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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: PURB (CAeditome ID:5814)

Gene summary for PURB

check button Gene summary
Gene informationGene symbol

PURB

Gene ID

5814

Gene namepurine rich element binding protein B
SynonymsPURBETA
Cytomap

7p13

Type of geneprotein-coding
Descriptiontranscriptional activator protein Pur-beta
Modification date20210518
UniProtAcc

Q96QR8

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
PURB

GO:0005654

Transcriptional activator protein Pur-beta

0000052


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RNA A-to-I events for PURB

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000146676.6
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_542691(44877540, -), CAediting_542692(44877544, -), CAediting_542693(44877546, -), CAediting_542694(44877550, -), CAediting_542695(44877557, -), CAediting_542696(44877558, -), CAediting_542697(44877559, -), CAediting_542698(44877560, -), CAediting_542699(44877568, -), CAediting_542700(44877591, -), CAediting_542701(44877599, -), CAediting_542702(44877611, -), CAediting_542703(44877623, -), CAediting_542704(44877633, -), CAediting_542705(44877640, -), CAediting_542706(44877646, -), CAediting_542707(44877655, -), CAediting_542708(44877660, -), CAediting_542709(44877676, -), CAediting_542710(44877679, -), CAediting_542711(44877680, -), CAediting_542712(44877682, -), CAediting_542713(44877692, -), CAediting_542714(44877695, -), CAediting_542715(44877696, -), CAediting_542716(44877704, -), CAediting_542717(44877717, -), CAediting_542718(44877721, -), CAediting_542719(44877741, -), CAediting_542720(44877742, -), CAediting_542721(44877747, -), CAediting_542722(44877752, -), CAediting_542723(44877757, -), CAediting_542724(44877807, -), CAediting_542725(44878045, -), CAediting_542726(44879071, -), CAediting_542727(44879073, -), CAediting_542728(44879108, -), CAediting_542729(44879109, -), CAediting_542730(44879113, -), CAediting_542731(44879129, -), CAediting_542732(44879137, -), CAediting_542733(44879138, -), CAediting_542734(44879152, -), CAediting_542735(44879162, -), CAediting_542736(44879169, -), CAediting_542737(44879173, -), CAediting_542738(44879179, -), CAediting_542739(44879187, -), CAediting_542740(44879205, -), CAediting_542741(44879209, -), CAediting_542742(44879210, -), CAediting_542743(44879214, -), CAediting_542744(44879216, -), CAediting_542745(44879217, -), CAediting_542746(44879218, -), CAediting_542747(44879219, -), CAediting_542748(44879223, -), CAediting_542749(44879234, -), CAediting_542750(44879235, -), CAediting_542751(44879236, -), CAediting_542752(44879244, -), CAediting_542753(44879245, -), CAediting_542754(44879259, -), CAediting_542755(44879291, -), CAediting_542756(44879294, -), CAediting_542757(44879299, -), CAediting_542758(44879300, -), CAediting_542759(44880792, -),

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RNA editing positional annotations for PURB using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_542691chr7_44877540_-UTR3
CAediting_542692chr7_44877544_-UTR3
CAediting_542693chr7_44877546_-UTR3
CAediting_542694chr7_44877550_-UTR3
CAediting_542695chr7_44877557_-UTR3
CAediting_542696chr7_44877558_-UTR3
CAediting_542697chr7_44877559_-UTR3
CAediting_542698chr7_44877560_-UTR3
CAediting_542699chr7_44877568_-UTR3
CAediting_542700chr7_44877591_-UTR3
CAediting_542701chr7_44877599_-UTR3
CAediting_542702chr7_44877611_-UTR3
CAediting_542703chr7_44877623_-UTR3
CAediting_542704chr7_44877633_-UTR3
CAediting_542705chr7_44877640_-UTR3
CAediting_542706chr7_44877646_-UTR3
CAediting_542707chr7_44877655_-UTR3
CAediting_542708chr7_44877660_-UTR3
CAediting_542709chr7_44877676_-UTR3
CAediting_542710chr7_44877679_-UTR3
CAediting_542711chr7_44877680_-UTR3
CAediting_542712chr7_44877682_-UTR3
CAediting_542713chr7_44877692_-UTR3
CAediting_542714chr7_44877695_-UTR3
CAediting_542715chr7_44877696_-UTR3
CAediting_542716chr7_44877704_-UTR3
CAediting_542717chr7_44877717_-UTR3
CAediting_542718chr7_44877721_-UTR3
CAediting_542719chr7_44877741_-UTR3
CAediting_542720chr7_44877742_-UTR3
CAediting_542721chr7_44877747_-UTR3
CAediting_542722chr7_44877752_-UTR3
CAediting_542723chr7_44877757_-UTR3
CAediting_542724chr7_44877807_-UTR3
CAediting_542725chr7_44878045_-UTR3
CAediting_542726chr7_44879071_-UTR3
CAediting_542727chr7_44879073_-UTR3
CAediting_542728chr7_44879108_-UTR3
CAediting_542729chr7_44879109_-UTR3
CAediting_542730chr7_44879113_-UTR3
CAediting_542731chr7_44879129_-UTR3
CAediting_542732chr7_44879137_-UTR3
CAediting_542733chr7_44879138_-UTR3
CAediting_542734chr7_44879152_-UTR3
CAediting_542735chr7_44879162_-UTR3
CAediting_542736chr7_44879169_-UTR3
CAediting_542737chr7_44879173_-UTR3
CAediting_542738chr7_44879179_-UTR3
CAediting_542739chr7_44879187_-UTR3
CAediting_542740chr7_44879205_-UTR3
CAediting_542741chr7_44879209_-UTR3
CAediting_542742chr7_44879210_-UTR3
CAediting_542743chr7_44879214_-UTR3
CAediting_542744chr7_44879216_-UTR3
CAediting_542745chr7_44879217_-UTR3
CAediting_542746chr7_44879218_-UTR3
CAediting_542747chr7_44879219_-UTR3
CAediting_542748chr7_44879223_-UTR3
CAediting_542749chr7_44879234_-UTR3
CAediting_542750chr7_44879235_-UTR3
CAediting_542751chr7_44879236_-UTR3
CAediting_542752chr7_44879244_-UTR3
CAediting_542753chr7_44879245_-UTR3
CAediting_542754chr7_44879259_-UTR3
CAediting_542755chr7_44879291_-UTR3
CAediting_542756chr7_44879294_-UTR3
CAediting_542757chr7_44879299_-UTR3
CAediting_542758chr7_44879300_-UTR3
CAediting_542759chr7_44880792_-UTR3

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_542691chr7_44877540_-SINEAluAluSz
CAediting_542692chr7_44877544_-SINEAluAluSz
CAediting_542693chr7_44877546_-SINEAluAluSz
CAediting_542694chr7_44877550_-SINEAluAluSz
CAediting_542695chr7_44877557_-SINEAluAluSz
CAediting_542696chr7_44877558_-SINEAluAluSz
CAediting_542697chr7_44877559_-SINEAluAluSz
CAediting_542698chr7_44877560_-SINEAluAluSz
CAediting_542699chr7_44877568_-SINEAluAluSz
CAediting_542700chr7_44877591_-SINEAluAluSz
CAediting_542701chr7_44877599_-SINEAluAluSz
CAediting_542702chr7_44877611_-SINEAluAluSz
CAediting_542703chr7_44877623_-SINEAluAluSz
CAediting_542704chr7_44877633_-SINEAluAluSz
CAediting_542705chr7_44877640_-SINEAluAluSz
CAediting_542706chr7_44877646_-SINEAluAluSz
CAediting_542707chr7_44877655_-SINEAluAluSz
CAediting_542708chr7_44877660_-SINEAluAluSz
CAediting_542709chr7_44877676_-SINEAluAluSz
CAediting_542710chr7_44877679_-SINEAluAluSz
CAediting_542711chr7_44877680_-SINEAluAluSz
CAediting_542712chr7_44877682_-SINEAluAluSz
CAediting_542713chr7_44877692_-SINEAluAluSz
CAediting_542714chr7_44877695_-SINEAluAluSz
CAediting_542715chr7_44877696_-SINEAluAluSz
CAediting_542716chr7_44877704_-SINEAluAluSz
CAediting_542717chr7_44877717_-SINEAluAluSz
CAediting_542718chr7_44877721_-SINEAluAluSz
CAediting_542719chr7_44877741_-SINEAluAluSz
CAediting_542720chr7_44877742_-SINEAluAluSz
CAediting_542721chr7_44877747_-SINEAluAluSz
CAediting_542722chr7_44877752_-SINEAluAluSz
CAediting_542723chr7_44877757_-SINEAluAluSz
CAediting_542724chr7_44877807_-SINEAluAluSz
CAediting_542726chr7_44879071_-SINEAluAluSg
CAediting_542727chr7_44879073_-SINEAluAluSg
CAediting_542728chr7_44879108_-SINEAluAluSg
CAediting_542729chr7_44879109_-SINEAluAluSg
CAediting_542730chr7_44879113_-SINEAluAluSg
CAediting_542731chr7_44879129_-SINEAluAluSg
CAediting_542732chr7_44879137_-SINEAluAluSg
CAediting_542733chr7_44879138_-SINEAluAluSg
CAediting_542734chr7_44879152_-SINEAluAluSg
CAediting_542735chr7_44879162_-SINEAluAluSg
CAediting_542736chr7_44879169_-SINEAluAluSg
CAediting_542737chr7_44879173_-SINEAluAluSg
CAediting_542738chr7_44879179_-SINEAluAluSg
CAediting_542739chr7_44879187_-SINEAluAluSg
CAediting_542740chr7_44879205_-SINEAluAluSg
CAediting_542741chr7_44879209_-SINEAluAluSg
CAediting_542742chr7_44879210_-SINEAluAluSg
CAediting_542743chr7_44879214_-SINEAluAluSg
CAediting_542744chr7_44879216_-SINEAluAluSg
CAediting_542745chr7_44879217_-SINEAluAluSg
CAediting_542746chr7_44879218_-SINEAluAluSg
CAediting_542747chr7_44879219_-SINEAluAluSg
CAediting_542748chr7_44879223_-SINEAluAluSg
CAediting_542749chr7_44879234_-SINEAluAluSg
CAediting_542750chr7_44879235_-SINEAluAluSg
CAediting_542751chr7_44879236_-SINEAluAluSg
CAediting_542752chr7_44879244_-SINEAluAluSg
CAediting_542753chr7_44879245_-SINEAluAluSg
CAediting_542754chr7_44879259_-SINEAluAluSg
CAediting_542755chr7_44879291_-SINEAluAluSg
CAediting_542756chr7_44879294_-SINEAluAluSg
CAediting_542757chr7_44879299_-SINEAluAluSg
CAediting_542758chr7_44879300_-SINEAluAluSg

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RNA A-to-I editing events in the alternative splicing sites for PURB

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000146676.6.PURB.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000146676.6.PURB.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PURB

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for PURB

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for PURB

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for PURB

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000395699.3protein_codingSoverviewSoverview

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
CAediting_542691ENST00000395699.3chr7_44877540_--2864.00-2858.20-2909.90
CAediting_542692ENST00000395699.3chr7_44877544_--2857.50-2858.20-2909.90
CAediting_542693ENST00000395699.3chr7_44877546_--2858.20-2858.20-2909.90
CAediting_542694ENST00000395699.3chr7_44877550_--2865.10-2858.20-2909.90
CAediting_542695ENST00000395699.3chr7_44877557_--2864.00-2858.20-2909.90
CAediting_542696ENST00000395699.3chr7_44877558_--2859.60-2858.20-2909.90
CAediting_542697ENST00000395699.3chr7_44877559_--2864.20-2858.20-2909.90
CAediting_542698ENST00000395699.3chr7_44877560_--2857.50-2858.20-2909.90
CAediting_542699ENST00000395699.3chr7_44877568_--2857.50-2858.20-2909.90
CAediting_542700ENST00000395699.3chr7_44877591_--2857.60-2858.20-2909.90
CAediting_542701ENST00000395699.3chr7_44877599_--2859.80-2858.20-2909.90
CAediting_542702ENST00000395699.3chr7_44877611_--2857.50-2858.20-2909.90
CAediting_542703ENST00000395699.3chr7_44877623_--2857.80-2858.20-2909.90
CAediting_542704ENST00000395699.3chr7_44877633_--2857.60-2858.20-2909.90
CAediting_542705ENST00000395699.3chr7_44877640_--2857.90-2858.20-2909.90
CAediting_542706ENST00000395699.3chr7_44877646_--2858.20-2858.20-2909.90
CAediting_542707ENST00000395699.3chr7_44877655_--2858.20-2858.20-2909.90
CAediting_542708ENST00000395699.3chr7_44877660_--2864.40-2858.20-2909.90
CAediting_542709ENST00000395699.3chr7_44877676_--2857.80-2858.20-2909.90
CAediting_542710ENST00000395699.3chr7_44877679_--2864.80-2858.20-2909.90
CAediting_542711ENST00000395699.3chr7_44877680_--2857.50-2858.20-2909.90
CAediting_542712ENST00000395699.3chr7_44877682_--2858.20-2858.20-2909.90
CAediting_542713ENST00000395699.3chr7_44877692_--2857.90-2858.20-2909.90
CAediting_542714ENST00000395699.3chr7_44877695_--2857.90-2858.20-2909.90
CAediting_542715ENST00000395699.3chr7_44877696_--2857.90-2858.20-2909.90
CAediting_542716ENST00000395699.3chr7_44877704_--2857.50-2858.20-2909.90
CAediting_542717ENST00000395699.3chr7_44877717_--2858.50-2858.20-2909.90
CAediting_542718ENST00000395699.3chr7_44877721_--2858.20-2858.20-2909.90
CAediting_542719ENST00000395699.3chr7_44877741_--2858.20-2858.20-2909.90
CAediting_542720ENST00000395699.3chr7_44877742_--2857.90-2858.20-2909.90
CAediting_542721ENST00000395699.3chr7_44877747_--2857.80-2858.20-2909.90
CAediting_542722ENST00000395699.3chr7_44877752_--2861.80-2858.20-2909.90
CAediting_542723ENST00000395699.3chr7_44877757_--2857.60-2858.20-2909.90
CAediting_542724ENST00000395699.3chr7_44877807_--2857.30-2858.20-2909.90
CAediting_542725ENST00000395699.3chr7_44878045_--2859.30-2858.20-2909.90
CAediting_542726ENST00000395699.3chr7_44879071_--2864.20-2858.20-2909.90
CAediting_542727ENST00000395699.3chr7_44879073_--2864.90-2858.20-2909.90
CAediting_542728ENST00000395699.3chr7_44879108_--2857.80-2858.20-2909.90
CAediting_542729ENST00000395699.3chr7_44879109_--2861.60-2858.20-2909.90
CAediting_542730ENST00000395699.3chr7_44879113_--2857.30-2858.20-2909.90
CAediting_542731ENST00000395699.3chr7_44879129_--2864.80-2858.20-2909.90
CAediting_542732ENST00000395699.3chr7_44879137_--2864.90-2858.20-2909.90
CAediting_542733ENST00000395699.3chr7_44879138_--2857.30-2858.20-2909.90
CAediting_542734ENST00000395699.3chr7_44879152_--2857.50-2858.20-2909.90
CAediting_542735ENST00000395699.3chr7_44879162_--2857.30-2858.20-2909.90
CAediting_542736ENST00000395699.3chr7_44879169_--2858.20-2858.20-2909.90
CAediting_542737ENST00000395699.3chr7_44879173_--2857.50-2858.20-2909.90
CAediting_542738ENST00000395699.3chr7_44879179_--2857.80-2858.20-2909.90
CAediting_542739ENST00000395699.3chr7_44879187_--2857.80-2858.20-2909.90
CAediting_542740ENST00000395699.3chr7_44879205_--2857.90-2858.20-2909.90
CAediting_542741ENST00000395699.3chr7_44879209_--2858.30-2858.20-2909.90
CAediting_542742ENST00000395699.3chr7_44879210_--2858.30-2858.20-2909.90
CAediting_542743ENST00000395699.3chr7_44879214_--2858.20-2858.20-2909.90
CAediting_542744ENST00000395699.3chr7_44879216_--2858.20-2858.20-2909.90
CAediting_542745ENST00000395699.3chr7_44879217_--2858.30-2858.20-2909.90
CAediting_542746ENST00000395699.3chr7_44879218_--2858.30-2858.20-2909.90
CAediting_542747ENST00000395699.3chr7_44879219_--2858.30-2858.20-2909.90
CAediting_542748ENST00000395699.3chr7_44879223_--2858.20-2858.20-2909.90
CAediting_542749ENST00000395699.3chr7_44879234_--2858.20-2858.20-2909.90
CAediting_542750ENST00000395699.3chr7_44879235_--2858.30-2858.20-2909.90
CAediting_542751ENST00000395699.3chr7_44879236_--2857.70-2858.20-2909.90
CAediting_542752ENST00000395699.3chr7_44879244_--2858.20-2858.20-2909.90
CAediting_542753ENST00000395699.3chr7_44879245_--2857.90-2858.20-2909.90
CAediting_542754ENST00000395699.3chr7_44879259_--2861.70-2858.20-2909.90
CAediting_542755ENST00000395699.3chr7_44879291_--2857.50-2858.20-2909.90
CAediting_542756ENST00000395699.3chr7_44879294_--2857.50-2858.20-2909.90
CAediting_542757ENST00000395699.3chr7_44879299_--2858.20-2858.20-2909.90
CAediting_542758ENST00000395699.3chr7_44879300_--2858.30-2858.20-2909.90
CAediting_542759ENST00000395699.3chr7_44880792_--2864.40-2858.20-2909.90

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Relation with ADAR for PURB

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
STADCAediting_542758chr7_44879300_-0.006465506014796470.227530596848682....
OVCAediting_542758chr7_44879300_-0.003312568521749050.19289791757946....

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Relation with cancer stages for PURB

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
LUSCpathologic_stageCAediting_542758chr7_44879300_-0.006723430720082570.291858707265171

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Relation with survival for PURB

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for PURB

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PURB

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource