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Editing gene: PYGB (CAeditome ID:5834)

Gene summary for PYGB

Gene summary

Gene information	Gene symbol	PYGB
	Gene ID	5834
	Gene name	glycogen phosphorylase B
	Synonyms	GPBB
	Cytomap	20p11.21
	Type of gene	protein-coding
	Description	glycogen phosphorylase, brain formphosphorylase, glycogen; brain
	Modification date	20210524
	UniProtAcc	P11216
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
PYGB	GO:0005737	Glycogen phosphorylase, brain form	10638593

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RNA A-to-I events for PYGB

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000100994.10

RNA A-to-I editing events in Cancer.

CAediting_1410140(25249953, +), CAediting_1410141(25265445, +), CAediting_1410142(25265472, +), CAediting_1410143(25265476, +), CAediting_1410144(25266508, +), CAediting_1410145(25266520, +), CAediting_1410146(25266755, +), CAediting_1410147(25266772, +), CAediting_1410148(25266776, +), CAediting_1410149(25284489, +), CAediting_1410150(25284498, +), CAediting_1410151(25284527, +), CAediting_1410152(25284534, +), CAediting_1410153(25284538, +), CAediting_1410154(25284539, +), CAediting_1410155(25284552, +), CAediting_1410156(25284560, +), CAediting_1410157(25284564, +), CAediting_1410158(25284609, +), CAediting_1410159(25284615, +), CAediting_1410160(25284623, +), CAediting_1410161(25284634, +), CAediting_1410162(25284635, +), CAediting_1410163(25284661, +), CAediting_1410164(25284687, +), CAediting_1410165(25284688, +), CAediting_1410166(25284689, +), CAediting_1410167(25284706, +), CAediting_1410168(25284718, +), CAediting_1410169(25287381, +), CAediting_1410170(25287390, +), CAediting_1410171(25287435, +), CAediting_1410172(25287458, +), CAediting_1410173(25287459, +), CAediting_1410174(25287461, +), CAediting_1410175(25287462, +), CAediting_1410176(25287463, +), CAediting_1410177(25287545, +), CAediting_1410178(25287550, +), CAediting_1410179(25287551, +), CAediting_1410180(25287560, +), CAediting_1410181(25287711, +), CAediting_1410182(25287722, +), CAediting_1410183(25287725, +), CAediting_1410184(25287779, +), CAediting_1410185(25287780, +), CAediting_1410186(25287781, +), CAediting_1410187(25287793, +), CAediting_1410188(25287794, +), CAediting_1410189(25287798, +), CAediting_1410190(25287800, +), CAediting_1410191(25287802, +), CAediting_1410192(25287803, +), CAediting_1410193(25287804, +), CAediting_1410194(25287850, +), CAediting_1410195(25287858, +), CAediting_1410196(25287866, +), CAediting_1410197(25287870, +), CAediting_1410198(25287874, +), CAediting_1410199(25287877, +), CAediting_1410200(25287901, +), CAediting_1410201(25287902, +), CAediting_1410202(25289412, +), CAediting_1410203(25289430, +), CAediting_1410204(25289449, +), CAediting_1410205(25289455, +), CAediting_1410206(25289467, +), CAediting_1410207(25289469, +), CAediting_1410208(25289474, +), CAediting_1410209(25289525, +), CAediting_1410210(25289531, +), CAediting_1410211(25289535, +), CAediting_1410212(25289583, +),

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RNA editing positional annotations for PYGB using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1410140	chr20_25249953_+	intronic
CAediting_1410141	chr20_25265445_+	intronic
CAediting_1410142	chr20_25265472_+	intronic
CAediting_1410143	chr20_25265476_+	intronic
CAediting_1410144	chr20_25266508_+	intronic
CAediting_1410145	chr20_25266520_+	intronic
CAediting_1410146	chr20_25266755_+	intronic
CAediting_1410147	chr20_25266772_+	intronic
CAediting_1410148	chr20_25266776_+	intronic
CAediting_1410149	chr20_25284489_+	intronic
CAediting_1410150	chr20_25284498_+	intronic
CAediting_1410151	chr20_25284527_+	intronic
CAediting_1410152	chr20_25284534_+	intronic
CAediting_1410153	chr20_25284538_+	intronic
CAediting_1410154	chr20_25284539_+	intronic
CAediting_1410155	chr20_25284552_+	intronic
CAediting_1410156	chr20_25284560_+	intronic
CAediting_1410157	chr20_25284564_+	intronic
CAediting_1410158	chr20_25284609_+	intronic
CAediting_1410159	chr20_25284615_+	intronic
CAediting_1410160	chr20_25284623_+	intronic
CAediting_1410161	chr20_25284634_+	intronic
CAediting_1410162	chr20_25284635_+	intronic
CAediting_1410163	chr20_25284661_+	intronic
CAediting_1410164	chr20_25284687_+	intronic
CAediting_1410165	chr20_25284688_+	intronic
CAediting_1410166	chr20_25284689_+	intronic
CAediting_1410167	chr20_25284706_+	intronic
CAediting_1410168	chr20_25284718_+	intronic
CAediting_1410169	chr20_25287381_+	intronic
CAediting_1410170	chr20_25287390_+	intronic
CAediting_1410171	chr20_25287435_+	intronic
CAediting_1410172	chr20_25287458_+	intronic
CAediting_1410173	chr20_25287459_+	intronic
CAediting_1410174	chr20_25287461_+	intronic
CAediting_1410175	chr20_25287462_+	intronic
CAediting_1410176	chr20_25287463_+	intronic
CAediting_1410177	chr20_25287545_+	intronic
CAediting_1410178	chr20_25287550_+	intronic
CAediting_1410179	chr20_25287551_+	intronic
CAediting_1410180	chr20_25287560_+	intronic
CAediting_1410181	chr20_25287711_+	intronic
CAediting_1410182	chr20_25287722_+	intronic
CAediting_1410183	chr20_25287725_+	intronic
CAediting_1410184	chr20_25287779_+	intronic
CAediting_1410185	chr20_25287780_+	intronic
CAediting_1410186	chr20_25287781_+	intronic
CAediting_1410187	chr20_25287793_+	intronic
CAediting_1410188	chr20_25287794_+	intronic
CAediting_1410189	chr20_25287798_+	intronic
CAediting_1410190	chr20_25287800_+	intronic
CAediting_1410191	chr20_25287802_+	intronic
CAediting_1410192	chr20_25287803_+	intronic
CAediting_1410193	chr20_25287804_+	intronic
CAediting_1410194	chr20_25287850_+	intronic
CAediting_1410195	chr20_25287858_+	intronic
CAediting_1410196	chr20_25287866_+	intronic
CAediting_1410197	chr20_25287870_+	intronic
CAediting_1410198	chr20_25287874_+	intronic
CAediting_1410199	chr20_25287877_+	intronic
CAediting_1410200	chr20_25287901_+	intronic
CAediting_1410201	chr20_25287902_+	intronic
CAediting_1410202	chr20_25289412_+	intronic
CAediting_1410203	chr20_25289430_+	intronic
CAediting_1410204	chr20_25289449_+	intronic
CAediting_1410205	chr20_25289455_+	intronic
CAediting_1410206	chr20_25289467_+	intronic
CAediting_1410207	chr20_25289469_+	intronic
CAediting_1410208	chr20_25289474_+	intronic
CAediting_1410209	chr20_25289525_+	intronic
CAediting_1410210	chr20_25289531_+	intronic
CAediting_1410211	chr20_25289535_+	intronic
CAediting_1410212	chr20_25289583_+	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1410140	chr20_25249953_+	SINE	Alu	AluSx3
CAediting_1410141	chr20_25265445_+	LINE	L1	L1M4
CAediting_1410142	chr20_25265472_+	LINE	L1	L1M4
CAediting_1410143	chr20_25265476_+	LINE	L1	L1M4
CAediting_1410144	chr20_25266508_+	LINE	L1	L1MB5
CAediting_1410145	chr20_25266520_+	LINE	L1	L1MB5
CAediting_1410146	chr20_25266755_+	LINE	L1	L1MB5
CAediting_1410147	chr20_25266772_+	LINE	L1	L1MB5
CAediting_1410148	chr20_25266776_+	LINE	L1	L1MB5
CAediting_1410149	chr20_25284489_+	SINE	Alu	AluJb
CAediting_1410150	chr20_25284498_+	SINE	Alu	AluJb
CAediting_1410151	chr20_25284527_+	SINE	Alu	AluJb
CAediting_1410152	chr20_25284534_+	SINE	Alu	AluJb
CAediting_1410153	chr20_25284538_+	SINE	Alu	AluJb
CAediting_1410154	chr20_25284539_+	SINE	Alu	AluJb
CAediting_1410155	chr20_25284552_+	SINE	Alu	AluJb
CAediting_1410156	chr20_25284560_+	SINE	Alu	AluJb
CAediting_1410157	chr20_25284564_+	SINE	Alu	AluJb
CAediting_1410158	chr20_25284609_+	SINE	Alu	AluJb
CAediting_1410159	chr20_25284615_+	SINE	Alu	AluJb
CAediting_1410160	chr20_25284623_+	SINE	Alu	AluJb
CAediting_1410161	chr20_25284634_+	SINE	Alu	AluJb
CAediting_1410162	chr20_25284635_+	SINE	Alu	AluJb
CAediting_1410163	chr20_25284661_+	SINE	Alu	AluJb
CAediting_1410164	chr20_25284687_+	SINE	Alu	AluJb
CAediting_1410165	chr20_25284688_+	SINE	Alu	AluJb
CAediting_1410166	chr20_25284689_+	SINE	Alu	AluJb
CAediting_1410167	chr20_25284706_+	SINE	Alu	AluJb
CAediting_1410168	chr20_25284718_+	SINE	Alu	AluJb
CAediting_1410169	chr20_25287381_+	SINE	Alu	AluJr
CAediting_1410170	chr20_25287390_+	SINE	Alu	AluJr
CAediting_1410171	chr20_25287435_+	SINE	Alu	AluJr
CAediting_1410172	chr20_25287458_+	SINE	Alu	AluJr
CAediting_1410173	chr20_25287459_+	SINE	Alu	AluJr
CAediting_1410174	chr20_25287461_+	SINE	Alu	AluJr
CAediting_1410175	chr20_25287462_+	SINE	Alu	AluJr
CAediting_1410176	chr20_25287463_+	SINE	Alu	AluJr
CAediting_1410177	chr20_25287545_+	SINE	Alu	AluJr
CAediting_1410178	chr20_25287550_+	SINE	Alu	AluJr
CAediting_1410179	chr20_25287551_+	SINE	Alu	AluJr
CAediting_1410180	chr20_25287560_+	SINE	Alu	AluJr
CAediting_1410181	chr20_25287711_+	SINE	Alu	AluJo
CAediting_1410182	chr20_25287722_+	SINE	Alu	AluJo
CAediting_1410183	chr20_25287725_+	SINE	Alu	AluJo
CAediting_1410184	chr20_25287779_+	SINE	Alu	AluJo
CAediting_1410185	chr20_25287780_+	SINE	Alu	AluJo
CAediting_1410186	chr20_25287781_+	SINE	Alu	AluJo
CAediting_1410187	chr20_25287793_+	SINE	Alu	AluJo
CAediting_1410188	chr20_25287794_+	SINE	Alu	AluJo
CAediting_1410189	chr20_25287798_+	SINE	Alu	AluJo
CAediting_1410190	chr20_25287800_+	SINE	Alu	AluJo
CAediting_1410191	chr20_25287802_+	SINE	Alu	AluJo
CAediting_1410192	chr20_25287803_+	SINE	Alu	AluJo
CAediting_1410193	chr20_25287804_+	SINE	Alu	AluJo
CAediting_1410194	chr20_25287850_+	SINE	Alu	AluJo
CAediting_1410195	chr20_25287858_+	SINE	Alu	AluJo
CAediting_1410196	chr20_25287866_+	SINE	Alu	AluJo
CAediting_1410197	chr20_25287870_+	SINE	Alu	AluJo
CAediting_1410198	chr20_25287874_+	SINE	Alu	AluJo
CAediting_1410199	chr20_25287877_+	SINE	Alu	AluJo
CAediting_1410200	chr20_25287901_+	SINE	Alu	AluJo
CAediting_1410201	chr20_25287902_+	SINE	Alu	AluJo
CAediting_1410202	chr20_25289412_+	SINE	Alu	AluJb
CAediting_1410203	chr20_25289430_+	SINE	Alu	AluJb
CAediting_1410204	chr20_25289449_+	SINE	Alu	AluJb
CAediting_1410205	chr20_25289455_+	SINE	Alu	AluJb
CAediting_1410206	chr20_25289467_+	SINE	Alu	AluJb
CAediting_1410207	chr20_25289469_+	SINE	Alu	AluJb
CAediting_1410208	chr20_25289474_+	SINE	Alu	AluJb
CAediting_1410209	chr20_25289525_+	SINE	Alu	AluJb
CAediting_1410210	chr20_25289531_+	SINE	Alu	AluJb
CAediting_1410211	chr20_25289535_+	SINE	Alu	AluJb
CAediting_1410212	chr20_25289583_+	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for PYGB

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000100994.10.PYGB.

Correlation between RNA A-to-I editing and PSI for ENSG00000100994.10.PYGB.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PYGB

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for PYGB

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for PYGB

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for PYGB

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for PYGB

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
STAD	CAediting_1410162	chr20_25284635_+	.	.	.	.	0.000922797992623741	0.363382067794278

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Relation with cancer stages for PYGB

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for PYGB

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for PYGB

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
PYGB	P11216	DB00114	Pyridoxal phosphate	Glycogen phosphorylase, brain form	SmallMoleculeDrug	approved\|investigational\|nutraceutical

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RelatedDiseases for PYGB

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
PYGB	C0010606	Adenoid Cystic Carcinoma	1	CTD_human
PYGB	C0036095	Salivary Gland Neoplasms	1	CTD_human
PYGB	C0151744	Myocardial Ischemia	1	CTD_human
PYGB	C0220636	Malignant neoplasm of salivary gland	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene