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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: AZI2 (CAeditome ID:64343)

Gene summary for AZI2

check button Gene summary
Gene informationGene symbol

AZI2

Gene ID

64343

Gene name5-azacytidine induced 2
SynonymsAZ2|NAP1|TILP
Cytomap

3p24.1

Type of geneprotein-coding
Description5-azacytidine-induced protein 25-azacytidine induced gene 2NAK-associated protein 1NF-kappa-B-activating kinase-associated protein 1
Modification date20210518
UniProtAcc

Q9H6S1

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for AZI2

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000163512.12

check button RNA A-to-I editing events in Cancer.
CAediting_263868(28331916, -), CAediting_263869(28333932, -), CAediting_263870(28333934, -), CAediting_263871(28333937, -), CAediting_263872(28333950, -), CAediting_263873(28333951, -), CAediting_263874(28333953, -), CAediting_263875(28333964, -), CAediting_263876(28333970, -), CAediting_263877(28333972, -), CAediting_263878(28333973, -), CAediting_263879(28333976, -), CAediting_263880(28333977, -), CAediting_263881(28333979, -), CAediting_263882(28333980, -), CAediting_263883(28333981, -), CAediting_263884(28333987, -), CAediting_263885(28333994, -), CAediting_263886(28333996, -), CAediting_263887(28333998, -), CAediting_263888(28333999, -), CAediting_263889(28334017, -), CAediting_263890(28334018, -), CAediting_263891(28334024, -), CAediting_263892(28334042, -), CAediting_263893(28334964, -), CAediting_263894(28334972, -), CAediting_263895(28334973, -), CAediting_263896(28334978, -), CAediting_263897(28334979, -), CAediting_263898(28334989, -), CAediting_263899(28334995, -), CAediting_263900(28334997, -), CAediting_263901(28335004, -), CAediting_263902(28335011, -), CAediting_263903(28335013, -), CAediting_263904(28335014, -), CAediting_263905(28335027, -), CAediting_263906(28335036, -), CAediting_263907(28335039, -), CAediting_263908(28335043, -), CAediting_263909(28335047, -), CAediting_263910(28335060, -), CAediting_263911(28335061, -), CAediting_263912(28335062, -), CAediting_263913(28335082, -), CAediting_263914(28335085, -), CAediting_263915(28348753, -),

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RNA editing positional annotations for AZI2 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
CAediting_263868chr3_28331916_-nonsynonymous SNVENST00000334100.9c.A682Gp.N228DD.N
CAediting_263868chr3_28331916_-nonsynonymous SNVENST00000420543.5c.A686Gp.Q229RD.N
CAediting_263868chr3_28331916_-nonsynonymous SNVENST00000457172.4c.A686Gp.Q229RD.N

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_263868chr3_28331916_-exonic
CAediting_263869chr3_28333932_-ncRNA_intronic
CAediting_263870chr3_28333934_-ncRNA_intronic
CAediting_263871chr3_28333937_-ncRNA_intronic
CAediting_263872chr3_28333950_-ncRNA_intronic
CAediting_263873chr3_28333951_-ncRNA_intronic
CAediting_263874chr3_28333953_-ncRNA_intronic
CAediting_263875chr3_28333964_-ncRNA_intronic
CAediting_263876chr3_28333970_-ncRNA_intronic
CAediting_263877chr3_28333972_-ncRNA_intronic
CAediting_263878chr3_28333973_-ncRNA_intronic
CAediting_263879chr3_28333976_-ncRNA_intronic
CAediting_263880chr3_28333977_-ncRNA_intronic
CAediting_263881chr3_28333979_-ncRNA_intronic
CAediting_263882chr3_28333980_-ncRNA_intronic
CAediting_263883chr3_28333981_-ncRNA_intronic
CAediting_263884chr3_28333987_-ncRNA_intronic
CAediting_263885chr3_28333994_-ncRNA_intronic
CAediting_263886chr3_28333996_-ncRNA_intronic
CAediting_263887chr3_28333998_-ncRNA_intronic
CAediting_263888chr3_28333999_-ncRNA_intronic
CAediting_263889chr3_28334017_-ncRNA_intronic
CAediting_263890chr3_28334018_-ncRNA_intronic
CAediting_263891chr3_28334024_-ncRNA_intronic
CAediting_263892chr3_28334042_-ncRNA_intronic
CAediting_263893chr3_28334964_-ncRNA_intronic
CAediting_263894chr3_28334972_-ncRNA_intronic
CAediting_263895chr3_28334973_-ncRNA_intronic
CAediting_263896chr3_28334978_-ncRNA_intronic
CAediting_263897chr3_28334979_-ncRNA_intronic
CAediting_263898chr3_28334989_-ncRNA_intronic
CAediting_263899chr3_28334995_-ncRNA_intronic
CAediting_263900chr3_28334997_-ncRNA_intronic
CAediting_263901chr3_28335004_-ncRNA_intronic
CAediting_263902chr3_28335011_-ncRNA_intronic
CAediting_263903chr3_28335013_-ncRNA_intronic
CAediting_263904chr3_28335014_-ncRNA_intronic
CAediting_263905chr3_28335027_-ncRNA_intronic
CAediting_263906chr3_28335036_-ncRNA_intronic
CAediting_263907chr3_28335039_-ncRNA_intronic
CAediting_263908chr3_28335043_-ncRNA_intronic
CAediting_263909chr3_28335047_-ncRNA_intronic
CAediting_263910chr3_28335060_-ncRNA_intronic
CAediting_263911chr3_28335061_-ncRNA_intronic
CAediting_263912chr3_28335062_-ncRNA_intronic
CAediting_263913chr3_28335082_-ncRNA_intronic
CAediting_263914chr3_28335085_-ncRNA_intronic
CAediting_263915chr3_28348753_-ncRNA_exonic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_263868chr3_28331916_-SINEAluAluJb
CAediting_263905chr3_28335027_-LINECR1L3
CAediting_263906chr3_28335036_-LINECR1L3
CAediting_263907chr3_28335039_-LINECR1L3
CAediting_263908chr3_28335043_-LINECR1L3
CAediting_263909chr3_28335047_-LINECR1L3
CAediting_263910chr3_28335060_-LINECR1L3
CAediting_263911chr3_28335061_-LINECR1L3
CAediting_263912chr3_28335062_-LINECR1L3
CAediting_263913chr3_28335082_-LINECR1L3
CAediting_263914chr3_28335085_-SINEMIRMIRb

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RNA A-to-I editing events in the alternative splicing sites for AZI2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000163512.12.AZI2.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000163512.12.AZI2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for AZI2

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for AZI2

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for AZI2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_688080chr9_63819626_+ENSG00000163512.12ENST00000334100hsa-miR-4477b28331817283318248mer-1a2833181728331838142-10
CAediting_688080chr9_63819626_+ENSG00000163512.12ENST00000420543hsa-miR-4477b28331817283318248mer-1a2833181728331838142-10
CAediting_228905chr2_188297554_+ENSG00000163512.12ENST00000479665hsa-miR-561-3p28323774283237807mer-m82832377328323797154-19.49
CAediting_228905chr2_188297554_+ENSG00000163512.12ENST00000479665hsa-miR-561-3p28323335283233417mer-m82832333428323355140-10.96

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1160181chr17_7017644_-ENSG00000163512.12ENST00000479665hsa-miR-195-3p28322337283223437mer-m82832233628322356146-8.38
CAediting_688081chr9_63819627_+ENSG00000163512.12ENST00000479665hsa-miR-4477b28323384283233907mer-m82832338328323403149-12.39
CAediting_1229413chr17_67471544_+ENSG00000163512.12ENST00000479665hsa-miR-548aa28323871283238777mer-m82832387028323898152-10.52
CAediting_1229414chr17_67471546_+ENSG00000163512.12ENST00000479665hsa-miR-548aa28323871283238777mer-m82832387028323898152-10.52
CAediting_1229415chr17_67471547_+ENSG00000163512.12ENST00000479665hsa-miR-548aa28323871283238777mer-m82832387028323898152-10.52
CAediting_748296chr10_51299626_+ENSG00000163512.12ENST00000479665hsa-miR-605-3p28323768283237747mer-m82832376728323784146-14.62

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for AZI2

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000295748.6processed_transcriptSoverviewSoverview
ENST00000334100.9protein_codingSoverviewSoverview
ENST00000420543.5protein_codingSoverviewSoverview
ENST00000457172.4protein_codingSoverviewSoverview
ENST00000463512.4retained_intronSoverviewSoverview
ENST00000470234.1retained_intronSoverviewSoverview
ENST00000479665.4protein_codingSoverviewSoverview
ENST00000488978.1retained_intronSoverviewSoverview
ENST00000414162.4protein_codingSoverviewSoverview

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
CAediting_263915ENST00000295748.6chr3_28348753_--755.60-753.30-755.60
CAediting_263868ENST00000334100.9chr3_28331916_--221.70-222.00-221.70
CAediting_263868ENST00000420543.5chr3_28331916_--395.70-394.80-398.00
CAediting_263915ENST00000420543.5chr3_28348753_--397.10-394.80-398.00
CAediting_263868ENST00000457172.4chr3_28331916_--305.60-305.50-307.90
CAediting_263915ENST00000457172.4chr3_28348753_--307.80-305.50-307.90
CAediting_263915ENST00000463512.4chr3_28348753_--415.70-413.40-415.70
CAediting_263868ENST00000470234.1chr3_28331916_--58.50-58.30-58.50
CAediting_263915ENST00000479665.4chr3_28348753_--1164.10-1161.80-1164.10
CAediting_263868ENST00000488978.1chr3_28331916_--142.70-142.50-142.70
CAediting_263915ENST00000414162.4chr3_28348753_--309.50-307.20-309.50

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Relation with ADAR for AZI2

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for AZI2

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for AZI2

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for AZI2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AZI2

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource