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Editing gene: GNB4 (CAeditome ID:59345)

Gene summary for GNB4

Gene summary

Gene information	Gene symbol	GNB4
	Gene ID	59345
	Gene name	G protein subunit beta 4
	Synonyms	CMTD1F
	Cytomap	3q26.33
	Type of gene	protein-coding
	Description	guanine nucleotide-binding protein subunit beta-4G protein beta-4 subunitguanine nucleotide binding protein (G protein), beta polypeptide 4transducin beta chain 4
	Modification date	20210518
	UniProtAcc	Q9HAV0
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
GNB4	GO:0044877	Guanine nucleotide-binding protein subunit beta-4	23209302

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RNA A-to-I events for GNB4

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000114450.8

RNA A-to-I editing events in Cancer.

CAediting_326398(179399219, -), CAediting_326399(179399225, -), CAediting_326400(179399232, -), CAediting_326401(179399238, -), CAediting_326402(179399245, -), CAediting_326403(179399250, -), CAediting_326404(179399255, -), CAediting_326405(179399260, -), CAediting_326406(179399279, -), CAediting_326407(179399286, -), CAediting_326408(179399288, -), CAediting_326409(179399299, -), CAediting_326410(179399300, -), CAediting_326411(179399309, -), CAediting_326412(179399314, -), CAediting_326413(179399318, -), CAediting_326414(179399324, -), CAediting_326415(179399335, -), CAediting_326416(179399341, -), CAediting_326417(179399349, -), CAediting_326418(179399351, -), CAediting_326419(179399367, -), CAediting_326420(179399372, -), CAediting_326421(179399373, -), CAediting_326422(179399374, -), CAediting_326423(179399376, -), CAediting_326424(179399378, -), CAediting_326425(179399379, -), CAediting_326426(179399380, -), CAediting_326427(179399381, -), CAediting_326428(179399382, -), CAediting_326429(179399396, -), CAediting_326430(179399397, -), CAediting_326431(179399398, -), CAediting_326432(179399404, -), CAediting_326433(179399406, -), CAediting_326434(179399411, -), CAediting_326435(179399416, -), CAediting_326436(179399430, -), CAediting_326437(179399445, -), CAediting_326438(179399453, -), CAediting_326439(179399454, -), CAediting_326440(179399466, -), CAediting_326441(179399470, -), CAediting_326442(179399475, -), CAediting_326443(179399476, -), CAediting_326444(179399478, -), CAediting_326445(179399484, -), CAediting_326446(179399492, -), CAediting_326447(179399494, -), CAediting_326448(179400188, -), CAediting_326449(179406861, -), CAediting_326450(179412357, -), CAediting_326451(179413063, -), CAediting_326452(179417614, -), CAediting_326453(179417660, -), CAediting_326454(179418362, -), CAediting_326455(179430362, -), CAediting_326456(179430381, -), CAediting_326457(179430592, -), CAediting_326458(179430706, -), CAediting_326459(179438432, -), CAediting_326460(179441483, -), CAediting_326461(179442759, -), CAediting_326462(179442765, -), CAediting_326463(179442771, -), CAediting_326464(179442838, -), CAediting_326465(179442849, -), CAediting_326466(179443427, -), CAediting_326467(179443430, -), CAediting_326468(179443454, -), CAediting_326469(179443525, -), CAediting_326470(179444629, -), CAediting_326471(179444652, -), CAediting_326472(179444704, -), CAediting_326473(179444706, -), CAediting_326474(179445320, -), CAediting_326475(179445337, -), CAediting_326476(179445356, -), CAediting_326477(179445361, -), CAediting_326478(179445376, -), CAediting_326479(179445392, -),

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RNA editing positional annotations for GNB4 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_326398	chr3_179399219_-	UTR3
CAediting_326399	chr3_179399225_-	UTR3
CAediting_326400	chr3_179399232_-	UTR3
CAediting_326401	chr3_179399238_-	UTR3
CAediting_326402	chr3_179399245_-	UTR3
CAediting_326403	chr3_179399250_-	UTR3
CAediting_326404	chr3_179399255_-	UTR3
CAediting_326405	chr3_179399260_-	UTR3
CAediting_326406	chr3_179399279_-	UTR3
CAediting_326407	chr3_179399286_-	UTR3
CAediting_326408	chr3_179399288_-	UTR3
CAediting_326409	chr3_179399299_-	UTR3
CAediting_326410	chr3_179399300_-	UTR3
CAediting_326411	chr3_179399309_-	UTR3
CAediting_326412	chr3_179399314_-	UTR3
CAediting_326413	chr3_179399318_-	UTR3
CAediting_326414	chr3_179399324_-	UTR3
CAediting_326415	chr3_179399335_-	UTR3
CAediting_326416	chr3_179399341_-	UTR3
CAediting_326417	chr3_179399349_-	UTR3
CAediting_326418	chr3_179399351_-	UTR3
CAediting_326419	chr3_179399367_-	UTR3
CAediting_326420	chr3_179399372_-	UTR3
CAediting_326421	chr3_179399373_-	UTR3
CAediting_326422	chr3_179399374_-	UTR3
CAediting_326423	chr3_179399376_-	UTR3
CAediting_326424	chr3_179399378_-	UTR3
CAediting_326425	chr3_179399379_-	UTR3
CAediting_326426	chr3_179399380_-	UTR3
CAediting_326427	chr3_179399381_-	UTR3
CAediting_326428	chr3_179399382_-	UTR3
CAediting_326429	chr3_179399396_-	UTR3
CAediting_326430	chr3_179399397_-	UTR3
CAediting_326431	chr3_179399398_-	UTR3
CAediting_326432	chr3_179399404_-	UTR3
CAediting_326433	chr3_179399406_-	UTR3
CAediting_326434	chr3_179399411_-	UTR3
CAediting_326435	chr3_179399416_-	UTR3
CAediting_326436	chr3_179399430_-	UTR3
CAediting_326437	chr3_179399445_-	UTR3
CAediting_326438	chr3_179399453_-	UTR3
CAediting_326439	chr3_179399454_-	UTR3
CAediting_326440	chr3_179399466_-	UTR3
CAediting_326441	chr3_179399470_-	UTR3
CAediting_326442	chr3_179399475_-	UTR3
CAediting_326443	chr3_179399476_-	UTR3
CAediting_326444	chr3_179399478_-	UTR3
CAediting_326445	chr3_179399484_-	UTR3
CAediting_326446	chr3_179399492_-	UTR3
CAediting_326447	chr3_179399494_-	UTR3
CAediting_326448	chr3_179400188_-	UTR3
CAediting_326449	chr3_179406861_-	intronic
CAediting_326450	chr3_179412357_-	ncRNA_intronic
CAediting_326451	chr3_179413063_-	ncRNA_intronic
CAediting_326452	chr3_179417614_-	intronic
CAediting_326453	chr3_179417660_-	intronic
CAediting_326454	chr3_179418362_-	intronic
CAediting_326455	chr3_179430362_-	intronic
CAediting_326456	chr3_179430381_-	intronic
CAediting_326457	chr3_179430592_-	intronic
CAediting_326458	chr3_179430706_-	intronic
CAediting_326459	chr3_179438432_-	intronic
CAediting_326460	chr3_179441483_-	intronic
CAediting_326461	chr3_179442759_-	intronic
CAediting_326462	chr3_179442765_-	intronic
CAediting_326463	chr3_179442771_-	intronic
CAediting_326464	chr3_179442838_-	intronic
CAediting_326465	chr3_179442849_-	intronic
CAediting_326466	chr3_179443427_-	intronic
CAediting_326467	chr3_179443430_-	intronic
CAediting_326468	chr3_179443454_-	intronic
CAediting_326469	chr3_179443525_-	intronic
CAediting_326470	chr3_179444629_-	intronic
CAediting_326471	chr3_179444652_-	intronic
CAediting_326472	chr3_179444704_-	intronic
CAediting_326473	chr3_179444706_-	intronic
CAediting_326474	chr3_179445320_-	intronic
CAediting_326475	chr3_179445337_-	intronic
CAediting_326476	chr3_179445356_-	intronic
CAediting_326477	chr3_179445361_-	intronic
CAediting_326478	chr3_179445376_-	intronic
CAediting_326479	chr3_179445392_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_326398	chr3_179399219_-	SINE	Alu	AluSz
CAediting_326399	chr3_179399225_-	SINE	Alu	AluSz
CAediting_326400	chr3_179399232_-	SINE	Alu	AluSz
CAediting_326401	chr3_179399238_-	SINE	Alu	AluSz
CAediting_326402	chr3_179399245_-	SINE	Alu	AluSz
CAediting_326403	chr3_179399250_-	SINE	Alu	AluSz
CAediting_326404	chr3_179399255_-	SINE	Alu	AluSz
CAediting_326405	chr3_179399260_-	SINE	Alu	AluSz
CAediting_326406	chr3_179399279_-	SINE	Alu	AluSz
CAediting_326407	chr3_179399286_-	SINE	Alu	AluSz
CAediting_326408	chr3_179399288_-	SINE	Alu	AluSz
CAediting_326409	chr3_179399299_-	SINE	Alu	AluSz
CAediting_326410	chr3_179399300_-	SINE	Alu	AluSz
CAediting_326411	chr3_179399309_-	SINE	Alu	AluSz
CAediting_326412	chr3_179399314_-	SINE	Alu	AluSz
CAediting_326413	chr3_179399318_-	SINE	Alu	AluSz
CAediting_326414	chr3_179399324_-	SINE	Alu	AluSz
CAediting_326415	chr3_179399335_-	SINE	Alu	AluSz
CAediting_326416	chr3_179399341_-	SINE	Alu	AluSz
CAediting_326417	chr3_179399349_-	SINE	Alu	AluSz
CAediting_326418	chr3_179399351_-	SINE	Alu	AluSz
CAediting_326419	chr3_179399367_-	SINE	Alu	AluSz
CAediting_326420	chr3_179399372_-	SINE	Alu	AluSz
CAediting_326421	chr3_179399373_-	SINE	Alu	AluSz
CAediting_326422	chr3_179399374_-	SINE	Alu	AluSz
CAediting_326423	chr3_179399376_-	SINE	Alu	AluSz
CAediting_326424	chr3_179399378_-	SINE	Alu	AluSz
CAediting_326425	chr3_179399379_-	SINE	Alu	AluSz
CAediting_326426	chr3_179399380_-	SINE	Alu	AluSz
CAediting_326427	chr3_179399381_-	SINE	Alu	AluSz
CAediting_326428	chr3_179399382_-	SINE	Alu	AluSz
CAediting_326429	chr3_179399396_-	SINE	Alu	AluSz
CAediting_326430	chr3_179399397_-	SINE	Alu	AluSz
CAediting_326431	chr3_179399398_-	SINE	Alu	AluSz
CAediting_326432	chr3_179399404_-	SINE	Alu	AluSz
CAediting_326433	chr3_179399406_-	SINE	Alu	AluSz
CAediting_326434	chr3_179399411_-	SINE	Alu	AluSz
CAediting_326435	chr3_179399416_-	SINE	Alu	AluSz
CAediting_326436	chr3_179399430_-	SINE	Alu	AluSz
CAediting_326437	chr3_179399445_-	SINE	Alu	AluSz
CAediting_326438	chr3_179399453_-	SINE	Alu	AluSz
CAediting_326439	chr3_179399454_-	SINE	Alu	AluSz
CAediting_326440	chr3_179399466_-	SINE	Alu	AluSz
CAediting_326441	chr3_179399470_-	SINE	Alu	AluSz
CAediting_326442	chr3_179399475_-	SINE	Alu	AluSz
CAediting_326443	chr3_179399476_-	SINE	Alu	AluSz
CAediting_326444	chr3_179399478_-	SINE	Alu	AluSz
CAediting_326445	chr3_179399484_-	SINE	Alu	AluSz
CAediting_326446	chr3_179399492_-	SINE	Alu	AluSz
CAediting_326447	chr3_179399494_-	SINE	Alu	AluSz
CAediting_326449	chr3_179406861_-	SINE	Alu	AluSz
CAediting_326450	chr3_179412357_-	SINE	Alu	AluJo
CAediting_326451	chr3_179413063_-	SINE	Alu	AluJb
CAediting_326452	chr3_179417614_-	SINE	Alu	AluSz
CAediting_326453	chr3_179417660_-	SINE	Alu	AluSz
CAediting_326454	chr3_179418362_-	SINE	Alu	AluSq2
CAediting_326455	chr3_179430362_-	SINE	Alu	AluJb
CAediting_326456	chr3_179430381_-	SINE	Alu	AluJb
CAediting_326457	chr3_179430592_-	SINE	Alu	AluJr
CAediting_326458	chr3_179430706_-	SINE	Alu	AluJr
CAediting_326459	chr3_179438432_-	SINE	MIR	MIRb
CAediting_326460	chr3_179441483_-	SINE	Alu	AluSx1
CAediting_326461	chr3_179442759_-	SINE	Alu	AluJr
CAediting_326462	chr3_179442765_-	SINE	Alu	AluJr
CAediting_326463	chr3_179442771_-	SINE	Alu	AluJr
CAediting_326464	chr3_179442838_-	SINE	Alu	AluJr
CAediting_326465	chr3_179442849_-	SINE	Alu	AluJr
CAediting_326466	chr3_179443427_-	SINE	Alu	AluSx
CAediting_326467	chr3_179443430_-	SINE	Alu	AluSx
CAediting_326468	chr3_179443454_-	SINE	Alu	AluSx
CAediting_326469	chr3_179443525_-	SINE	Alu	AluSx
CAediting_326470	chr3_179444629_-	SINE	Alu	AluJb
CAediting_326471	chr3_179444652_-	SINE	Alu	AluJb
CAediting_326472	chr3_179444704_-	SINE	Alu	AluJb
CAediting_326473	chr3_179444706_-	SINE	Alu	AluJb
CAediting_326474	chr3_179445320_-	SINE	Alu	AluJb
CAediting_326475	chr3_179445337_-	SINE	Alu	AluJb
CAediting_326476	chr3_179445356_-	SINE	Alu	AluJb
CAediting_326477	chr3_179445361_-	SINE	Alu	AluJb
CAediting_326478	chr3_179445376_-	SINE	Alu	AluJb
CAediting_326479	chr3_179445392_-	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for GNB4

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000114450.8.GNB4.

Correlation between RNA A-to-I editing and PSI for ENSG00000114450.8.GNB4.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GNB4

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for GNB4

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for GNB4

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for GNB4

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000232564.6	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_326398	ENST00000232564.6	chr3_179399219_-	-1998.70	-1998.70	-2034.00
CAediting_326399	ENST00000232564.6	chr3_179399225_-	-2002.10	-1998.70	-2034.00
CAediting_326400	ENST00000232564.6	chr3_179399232_-	-1997.80	-1998.70	-2034.00
CAediting_326401	ENST00000232564.6	chr3_179399238_-	-1998.00	-1998.70	-2034.00
CAediting_326402	ENST00000232564.6	chr3_179399245_-	-2005.30	-1998.70	-2034.00
CAediting_326403	ENST00000232564.6	chr3_179399250_-	-1998.00	-1998.70	-2034.00
CAediting_326404	ENST00000232564.6	chr3_179399255_-	-1998.30	-1998.70	-2034.00
CAediting_326405	ENST00000232564.6	chr3_179399260_-	-1998.30	-1998.70	-2034.00
CAediting_326406	ENST00000232564.6	chr3_179399279_-	-1997.90	-1998.70	-2034.00
CAediting_326407	ENST00000232564.6	chr3_179399286_-	-1997.80	-1998.70	-2034.00
CAediting_326408	ENST00000232564.6	chr3_179399288_-	-1998.00	-1998.70	-2034.00
CAediting_326409	ENST00000232564.6	chr3_179399299_-	-1998.70	-1998.70	-2034.00
CAediting_326410	ENST00000232564.6	chr3_179399300_-	-1998.20	-1998.70	-2034.00
CAediting_326411	ENST00000232564.6	chr3_179399309_-	-1997.80	-1998.70	-2034.00
CAediting_326412	ENST00000232564.6	chr3_179399314_-	-1998.00	-1998.70	-2034.00
CAediting_326413	ENST00000232564.6	chr3_179399318_-	-1997.80	-1998.70	-2034.00
CAediting_326414	ENST00000232564.6	chr3_179399324_-	-1997.80	-1998.70	-2034.00
CAediting_326415	ENST00000232564.6	chr3_179399335_-	-1998.00	-1998.70	-2034.00
CAediting_326416	ENST00000232564.6	chr3_179399341_-	-1998.40	-1998.70	-2034.00
CAediting_326417	ENST00000232564.6	chr3_179399349_-	-1998.30	-1998.70	-2034.00
CAediting_326418	ENST00000232564.6	chr3_179399351_-	-1998.30	-1998.70	-2034.00
CAediting_326419	ENST00000232564.6	chr3_179399367_-	-1998.40	-1998.70	-2034.00
CAediting_326420	ENST00000232564.6	chr3_179399372_-	-2000.00	-1998.70	-2034.00
CAediting_326421	ENST00000232564.6	chr3_179399373_-	-1999.10	-1998.70	-2034.00
CAediting_326422	ENST00000232564.6	chr3_179399374_-	-1998.70	-1998.70	-2034.00
CAediting_326423	ENST00000232564.6	chr3_179399376_-	-2002.00	-1998.70	-2034.00
CAediting_326424	ENST00000232564.6	chr3_179399378_-	-1998.70	-1998.70	-2034.00
CAediting_326425	ENST00000232564.6	chr3_179399379_-	-1999.40	-1998.70	-2034.00
CAediting_326426	ENST00000232564.6	chr3_179399380_-	-1999.20	-1998.70	-2034.00
CAediting_326427	ENST00000232564.6	chr3_179399381_-	-1998.70	-1998.70	-2034.00
CAediting_326428	ENST00000232564.6	chr3_179399382_-	-1999.00	-1998.70	-2034.00
CAediting_326429	ENST00000232564.6	chr3_179399396_-	-2000.30	-1998.70	-2034.00
CAediting_326430	ENST00000232564.6	chr3_179399397_-	-1999.90	-1998.70	-2034.00
CAediting_326431	ENST00000232564.6	chr3_179399398_-	-2001.80	-1998.70	-2034.00
CAediting_326432	ENST00000232564.6	chr3_179399404_-	-2000.60	-1998.70	-2034.00
CAediting_326433	ENST00000232564.6	chr3_179399406_-	-1998.40	-1998.70	-2034.00
CAediting_326434	ENST00000232564.6	chr3_179399411_-	-2000.20	-1998.70	-2034.00
CAediting_326435	ENST00000232564.6	chr3_179399416_-	-2000.50	-1998.70	-2034.00
CAediting_326436	ENST00000232564.6	chr3_179399430_-	-2001.90	-1998.70	-2034.00
CAediting_326437	ENST00000232564.6	chr3_179399445_-	-2001.80	-1998.70	-2034.00
CAediting_326438	ENST00000232564.6	chr3_179399453_-	-1999.30	-1998.70	-2034.00
CAediting_326439	ENST00000232564.6	chr3_179399454_-	-1998.70	-1998.70	-2034.00
CAediting_326440	ENST00000232564.6	chr3_179399466_-	-1999.20	-1998.70	-2034.00
CAediting_326441	ENST00000232564.6	chr3_179399470_-	-2001.10	-1998.70	-2034.00
CAediting_326442	ENST00000232564.6	chr3_179399475_-	-1999.20	-1998.70	-2034.00
CAediting_326443	ENST00000232564.6	chr3_179399476_-	-1998.80	-1998.70	-2034.00
CAediting_326444	ENST00000232564.6	chr3_179399478_-	-2001.80	-1998.70	-2034.00
CAediting_326445	ENST00000232564.6	chr3_179399484_-	-1998.70	-1998.70	-2034.00
CAediting_326446	ENST00000232564.6	chr3_179399492_-	-2002.50	-1998.70	-2034.00
CAediting_326447	ENST00000232564.6	chr3_179399494_-	-1999.50	-1998.70	-2034.00
CAediting_326448	ENST00000232564.6	chr3_179400188_-	-1999.10	-1998.70	-2034.00

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Relation with ADAR for GNB4

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
LUSC	CAediting_326402	chr3_179399245_-	0.00148953212132509	0.245380217562829	.	.	.	.
GBM	CAediting_326402	chr3_179399245_-	0.047559370434171	0.184374078234931	.	.	.	.
STAD	CAediting_326402	chr3_179399245_-	0.0354342437149347	0.155178767819386	.	.	.	.
LGG	CAediting_326412	chr3_179399314_-	.	.	0.0352459538918843	0.289885940874602	.	.
STAD	CAediting_326412	chr3_179399314_-	0.026023687356768	0.225998884496275	.	.	.	.
ESCA	CAediting_326412	chr3_179399314_-	0.0210999654269777	0.269554651099762	.	.	.	.
BRCA	CAediting_326423	chr3_179399376_-	3.59969407399672e-05	0.223058938385004	.	.	.	.
BRCA	CAediting_326437	chr3_179399445_-	0.000150559454264142	0.230767363585212	.	.	.	.
OV	CAediting_326437	chr3_179399445_-	0.0224199344050012	0.201706044852053	.	.	.	.
BRCA	CAediting_326439	chr3_179399454_-	0.0100753167586532	0.131861644155373	.	.	.	.
CESC	CAediting_326439	chr3_179399454_-	.	.	0.00943662325457109	0.290359354188579	.	.
SKCM	CAediting_326439	chr3_179399454_-	0.0370210959307382	0.198225017140389	.	.	.	.
BRCA	CAediting_326443	chr3_179399476_-	3.12631018479324e-05	0.246544025504382	.	.	.	.
ESCA	CAediting_326443	chr3_179399476_-	0.015606989629609	0.316187075636585	.	.	.	.
STAD	CAediting_326444	chr3_179399478_-	.	.	.	.	0.0178705563287366	0.201364185381411

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Relation with cancer stages for GNB4

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
BRCA	pathologic_stage	CAediting_326437	chr3_179399445_-	0.00962580804806753	0.160603197035412
BRCA	pathologic_stage	CAediting_326443	chr3_179399476_-	0.0265804020028387	0.134224744420062
CESC	clinical_stage	CAediting_326437	chr3_179399445_-	0.040209387005388	0.275046566943385
ESCA	pathologic_stage	CAediting_326423	chr3_179399376_-	0.00256883494171263	-0.370670112670798
OV	clinical_stage	CAediting_326423	chr3_179399376_-	0.0221201750981383	0.302651127314454
OV	clinical_stage	CAediting_326438	chr3_179399453_-	0.0421570800231549	0.202608004613851
OV	clinical_stage	CAediting_326442	chr3_179399475_-	0.0441459419531194	-0.236299997459382
STAD	pathologic_stage	CAediting_326439	chr3_179399454_-	0.0134194416380217	-0.177248459007903

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Relation with survival for GNB4

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
HNSC	CAediting_326402	chr3_179399245_-	0.0100679877642481	0.00832509	62.2275
STAD	CAediting_326438	chr3_179399453_-	0.00931631629658558	0.0218531	0.00486749
ESCA	CAediting_326439	chr3_179399454_-	0.0137767148234733	0.0112277	108.375

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RelatedDrugs for GNB4

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for GNB4

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
GNB4	C0004238	Atrial Fibrillation	2	CTD_human
GNB4	C0235480	Paroxysmal atrial fibrillation	2	CTD_human
GNB4	C2585653	Persistent atrial fibrillation	2	CTD_human
GNB4	C3468561	familial atrial fibrillation	2	CTD_human
GNB4	C3554654	CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE F	2	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
GNB4	C0009402	Colorectal Carcinoma	1	CTD_human
GNB4	C0009404	Colorectal Neoplasms	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene