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Editing gene: RAD51 (CAeditome ID:5888)

Gene summary for RAD51

Gene summary

Gene information	Gene symbol	RAD51
	Gene ID	5888
	Gene name	RAD51 recombinase
	Synonyms	BRCC5\|FANCR\|HRAD51\|HsRad51\|HsT16930\|MRMV2\|RAD51A\|RECA
	Cytomap	15q15.1
	Type of gene	protein-coding
	Description	DNA repair protein RAD51 homolog 1BRCA1/BRCA2-containing complex, subunit 5RAD51 homolog ARecA, E. coli, homolog ofRecA-like proteinrecombination protein A
	Modification date	20210518
	UniProtAcc	Q06609
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
RAD51	GO:0000724	DNA repair protein RAD51 homolog 1	16428451
RAD51	GO:0003682	DNA repair protein RAD51 homolog 1	23401855
RAD51	GO:0003690	DNA repair protein RAD51 homolog 1	7988572
RAD51	GO:0003697	DNA repair protein RAD51 homolog 1	7988572
RAD51	GO:0005524	DNA repair protein RAD51 homolog 1	16428451
RAD51	GO:0017116	DNA repair protein RAD51 homolog 1	7988572
RAD51	GO:0017116	DNA repair protein RAD51 homolog 1	8929543
RAD51	GO:0000724	DNA repair protein RAD51 homolog 1	17996710
RAD51	GO:0000724	DNA repair protein RAD51 homolog 1	17996711
RAD51	GO:0000724	DNA repair protein RAD51 homolog 1	27239033
RAD51	GO:0006268	DNA repair protein RAD51 homolog 1	7988572
RAD51	GO:0006974	DNA repair protein RAD51 homolog 1	17996710
RAD51	GO:0006974	DNA repair protein RAD51 homolog 1	17996711
RAD51	GO:0006974	DNA repair protein RAD51 homolog 1	23509288
RAD51	GO:0006974	DNA repair protein RAD51 homolog 1	25585578
RAD51	GO:0006974	DNA repair protein RAD51 homolog 1	27239033
RAD51	GO:0010569	DNA repair protein RAD51 homolog 1	23754376
RAD51	GO:0031297	DNA repair protein RAD51 homolog 1	25585578
RAD51	GO:0051106	DNA repair protein RAD51 homolog 1	8929543
RAD51	GO:0071479	DNA repair protein RAD51 homolog 1	23509288
RAD51	GO:0071479	DNA repair protein RAD51 homolog 1	23754376
RAD51	GO:0072757	DNA repair protein RAD51 homolog 1	23509288
RAD51	GO:0000228	DNA repair protein RAD51 homolog 1	23754376
RAD51	GO:0000781	DNA repair protein RAD51 homolog 1	21076401
RAD51	GO:0000785	DNA repair protein RAD51 homolog 1	25585578
RAD51	GO:0000785	DNA repair protein RAD51 homolog 1	26323318
RAD51	GO:0000800	DNA repair protein RAD51 homolog 1	9774970
RAD51	GO:0005634	DNA repair protein RAD51 homolog 1	12442171
RAD51	GO:0005634	DNA repair protein RAD51 homolog 1	16215984
RAD51	GO:0005634	DNA repair protein RAD51 homolog 1	18417535
RAD51	GO:0005634	DNA repair protein RAD51 homolog 1	25585578
RAD51	GO:0005634	DNA repair protein RAD51 homolog 1	26323318
RAD51	GO:0005634	DNA repair protein RAD51 homolog 1	26681308
RAD51	GO:0005634	DNA repair protein RAD51 homolog 1	26833090
RAD51	GO:0005737	DNA repair protein RAD51 homolog 1	16215984
RAD51	GO:0005737	DNA repair protein RAD51 homolog 1	25585578
RAD51	GO:0005737	DNA repair protein RAD51 homolog 1	26681308
RAD51	GO:0005739	DNA repair protein RAD51 homolog 1	20413593
RAD51	GO:0016605	DNA repair protein RAD51 homolog 1	11309417
RAD51	GO:0035861	DNA repair protein RAD51 homolog 1	24550317
RAD51	GO:0048471	DNA repair protein RAD51 homolog 1	16215984
RAD51	GO:0032991	DNA repair protein RAD51 homolog 1	16990250
RAD51	GO:0032991	DNA repair protein RAD51 homolog 1	26833090

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RNA A-to-I events for RAD51

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000051180.15

RNA A-to-I editing events in Cancer.

CAediting_1028869(40701842, +), CAediting_1028870(40701884, +), CAediting_1028871(40709446, +), CAediting_1028872(40710300, +), CAediting_1028873(40721118, +), CAediting_1028874(40724554, +), CAediting_1028875(40727408, +), CAediting_1028876(40730248, +), CAediting_1028877(40730358, +), CAediting_1028878(40730383, +), CAediting_1028879(40730393, +), CAediting_1028880(40730397, +), CAediting_1028881(40731850, +), CAediting_1028882(40731878, +), CAediting_1028883(40731879, +), CAediting_1028884(40731903, +), CAediting_1028885(40731962, +), CAediting_1028886(40731998, +), CAediting_1028887(40732002, +), CAediting_1028888(40732003, +), CAediting_1028889(40732018, +), CAediting_1028890(40732024, +),

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RNA editing positional annotations for RAD51 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1028869	chr15_40701842_+	exonic
CAediting_1028870	chr15_40701884_+	exonic
CAediting_1028871	chr15_40709446_+	intronic
CAediting_1028872	chr15_40710300_+	intronic
CAediting_1028873	chr15_40721118_+	intronic
CAediting_1028874	chr15_40724554_+	intronic
CAediting_1028875	chr15_40727408_+	intronic
CAediting_1028876	chr15_40730248_+	intronic
CAediting_1028877	chr15_40730358_+	intronic
CAediting_1028878	chr15_40730383_+	intronic
CAediting_1028879	chr15_40730393_+	intronic
CAediting_1028880	chr15_40730397_+	intronic
CAediting_1028881	chr15_40731850_+	UTR3
CAediting_1028882	chr15_40731878_+	UTR3
CAediting_1028883	chr15_40731879_+	UTR3
CAediting_1028884	chr15_40731903_+	UTR3
CAediting_1028885	chr15_40731962_+	UTR3
CAediting_1028886	chr15_40731998_+	UTR3
CAediting_1028887	chr15_40732002_+	UTR3
CAediting_1028888	chr15_40732003_+	UTR3
CAediting_1028889	chr15_40732018_+	UTR3
CAediting_1028890	chr15_40732024_+	UTR3

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1028869	chr15_40701842_+	SINE	Alu	AluSc
CAediting_1028870	chr15_40701884_+	SINE	Alu	AluSc
CAediting_1028871	chr15_40709446_+	SINE	Alu	AluSx1
CAediting_1028872	chr15_40710300_+	SINE	Alu	AluSx
CAediting_1028873	chr15_40721118_+	SINE	Alu	AluSx
CAediting_1028874	chr15_40724554_+	SINE	Alu	AluJr
CAediting_1028875	chr15_40727408_+	SINE	Alu	AluSx1
CAediting_1028876	chr15_40730248_+	SINE	Alu	AluJr
CAediting_1028877	chr15_40730358_+	SINE	Alu	AluJr
CAediting_1028878	chr15_40730383_+	SINE	Alu	AluJr
CAediting_1028879	chr15_40730393_+	SINE	Alu	AluJr
CAediting_1028880	chr15_40730397_+	SINE	Alu	AluJr
CAediting_1028881	chr15_40731850_+	SINE	Alu	AluJb
CAediting_1028882	chr15_40731878_+	SINE	Alu	AluJb
CAediting_1028883	chr15_40731879_+	SINE	Alu	AluJb
CAediting_1028884	chr15_40731903_+	SINE	Alu	AluJb
CAediting_1028885	chr15_40731962_+	SINE	Alu	AluJb
CAediting_1028886	chr15_40731998_+	SINE	Alu	AluJb
CAediting_1028887	chr15_40732002_+	SINE	Alu	AluJb
CAediting_1028888	chr15_40732003_+	SINE	Alu	AluJb
CAediting_1028889	chr15_40732018_+	SINE	Alu	AluJb
CAediting_1028890	chr15_40732024_+	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for RAD51

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000051180.15.RAD51.

Correlation between RNA A-to-I editing and PSI for ENSG00000051180.15.RAD51.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for RAD51

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for RAD51

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for RAD51

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1368054	chr19_46709310_-	ENSG00000051180.15	ENST00000525066	hsa-miR-320e	40728782	40728788	7mer-m8	40728772	40728789	151	-21.12
CAediting_1368054	chr19_46709310_-	ENSG00000051180.15	ENST00000531277	hsa-miR-320e	40728782	40728788	7mer-m8	40728772	40728789	151	-21.12

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for RAD51

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for RAD51

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
BRCA	CAediting_1028887	chr15_40732002_+	0.0181401856182489	0.252839148953304	.	.	.	.
CESC	CAediting_1028887	chr15_40732002_+	0.0173241891238913	0.285708817397464	.	.	.	.

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Relation with cancer stages for RAD51

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
TGCT	clinical_stage	CAediting_1028887	chr15_40732002_+	0.0241962438684578	0.365117440042383

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Relation with survival for RAD51

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for RAD51

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for RAD51

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
RAD51	C0006142	Malignant neoplasm of breast	2	CTD_human;UNIPROT
RAD51	C0015625	Fanconi Anemia	2	GENOMICS_ENGLAND;ORPHANET
RAD51	C0677776	Hereditary Breast and Ovarian Cancer Syndrome	2	ORPHANET
RAD51	C4284093	FANCONI ANEMIA, COMPLEMENTATION GROUP R	2	CTD_human;UNIPROT
RAD51	C0018671	Head and Neck Neoplasms	1	CTD_human
RAD51	C0018675	Head Neoplasms	1	CTD_human
RAD51	C0023465	Acute monocytic leukemia	1	GENOMICS_ENGLAND
RAD51	C0023467	Leukemia, Myelocytic, Acute	1	GENOMICS_ENGLAND
RAD51	C0027533	Neck Neoplasms	1	CTD_human
RAD51	C0265219	Miller Dieker syndrome	1	GENOMICS_ENGLAND
RAD51	C0278996	Malignant Head and Neck Neoplasm	1	CTD_human
RAD51	C0746787	Cancer of Neck	1	CTD_human
RAD51	C0751177	Cancer of Head	1	CTD_human
RAD51	C0887900	Upper Aerodigestive Tract Neoplasms	1	CTD_human
RAD51	C1449861	Micronuclei, Chromosome-Defective	1	CTD_human
RAD51	C1449862	Micronuclei, Genotoxicant-Induced	1	CTD_human
RAD51	C3281089	MIRROR MOVEMENTS 2	1	CTD_human;GENOMICS_ENGLAND
RAD51	C3463824	MYELODYSPLASTIC SYNDROME	1	GENOMICS_ENGLAND

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene