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Editing gene: RBAK (CAeditome ID:57786)

Gene summary for RBAK

Gene summary

Gene information	Gene symbol	RBAK
	Gene ID	57786
	Gene name	RB associated KRAB zinc finger
	Synonyms	ZNF769
	Cytomap	7p22.1
	Type of gene	protein-coding
	Description	RB-associated KRAB zinc finger proteinRB-associated KRAB repressorzinc finger protein 769
	Modification date	20210518
	UniProtAcc	Q9NYW8
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
RBAK	GO:0005654	RB-associated KRAB zinc finger protein	0000052

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RNA A-to-I events for RBAK

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000146587.16

RNA A-to-I editing events in Cancer.

CAediting_523311(5047166, +), CAediting_523312(5047218, +), CAediting_523313(5047235, +), CAediting_523314(5047359, +), CAediting_523315(5047631, +), CAediting_523316(5047633, +), CAediting_523317(5047662, +), CAediting_523318(5050111, +), CAediting_523319(5054686, +), CAediting_523320(5056201, +), CAediting_523321(5056208, +), CAediting_523322(5056328, +), CAediting_523323(5056347, +), CAediting_523324(5056354, +), CAediting_523325(5056380, +), CAediting_523326(5058144, +), CAediting_523327(5059421, +), CAediting_523328(5061511, +), CAediting_523329(5064997, +),

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RNA editing positional annotations for RBAK using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_523311	chr7_5047166_+	intronic
CAediting_523312	chr7_5047218_+	intronic
CAediting_523313	chr7_5047235_+	intronic
CAediting_523314	chr7_5047359_+	intronic
CAediting_523315	chr7_5047631_+	intronic
CAediting_523316	chr7_5047633_+	intronic
CAediting_523317	chr7_5047662_+	intronic
CAediting_523318	chr7_5050111_+	intronic
CAediting_523319	chr7_5054686_+	intronic
CAediting_523320	chr7_5056201_+	intronic
CAediting_523321	chr7_5056208_+	intronic
CAediting_523322	chr7_5056328_+	intronic
CAediting_523323	chr7_5056347_+	intronic
CAediting_523324	chr7_5056354_+	intronic
CAediting_523325	chr7_5056380_+	intronic
CAediting_523326	chr7_5058144_+	ncRNA_intronic
CAediting_523327	chr7_5059421_+	ncRNA_intronic
CAediting_523328	chr7_5061511_+	ncRNA_intronic
CAediting_523329	chr7_5064997_+	exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_523311	chr7_5047166_+	SINE	Alu	AluJr
CAediting_523312	chr7_5047218_+	SINE	Alu	AluJr
CAediting_523313	chr7_5047235_+	SINE	Alu	AluJr
CAediting_523314	chr7_5047359_+	SINE	Alu	AluJr
CAediting_523315	chr7_5047631_+	SINE	Alu	AluSx4
CAediting_523316	chr7_5047633_+	SINE	Alu	AluSx4
CAediting_523317	chr7_5047662_+	SINE	Alu	AluSx4
CAediting_523318	chr7_5050111_+	SINE	Alu	AluJr
CAediting_523319	chr7_5054686_+	SINE	Alu	AluJr
CAediting_523320	chr7_5056201_+	SINE	Alu	AluJb
CAediting_523321	chr7_5056208_+	SINE	Alu	AluJb
CAediting_523322	chr7_5056328_+	SINE	Alu	AluJb
CAediting_523323	chr7_5056347_+	SINE	Alu	AluJb
CAediting_523324	chr7_5056354_+	SINE	Alu	AluJb
CAediting_523325	chr7_5056380_+	SINE	Alu	AluJb
CAediting_523326	chr7_5058144_+	SINE	Alu	AluSz
CAediting_523327	chr7_5059421_+	SINE	Alu	AluSq2
CAediting_523328	chr7_5061511_+	SINE	Alu	FLAM_C

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RNA A-to-I editing events in the alternative splicing sites for RBAK

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000146587.16.RBAK.

Correlation between RNA A-to-I editing and PSI for ENSG00000146587.16.RBAK.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for RBAK

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for RBAK

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for RBAK

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000146587.16	ENST00000353796	hsa-miR-200b-3p	5066083	5066089	7mer-1a	5066067	5066089	143	-17.61
CAediting_1368054	chr19_46709310_-	ENSG00000146587.16	ENST00000353796	hsa-miR-320e	5066490	5066496	7mer-m8	5066480	5066497	145	-17.62
CAediting_228905	chr2_188297554_+	ENSG00000146587.16	ENST00000353796	hsa-miR-561-3p	5065622	5065628	7mer-m8	5065607	5065629	143	-8.46

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000146587.16	ENST00000353796	hsa-miR-200b-3p	5066631	5066637	7mer-m8	5066618	5066638	141	-7.73
CAediting_77128	chr1_85133844_+	ENSG00000146587.16	ENST00000353796	hsa-miR-4423-3p	5066534	5066540	7mer-m8	5066520	5066541	149	-13.62
CAediting_228905	chr2_188297554_+	ENSG00000146587.16	ENST00000353796	hsa-miR-561-3p	5067246	5067253	8mer-1a	5067232	5067253	153	-3.69
CAediting_524911	chr7_5495852_-	ENSG00000146587.16	ENST00000353796	hsa-miR-589-3p	5066861	5066867	7mer-m8	5066846	5066868	152	-16.53

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for RBAK

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000353796.6	protein_coding
ENST00000396912.1	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_523329	ENST00000353796.6	chr7_5064997_+	-1048.90	-1048.20	-1048.90
CAediting_523329	ENST00000396912.1	chr7_5064997_+	-1712.70	-1712.00	-1712.70

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Relation with ADAR for RBAK

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for RBAK

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for RBAK

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for RBAK

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for RBAK

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene