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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: ACTA1 (CAeditome ID:58) |
Gene summary for ACTA1 |
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Gene information | Gene symbol | ACTA1 | Gene ID | 58 |
Gene name | actin alpha 1, skeletal muscle | |
Synonyms | ACTA|ASMA|CFTD|CFTD1|CFTDM|MPFD|NEM1|NEM2|NEM3|SHPM | |
Cytomap | 1q42.13 | |
Type of gene | protein-coding | |
Description | actin, alpha skeletal musclenemaline myopathy type 3 | |
Modification date | 20210518 | |
UniProtAcc | P68133 | |
Context |
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Gene | GO ID | GO term | PubMed ID |
ACTA1 | GO:0001725 | Actin, alpha skeletal muscle | 15198992 |
ACTA1 | GO:0005865 | Actin, alpha skeletal muscle | 15198992 |
ACTA1 | GO:0005884 | Actin, alpha skeletal muscle | 12849983 |
ACTA1 | GO:0030017 | Actin, alpha skeletal muscle | 1423520 |
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RNA A-to-I events for ACTA1 |
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CAediting_145013(229431619, -), |
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RNA editing positional annotations for ACTA1 using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
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CAeditome ID | Position | Variant type |
CAediting_145013 | chr1_229431619_- | exonic |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
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RNA A-to-I editing events in the alternative splicing sites for ACTA1 |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ACTA1 |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for ACTA1 |
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The effects of the RNA editing to the miRNA binding sites for ACTA1 |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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The effects of the RNA editing to the stability of the RNA structures for ACTA1 |
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ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
ENST00000366683.3 | protein_coding | ![]() | ![]() |
ENST00000366684.6 | protein_coding | ![]() | ![]() |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
CAediting_145013 | ENST00000366683.3 | chr1_229431619_- | -376.50 | -376.40 | -376.50 |
CAediting_145013 | ENST00000366684.6 | chr1_229431619_- | -520.90 | -519.60 | -520.90 |
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Relation with ADAR for ACTA1 |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for ACTA1 |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for ACTA1 |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for ACTA1 |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
ACTA1 | P68133 | DB02772 | Sucrose | Actin, alpha skeletal muscle | SmallMoleculeDrug | approved|experimental|investigational |
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RelatedDiseases for ACTA1 |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
ACTA1 | C3711389 | Actin-Accumulation Myopathy | 16 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
ACTA1 | C0546264 | Congenital Fiber Type Disproportion | 5 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
ACTA1 | C0007194 | Hypertrophic Cardiomyopathy | 4 | CLINGEN;GENOMICS_ENGLAND |
ACTA1 | C0007193 | Cardiomyopathy, Dilated | 2 | GENOMICS_ENGLAND |
ACTA1 | C0149721 | Left Ventricular Hypertrophy | 1 | CTD_human |
ACTA1 | C0206157 | Myopathies, Nemaline | 1 | GENOMICS_ENGLAND |
ACTA1 | C0270969 | Zebra body myopathy | 1 | ORPHANET |
ACTA1 | C0410180 | Eichsfeld type congenital muscular dystrophy | 1 | ORPHANET |
ACTA1 | C1834339 | Myopathy, Actin, Congenital, with Excess of Thin Myofilaments | 1 | GENOMICS_ENGLAND |
ACTA1 | C2750537 | Myopathy, Actin, Congenital, With Cores | 1 | GENOMICS_ENGLAND |
ACTA1 | C4225181 | MYOPATHY, SCAPULOHUMEROPERONEAL | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |