Home

Download

Statistics

Examples

Help

Contact

Editing gene: RBL2 (CAeditome ID:5934)

Gene summary for RBL2

Gene summary

Gene information	Gene symbol	RBL2
	Gene ID	5934
	Gene name	RB transcriptional corepressor like 2
	Synonyms	P130\|Rb2
	Cytomap	16q12.2
	Type of gene	protein-coding
	Description	retinoblastoma-like protein 2130 kDa retinoblastoma-associated proteinPRB2RBR-2retinoblastoma-like 2retinoblastoma-related protein 2
	Modification date	20210518
	UniProtAcc	Q08999
	Context	- 30652113(RBL2/p130: a direct AKT substrate and mediator of AKT inhibition-induced apoptosis)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
RBL2	GO:1990841	Retinoblastoma-like protein 2	25100735
RBL2	GO:0043550	Retinoblastoma-like protein 2	16286473
RBL2	GO:0005654	Retinoblastoma-like protein 2	0000052
RBL2	GO:0005694	Retinoblastoma-like protein 2	0000052
RBL2	GO:0005730	Retinoblastoma-like protein 2	0000052
RBL2	GO:0005829	Retinoblastoma-like protein 2	0000052

Top

RNA A-to-I events for RBL2

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000103479.13

RNA A-to-I editing events in Cancer.

CAediting_1116368(53438685, +), CAediting_1116369(53438688, +), CAediting_1116370(53438715, +), CAediting_1116371(53438723, +), CAediting_1116372(53438764, +), CAediting_1116373(53438794, +), CAediting_1116374(53439818, +), CAediting_1116375(53439826, +), CAediting_1116376(53439827, +), CAediting_1116377(53439844, +), CAediting_1116378(53439852, +), CAediting_1116379(53439875, +), CAediting_1116380(53439942, +), CAediting_1116381(53439958, +), CAediting_1116382(53440025, +), CAediting_1116383(53440087, +), CAediting_1116384(53440120, +), CAediting_1116385(53440131, +), CAediting_1116386(53440134, +), CAediting_1116387(53440135, +), CAediting_1116388(53440136, +), CAediting_1116389(53440143, +), CAediting_1116390(53440154, +), CAediting_1116391(53440189, +), CAediting_1116392(53440202, +), CAediting_1116393(53440211, +), CAediting_1116394(53440575, +), CAediting_1116395(53440579, +), CAediting_1116396(53440593, +), CAediting_1116397(53440647, +), CAediting_1116398(53440680, +), CAediting_1116399(53440693, +), CAediting_1116400(53440738, +), CAediting_1116401(53440783, +), CAediting_1116402(53441841, +), CAediting_1116403(53441845, +), CAediting_1116404(53441921, +), CAediting_1116405(53441938, +), CAediting_1116406(53442007, +), CAediting_1116407(53442067, +), CAediting_1116408(53442080, +), CAediting_1116409(53442209, +), CAediting_1116410(53442215, +), CAediting_1116411(53442218, +), CAediting_1116412(53444473, +), CAediting_1116413(53445165, +), CAediting_1116414(53447731, +), CAediting_1116415(53447745, +), CAediting_1116416(53447748, +), CAediting_1116417(53449474, +), CAediting_1116418(53449507, +), CAediting_1116419(53449515, +), CAediting_1116420(53449516, +), CAediting_1116421(53449524, +), CAediting_1116422(53449529, +), CAediting_1116423(53451244, +), CAediting_1116424(53455892, +), CAediting_1116425(53455914, +), CAediting_1116426(53455941, +), CAediting_1116427(53455968, +), CAediting_1116428(53455986, +), CAediting_1116429(53455987, +), CAediting_1116430(53455991, +), CAediting_1116431(53456026, +), CAediting_1116432(53456065, +), CAediting_1116433(53456072, +), CAediting_1116434(53456078, +), CAediting_1116435(53456163, +), CAediting_1116436(53456187, +), CAediting_1116437(53466643, +), CAediting_1116438(53467457, +), CAediting_1116439(53467487, +), CAediting_1116440(53467576, +), CAediting_1116441(53467590, +), CAediting_1116442(53467623, +), CAediting_1116443(53468275, +), CAediting_1116444(53468357, +), CAediting_1116445(53468361, +), CAediting_1116446(53469015, +), CAediting_1116447(53469020, +), CAediting_1116448(53469034, +), CAediting_1116449(53469046, +), CAediting_1116450(53469110, +), CAediting_1116451(53469138, +), CAediting_1116452(53469139, +), CAediting_1116453(53469145, +), CAediting_1116454(53469150, +), CAediting_1116455(53469155, +), CAediting_1116456(53469185, +), CAediting_1116457(53477486, +), CAediting_1116458(53478874, +), CAediting_1116459(53490223, +), CAediting_1116460(53490420, +), CAediting_1116461(53490478, +), CAediting_1116462(53490606, +), CAediting_1116463(53490607, +), CAediting_1116464(53490617, +),

Top

RNA editing positional annotations for RBL2 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_1116459	chr16_53490223_+	nonsynonymous SNV	ENST00000262133.9	c.A3343G	p.K1115E	D	D	D

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1116368	chr16_53438685_+	intronic
CAediting_1116369	chr16_53438688_+	intronic
CAediting_1116370	chr16_53438715_+	intronic
CAediting_1116371	chr16_53438723_+	intronic
CAediting_1116372	chr16_53438764_+	intronic
CAediting_1116373	chr16_53438794_+	intronic
CAediting_1116374	chr16_53439818_+	intronic
CAediting_1116375	chr16_53439826_+	intronic
CAediting_1116376	chr16_53439827_+	intronic
CAediting_1116377	chr16_53439844_+	intronic
CAediting_1116378	chr16_53439852_+	intronic
CAediting_1116379	chr16_53439875_+	intronic
CAediting_1116380	chr16_53439942_+	intronic
CAediting_1116381	chr16_53439958_+	intronic
CAediting_1116382	chr16_53440025_+	intronic
CAediting_1116383	chr16_53440087_+	intronic
CAediting_1116384	chr16_53440120_+	intronic
CAediting_1116385	chr16_53440131_+	intronic
CAediting_1116386	chr16_53440134_+	intronic
CAediting_1116387	chr16_53440135_+	intronic
CAediting_1116388	chr16_53440136_+	intronic
CAediting_1116389	chr16_53440143_+	intronic
CAediting_1116390	chr16_53440154_+	intronic
CAediting_1116391	chr16_53440189_+	intronic
CAediting_1116392	chr16_53440202_+	intronic
CAediting_1116393	chr16_53440211_+	intronic
CAediting_1116394	chr16_53440575_+	intronic
CAediting_1116395	chr16_53440579_+	intronic
CAediting_1116396	chr16_53440593_+	intronic
CAediting_1116397	chr16_53440647_+	intronic
CAediting_1116398	chr16_53440680_+	intronic
CAediting_1116399	chr16_53440693_+	intronic
CAediting_1116400	chr16_53440738_+	intronic
CAediting_1116401	chr16_53440783_+	intronic
CAediting_1116402	chr16_53441841_+	intronic
CAediting_1116403	chr16_53441845_+	intronic
CAediting_1116404	chr16_53441921_+	intronic
CAediting_1116405	chr16_53441938_+	intronic
CAediting_1116406	chr16_53442007_+	intronic
CAediting_1116407	chr16_53442067_+	intronic
CAediting_1116408	chr16_53442080_+	intronic
CAediting_1116409	chr16_53442209_+	intronic
CAediting_1116410	chr16_53442215_+	intronic
CAediting_1116411	chr16_53442218_+	intronic
CAediting_1116412	chr16_53444473_+	intronic
CAediting_1116413	chr16_53445165_+	intronic
CAediting_1116414	chr16_53447731_+	ncRNA_intronic
CAediting_1116415	chr16_53447745_+	ncRNA_intronic
CAediting_1116416	chr16_53447748_+	ncRNA_intronic
CAediting_1116417	chr16_53449474_+	ncRNA_intronic
CAediting_1116418	chr16_53449507_+	ncRNA_exonic
CAediting_1116419	chr16_53449515_+	ncRNA_exonic
CAediting_1116420	chr16_53449516_+	ncRNA_exonic
CAediting_1116421	chr16_53449524_+	ncRNA_exonic
CAediting_1116422	chr16_53449529_+	ncRNA_exonic
CAediting_1116423	chr16_53451244_+	ncRNA_intronic
CAediting_1116424	chr16_53455892_+	ncRNA_intronic
CAediting_1116425	chr16_53455914_+	ncRNA_intronic
CAediting_1116426	chr16_53455941_+	ncRNA_intronic
CAediting_1116427	chr16_53455968_+	ncRNA_intronic
CAediting_1116428	chr16_53455986_+	ncRNA_intronic
CAediting_1116429	chr16_53455987_+	ncRNA_intronic
CAediting_1116430	chr16_53455991_+	ncRNA_intronic
CAediting_1116431	chr16_53456026_+	ncRNA_intronic
CAediting_1116432	chr16_53456065_+	ncRNA_intronic
CAediting_1116433	chr16_53456072_+	ncRNA_intronic
CAediting_1116434	chr16_53456078_+	ncRNA_intronic
CAediting_1116435	chr16_53456163_+	ncRNA_intronic
CAediting_1116436	chr16_53456187_+	ncRNA_intronic
CAediting_1116437	chr16_53466643_+	ncRNA_intronic
CAediting_1116438	chr16_53467457_+	ncRNA_intronic
CAediting_1116439	chr16_53467487_+	ncRNA_intronic
CAediting_1116440	chr16_53467576_+	ncRNA_intronic
CAediting_1116441	chr16_53467590_+	ncRNA_intronic
CAediting_1116442	chr16_53467623_+	ncRNA_intronic
CAediting_1116443	chr16_53468275_+	ncRNA_intronic
CAediting_1116444	chr16_53468357_+	ncRNA_intronic
CAediting_1116445	chr16_53468361_+	ncRNA_intronic
CAediting_1116446	chr16_53469015_+	ncRNA_intronic
CAediting_1116447	chr16_53469020_+	ncRNA_intronic
CAediting_1116448	chr16_53469034_+	ncRNA_intronic
CAediting_1116449	chr16_53469046_+	ncRNA_intronic
CAediting_1116450	chr16_53469110_+	ncRNA_intronic
CAediting_1116451	chr16_53469138_+	ncRNA_intronic
CAediting_1116452	chr16_53469139_+	ncRNA_intronic
CAediting_1116453	chr16_53469145_+	ncRNA_intronic
CAediting_1116454	chr16_53469150_+	ncRNA_intronic
CAediting_1116455	chr16_53469155_+	ncRNA_intronic
CAediting_1116456	chr16_53469185_+	ncRNA_intronic
CAediting_1116457	chr16_53477486_+	ncRNA_intronic
CAediting_1116458	chr16_53478874_+	ncRNA_intronic
CAediting_1116459	chr16_53490223_+	exonic
CAediting_1116460	chr16_53490420_+	ncRNA_exonic
CAediting_1116461	chr16_53490478_+	ncRNA_exonic
CAediting_1116462	chr16_53490606_+	ncRNA_exonic
CAediting_1116463	chr16_53490607_+	ncRNA_exonic
CAediting_1116464	chr16_53490617_+	ncRNA_exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1116368	chr16_53438685_+	SINE	Alu	AluSz6
CAediting_1116369	chr16_53438688_+	SINE	Alu	AluSz6
CAediting_1116370	chr16_53438715_+	SINE	Alu	AluSz6
CAediting_1116371	chr16_53438723_+	SINE	Alu	AluSz6
CAediting_1116372	chr16_53438764_+	SINE	Alu	AluSz6
CAediting_1116373	chr16_53438794_+	SINE	Alu	AluSz6
CAediting_1116374	chr16_53439818_+	SINE	Alu	AluJr
CAediting_1116375	chr16_53439826_+	SINE	Alu	AluJr
CAediting_1116376	chr16_53439827_+	SINE	Alu	AluJr
CAediting_1116377	chr16_53439844_+	SINE	Alu	AluJr
CAediting_1116378	chr16_53439852_+	SINE	Alu	AluJr
CAediting_1116379	chr16_53439875_+	SINE	Alu	AluJr
CAediting_1116380	chr16_53439942_+	SINE	Alu	AluJr
CAediting_1116381	chr16_53439958_+	SINE	Alu	AluJr
CAediting_1116382	chr16_53440025_+	SINE	Alu	AluSq2
CAediting_1116383	chr16_53440087_+	SINE	Alu	AluSq2
CAediting_1116384	chr16_53440120_+	SINE	Alu	AluSq2
CAediting_1116385	chr16_53440131_+	SINE	Alu	AluSq2
CAediting_1116386	chr16_53440134_+	SINE	Alu	AluSq2
CAediting_1116387	chr16_53440135_+	SINE	Alu	AluSq2
CAediting_1116388	chr16_53440136_+	SINE	Alu	AluSq2
CAediting_1116389	chr16_53440143_+	SINE	Alu	AluSq2
CAediting_1116390	chr16_53440154_+	SINE	Alu	AluSq2
CAediting_1116391	chr16_53440189_+	SINE	Alu	AluSq2
CAediting_1116392	chr16_53440202_+	SINE	Alu	AluSq2
CAediting_1116393	chr16_53440211_+	SINE	Alu	AluSq2
CAediting_1116394	chr16_53440575_+	SINE	Alu	AluSx
CAediting_1116395	chr16_53440579_+	SINE	Alu	AluSx
CAediting_1116396	chr16_53440593_+	SINE	Alu	AluSx
CAediting_1116397	chr16_53440647_+	SINE	Alu	AluSx
CAediting_1116398	chr16_53440680_+	SINE	Alu	AluSx
CAediting_1116399	chr16_53440693_+	SINE	Alu	AluSx
CAediting_1116400	chr16_53440738_+	SINE	Alu	AluSx
CAediting_1116401	chr16_53440783_+	SINE	Alu	AluSx
CAediting_1116402	chr16_53441841_+	SINE	Alu	AluSx3
CAediting_1116403	chr16_53441845_+	SINE	Alu	AluSx3
CAediting_1116404	chr16_53441921_+	SINE	Alu	AluSx3
CAediting_1116405	chr16_53441938_+	SINE	Alu	AluSx3
CAediting_1116406	chr16_53442007_+	SINE	Alu	AluSx3
CAediting_1116407	chr16_53442067_+	SINE	Alu	AluSx3
CAediting_1116408	chr16_53442080_+	SINE	Alu	AluSx3
CAediting_1116409	chr16_53442209_+	SINE	Alu	AluJo
CAediting_1116410	chr16_53442215_+	SINE	Alu	AluJo
CAediting_1116411	chr16_53442218_+	SINE	Alu	AluJo
CAediting_1116412	chr16_53444473_+	SINE	Alu	AluSx1
CAediting_1116413	chr16_53445165_+	SINE	Alu	AluJb
CAediting_1116414	chr16_53447731_+	SINE	Alu	AluSx1
CAediting_1116415	chr16_53447745_+	SINE	Alu	AluSx1
CAediting_1116416	chr16_53447748_+	SINE	Alu	AluSx1
CAediting_1116417	chr16_53449474_+	SINE	Alu	AluSx
CAediting_1116418	chr16_53449507_+	SINE	Alu	AluSx
CAediting_1116419	chr16_53449515_+	SINE	Alu	AluSx
CAediting_1116420	chr16_53449516_+	SINE	Alu	AluSx
CAediting_1116421	chr16_53449524_+	SINE	Alu	AluSx
CAediting_1116422	chr16_53449529_+	SINE	Alu	AluSx
CAediting_1116423	chr16_53451244_+	SINE	Alu	AluJo
CAediting_1116424	chr16_53455892_+	SINE	Alu	AluJo
CAediting_1116425	chr16_53455914_+	SINE	Alu	AluJo
CAediting_1116426	chr16_53455941_+	SINE	Alu	AluJo
CAediting_1116427	chr16_53455968_+	SINE	Alu	AluJo
CAediting_1116428	chr16_53455986_+	SINE	Alu	AluJo
CAediting_1116429	chr16_53455987_+	SINE	Alu	AluJo
CAediting_1116430	chr16_53455991_+	SINE	Alu	AluJo
CAediting_1116431	chr16_53456026_+	SINE	Alu	AluJo
CAediting_1116432	chr16_53456065_+	SINE	Alu	AluJo
CAediting_1116433	chr16_53456072_+	SINE	Alu	AluJo
CAediting_1116434	chr16_53456078_+	SINE	Alu	AluJo
CAediting_1116435	chr16_53456163_+	SINE	Alu	AluJo
CAediting_1116436	chr16_53456187_+	SINE	Alu	AluJo
CAediting_1116437	chr16_53466643_+	DNA	hAT-Charlie	MER1A
CAediting_1116438	chr16_53467457_+	SINE	Alu	AluSz6
CAediting_1116439	chr16_53467487_+	SINE	Alu	AluSz6
CAediting_1116440	chr16_53467576_+	SINE	Alu	AluSz6
CAediting_1116441	chr16_53467590_+	SINE	Alu	AluSz6
CAediting_1116442	chr16_53467623_+	SINE	Alu	AluSz6
CAediting_1116443	chr16_53468275_+	SINE	Alu	AluJo
CAediting_1116444	chr16_53468357_+	SINE	Alu	AluJo
CAediting_1116445	chr16_53468361_+	SINE	Alu	AluJo
CAediting_1116446	chr16_53469015_+	SINE	Alu	AluSx
CAediting_1116447	chr16_53469020_+	SINE	Alu	AluSx
CAediting_1116448	chr16_53469034_+	SINE	Alu	AluSx
CAediting_1116449	chr16_53469046_+	SINE	Alu	AluSx
CAediting_1116450	chr16_53469110_+	SINE	Alu	AluSx
CAediting_1116451	chr16_53469138_+	SINE	Alu	AluSx
CAediting_1116452	chr16_53469139_+	SINE	Alu	AluSx
CAediting_1116453	chr16_53469145_+	SINE	Alu	AluSx
CAediting_1116454	chr16_53469150_+	SINE	Alu	AluSx
CAediting_1116455	chr16_53469155_+	SINE	Alu	AluSx
CAediting_1116456	chr16_53469185_+	SINE	Alu	AluSx
CAediting_1116457	chr16_53477486_+	SINE	Alu	AluSz6
CAediting_1116458	chr16_53478874_+	SINE	Alu	AluSz

Top

RNA A-to-I editing events in the alternative splicing sites for RBL2

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000103479.13.RBL2.

Correlation between RNA A-to-I editing and PSI for ENSG00000103479.13.RBL2.

Top

Differntial gene expression between RNA A-to-I edited versus non-edited samples for RBL2

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

Top

Protein coding region RNA A-to-I editings for RBL2

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

Top

The effects of the RNA editing to the miRNA binding sites for RBL2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for RBL2

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

Top

Relation with ADAR for RBL2

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

Top

Relation with cancer stages for RBL2

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

Top

Relation with survival for RBL2

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

Top

RelatedDrugs for RBL2

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for RBL2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
RBL2	C0023434	Chronic Lymphocytic Leukemia	1	CTD_human
RBL2	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
RBL2	C0919267	ovarian neoplasm	1	CTD_human
RBL2	C1140680	Malignant neoplasm of ovary	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene