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Editing gene: QDPR (CAeditome ID:5860)

Gene summary for QDPR

Gene summary

Gene information	Gene symbol	QDPR
	Gene ID	5860
	Gene name	quinoid dihydropteridine reductase
	Synonyms	DHPR\|HDHPR\|PKU2\|SDR33C1
	Cytomap	4p15.32
	Type of gene	protein-coding
	Description	dihydropteridine reductase6,7-dihydropteridine reductaseshort chain dehydrogenase/reductase family 33C member 1testis secretory sperm-binding protein Li 236P
	Modification date	20210518
	UniProtAcc	P09417
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
QDPR	GO:0005737	Dihydropteridine reductase	0000054

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RNA A-to-I events for QDPR

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000151552.10

RNA A-to-I editing events in Cancer.

CAediting_351153(17461064, -), CAediting_351154(17461069, -), CAediting_351155(17461073, -), CAediting_351156(17461094, -), CAediting_351157(17461112, -), CAediting_351158(17461125, -), CAediting_351159(17461129, -), CAediting_351160(17461134, -), CAediting_351161(17461135, -), CAediting_351162(17461137, -), CAediting_351163(17461216, -), CAediting_351164(17461220, -), CAediting_351165(17461221, -), CAediting_351166(17461248, -), CAediting_351167(17461249, -), CAediting_351168(17461289, -), CAediting_351169(17461290, -), CAediting_351170(17461298, -), CAediting_351171(17474122, -), CAediting_351172(17474139, -), CAediting_351173(17474143, -), CAediting_351174(17474144, -), CAediting_351175(17474157, -), CAediting_351176(17474158, -), CAediting_351177(17474171, -), CAediting_351178(17474185, -), CAediting_351179(17474193, -), CAediting_351180(17474194, -), CAediting_351181(17474371, -), CAediting_351182(17474436, -), CAediting_351183(17474453, -), CAediting_351184(17474494, -), CAediting_351185(17474574, -), CAediting_351186(17474581, -), CAediting_351187(17474910, -), CAediting_351188(17474945, -), CAediting_351189(17474951, -), CAediting_351190(17475315, -), CAediting_351191(17475316, -), CAediting_351192(17475324, -), CAediting_351193(17475341, -), CAediting_351194(17475344, -), CAediting_351195(17475356, -), CAediting_351196(17475366, -), CAediting_351197(17475387, -), CAediting_351198(17478321, -), CAediting_351199(17479150, -), CAediting_351200(17479885, -), CAediting_351201(17479904, -), CAediting_351202(17479923, -), CAediting_351203(17483777, -), CAediting_351204(17483781, -), CAediting_351205(17483787, -), CAediting_351206(17483788, -), CAediting_351207(17483801, -), CAediting_351208(17483976, -), CAediting_351209(17484090, -), CAediting_351210(17484241, -), CAediting_351211(17484314, -), CAediting_351212(17484348, -), CAediting_351213(17484689, -), CAediting_351214(17484690, -), CAediting_351215(17484704, -), CAediting_351216(17484750, -), CAediting_351217(17484753, -), CAediting_351218(17484812, -), CAediting_351219(17484828, -), CAediting_351220(17484865, -), CAediting_351221(17484876, -), CAediting_351222(17485298, -), CAediting_351223(17485334, -), CAediting_351224(17485498, -), CAediting_351225(17485522, -), CAediting_351226(17486017, -), CAediting_351227(17496362, -), CAediting_351228(17496363, -), CAediting_351229(17499657, -), CAediting_351230(17499663, -), CAediting_351231(17499668, -), CAediting_351232(17499672, -), CAediting_351233(17499751, -), CAediting_351234(17499771, -), CAediting_351235(17503868, -), CAediting_351236(17508352, -), CAediting_351237(17508353, -),

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RNA editing positional annotations for QDPR using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_351153	chr4_17461064_-	intronic
CAediting_351154	chr4_17461069_-	intronic
CAediting_351155	chr4_17461073_-	intronic
CAediting_351156	chr4_17461094_-	intronic
CAediting_351157	chr4_17461112_-	intronic
CAediting_351158	chr4_17461125_-	intronic
CAediting_351159	chr4_17461129_-	intronic
CAediting_351160	chr4_17461134_-	intronic
CAediting_351161	chr4_17461135_-	intronic
CAediting_351162	chr4_17461137_-	intronic
CAediting_351163	chr4_17461216_-	intronic
CAediting_351164	chr4_17461220_-	intronic
CAediting_351165	chr4_17461221_-	intronic
CAediting_351166	chr4_17461248_-	intronic
CAediting_351167	chr4_17461249_-	intronic
CAediting_351168	chr4_17461289_-	intronic
CAediting_351169	chr4_17461290_-	intronic
CAediting_351170	chr4_17461298_-	intronic
CAediting_351171	chr4_17474122_-	intronic
CAediting_351172	chr4_17474139_-	intronic
CAediting_351173	chr4_17474143_-	intronic
CAediting_351174	chr4_17474144_-	intronic
CAediting_351175	chr4_17474157_-	intronic
CAediting_351176	chr4_17474158_-	intronic
CAediting_351177	chr4_17474171_-	intronic
CAediting_351178	chr4_17474185_-	intronic
CAediting_351179	chr4_17474193_-	intronic
CAediting_351180	chr4_17474194_-	intronic
CAediting_351181	chr4_17474371_-	intronic
CAediting_351182	chr4_17474436_-	intronic
CAediting_351183	chr4_17474453_-	intronic
CAediting_351184	chr4_17474494_-	intronic
CAediting_351185	chr4_17474574_-	intronic
CAediting_351186	chr4_17474581_-	intronic
CAediting_351187	chr4_17474910_-	intronic
CAediting_351188	chr4_17474945_-	intronic
CAediting_351189	chr4_17474951_-	intronic
CAediting_351190	chr4_17475315_-	intronic
CAediting_351191	chr4_17475316_-	intronic
CAediting_351192	chr4_17475324_-	intronic
CAediting_351193	chr4_17475341_-	intronic
CAediting_351194	chr4_17475344_-	intronic
CAediting_351195	chr4_17475356_-	intronic
CAediting_351196	chr4_17475366_-	intronic
CAediting_351197	chr4_17475387_-	intronic
CAediting_351198	chr4_17478321_-	intronic
CAediting_351199	chr4_17479150_-	intronic
CAediting_351200	chr4_17479885_-	intronic
CAediting_351201	chr4_17479904_-	intronic
CAediting_351202	chr4_17479923_-	intronic
CAediting_351203	chr4_17483777_-	intronic
CAediting_351204	chr4_17483781_-	intronic
CAediting_351205	chr4_17483787_-	intronic
CAediting_351206	chr4_17483788_-	intronic
CAediting_351207	chr4_17483801_-	intronic
CAediting_351208	chr4_17483976_-	intronic
CAediting_351209	chr4_17484090_-	intronic
CAediting_351210	chr4_17484241_-	intronic
CAediting_351211	chr4_17484314_-	intronic
CAediting_351212	chr4_17484348_-	intronic
CAediting_351213	chr4_17484689_-	intronic
CAediting_351214	chr4_17484690_-	intronic
CAediting_351215	chr4_17484704_-	intronic
CAediting_351216	chr4_17484750_-	intronic
CAediting_351217	chr4_17484753_-	intronic
CAediting_351218	chr4_17484812_-	intronic
CAediting_351219	chr4_17484828_-	intronic
CAediting_351220	chr4_17484865_-	intronic
CAediting_351221	chr4_17484876_-	intronic
CAediting_351222	chr4_17485298_-	intronic
CAediting_351223	chr4_17485334_-	intronic
CAediting_351224	chr4_17485498_-	intronic
CAediting_351225	chr4_17485522_-	intronic
CAediting_351226	chr4_17486017_-	intronic
CAediting_351227	chr4_17496362_-	intronic
CAediting_351228	chr4_17496363_-	intronic
CAediting_351229	chr4_17499657_-	intronic
CAediting_351230	chr4_17499663_-	intronic
CAediting_351231	chr4_17499668_-	intronic
CAediting_351232	chr4_17499672_-	intronic
CAediting_351233	chr4_17499751_-	intronic
CAediting_351234	chr4_17499771_-	intronic
CAediting_351235	chr4_17503868_-	intronic
CAediting_351236	chr4_17508352_-	intronic
CAediting_351237	chr4_17508353_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_351153	chr4_17461064_-	SINE	Alu	AluSz
CAediting_351154	chr4_17461069_-	SINE	Alu	AluSz
CAediting_351155	chr4_17461073_-	SINE	Alu	AluSz
CAediting_351156	chr4_17461094_-	SINE	Alu	AluSz
CAediting_351157	chr4_17461112_-	SINE	Alu	AluSz
CAediting_351158	chr4_17461125_-	SINE	Alu	AluSz
CAediting_351159	chr4_17461129_-	SINE	Alu	AluSz
CAediting_351160	chr4_17461134_-	SINE	Alu	AluSz
CAediting_351161	chr4_17461135_-	SINE	Alu	AluSz
CAediting_351162	chr4_17461137_-	SINE	Alu	AluSz
CAediting_351163	chr4_17461216_-	SINE	Alu	AluSz
CAediting_351164	chr4_17461220_-	SINE	Alu	AluSz
CAediting_351165	chr4_17461221_-	SINE	Alu	AluSz
CAediting_351166	chr4_17461248_-	SINE	Alu	AluSz
CAediting_351167	chr4_17461249_-	SINE	Alu	AluSz
CAediting_351168	chr4_17461289_-	SINE	Alu	AluSz
CAediting_351169	chr4_17461290_-	SINE	Alu	AluSz
CAediting_351170	chr4_17461298_-	SINE	Alu	AluSz
CAediting_351171	chr4_17474122_-	SINE	MIR	MIR
CAediting_351172	chr4_17474139_-	SINE	MIR	MIR
CAediting_351173	chr4_17474143_-	SINE	MIR	MIR
CAediting_351174	chr4_17474144_-	SINE	MIR	MIR
CAediting_351175	chr4_17474157_-	SINE	MIR	MIR
CAediting_351176	chr4_17474158_-	SINE	MIR	MIR
CAediting_351177	chr4_17474171_-	SINE	MIR	MIR
CAediting_351178	chr4_17474185_-	SINE	MIR	MIR
CAediting_351179	chr4_17474193_-	SINE	MIR	MIR
CAediting_351180	chr4_17474194_-	SINE	MIR	MIR
CAediting_351181	chr4_17474371_-	SINE	Alu	AluSx3
CAediting_351182	chr4_17474436_-	SINE	Alu	AluSx3
CAediting_351183	chr4_17474453_-	SINE	Alu	AluSx3
CAediting_351184	chr4_17474494_-	SINE	Alu	AluSx3
CAediting_351185	chr4_17474574_-	SINE	Alu	AluSx3
CAediting_351186	chr4_17474581_-	SINE	Alu	AluSx3
CAediting_351187	chr4_17474910_-	SINE	Alu	AluJr
CAediting_351188	chr4_17474945_-	SINE	Alu	AluJr
CAediting_351189	chr4_17474951_-	SINE	Alu	AluJr
CAediting_351190	chr4_17475315_-	SINE	MIR	MIR
CAediting_351191	chr4_17475316_-	SINE	MIR	MIR
CAediting_351192	chr4_17475324_-	SINE	MIR	MIR
CAediting_351193	chr4_17475341_-	SINE	MIR	MIR
CAediting_351194	chr4_17475344_-	SINE	MIR	MIR
CAediting_351195	chr4_17475356_-	SINE	MIR	MIR
CAediting_351196	chr4_17475366_-	SINE	MIR	MIR
CAediting_351198	chr4_17478321_-	LTR	ERVL	LTR79
CAediting_351199	chr4_17479150_-	SINE	Alu	AluJb
CAediting_351208	chr4_17483976_-	SINE	Alu	AluSc
CAediting_351209	chr4_17484090_-	SINE	Alu	AluSc
CAediting_351210	chr4_17484241_-	SINE	Alu	AluSc
CAediting_351213	chr4_17484689_-	SINE	Alu	AluSx1
CAediting_351214	chr4_17484690_-	SINE	Alu	AluSx1
CAediting_351215	chr4_17484704_-	SINE	Alu	AluSx1
CAediting_351216	chr4_17484750_-	SINE	Alu	AluSx1
CAediting_351217	chr4_17484753_-	SINE	Alu	AluSx1
CAediting_351218	chr4_17484812_-	SINE	Alu	AluSx1
CAediting_351219	chr4_17484828_-	SINE	Alu	AluSx1
CAediting_351220	chr4_17484865_-	SINE	Alu	AluSx1
CAediting_351221	chr4_17484876_-	SINE	Alu	AluSx1
CAediting_351222	chr4_17485298_-	SINE	Alu	AluJr
CAediting_351223	chr4_17485334_-	SINE	Alu	AluJr
CAediting_351224	chr4_17485498_-	SINE	Alu	AluJr
CAediting_351225	chr4_17485522_-	SINE	Alu	AluJr
CAediting_351226	chr4_17486017_-	SINE	Alu	AluY
CAediting_351227	chr4_17496362_-	SINE	Alu	AluSp
CAediting_351228	chr4_17496363_-	SINE	Alu	AluSp
CAediting_351229	chr4_17499657_-	SINE	Alu	AluJr
CAediting_351230	chr4_17499663_-	SINE	Alu	AluJr
CAediting_351231	chr4_17499668_-	SINE	Alu	AluJr
CAediting_351232	chr4_17499672_-	SINE	Alu	AluJr
CAediting_351233	chr4_17499751_-	SINE	Alu	AluJr
CAediting_351234	chr4_17499771_-	SINE	Alu	AluJr
CAediting_351235	chr4_17503868_-	SINE	Alu	AluSx1
CAediting_351236	chr4_17508352_-	SINE	Alu	AluSz6
CAediting_351237	chr4_17508353_-	SINE	Alu	AluSz6

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RNA A-to-I editing events in the alternative splicing sites for QDPR

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000151552.10.QDPR.

Correlation between RNA A-to-I editing and PSI for ENSG00000151552.10.QDPR.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for QDPR

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for QDPR

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for QDPR

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1399425	chr20_1392958_-	ENSG00000151552.10	ENST00000513615	hsa-miR-6869-5p	17460738	17460744	7mer-m8	17460737	17460758	152	-23.45
CAediting_604450	chr7_133034877_-	ENSG00000151552.10	ENST00000507439	hsa-miR-3654	17487060	17487066	7mer-m8	17487059	17487077	155	-22.13
CAediting_604450	chr7_133034877_-	ENSG00000151552.10	ENST00000428702	hsa-miR-3654	17487060	17487066	7mer-m8	17487059	17487077	155	-22.13
CAediting_1229414	chr17_67471546_+	ENSG00000151552.10	ENST00000505710	hsa-miR-548aa	17490550	17490556	7mer-m8	17490549	17490577	148	-15.57
CAediting_414656	chr5_72878640_+	ENSG00000151552.10	ENST00000505710	hsa-miR-4804-3p	17490170	17490176	7mer-m8	17490169	17490189	140	-9.73

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for QDPR

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for QDPR

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
PCPG	CAediting_351203	chr4_17483777_-	0.00310233934303639	0.402409071543341	.	.	.	.
BRCA	CAediting_351204	chr4_17483781_-	0.030702394777467	0.233206198243607	.	.	.	.
LIHC	CAediting_351204	chr4_17483781_-	.	.	.	.	0.0294317606159222	0.286160539233224
LGG	CAediting_351205	chr4_17483787_-	5.40275705885406e-07	0.450871112042116	.	.	.	.
BRCA	CAediting_351205	chr4_17483787_-	3.58170713749176e-05	0.32351423491787	.	.	.	.
LIHC	CAediting_351205	chr4_17483787_-	4.32798945888017e-05	0.430668486427814	.	.	.	.
PCPG	CAediting_351205	chr4_17483787_-	1.8510424505354e-05	0.365988199432038	.	.	.	.
SKCM	CAediting_351205	chr4_17483787_-	1.05336363949331e-05	0.470682352710363	.	.	.	.
LGG	CAediting_351206	chr4_17483788_-	0.024995409673694	0.282281792499621	.	.	.	.
BRCA	CAediting_351206	chr4_17483788_-	2.13216828747935e-06	0.406369386284384	.	.	.	.
LIHC	CAediting_351206	chr4_17483788_-	3.48989481610423e-05	0.473396617177356	.	.	.	.
PCPG	CAediting_351206	chr4_17483788_-	0.00043172981883857	0.352273467595621	.	.	.	.
BRCA	CAediting_351212	chr4_17484348_-	0.00644886228027517	0.347930187182972	.	.	.	.

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Relation with cancer stages for QDPR

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for QDPR

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for QDPR

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
QDPR	P09417	DB00157	NADH	Dihydropteridine reductase	SmallMoleculeDrug	approved\|nutraceutical

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RelatedDiseases for QDPR

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
QDPR	C0268465	Phenylketonuria II	11	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
QDPR	C0013421	Dystonia	2	GENOMICS_ENGLAND
QDPR	C0031485	Phenylketonurias	1	CTD_human
QDPR	C0751434	Classical phenylketonuria	1	CTD_human
QDPR	C0751435	Hyperphenylalaninaemia	1	CTD_human
QDPR	C0751436	Hyperphenylalaninemia, Non-Phenylketonuric	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene