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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: OSTC (CAeditome ID:58505)

Gene summary for OSTC

check button Gene summary
Gene informationGene symbol

OSTC

Gene ID

58505

Gene nameoligosaccharyltransferase complex non-catalytic subunit
SynonymsDC2
Cytomap

4q25

Type of geneprotein-coding
Descriptionoligosaccharyltransferase complex subunit OSTChydrophobic protein HSF-28oligosaccharyltransferase complex subunit (non-catalytic)
Modification date20210518
UniProtAcc

Q9NRP0

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
OSTC

GO:0008250

Oligosaccharyltransferase complex subunit OSTC

15835887


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RNA A-to-I events for OSTC

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000198856.11

check button RNA A-to-I editing events in Cancer.
CAediting_379507(108659140, +), CAediting_379508(108659162, +), CAediting_379509(108659204, +), CAediting_379510(108659219, +), CAediting_379511(108659232, +), CAediting_379512(108659242, +), CAediting_379513(108659513, +), CAediting_379514(108659514, +), CAediting_379515(108659519, +), CAediting_379516(108659530, +), CAediting_379517(108659537, +), CAediting_379518(108659557, +), CAediting_379519(108659565, +), CAediting_379520(108659581, +), CAediting_379521(108659612, +), CAediting_379522(108659626, +), CAediting_379523(108659630, +), CAediting_379524(108659648, +), CAediting_379525(108659654, +), CAediting_379526(108659694, +), CAediting_379527(108659701, +), CAediting_379528(108659780, +), CAediting_379529(108659786, +), CAediting_379530(108659791, +), CAediting_379531(108660921, +), CAediting_379532(108660926, +), CAediting_379533(108660945, +), CAediting_379534(108660953, +), CAediting_379535(108660961, +), CAediting_379536(108660962, +), CAediting_379537(108660997, +), CAediting_379538(108661015, +), CAediting_379539(108661052, +), CAediting_379540(108661063, +), CAediting_379541(108661066, +), CAediting_379542(108661067, +), CAediting_379543(108661071, +), CAediting_379544(108661084, +), CAediting_379545(108661097, +), CAediting_379546(108661098, +), CAediting_379547(108661130, +), CAediting_379548(108661135, +), CAediting_379549(108661138, +), CAediting_379550(108661139, +), CAediting_379551(108661143, +), CAediting_379552(108661146, +), CAediting_379553(108661150, +), CAediting_379554(108661163, +), CAediting_379555(108661169, +), CAediting_379556(108661170, +), CAediting_379557(108661188, +), CAediting_379558(108661200, +), CAediting_379559(108661634, +), CAediting_379560(108661637, +), CAediting_379561(108661646, +), CAediting_379562(108661808, +), CAediting_379563(108661873, +), CAediting_379564(108663276, +), CAediting_379565(108663305, +), CAediting_379566(108663341, +), CAediting_379567(108663351, +), CAediting_379568(108663471, +), CAediting_379569(108664687, +), CAediting_379570(108666524, +), CAediting_379571(108666590, +), CAediting_379572(108666591, +), CAediting_379573(108666773, +), CAediting_379574(108666811, +), CAediting_379575(108666884, +), CAediting_379576(108666885, +), CAediting_379577(108666914, +), CAediting_379578(108666925, +), CAediting_379579(108666946, +), CAediting_379580(108667615, +),

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RNA editing positional annotations for OSTC using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
CAediting_379564chr4_108663276_+nonsynonymous SNVENST00000512478.2c.A475Gp.I159VD.N

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_379507chr4_108659140_+intronic
CAediting_379508chr4_108659162_+intronic
CAediting_379509chr4_108659204_+intronic
CAediting_379510chr4_108659219_+intronic
CAediting_379511chr4_108659232_+intronic
CAediting_379512chr4_108659242_+intronic
CAediting_379513chr4_108659513_+intronic
CAediting_379514chr4_108659514_+intronic
CAediting_379515chr4_108659519_+intronic
CAediting_379516chr4_108659530_+intronic
CAediting_379517chr4_108659537_+intronic
CAediting_379518chr4_108659557_+intronic
CAediting_379519chr4_108659565_+intronic
CAediting_379520chr4_108659581_+intronic
CAediting_379521chr4_108659612_+intronic
CAediting_379522chr4_108659626_+intronic
CAediting_379523chr4_108659630_+intronic
CAediting_379524chr4_108659648_+intronic
CAediting_379525chr4_108659654_+intronic
CAediting_379526chr4_108659694_+intronic
CAediting_379527chr4_108659701_+intronic
CAediting_379528chr4_108659780_+intronic
CAediting_379529chr4_108659786_+intronic
CAediting_379530chr4_108659791_+intronic
CAediting_379531chr4_108660921_+intronic
CAediting_379532chr4_108660926_+intronic
CAediting_379533chr4_108660945_+intronic
CAediting_379534chr4_108660953_+intronic
CAediting_379535chr4_108660961_+intronic
CAediting_379536chr4_108660962_+intronic
CAediting_379537chr4_108660997_+intronic
CAediting_379538chr4_108661015_+intronic
CAediting_379539chr4_108661052_+intronic
CAediting_379540chr4_108661063_+intronic
CAediting_379541chr4_108661066_+intronic
CAediting_379542chr4_108661067_+intronic
CAediting_379543chr4_108661071_+intronic
CAediting_379544chr4_108661084_+intronic
CAediting_379545chr4_108661097_+intronic
CAediting_379546chr4_108661098_+intronic
CAediting_379547chr4_108661130_+intronic
CAediting_379548chr4_108661135_+intronic
CAediting_379549chr4_108661138_+intronic
CAediting_379550chr4_108661139_+intronic
CAediting_379551chr4_108661143_+intronic
CAediting_379552chr4_108661146_+intronic
CAediting_379553chr4_108661150_+intronic
CAediting_379554chr4_108661163_+intronic
CAediting_379555chr4_108661169_+intronic
CAediting_379556chr4_108661170_+intronic
CAediting_379557chr4_108661188_+intronic
CAediting_379558chr4_108661200_+intronic
CAediting_379559chr4_108661634_+intronic
CAediting_379560chr4_108661637_+intronic
CAediting_379561chr4_108661646_+intronic
CAediting_379562chr4_108661808_+intronic
CAediting_379563chr4_108661873_+intronic
CAediting_379564chr4_108663276_+exonic
CAediting_379565chr4_108663305_+exonic
CAediting_379566chr4_108663341_+intronic
CAediting_379567chr4_108663351_+intronic
CAediting_379568chr4_108663471_+intronic
CAediting_379569chr4_108664687_+intronic
CAediting_379570chr4_108666524_+intronic
CAediting_379571chr4_108666590_+intronic
CAediting_379572chr4_108666591_+intronic
CAediting_379573chr4_108666773_+intronic
CAediting_379574chr4_108666811_+intronic
CAediting_379575chr4_108666884_+intronic
CAediting_379576chr4_108666885_+intronic
CAediting_379577chr4_108666914_+intronic
CAediting_379578chr4_108666925_+intronic
CAediting_379579chr4_108666946_+intronic
CAediting_379580chr4_108667615_+UTR3

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_379507chr4_108659140_+SINEAluAluSx3
CAediting_379508chr4_108659162_+SINEAluAluSx3
CAediting_379509chr4_108659204_+SINEAluAluSx3
CAediting_379510chr4_108659219_+SINEAluAluSx3
CAediting_379511chr4_108659232_+SINEAluAluSx3
CAediting_379512chr4_108659242_+SINEAluAluSx3
CAediting_379513chr4_108659513_+SINEAluAluY
CAediting_379514chr4_108659514_+SINEAluAluY
CAediting_379515chr4_108659519_+SINEAluAluY
CAediting_379516chr4_108659530_+SINEAluAluY
CAediting_379517chr4_108659537_+SINEAluAluY
CAediting_379518chr4_108659557_+SINEAluAluY
CAediting_379519chr4_108659565_+SINEAluAluY
CAediting_379520chr4_108659581_+SINEAluAluY
CAediting_379521chr4_108659612_+SINEAluAluY
CAediting_379522chr4_108659626_+SINEAluAluY
CAediting_379523chr4_108659630_+SINEAluAluY
CAediting_379524chr4_108659648_+SINEAluAluY
CAediting_379525chr4_108659654_+SINEAluAluY
CAediting_379526chr4_108659694_+SINEAluAluY
CAediting_379527chr4_108659701_+SINEAluAluY
CAediting_379528chr4_108659780_+SINEAluAluY
CAediting_379529chr4_108659786_+SINEAluAluY
CAediting_379530chr4_108659791_+SINEAluAluY
CAediting_379533chr4_108660945_+SINEAluAluSz
CAediting_379534chr4_108660953_+SINEAluAluSz
CAediting_379535chr4_108660961_+SINEAluAluSz
CAediting_379536chr4_108660962_+SINEAluAluSz
CAediting_379537chr4_108660997_+SINEAluAluSz
CAediting_379538chr4_108661015_+SINEAluAluSz
CAediting_379539chr4_108661052_+SINEAluAluSz
CAediting_379540chr4_108661063_+SINEAluAluSz
CAediting_379541chr4_108661066_+SINEAluAluSz
CAediting_379542chr4_108661067_+SINEAluAluSz
CAediting_379543chr4_108661071_+SINEAluAluSz
CAediting_379544chr4_108661084_+SINEAluAluSz
CAediting_379545chr4_108661097_+SINEAluAluSz
CAediting_379546chr4_108661098_+SINEAluAluSz
CAediting_379547chr4_108661130_+SINEAluAluSz
CAediting_379548chr4_108661135_+SINEAluAluSz
CAediting_379549chr4_108661138_+SINEAluAluSz
CAediting_379550chr4_108661139_+SINEAluAluSz
CAediting_379551chr4_108661143_+SINEAluAluSz
CAediting_379552chr4_108661146_+SINEAluAluSz
CAediting_379553chr4_108661150_+SINEAluAluSz
CAediting_379554chr4_108661163_+SINEAluAluSz
CAediting_379555chr4_108661169_+SINEAluAluSz
CAediting_379556chr4_108661170_+SINEAluAluSz
CAediting_379557chr4_108661188_+SINEAluAluSz
CAediting_379558chr4_108661200_+SINEAluAluSz
CAediting_379559chr4_108661634_+SINEAluAluSz
CAediting_379560chr4_108661637_+SINEAluAluSz
CAediting_379561chr4_108661646_+SINEAluAluSz
CAediting_379562chr4_108661808_+SINEAluAluSz
CAediting_379563chr4_108661873_+SINEAluAluSz
CAediting_379564chr4_108663276_+SINEAluAluY
CAediting_379565chr4_108663305_+SINEAluAluY
CAediting_379566chr4_108663341_+SINEAluAluY
CAediting_379567chr4_108663351_+SINEAluAluY
CAediting_379568chr4_108663471_+SINEAluAluY
CAediting_379569chr4_108664687_+SINEAluAluSc
CAediting_379570chr4_108666524_+SINEAluAluSq2
CAediting_379571chr4_108666590_+SINEAluAluSq2
CAediting_379572chr4_108666591_+SINEAluAluSq2
CAediting_379573chr4_108666773_+SINEAluAluSq2
CAediting_379574chr4_108666811_+SINEAluAluSq2
CAediting_379575chr4_108666884_+SINEAluAluSq2
CAediting_379576chr4_108666885_+SINEAluAluSq2
CAediting_379577chr4_108666914_+SINEAluAluSq2
CAediting_379578chr4_108666925_+SINEAluAluSq2
CAediting_379579chr4_108666946_+SINEAluAluSq2

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RNA A-to-I editing events in the alternative splicing sites for OSTC

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESCAediting_379565chr4_108663305_+108663304:1086633125SS2+0iCAGGTACAT7.79CGGGTACAT4.13
MEX_1CAediting_379565chr4_108663305_+108663304:1086633125SS2+0iCAGGTACAT7.79CGGGTACAT4.13
ESCAediting_379569chr4_108664687_+108664668:1086646903SS0+1iACTGCAATCTCCGCCTCCCAGGT-8.46ACTGCAATCTCCGCCTCCCGGGT0.29
MEX_2CAediting_379569chr4_108664687_+108664668:1086646903SS0+1iACTGCAATCTCCGCCTCCCAGGT-8.46ACTGCAATCTCCGCCTCCCGGGT0.29

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000198856.11.OSTC.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000198856.11.OSTC.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for OSTC

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for OSTC

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for OSTC

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_379580chr4_108667615_+ENSG00000198856.11ENST00000613215hsa-miR-4659a-5p1086676111086676166mer108667596108667617141.00-18.42
CAediting_379580chr4_108667615_+ENSG00000198856.11ENST00000613215hsa-miR-4659b-5p1086676111086676166mer108667599108667617141.00-19.19
CAediting_379580chr4_108667615_+ENSG00000198856.11ENST00000361564hsa-miR-4659a-5p1086676111086676166mer108667596108667617141.00-18.42
CAediting_379580chr4_108667615_+ENSG00000198856.11ENST00000361564hsa-miR-4659b-5p1086676111086676166mer108667599108667617141.00-19.19

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_379580chr4_108667615_+ENSG00000198856.11ENST00000613215hsa-miR-452-3p1086676091086676146mer108667592108667615146-18.35
CAediting_379580chr4_108667615_+ENSG00000198856.11ENST00000613215hsa-miR-513b-3p1086676121086676187mer-m8108667598108667619155-13.88
CAediting_379580chr4_108667615_+ENSG00000198856.11ENST00000361564hsa-miR-452-3p1086676091086676146mer108667592108667615146-18.35
CAediting_379580chr4_108667615_+ENSG00000198856.11ENST00000361564hsa-miR-513b-3p1086676121086676187mer-m8108667598108667619155-13.88

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for OSTC

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000361564.7protein_codingSoverviewSoverview
ENST00000512478.2protein_codingSoverviewSoverview
ENST00000613215.3protein_codingSoverviewSoverview

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
CAediting_379580ENST00000361564.7chr4_108667615_+-293.50-291.90-293.50
CAediting_379564ENST00000512478.2chr4_108663276_+-192.60-191.00-191.80
CAediting_379565ENST00000512478.2chr4_108663305_+-190.50-191.00-191.80
CAediting_379580ENST00000613215.3chr4_108667615_+-240.10-238.40-240.10

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Relation with ADAR for OSTC

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for OSTC

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for OSTC

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for OSTC

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for OSTC

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource