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Editing gene: PEX2 (CAeditome ID:5828)

Gene summary for PEX2

Gene summary

Gene information	Gene symbol	PEX2
	Gene ID	5828
	Gene name	peroxisomal biogenesis factor 2
	Synonyms	PAF1\|PBD5A\|PBD5B\|PMP3\|PMP35\|PXMP3\|RNF72\|ZWS3
	Cytomap	8q21.13
	Type of gene	protein-coding
	Description	peroxisome biogenesis factor 235 kDa peroxisomal membrane proteinRING finger protein 72peroxisomal membrane protein 3, 35kDaperoxisome assembly factor 1
	Modification date	20210518
	UniProtAcc	P28328
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
PEX2	GO:0016593	Peroxisome biogenesis factor 2	18987311

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RNA A-to-I events for PEX2

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000164751.13

RNA A-to-I editing events in Cancer.

CAediting_646943(76981214, -), CAediting_646944(76981555, -), CAediting_646945(76981589, -), CAediting_646946(76981590, -), CAediting_646947(76981592, -), CAediting_646948(76981595, -), CAediting_646949(76982542, -), CAediting_646950(76982555, -), CAediting_646951(76982567, -), CAediting_646952(76982569, -), CAediting_646953(76982577, -), CAediting_646954(76982586, -), CAediting_646955(76982618, -), CAediting_646956(76982622, -), CAediting_646957(76982646, -), CAediting_646958(76982652, -), CAediting_646959(76982660, -), CAediting_646960(76982697, -), CAediting_646961(76982709, -), CAediting_646962(76982726, -), CAediting_646963(76982747, -), CAediting_646964(76982762, -), CAediting_646965(76982776, -), CAediting_646966(76982783, -),

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RNA editing positional annotations for PEX2 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_646943	chr8_76981214_-	UTR3
CAediting_646944	chr8_76981555_-	UTR3
CAediting_646945	chr8_76981589_-	UTR3
CAediting_646946	chr8_76981590_-	UTR3
CAediting_646947	chr8_76981592_-	UTR3
CAediting_646948	chr8_76981595_-	UTR3
CAediting_646949	chr8_76982542_-	UTR3
CAediting_646950	chr8_76982555_-	UTR3
CAediting_646951	chr8_76982567_-	UTR3
CAediting_646952	chr8_76982569_-	UTR3
CAediting_646953	chr8_76982577_-	UTR3
CAediting_646954	chr8_76982586_-	UTR3
CAediting_646955	chr8_76982618_-	UTR3
CAediting_646956	chr8_76982622_-	UTR3
CAediting_646957	chr8_76982646_-	UTR3
CAediting_646958	chr8_76982652_-	UTR3
CAediting_646959	chr8_76982660_-	UTR3
CAediting_646960	chr8_76982697_-	UTR3
CAediting_646961	chr8_76982709_-	UTR3
CAediting_646962	chr8_76982726_-	UTR3
CAediting_646963	chr8_76982747_-	UTR3
CAediting_646964	chr8_76982762_-	UTR3
CAediting_646965	chr8_76982776_-	UTR3
CAediting_646966	chr8_76982783_-	UTR3

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_646943	chr8_76981214_-	SINE	Alu	AluJb
CAediting_646944	chr8_76981555_-	SINE	Alu	AluJo
CAediting_646945	chr8_76981589_-	SINE	Alu	AluJo
CAediting_646946	chr8_76981590_-	SINE	Alu	AluJo
CAediting_646947	chr8_76981592_-	SINE	Alu	AluJo
CAediting_646948	chr8_76981595_-	SINE	Alu	AluJo
CAediting_646949	chr8_76982542_-	SINE	Alu	AluSc8
CAediting_646950	chr8_76982555_-	SINE	Alu	AluSc8
CAediting_646951	chr8_76982567_-	SINE	Alu	AluSc8
CAediting_646952	chr8_76982569_-	SINE	Alu	AluSc8
CAediting_646953	chr8_76982577_-	SINE	Alu	AluSc8
CAediting_646954	chr8_76982586_-	SINE	Alu	AluSc8
CAediting_646955	chr8_76982618_-	SINE	Alu	AluSc8
CAediting_646956	chr8_76982622_-	SINE	Alu	AluSc8
CAediting_646957	chr8_76982646_-	SINE	Alu	AluSc8
CAediting_646958	chr8_76982652_-	SINE	Alu	AluSc8
CAediting_646959	chr8_76982660_-	SINE	Alu	AluSc8
CAediting_646960	chr8_76982697_-	SINE	Alu	AluSc8
CAediting_646961	chr8_76982709_-	SINE	Alu	AluSc8
CAediting_646962	chr8_76982726_-	SINE	Alu	AluSc8
CAediting_646963	chr8_76982747_-	SINE	Alu	AluSc8
CAediting_646964	chr8_76982762_-	SINE	Alu	AluSc8
CAediting_646965	chr8_76982776_-	SINE	Alu	AluSc8
CAediting_646966	chr8_76982783_-	SINE	Alu	AluSc8

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RNA A-to-I editing events in the alternative splicing sites for PEX2

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000164751.13.PEX2.

Correlation between RNA A-to-I editing and PSI for ENSG00000164751.13.PEX2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PEX2

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for PEX2

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for PEX2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_646956	chr8_76982622_-	ENSG00000164751.13	ENST00000357039	hsa-miR-3190-5p	76982617	76982623	7mer-m8	76982616	76982634	148.00	-20.60
CAediting_646956	chr8_76982622_-	ENSG00000164751.13	ENST00000357039	hsa-miR-548s	76982618	76982624	7mer-m8	76982617	76982639	149.00	-16.48
CAediting_646944	chr8_76981555_-	ENSG00000164751.13	ENST00000357039	hsa-miR-5697	76981555	76981561	7mer-m8	76981554	76981575	140.00	-10.68
CAediting_646945	chr8_76981589_-	ENSG00000164751.13	ENST00000357039	hsa-miR-4252	76981585	76981591	7mer-m8	76981584	76981603	160.00	-25.30
CAediting_646945	chr8_76981589_-	ENSG00000164751.13	ENST00000357039	hsa-miR-5008-3p	76981589	76981595	7mer-m8	76981588	76981605	146.00	-17.64
CAediting_646945	chr8_76981589_-	ENSG00000164751.13	ENST00000357039	hsa-miR-7157-3p	76981589	76981595	7mer-m8	76981588	76981608	146.00	-14.66
CAediting_646950	chr8_76982555_-	ENSG00000164751.13	ENST00000357039	hsa-miR-106a-3p	76982553	76982558	6mer	76982552	76982573	145.00	-21.13
CAediting_646951	chr8_76982567_-	ENSG00000164751.13	ENST00000357039	hsa-miR-3189-3p	76982566	76982572	7mer-m8	76982565	76982588	157.00	-27.21
CAediting_646951	chr8_76982567_-	ENSG00000164751.13	ENST00000357039	hsa-miR-6813-3p	76982565	76982571	7mer-m8	76982564	76982584	140.00	-12.88
CAediting_646952	chr8_76982569_-	ENSG00000164751.13	ENST00000357039	hsa-miR-6771-5p	76982567	76982574	8mer-1a	76982567	76982586	152.00	-27.57
CAediting_646958	chr8_76982652_-	ENSG00000164751.13	ENST00000357039	hsa-miR-4801	76982651	76982656	6mer	76982650	76982672	146.00	-18.71
CAediting_646959	chr8_76982660_-	ENSG00000164751.13	ENST00000357039	hsa-miR-548ae-3p	76982655	76982661	7mer-m8	76982654	76982674	146.00	-12.43
CAediting_646959	chr8_76982660_-	ENSG00000164751.13	ENST00000357039	hsa-miR-548ae-3p	76982655	76982661	7mer-m8	76982654	76982674	146.00	-12.43
CAediting_646959	chr8_76982660_-	ENSG00000164751.13	ENST00000357039	hsa-miR-548ah-3p	76982655	76982661	7mer-m8	76982654	76982675	146.00	-12.43
CAediting_646959	chr8_76982660_-	ENSG00000164751.13	ENST00000357039	hsa-miR-548aj-3p	76982655	76982661	7mer-m8	76982654	76982674	146.00	-10.32
CAediting_646959	chr8_76982660_-	ENSG00000164751.13	ENST00000357039	hsa-miR-548aj-3p	76982655	76982661	7mer-m8	76982654	76982674	146.00	-10.32
CAediting_646959	chr8_76982660_-	ENSG00000164751.13	ENST00000357039	hsa-miR-548am-3p	76982655	76982661	7mer-m8	76982654	76982675	146.00	-12.43
CAediting_646959	chr8_76982660_-	ENSG00000164751.13	ENST00000357039	hsa-miR-548aq-3p	76982655	76982661	7mer-m8	76982654	76982675	146.00	-12.43
CAediting_646959	chr8_76982660_-	ENSG00000164751.13	ENST00000357039	hsa-miR-548j-3p	76982655	76982661	7mer-m8	76982654	76982674	146.00	-12.43
CAediting_646959	chr8_76982660_-	ENSG00000164751.13	ENST00000357039	hsa-miR-548x-3p	76982655	76982661	7mer-m8	76982654	76982673	146.00	-10.32
CAediting_646959	chr8_76982660_-	ENSG00000164751.13	ENST00000357039	hsa-miR-548x-3p	76982655	76982661	7mer-m8	76982654	76982673	146.00	-10.32
CAediting_646960	chr8_76982697_-	ENSG00000164751.13	ENST00000357039	hsa-miR-4691-3p	76982693	76982699	7mer-m8	76982692	76982719	150.00	-26.36
CAediting_646962	chr8_76982726_-	ENSG00000164751.13	ENST00000357039	hsa-miR-4539	76982726	76982731	6mer	76982725	76982744	141.00	-23.42
CAediting_646966	chr8_76982783_-	ENSG00000164751.13	ENST00000357039	hsa-miR-3940-3p	76982779	76982785	7mer-m8	76982778	76982799	155.00	-22.47
CAediting_646954	chr8_76982586_-	ENSG00000164751.13	ENST00000357039	hsa-miR-3937	76982582	76982588	7mer-m8	76982581	76982603	150.00	-23.25

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_646954	chr8_76982586_-	ENSG00000164751.13	ENST00000357039	hsa-miR-12114	76982583	76982589	7mer-m8	76982582	76982600	140	-22.11
CAediting_646966	chr8_76982783_-	ENSG00000164751.13	ENST00000357039	hsa-miR-1262	76982783	76982789	7mer-m8	76982782	76982803	146	-19.1
CAediting_646952	chr8_76982569_-	ENSG00000164751.13	ENST00000357039	hsa-miR-1273h-5p	76982568	76982575	8mer-1a	76982568	76982588	149	-22.56
CAediting_646949	chr8_76982542_-	ENSG00000164751.13	ENST00000357039	hsa-miR-128-3p	76982537	76982543	7mer-m8	76982536	76982557	150	-15.77
CAediting_646949	chr8_76982542_-	ENSG00000164751.13	ENST00000357039	hsa-miR-128-3p	76982537	76982543	7mer-m8	76982536	76982557	150	-15.77
CAediting_646955	chr8_76982618_-	ENSG00000164751.13	ENST00000357039	hsa-miR-3064-5p	76982617	76982622	6mer	76982616	76982636	143	-21.6
CAediting_646956	chr8_76982622_-	ENSG00000164751.13	ENST00000357039	hsa-miR-3064-5p	76982617	76982622	6mer	76982616	76982636	143	-21.6
CAediting_646952	chr8_76982569_-	ENSG00000164751.13	ENST00000357039	hsa-miR-30b-3p	76982568	76982575	8mer-1a	76982568	76982589	155	-20.3
CAediting_646954	chr8_76982586_-	ENSG00000164751.13	ENST00000357039	hsa-miR-3165	76982584	76982590	7mer-m8	76982583	76982605	144	-15.11
CAediting_646954	chr8_76982586_-	ENSG00000164751.13	ENST00000357039	hsa-miR-3665	76982581	76982587	7mer-m8	76982580	76982597	140	-18.39
CAediting_646949	chr8_76982542_-	ENSG00000164751.13	ENST00000357039	hsa-miR-3681-3p	76982537	76982543	7mer-m8	76982536	76982557	154	-16.39
CAediting_646950	chr8_76982555_-	ENSG00000164751.13	ENST00000357039	hsa-miR-3686	76982551	76982557	7mer-m8	76982550	76982571	140	-11.18
CAediting_646952	chr8_76982569_-	ENSG00000164751.13	ENST00000357039	hsa-miR-3689a-3p	76982568	76982575	8mer-1a	76982568	76982589	149	-23.39
CAediting_646952	chr8_76982569_-	ENSG00000164751.13	ENST00000357039	hsa-miR-3689b-3p	76982568	76982575	8mer-1a	76982568	76982589	149	-23.44
CAediting_646952	chr8_76982569_-	ENSG00000164751.13	ENST00000357039	hsa-miR-3689c	76982568	76982575	8mer-1a	76982568	76982589	149	-23.44
CAediting_646945	chr8_76981589_-	ENSG00000164751.13	ENST00000357039	hsa-miR-4289	76981587	76981593	7mer-m8	76981586	76981604	153	-15.56
CAediting_646946	chr8_76981590_-	ENSG00000164751.13	ENST00000357039	hsa-miR-4289	76981587	76981593	7mer-m8	76981586	76981604	153	-15.56
CAediting_646947	chr8_76981592_-	ENSG00000164751.13	ENST00000357039	hsa-miR-4289	76981587	76981593	7mer-m8	76981586	76981604	153	-15.56
CAediting_646961	chr8_76982709_-	ENSG00000164751.13	ENST00000357039	hsa-miR-4478	76982705	76982711	7mer-m8	76982704	76982719	149	-25.05
CAediting_646953	chr8_76982577_-	ENSG00000164751.13	ENST00000357039	hsa-miR-4478	76982573	76982579	7mer-m8	76982572	76982587	145	-20.53
CAediting_646961	chr8_76982709_-	ENSG00000164751.13	ENST00000357039	hsa-miR-4649-3p	76982708	76982714	7mer-m8	76982707	76982727	140	-14.11
CAediting_646966	chr8_76982783_-	ENSG00000164751.13	ENST00000357039	hsa-miR-4701-3p	76982783	76982789	7mer-m8	76982782	76982800	151	-19.98
CAediting_646955	chr8_76982618_-	ENSG00000164751.13	ENST00000357039	hsa-miR-4794	76982617	76982623	7mer-m8	76982616	76982637	152	-19.2
CAediting_646956	chr8_76982622_-	ENSG00000164751.13	ENST00000357039	hsa-miR-4794	76982617	76982623	7mer-m8	76982616	76982637	152	-19.2
CAediting_646965	chr8_76982776_-	ENSG00000164751.13	ENST00000357039	hsa-miR-508-5p	76982774	76982780	7mer-m8	76982773	76982795	150	-20.08
CAediting_646960	chr8_76982697_-	ENSG00000164751.13	ENST00000357039	hsa-miR-5690	76982693	76982699	7mer-m8	76982692	76982712	145	-16.75
CAediting_646949	chr8_76982542_-	ENSG00000164751.13	ENST00000357039	hsa-miR-5693	76982539	76982545	7mer-m8	76982538	76982559	150	-20.61
CAediting_646965	chr8_76982776_-	ENSG00000164751.13	ENST00000357039	hsa-miR-6512-3p	76982776	76982782	7mer-m8	76982775	76982796	142	-19.67
CAediting_646963	chr8_76982747_-	ENSG00000164751.13	ENST00000357039	hsa-miR-6516-5p	76982746	76982752	7mer-m8	76982745	76982767	152	-16.77
CAediting_646964	chr8_76982762_-	ENSG00000164751.13	ENST00000357039	hsa-miR-6529-5p	76982757	76982763	7mer-m8	76982756	76982776	148	-16.73
CAediting_646966	chr8_76982783_-	ENSG00000164751.13	ENST00000357039	hsa-miR-661	76982780	76982786	7mer-m8	76982779	76982802	154	-22.7
CAediting_646955	chr8_76982618_-	ENSG00000164751.13	ENST00000357039	hsa-miR-664a-5p	76982617	76982623	7mer-m8	76982616	76982638	148	-14.15
CAediting_646956	chr8_76982622_-	ENSG00000164751.13	ENST00000357039	hsa-miR-664a-5p	76982617	76982623	7mer-m8	76982616	76982638	148	-14.15
CAediting_646965	chr8_76982776_-	ENSG00000164751.13	ENST00000357039	hsa-miR-6720-5p	76982776	76982782	7mer-m8	76982775	76982796	152	-27.68
CAediting_646966	chr8_76982783_-	ENSG00000164751.13	ENST00000357039	hsa-miR-6736-5p	76982783	76982789	7mer-m8	76982782	76982804	148	-24.14
CAediting_646966	chr8_76982783_-	ENSG00000164751.13	ENST00000357039	hsa-miR-6742-3p	76982781	76982787	7mer-m8	76982780	76982799	140	-14.14
CAediting_646952	chr8_76982569_-	ENSG00000164751.13	ENST00000357039	hsa-miR-6779-5p	76982568	76982575	8mer-1a	76982568	76982591	146	-20.46
CAediting_646961	chr8_76982709_-	ENSG00000164751.13	ENST00000357039	hsa-miR-7160-5p	76982707	76982713	7mer-m8	76982706	76982726	147	-20.02
CAediting_646965	chr8_76982776_-	ENSG00000164751.13	ENST00000357039	hsa-miR-766-3p	76982775	76982781	7mer-m8	76982774	76982795	145	-20.72
CAediting_646952	chr8_76982569_-	ENSG00000164751.13	ENST00000357039	hsa-miR-887-5p	76982567	76982574	8mer-1a	76982567	76982586	143	-15.14

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1229414	chr17_67471546_+	ENSG00000164751.13	ENST00000357039	hsa-miR-548aa	76981269	76981275	7mer-m8	76981268	76981292	140	-12.14
CAediting_1229415	chr17_67471547_+	ENSG00000164751.13	ENST00000357039	hsa-miR-548aa	76982442	76982449	8mer-1a	76982442	76982466	140	-9
CAediting_1160181	chr17_7017644_-	ENSG00000164751.13	ENST00000357039	hsa-miR-195-3p	76982143	76982150	8mer-1a	76982143	76982167	150	-12.07
CAediting_1160181	chr17_7017644_-	ENSG00000164751.13	ENST00000357039	hsa-miR-195-3p	76980303	76980309	7mer-m8	76980302	76980323	142	-9.93
CAediting_580943	chr7_100356700_+	ENSG00000164751.13	ENST00000357039	hsa-miR-6840-3p	76982731	76982737	7mer-m8	76982730	76982751	140	-25.68
CAediting_604450	chr7_133034877_-	ENSG00000164751.13	ENST00000357039	hsa-miR-3654	76981040	76981046	7mer-m8	76981039	76981057	140	-14.09
CAediting_524911	chr7_5495852_-	ENSG00000164751.13	ENST00000357039	hsa-miR-589-3p	76982790	76982796	7mer-m8	76982789	76982813	158	-22.45

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1160181	chr17_7017644_-	ENSG00000164751.13	ENST00000357039	hsa-miR-195-3p	76982302	76982309	8mer-1a	76982302	76982323	155	-10.21
CAediting_393	chr1_1167164_+	ENSG00000164751.13	ENST00000357039	hsa-miR-200b-3p	76980752	76980759	8mer-1a	76980752	76980775	149	-10.41

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for PEX2

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000357039.7	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_646943	ENST00000357039.7	chr8_76981214_-	-1236.80	-1234.70	-1270.60
CAediting_646944	ENST00000357039.7	chr8_76981555_-	-1234.70	-1234.70	-1270.60
CAediting_646945	ENST00000357039.7	chr8_76981589_-	-1240.30	-1234.70	-1270.60
CAediting_646946	ENST00000357039.7	chr8_76981590_-	-1235.10	-1234.70	-1270.60
CAediting_646947	ENST00000357039.7	chr8_76981592_-	-1238.90	-1234.70	-1270.60
CAediting_646948	ENST00000357039.7	chr8_76981595_-	-1241.00	-1234.70	-1270.60
CAediting_646949	ENST00000357039.7	chr8_76982542_-	-1234.10	-1234.70	-1270.60
CAediting_646950	ENST00000357039.7	chr8_76982555_-	-1236.70	-1234.70	-1270.60
CAediting_646951	ENST00000357039.7	chr8_76982567_-	-1236.70	-1234.70	-1270.60
CAediting_646952	ENST00000357039.7	chr8_76982569_-	-1234.70	-1234.70	-1270.60
CAediting_646953	ENST00000357039.7	chr8_76982577_-	-1234.10	-1234.70	-1270.60
CAediting_646954	ENST00000357039.7	chr8_76982586_-	-1234.30	-1234.70	-1270.60
CAediting_646955	ENST00000357039.7	chr8_76982618_-	-1235.80	-1234.70	-1270.60
CAediting_646956	ENST00000357039.7	chr8_76982622_-	-1239.70	-1234.70	-1270.60
CAediting_646957	ENST00000357039.7	chr8_76982646_-	-1236.20	-1234.70	-1270.60
CAediting_646958	ENST00000357039.7	chr8_76982652_-	-1234.90	-1234.70	-1270.60
CAediting_646959	ENST00000357039.7	chr8_76982660_-	-1235.70	-1234.70	-1270.60
CAediting_646960	ENST00000357039.7	chr8_76982697_-	-1238.40	-1234.70	-1270.60
CAediting_646961	ENST00000357039.7	chr8_76982709_-	-1236.10	-1234.70	-1270.60
CAediting_646962	ENST00000357039.7	chr8_76982726_-	-1238.20	-1234.70	-1270.60
CAediting_646963	ENST00000357039.7	chr8_76982747_-	-1234.70	-1234.70	-1270.60
CAediting_646964	ENST00000357039.7	chr8_76982762_-	-1236.60	-1234.70	-1270.60
CAediting_646965	ENST00000357039.7	chr8_76982776_-	-1234.50	-1234.70	-1270.60
CAediting_646966	ENST00000357039.7	chr8_76982783_-	-1238.40	-1234.70	-1270.60

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Relation with ADAR for PEX2

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
BLCA	CAediting_646956	chr8_76982622_-	.	.	0.0441978513753405	0.224208564460226	.	.
LUAD	CAediting_646956	chr8_76982622_-	0.0221651388606614	0.192552054256332	.	.	.	.
STAD	CAediting_646956	chr8_76982622_-	.	.	4.48901848596171e-07	0.374554611709866	.	.
UCEC	CAediting_646956	chr8_76982622_-	.	.	0.0179939863228374	0.22523115188713	.	.
ESCA	CAediting_646956	chr8_76982622_-	0.00065575787053598	0.360283910831535	.	.	.	.

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Relation with cancer stages for PEX2

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for PEX2

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
COAD	CAediting_646956	chr8_76982622_-	0.0147744849788086	0.00602511	2775080

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RelatedDrugs for PEX2

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for PEX2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
PEX2	C3553940	PEROXISOME BIOGENESIS DISORDER 5A (ZELLWEGER)	6	CTD_human;GENOMICS_ENGLAND
PEX2	C3542026	PEROXISOME BIOGENESIS DISORDER 5B	5	CTD_human;GENOMICS_ENGLAND;UNIPROT
PEX2	C1832200	Peroxisome biogenesis disorders	3	CTD_human;GENOMICS_ENGLAND
PEX2	C0043459	Zellweger Syndrome	1	CTD_human;GENOMICS_ENGLAND
PEX2	C0282527	Infantile Refsum Disease (disorder)	1	CTD_human;GENOMICS_ENGLAND;ORPHANET
PEX2	C0751594	Zellweger-Like Syndrome	1	CTD_human
PEX2	C3658299	Zellweger Spectrum	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene