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Editing gene: TRPV4 (CAeditome ID:59341)

Gene summary for TRPV4

Gene summary

Gene information	Gene symbol	TRPV4
	Gene ID	59341
	Gene name	transient receptor potential cation channel subfamily V member 4
	Synonyms	BCYM3\|CMT2C\|HMSN2C\|OTRPC4\|SMAL\|SPSMA\|SSQTL1\|TRP12\|VRL2\|VROAC
	Cytomap	12q24.11
	Type of gene	protein-coding
	Description	transient receptor potential cation channel subfamily V member 4OSM9-like transient receptor potential channel 4osm-9-like TRP channel 4osmosensitive transient receptor potential channel 4transient receptor potential protein 12vanilloid receptor-like
	Modification date	20210518
	UniProtAcc	Q9HBA0
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
TRPV4	GO:0005261	Transient receptor potential cation channel subfamily V member 4	12724311
TRPV4	GO:0005262	Transient receptor potential cation channel subfamily V member 4	18458941
TRPV4	GO:0005262	Transient receptor potential cation channel subfamily V member 4	29899501
TRPV4	GO:0006816	Transient receptor potential cation channel subfamily V member 4	18458941
TRPV4	GO:0006874	Transient receptor potential cation channel subfamily V member 4	12724311
TRPV4	GO:0007204	Transient receptor potential cation channel subfamily V member 4	18458941
TRPV4	GO:1902656	Transient receptor potential cation channel subfamily V member 4	29899501
TRPV4	GO:0005886	Transient receptor potential cation channel subfamily V member 4	15753126
TRPV4	GO:0005886	Transient receptor potential cation channel subfamily V member 4	23136043
TRPV4	GO:0005886	Transient receptor potential cation channel subfamily V member 4	29899501

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RNA A-to-I events for TRPV4

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000111199.9

RNA A-to-I editing events in Cancer.

CAediting_922121(109784600, -), CAediting_922122(109784611, -), CAediting_922123(109784722, -), CAediting_922124(109784744, -), CAediting_922125(109784761, -), CAediting_922126(109784762, -), CAediting_922127(109784768, -), CAediting_922128(109784779, -), CAediting_922129(109785094, -), CAediting_922130(109785124, -), CAediting_922131(109785136, -), CAediting_922132(109785137, -), CAediting_922133(109785150, -), CAediting_922134(109785159, -), CAediting_922135(109785182, -), CAediting_922136(109785186, -), CAediting_922137(109785228, -), CAediting_922138(109785235, -), CAediting_922139(109785259, -), CAediting_922140(109785261, -), CAediting_922141(109785262, -), CAediting_922142(109785270, -), CAediting_922143(109785287, -), CAediting_922144(109785303, -), CAediting_922145(109785486, -), CAediting_922146(109785491, -), CAediting_922147(109785495, -), CAediting_922148(109785515, -), CAediting_922149(109785530, -), CAediting_922150(109785556, -), CAediting_922151(109785583, -), CAediting_922152(109785586, -), CAediting_922153(109785587, -), CAediting_922154(109785588, -), CAediting_922155(109785595, -), CAediting_922156(109785596, -), CAediting_922157(109785597, -), CAediting_922158(109785612, -), CAediting_922159(109785651, -), CAediting_922160(109785656, -), CAediting_922161(109785691, -), CAediting_922162(109785692, -), CAediting_922163(109785774, -), CAediting_922164(109785776, -), CAediting_922165(109785788, -), CAediting_922166(109785798, -), CAediting_922167(109785815, -), CAediting_922168(109785816, -), CAediting_922169(109785830, -), CAediting_922170(109785868, -), CAediting_922171(109785879, -), CAediting_922172(109785886, -), CAediting_922173(109785889, -), CAediting_922174(109785918, -), CAediting_922175(109785926, -), CAediting_922176(109785930, -), CAediting_922177(109785931, -), CAediting_922178(109785943, -), CAediting_922179(109785944, -), CAediting_922180(109785951, -), CAediting_922181(109785961, -), CAediting_922182(109785975, -), CAediting_922183(109785997, -), CAediting_922184(109791621, -), CAediting_922185(109794773, -), CAediting_922186(109794774, -), CAediting_922187(109794826, -), CAediting_922188(109794838, -), CAediting_922189(109794855, -), CAediting_922190(109795824, -), CAediting_922191(109795846, -), CAediting_922192(109795983, -), CAediting_922193(109796009, -), CAediting_922194(109796010, -), CAediting_922195(109796026, -), CAediting_922196(109799762, -), CAediting_922197(109800122, -), CAediting_922198(109800125, -), CAediting_922199(109801057, -), CAediting_922200(109801110, -), CAediting_922201(109801145, -), CAediting_922202(109801149, -), CAediting_922203(109801169, -), CAediting_922204(109801213, -), CAediting_922205(109801227, -), CAediting_922206(109801237, -), CAediting_922207(109801675, -), CAediting_922208(109801681, -), CAediting_922209(109801682, -), CAediting_922210(109801735, -), CAediting_922211(109801747, -), CAediting_922212(109801823, -), CAediting_922213(109802195, -), CAediting_922214(109802220, -), CAediting_922215(109802227, -), CAediting_922216(109802268, -), CAediting_922217(109802398, -), CAediting_922218(109802413, -), CAediting_922219(109802462, -), CAediting_922220(109802466, -), CAediting_922221(109802470, -), CAediting_922222(109802472, -), CAediting_922223(109802478, -), CAediting_922224(109802479, -), CAediting_922225(109802480, -), CAediting_922226(109802505, -), CAediting_922227(109802520, -), CAediting_922228(109802575, -), CAediting_922229(109802675, -), CAediting_922230(109802706, -), CAediting_922231(109802729, -), CAediting_922232(109806315, -), CAediting_922233(109806332, -), CAediting_922234(109806349, -), CAediting_922235(109806637, -), CAediting_922236(109807497, -), CAediting_922237(109811575, -), CAediting_922238(109818442, -), CAediting_922239(109818616, -), CAediting_922240(109818619, -), CAediting_922241(109825029, -),

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RNA editing positional annotations for TRPV4 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_922121	chr12_109784600_-	intronic
CAediting_922122	chr12_109784611_-	intronic
CAediting_922123	chr12_109784722_-	intronic
CAediting_922124	chr12_109784744_-	intronic
CAediting_922125	chr12_109784761_-	intronic
CAediting_922126	chr12_109784762_-	intronic
CAediting_922127	chr12_109784768_-	intronic
CAediting_922128	chr12_109784779_-	intronic
CAediting_922129	chr12_109785094_-	intronic
CAediting_922130	chr12_109785124_-	intronic
CAediting_922131	chr12_109785136_-	intronic
CAediting_922132	chr12_109785137_-	intronic
CAediting_922133	chr12_109785150_-	intronic
CAediting_922134	chr12_109785159_-	intronic
CAediting_922135	chr12_109785182_-	intronic
CAediting_922136	chr12_109785186_-	intronic
CAediting_922137	chr12_109785228_-	intronic
CAediting_922138	chr12_109785235_-	intronic
CAediting_922139	chr12_109785259_-	intronic
CAediting_922140	chr12_109785261_-	intronic
CAediting_922141	chr12_109785262_-	intronic
CAediting_922142	chr12_109785270_-	intronic
CAediting_922143	chr12_109785287_-	intronic
CAediting_922144	chr12_109785303_-	intronic
CAediting_922145	chr12_109785486_-	intronic
CAediting_922146	chr12_109785491_-	intronic
CAediting_922147	chr12_109785495_-	intronic
CAediting_922148	chr12_109785515_-	intronic
CAediting_922149	chr12_109785530_-	intronic
CAediting_922150	chr12_109785556_-	intronic
CAediting_922151	chr12_109785583_-	intronic
CAediting_922152	chr12_109785586_-	intronic
CAediting_922153	chr12_109785587_-	intronic
CAediting_922154	chr12_109785588_-	intronic
CAediting_922155	chr12_109785595_-	intronic
CAediting_922156	chr12_109785596_-	intronic
CAediting_922157	chr12_109785597_-	intronic
CAediting_922158	chr12_109785612_-	intronic
CAediting_922159	chr12_109785651_-	intronic
CAediting_922160	chr12_109785656_-	intronic
CAediting_922161	chr12_109785691_-	intronic
CAediting_922162	chr12_109785692_-	intronic
CAediting_922163	chr12_109785774_-	intronic
CAediting_922164	chr12_109785776_-	intronic
CAediting_922165	chr12_109785788_-	intronic
CAediting_922166	chr12_109785798_-	intronic
CAediting_922167	chr12_109785815_-	intronic
CAediting_922168	chr12_109785816_-	intronic
CAediting_922169	chr12_109785830_-	intronic
CAediting_922170	chr12_109785868_-	intronic
CAediting_922171	chr12_109785879_-	intronic
CAediting_922172	chr12_109785886_-	intronic
CAediting_922173	chr12_109785889_-	intronic
CAediting_922174	chr12_109785918_-	intronic
CAediting_922175	chr12_109785926_-	intronic
CAediting_922176	chr12_109785930_-	intronic
CAediting_922177	chr12_109785931_-	intronic
CAediting_922178	chr12_109785943_-	intronic
CAediting_922179	chr12_109785944_-	intronic
CAediting_922180	chr12_109785951_-	intronic
CAediting_922181	chr12_109785961_-	intronic
CAediting_922182	chr12_109785975_-	intronic
CAediting_922183	chr12_109785997_-	intronic
CAediting_922184	chr12_109791621_-	intronic
CAediting_922185	chr12_109794773_-	intronic
CAediting_922186	chr12_109794774_-	intronic
CAediting_922187	chr12_109794826_-	intronic
CAediting_922188	chr12_109794838_-	intronic
CAediting_922189	chr12_109794855_-	intronic
CAediting_922190	chr12_109795824_-	intronic
CAediting_922191	chr12_109795846_-	intronic
CAediting_922192	chr12_109795983_-	intronic
CAediting_922193	chr12_109796009_-	intronic
CAediting_922194	chr12_109796010_-	intronic
CAediting_922195	chr12_109796026_-	intronic
CAediting_922196	chr12_109799762_-	intronic
CAediting_922197	chr12_109800122_-	intronic
CAediting_922198	chr12_109800125_-	intronic
CAediting_922199	chr12_109801057_-	intronic
CAediting_922200	chr12_109801110_-	intronic
CAediting_922201	chr12_109801145_-	intronic
CAediting_922202	chr12_109801149_-	intronic
CAediting_922203	chr12_109801169_-	intronic
CAediting_922204	chr12_109801213_-	intronic
CAediting_922205	chr12_109801227_-	intronic
CAediting_922206	chr12_109801237_-	intronic
CAediting_922207	chr12_109801675_-	intronic
CAediting_922208	chr12_109801681_-	intronic
CAediting_922209	chr12_109801682_-	intronic
CAediting_922210	chr12_109801735_-	intronic
CAediting_922211	chr12_109801747_-	intronic
CAediting_922212	chr12_109801823_-	intronic
CAediting_922213	chr12_109802195_-	intronic
CAediting_922214	chr12_109802220_-	intronic
CAediting_922215	chr12_109802227_-	intronic
CAediting_922216	chr12_109802268_-	intronic
CAediting_922217	chr12_109802398_-	intronic
CAediting_922218	chr12_109802413_-	intronic
CAediting_922219	chr12_109802462_-	intronic
CAediting_922220	chr12_109802466_-	intronic
CAediting_922221	chr12_109802470_-	intronic
CAediting_922222	chr12_109802472_-	intronic
CAediting_922223	chr12_109802478_-	intronic
CAediting_922224	chr12_109802479_-	intronic
CAediting_922225	chr12_109802480_-	intronic
CAediting_922226	chr12_109802505_-	intronic
CAediting_922227	chr12_109802520_-	intronic
CAediting_922228	chr12_109802575_-	intronic
CAediting_922229	chr12_109802675_-	intronic
CAediting_922230	chr12_109802706_-	intronic
CAediting_922231	chr12_109802729_-	intronic
CAediting_922232	chr12_109806315_-	intronic
CAediting_922233	chr12_109806332_-	intronic
CAediting_922234	chr12_109806349_-	intronic
CAediting_922235	chr12_109806637_-	intronic
CAediting_922236	chr12_109807497_-	intronic
CAediting_922237	chr12_109811575_-	intronic
CAediting_922238	chr12_109818442_-	ncRNA_intronic
CAediting_922239	chr12_109818616_-	ncRNA_intronic
CAediting_922240	chr12_109818619_-	ncRNA_intronic
CAediting_922241	chr12_109825029_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_922121	chr12_109784600_-	SINE	Alu	AluSx1
CAediting_922122	chr12_109784611_-	SINE	Alu	AluSx1
CAediting_922123	chr12_109784722_-	SINE	Alu	AluSx1
CAediting_922124	chr12_109784744_-	SINE	Alu	AluSx1
CAediting_922125	chr12_109784761_-	SINE	Alu	AluSx1
CAediting_922126	chr12_109784762_-	SINE	Alu	AluSx1
CAediting_922127	chr12_109784768_-	SINE	Alu	AluSx1
CAediting_922128	chr12_109784779_-	SINE	Alu	AluSx1
CAediting_922129	chr12_109785094_-	SINE	Alu	AluJb
CAediting_922130	chr12_109785124_-	SINE	Alu	AluJb
CAediting_922131	chr12_109785136_-	SINE	Alu	AluJb
CAediting_922132	chr12_109785137_-	SINE	Alu	AluJb
CAediting_922133	chr12_109785150_-	SINE	Alu	AluJb
CAediting_922134	chr12_109785159_-	SINE	Alu	AluJb
CAediting_922135	chr12_109785182_-	SINE	Alu	AluJb
CAediting_922136	chr12_109785186_-	SINE	Alu	AluJb
CAediting_922137	chr12_109785228_-	SINE	Alu	AluJb
CAediting_922138	chr12_109785235_-	SINE	Alu	AluJb
CAediting_922139	chr12_109785259_-	SINE	Alu	AluJb
CAediting_922140	chr12_109785261_-	SINE	Alu	AluJb
CAediting_922141	chr12_109785262_-	SINE	Alu	AluJb
CAediting_922142	chr12_109785270_-	SINE	Alu	AluJb
CAediting_922143	chr12_109785287_-	SINE	Alu	AluJb
CAediting_922144	chr12_109785303_-	SINE	Alu	AluJb
CAediting_922145	chr12_109785486_-	SINE	Alu	AluSx
CAediting_922146	chr12_109785491_-	SINE	Alu	AluSx
CAediting_922147	chr12_109785495_-	SINE	Alu	AluSx
CAediting_922148	chr12_109785515_-	SINE	Alu	AluSx
CAediting_922149	chr12_109785530_-	SINE	Alu	AluSx
CAediting_922150	chr12_109785556_-	SINE	Alu	AluSx
CAediting_922151	chr12_109785583_-	SINE	Alu	AluSx
CAediting_922152	chr12_109785586_-	SINE	Alu	AluSx
CAediting_922153	chr12_109785587_-	SINE	Alu	AluSx
CAediting_922154	chr12_109785588_-	SINE	Alu	AluSx
CAediting_922155	chr12_109785595_-	SINE	Alu	AluSx
CAediting_922156	chr12_109785596_-	SINE	Alu	AluSx
CAediting_922157	chr12_109785597_-	SINE	Alu	AluSx
CAediting_922158	chr12_109785612_-	SINE	Alu	AluSx
CAediting_922159	chr12_109785651_-	SINE	Alu	AluSx
CAediting_922160	chr12_109785656_-	SINE	Alu	AluSx
CAediting_922161	chr12_109785691_-	SINE	Alu	AluSx
CAediting_922162	chr12_109785692_-	SINE	Alu	AluSx
CAediting_922163	chr12_109785774_-	SINE	Alu	AluJr
CAediting_922164	chr12_109785776_-	SINE	Alu	AluJr
CAediting_922165	chr12_109785788_-	SINE	Alu	AluJr
CAediting_922166	chr12_109785798_-	SINE	Alu	AluJr
CAediting_922167	chr12_109785815_-	SINE	Alu	AluJr
CAediting_922168	chr12_109785816_-	SINE	Alu	AluJr
CAediting_922169	chr12_109785830_-	SINE	Alu	AluJr
CAediting_922170	chr12_109785868_-	SINE	Alu	AluJr
CAediting_922171	chr12_109785879_-	SINE	Alu	AluJr
CAediting_922172	chr12_109785886_-	SINE	Alu	AluJr
CAediting_922173	chr12_109785889_-	SINE	Alu	AluJr
CAediting_922174	chr12_109785918_-	SINE	Alu	AluJr
CAediting_922175	chr12_109785926_-	SINE	Alu	AluJr
CAediting_922176	chr12_109785930_-	SINE	Alu	AluJr
CAediting_922177	chr12_109785931_-	SINE	Alu	AluJr
CAediting_922178	chr12_109785943_-	SINE	Alu	AluJr
CAediting_922179	chr12_109785944_-	SINE	Alu	AluJr
CAediting_922180	chr12_109785951_-	SINE	Alu	AluJr
CAediting_922181	chr12_109785961_-	SINE	Alu	AluJr
CAediting_922182	chr12_109785975_-	SINE	Alu	AluJr
CAediting_922183	chr12_109785997_-	SINE	Alu	AluJr
CAediting_922184	chr12_109791621_-	SINE	Alu	AluSz6
CAediting_922185	chr12_109794773_-	SINE	Alu	AluSq
CAediting_922186	chr12_109794774_-	SINE	Alu	AluSq
CAediting_922187	chr12_109794826_-	SINE	Alu	AluSq
CAediting_922188	chr12_109794838_-	SINE	Alu	AluSq
CAediting_922189	chr12_109794855_-	SINE	Alu	AluSq
CAediting_922190	chr12_109795824_-	SINE	Alu	AluJb
CAediting_922191	chr12_109795846_-	SINE	Alu	AluJb
CAediting_922192	chr12_109795983_-	SINE	Alu	AluJb
CAediting_922193	chr12_109796009_-	SINE	Alu	AluJb
CAediting_922194	chr12_109796010_-	SINE	Alu	AluJb
CAediting_922195	chr12_109796026_-	SINE	Alu	AluJb
CAediting_922196	chr12_109799762_-	SINE	Alu	AluJr
CAediting_922197	chr12_109800122_-	SINE	Alu	AluSx1
CAediting_922198	chr12_109800125_-	SINE	Alu	AluSx1
CAediting_922199	chr12_109801057_-	SINE	Alu	AluJr4
CAediting_922200	chr12_109801110_-	SINE	Alu	AluJr4
CAediting_922201	chr12_109801145_-	SINE	Alu	AluJr4
CAediting_922202	chr12_109801149_-	SINE	Alu	AluJr4
CAediting_922203	chr12_109801169_-	SINE	Alu	AluJr
CAediting_922204	chr12_109801213_-	SINE	Alu	AluJr
CAediting_922205	chr12_109801227_-	SINE	Alu	AluJr
CAediting_922206	chr12_109801237_-	SINE	Alu	AluJr
CAediting_922207	chr12_109801675_-	SINE	Alu	AluJr
CAediting_922208	chr12_109801681_-	SINE	Alu	AluJr
CAediting_922209	chr12_109801682_-	SINE	Alu	AluJr
CAediting_922210	chr12_109801735_-	SINE	Alu	AluJr
CAediting_922211	chr12_109801747_-	SINE	Alu	AluJr
CAediting_922212	chr12_109801823_-	SINE	Alu	AluJr
CAediting_922213	chr12_109802195_-	SINE	Alu	AluJb
CAediting_922214	chr12_109802220_-	SINE	Alu	AluJb
CAediting_922215	chr12_109802227_-	SINE	Alu	AluJb
CAediting_922216	chr12_109802268_-	SINE	Alu	AluJb
CAediting_922217	chr12_109802398_-	SINE	Alu	AluSz
CAediting_922218	chr12_109802413_-	SINE	Alu	AluSz
CAediting_922219	chr12_109802462_-	SINE	Alu	AluSz
CAediting_922220	chr12_109802466_-	SINE	Alu	AluSz
CAediting_922221	chr12_109802470_-	SINE	Alu	AluSz
CAediting_922222	chr12_109802472_-	SINE	Alu	AluSz
CAediting_922223	chr12_109802478_-	SINE	Alu	AluSz
CAediting_922224	chr12_109802479_-	SINE	Alu	AluSz
CAediting_922225	chr12_109802480_-	SINE	Alu	AluSz
CAediting_922226	chr12_109802505_-	SINE	Alu	AluSz
CAediting_922227	chr12_109802520_-	SINE	Alu	AluSz
CAediting_922228	chr12_109802575_-	SINE	Alu	AluSz
CAediting_922229	chr12_109802675_-	SINE	Alu	AluJb
CAediting_922230	chr12_109802706_-	SINE	Alu	AluJb
CAediting_922231	chr12_109802729_-	SINE	Alu	AluJb
CAediting_922232	chr12_109806315_-	SINE	Alu	AluSx
CAediting_922233	chr12_109806332_-	SINE	Alu	AluSx
CAediting_922234	chr12_109806349_-	SINE	Alu	AluSx
CAediting_922235	chr12_109806637_-	SINE	Alu	AluJr
CAediting_922236	chr12_109807497_-	SINE	Alu	AluJb
CAediting_922237	chr12_109811575_-	SINE	Alu	AluSz
CAediting_922238	chr12_109818442_-	SINE	MIR	MIRb
CAediting_922239	chr12_109818616_-	SINE	MIR	MIR
CAediting_922240	chr12_109818619_-	SINE	MIR	MIR

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RNA A-to-I editing events in the alternative splicing sites for TRPV4

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000111199.9.TRPV4.

Correlation between RNA A-to-I editing and PSI for ENSG00000111199.9.TRPV4.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TRPV4

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for TRPV4

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for TRPV4

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_748296	chr10_51299626_+	ENSG00000111199.9	ENST00000538125	hsa-miR-605-3p	109788456	109788463	8mer-1a	109788456	109788476	155	-18.95
CAediting_846604	chr11_93733708_-	ENSG00000111199.9	ENST00000538125	hsa-miR-1304-3p	109788615	109788622	8mer-1a	109788615	109788638	152	-20.56
CAediting_688080	chr9_63819626_+	ENSG00000111199.9	ENST00000538125	hsa-miR-4477b	109788473	109788479	7mer-m8	109788472	109788494	141	-11.68
CAediting_1306324	chr19_13836464_-	ENSG00000111199.9	ENST00000538125	hsa-miR-27a-3p	109783676	109783681	6mer	109783675	109783693	140	-23.97
CAediting_1229414	chr17_67471546_+	ENSG00000111199.9	ENST00000538125	hsa-miR-548aa	109792737	109792743	7mer-m8	109792736	109792761	141	-18.26
CAediting_1229414	chr17_67471546_+	ENSG00000111199.9	ENST00000538125	hsa-miR-548aa	109788524	109788530	7mer-m8	109788523	109788549	155	-18.67
CAediting_77128	chr1_85133844_+	ENSG00000111199.9	ENST00000538125	hsa-miR-4423-3p	109788642	109788648	7mer-m8	109788641	109788661	140	-13.9
CAediting_442554	chr5_154685830_+	ENSG00000111199.9	ENST00000538125	hsa-miR-1303	109788428	109788434	7mer-m8	109788427	109788447	158	-24.05
CAediting_604450	chr7_133034877_-	ENSG00000111199.9	ENST00000538125	hsa-miR-3654	109783572	109783578	7mer-m8	109783571	109783591	151	-22.65

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TRPV4

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for TRPV4

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for TRPV4

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
KIRC	pathologic_stage	CAediting_922131	chr12_109785136_-	0.0340959229398537	0.228798443043669

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Relation with survival for TRPV4

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for TRPV4

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
TRPV4	Q9HBA0	DB09061	Cannabidiol	Transient receptor potential cation channel subfamily V member 4	SmallMoleculeDrug	approved\|investigational
TRPV4	Q9HBA0	DB11148	Butamben	Transient receptor potential cation channel subfamily V member 4	SmallMoleculeDrug	approved\|withdrawn

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RelatedDiseases for TRPV4

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
TRPV4	C1853710	HEREDITARY MOTOR AND SENSORY NEUROPATHY, TYPE IIC (disorder)	8	CTD_human;GENOMICS_ENGLAND;UNIPROT
TRPV4	C0265281	Metatropic dwarfism	6	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TRPV4	C0751335	Scapuloperoneal Form of Spinal Muscular Atrophy	4	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TRPV4	C0265280	Spondylometaphyseal dysplasia, Kozlowski type	3	CTD_human;GENOMICS_ENGLAND;UNIPROT
TRPV4	C1838492	SPINAL MUSCULAR ATROPHY, DISTAL, CONGENITAL NONPROGRESSIVE (disorder)	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TRPV4	C0005940	Bone Diseases	2	CTD_human
TRPV4	C0432227	Brachyolmia Type 3	2	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TRPV4	C0007959	Charcot-Marie-Tooth Disease	1	CTD_human
TRPV4	C0009676	Confusion	1	GENOMICS_ENGLAND
TRPV4	C0013366	Dyschondroplasias	1	CTD_human
TRPV4	C0020429	Hyperalgesia	1	CTD_human
TRPV4	C0020625	Hyponatremia	1	CTD_human
TRPV4	C0022107	Irritable Mood	1	GENOMICS_ENGLAND
TRPV4	C0024117	Chronic Obstructive Airway Disease	1	CTD_human
TRPV4	C0025237	Melnick-Needles Syndrome	1	CTD_human
TRPV4	C0026760	Multiple Epiphyseal Dysplasia	1	CTD_human
TRPV4	C0026847	Spinal Muscular Atrophy	1	CTD_human
TRPV4	C0029408	Degenerative polyarthritis	1	CTD_human
TRPV4	C0029422	Osteochondrodysplasias	1	CTD_human
TRPV4	C0036391	Schwartz-Jampel Syndrome	1	CTD_human
TRPV4	C0038015	Spondyloepiphyseal Dysplasia	1	CTD_human
TRPV4	C0042035	Urination Disorders	1	CTD_human
TRPV4	C0086743	Osteoarthrosis Deformans	1	CTD_human
TRPV4	C0205713	Roussy-Levy Syndrome (disorder)	1	CTD_human
TRPV4	C0233514	Abnormal behavior	1	GENOMICS_ENGLAND
TRPV4	C0233715	Speech impairment	1	GENOMICS_ENGLAND
TRPV4	C0233754	Derealization	1	GENOMICS_ENGLAND
TRPV4	C0233794	Memory impairment	1	GENOMICS_ENGLAND
TRPV4	C0270765	Myelopathic Muscular Atrophy	1	CTD_human
TRPV4	C0270911	Charcot-Marie-Tooth Disease, Type Ia (disorder)	1	CTD_human
TRPV4	C0270912	Charcot-Marie-Tooth Disease, Type Ib	1	CTD_human
TRPV4	C0270914	Hereditary Motor and Sensory-Neuropathy Type II	1	CTD_human
TRPV4	C0393541	Distal Spinal Muscular Atrophy	1	CTD_human
TRPV4	C0393546	Oculopharyngeal Spinal Muscular Atrophy	1	CTD_human
TRPV4	C0393547	Bulbospinal Neuronopathy	1	CTD_human
TRPV4	C0410480	Avascular Necrosis of Femur Head	1	CTD_human;ORPHANET
TRPV4	C0432272	Van Buchem disease	1	CTD_human
TRPV4	C0458247	Allodynia	1	CTD_human
TRPV4	C0562557	Sexually disinhibited behavior	1	GENOMICS_ENGLAND
TRPV4	C0751036	Hereditary Motor and Sensory Neuropathy Type I	1	CTD_human
TRPV4	C0751211	Hyperalgesia, Primary	1	CTD_human
TRPV4	C0751212	Hyperalgesia, Secondary	1	CTD_human
TRPV4	C0751213	Tactile Allodynia	1	CTD_human
TRPV4	C0751214	Hyperalgesia, Thermal	1	CTD_human
TRPV4	C0751226	Hypersomnia, Recurrent	1	GENOMICS_ENGLAND
TRPV4	C0751334	Progressive Proximal Myelopathic Muscular Atrophy	1	CTD_human
TRPV4	C0917981	Progressive Muscular Atrophy	1	CTD_human
TRPV4	C1527303	Chronic Airflow Obstruction	1	CTD_human
TRPV4	C1847406	Digital Arthropathy-Brachydactyly, Familial	1	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TRPV4	C1868616	Parastremmatic dwarfism	1	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TRPV4	C2700617	Irritation - emotion	1	GENOMICS_ENGLAND
TRPV4	C2936719	Mechanical Allodynia	1	CTD_human
TRPV4	C3159322	SPONDYLOEPIPHYSEAL DYSPLASIA, MAROTEAUX TYPE	1	CTD_human;GENOMICS_ENGLAND;ORPHANET
TRPV4	C3541456	Spondyloepiphyseal Dysplasia Tarda, X-Linked	1	CTD_human
TRPV4	C3661519	Hereditary Motor Neuronopathy	1	CTD_human
TRPV4	C3711162	Metatropic Dysplasia Type 1	1	CTD_human
TRPV4	C4479260	AVASCULAR NECROSIS OF FEMORAL HEAD, PRIMARY, 2	1	ORPHANET
TRPV4	C4551479	Schwartz-Jampel Syndrome, Type 1	1	CTD_human
TRPV4	C4551562	AVASCULAR NECROSIS OF FEMORAL HEAD, PRIMARY, 1	1	ORPHANET
TRPV4	C4552810	Irritability, CTCAE	1	GENOMICS_ENGLAND

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene