Gene symbol	CDH22
	Gene ID	64405
	Gene name	cadherin 22
	Synonyms	C20orf25\|dJ998H6.1
	Cytomap	20q13.12
	Type of gene	protein-coding
	Description	cadherin-22PB-cadherincadherin 22, type 2cadherin-like 22ortholog of rat PB-cadherinpituitary and brain cadherin
	Modification date	20210518
	UniProtAcc	Q9UJ99
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for CDH22

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000149654.8

RNA A-to-I editing events in Cancer.

CAediting_1431920(46173904, -), CAediting_1431921(46173984, -), CAediting_1431922(46174004, -), CAediting_1431923(46174088, -), CAediting_1431924(46174089, -), CAediting_1431925(46181893, -), CAediting_1431926(46181955, -), CAediting_1431927(46229119, -), CAediting_1431928(46229130, -), CAediting_1431929(46229217, -), CAediting_1431930(46229257, -), CAediting_1431931(46229266, -), CAediting_1431932(46229377, -), CAediting_1431933(46231812, -), CAediting_1431934(46231835, -), CAediting_1431935(46231839, -), CAediting_1431936(46231846, -), CAediting_1431937(46231896, -), CAediting_1431938(46231897, -), CAediting_1431939(46231899, -), CAediting_1431940(46231965, -), CAediting_1431941(46232034, -),

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RNA editing positional annotations for CDH22 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1431920	chr20_46173904_-	UTR3
CAediting_1431921	chr20_46173984_-	UTR3
CAediting_1431922	chr20_46174004_-	UTR3
CAediting_1431923	chr20_46174088_-	UTR3
CAediting_1431924	chr20_46174089_-	UTR3
CAediting_1431925	chr20_46181893_-	intronic
CAediting_1431926	chr20_46181955_-	intronic
CAediting_1431927	chr20_46229119_-	intronic
CAediting_1431928	chr20_46229130_-	intronic
CAediting_1431929	chr20_46229217_-	intronic
CAediting_1431930	chr20_46229257_-	intronic
CAediting_1431931	chr20_46229266_-	intronic
CAediting_1431932	chr20_46229377_-	intronic
CAediting_1431933	chr20_46231812_-	intronic
CAediting_1431934	chr20_46231835_-	intronic
CAediting_1431935	chr20_46231839_-	intronic
CAediting_1431936	chr20_46231846_-	intronic
CAediting_1431937	chr20_46231896_-	intronic
CAediting_1431938	chr20_46231897_-	intronic
CAediting_1431939	chr20_46231899_-	intronic
CAediting_1431940	chr20_46231965_-	intronic
CAediting_1431941	chr20_46232034_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1431920	chr20_46173904_-	SINE	MIR	MIR
CAediting_1431921	chr20_46173984_-	SINE	MIR	MIRb
CAediting_1431922	chr20_46174004_-	SINE	MIR	MIRb
CAediting_1431923	chr20_46174088_-	SINE	MIR	MIRb
CAediting_1431924	chr20_46174089_-	SINE	MIR	MIRb
CAediting_1431925	chr20_46181893_-	SINE	Alu	AluSx1
CAediting_1431926	chr20_46181955_-	SINE	Alu	AluSx1
CAediting_1431929	chr20_46229217_-	SINE	MIR	MIRb
CAediting_1431930	chr20_46229257_-	SINE	MIR	MIRb
CAediting_1431931	chr20_46229266_-	SINE	MIR	MIRb
CAediting_1431932	chr20_46229377_-	SINE	MIR	MIRb
CAediting_1431933	chr20_46231812_-	SINE	MIR	MIRb
CAediting_1431934	chr20_46231835_-	SINE	MIR	MIRb
CAediting_1431935	chr20_46231839_-	SINE	MIR	MIRb
CAediting_1431936	chr20_46231846_-	SINE	MIR	MIRb
CAediting_1431937	chr20_46231896_-	SINE	MIR	MIRb
CAediting_1431938	chr20_46231897_-	SINE	MIR	MIRb
CAediting_1431939	chr20_46231899_-	SINE	MIR	MIRb

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RNA A-to-I editing events in the alternative splicing sites for CDH22

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000149654.8.CDH22.

Correlation between RNA A-to-I editing and PSI for ENSG00000149654.8.CDH22.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CDH22

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CDH22

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for CDH22

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CDH22

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for CDH22

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
PCPG	CAediting_1431922	chr20_46174004_-	0.000333163123661353	0.346738450230576	.	.	.	.
LGG	CAediting_1431924	chr20_46174089_-	7.30899219573033e-07	0.343403221447031	.	.	.	.
PCPG	CAediting_1431924	chr20_46174089_-	1.59883383535885e-05	0.365910860943602	.	.	.	.

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Relation with cancer stages for CDH22

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for CDH22

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
LGG	CAediting_1431924	chr20_46174089_-	0.00527789568012504	0.00702768	65.3651

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RelatedDrugs for CDH22

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CDH22

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
CDH22	C0009402	Colorectal Carcinoma	1	CTD_human
CDH22	C0009404	Colorectal Neoplasms	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene