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Editing gene: PTPN6 (CAeditome ID:5777)

Gene summary for PTPN6

Gene summary

Gene information	Gene symbol	PTPN6
	Gene ID	5777
	Gene name	protein tyrosine phosphatase non-receptor type 6
	Synonyms	HCP\|HCPH\|HPTP1C\|PTP-1C\|SH-PTP1\|SHP-1\|SHP-1L\|SHP1
	Cytomap	12p13.31
	Type of gene	protein-coding
	Description	tyrosine-protein phosphatase non-receptor type 6hematopoietic cell phosphatasehematopoietic cell protein-tyrosine phosphataseprotein-tyrosine phosphatase 1Cprotein-tyrosine phosphatase SHP-1
	Modification date	20210518
	UniProtAcc	P29350
	Context	- 33615510(PTPN6 promotes chemosensitivity of colorectal cancer cells via inhibiting the SP1/MAPK signalling pathway)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
PTPN6	GO:0005001	Tyrosine-protein phosphatase non-receptor type 6	11266449
PTPN6	GO:0006470	Tyrosine-protein phosphatase non-receptor type 6	11266449
PTPN6	GO:0018108	Tyrosine-protein phosphatase non-receptor type 6	18802077
PTPN6	GO:0018108	Tyrosine-protein phosphatase non-receptor type 6	9285411
PTPN6	GO:0030154	Tyrosine-protein phosphatase non-receptor type 6	11266449
PTPN6	GO:0070372	Tyrosine-protein phosphatase non-receptor type 6	11266449
PTPN6	GO:0005634	Tyrosine-protein phosphatase non-receptor type 6	19838216
PTPN6	GO:0005654	Tyrosine-protein phosphatase non-receptor type 6	0000052
PTPN6	GO:0005730	Tyrosine-protein phosphatase non-receptor type 6	0000052
PTPN6	GO:0005737	Tyrosine-protein phosphatase non-receptor type 6	10940933
PTPN6	GO:0005737	Tyrosine-protein phosphatase non-receptor type 6	19838216

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RNA A-to-I events for PTPN6

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000111679.15

RNA A-to-I editing events in Cancer.

CAediting_865774(6947406, +), CAediting_865775(6947408, +), CAediting_865776(6947423, +), CAediting_865777(6947431, +), CAediting_865778(6947442, +), CAediting_865779(6947469, +), CAediting_865780(6947474, +), CAediting_865781(6947488, +), CAediting_865782(6947505, +), CAediting_865783(6947508, +), CAediting_865784(6947514, +), CAediting_865785(6947515, +), CAediting_865786(6947519, +), CAediting_865787(6947522, +), CAediting_865788(6947565, +), CAediting_865789(6947570, +), CAediting_865790(6947571, +), CAediting_865791(6947576, +), CAediting_865792(6947589, +), CAediting_865793(6947597, +), CAediting_865794(6947603, +), CAediting_865795(6947639, +), CAediting_865796(6947649, +), CAediting_865797(6947651, +), CAediting_865798(6947689, +), CAediting_865799(6948022, +), CAediting_865800(6948047, +), CAediting_865801(6948054, +), CAediting_865802(6948061, +), CAediting_865803(6948084, +), CAediting_865804(6948085, +), CAediting_865805(6948086, +), CAediting_865806(6948087, +), CAediting_865807(6948100, +), CAediting_865808(6948102, +), CAediting_865809(6948104, +), CAediting_865810(6948115, +), CAediting_865811(6948141, +), CAediting_865812(6948152, +), CAediting_865813(6948162, +), CAediting_865814(6948171, +), CAediting_865815(6948185, +), CAediting_865816(6948209, +), CAediting_865817(6948211, +), CAediting_865818(6948216, +), CAediting_865819(6948217, +), CAediting_865820(6948231, +), CAediting_865821(6948232, +), CAediting_865822(6948249, +), CAediting_865823(6948289, +), CAediting_865824(6948295, +), CAediting_865825(6948299, +), CAediting_865826(6948332, +), CAediting_865827(6948342, +), CAediting_865828(6948345, +), CAediting_865829(6948351, +), CAediting_865830(6948361, +), CAediting_865831(6948377, +), CAediting_865832(6948381, +), CAediting_865833(6948400, +), CAediting_865834(6948405, +), CAediting_865835(6948418, +), CAediting_865836(6948419, +), CAediting_865837(6948422, +), CAediting_865838(6948423, +), CAediting_865839(6948667, +), CAediting_865840(6948677, +), CAediting_865841(6948678, +), CAediting_865842(6948685, +), CAediting_865843(6948686, +), CAediting_865844(6948691, +), CAediting_865845(6948694, +), CAediting_865846(6948712, +), CAediting_865847(6948724, +), CAediting_865848(6948729, +), CAediting_865849(6948743, +), CAediting_865850(6948755, +), CAediting_865851(6948761, +), CAediting_865852(6948763, +), CAediting_865853(6948779, +), CAediting_865854(6948786, +), CAediting_865855(6948788, +), CAediting_865856(6948792, +), CAediting_865857(6948793, +), CAediting_865858(6948797, +), CAediting_865859(6948805, +), CAediting_865860(6948817, +), CAediting_865861(6948824, +), CAediting_865862(6948830, +), CAediting_865863(6948834, +), CAediting_865864(6948837, +), CAediting_865865(6948841, +), CAediting_865866(6948847, +), CAediting_865867(6948856, +), CAediting_865868(6948857, +), CAediting_865869(6948865, +), CAediting_865870(6948866, +), CAediting_865871(6948873, +), CAediting_865872(6948879, +), CAediting_865873(6948886, +), CAediting_865874(6948890, +), CAediting_865875(6948895, +), CAediting_865876(6948897, +), CAediting_865877(6948905, +), CAediting_865878(6948915, +), CAediting_865879(6948921, +), CAediting_865880(6948932, +), CAediting_865881(6948941, +), CAediting_865882(6949845, +), CAediting_865883(6949878, +), CAediting_865884(6949893, +), CAediting_865885(6949894, +), CAediting_865886(6949911, +), CAediting_865887(6949921, +), CAediting_865888(6949923, +), CAediting_865889(6949927, +), CAediting_865890(6949965, +), CAediting_865891(6949982, +), CAediting_865892(6950041, +), CAediting_865893(6950042, +), CAediting_865894(6950063, +), CAediting_865895(6951168, +),

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RNA editing positional annotations for PTPN6 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_865774	chr12_6947406_+	ncRNA_intronic
CAediting_865775	chr12_6947408_+	ncRNA_intronic
CAediting_865776	chr12_6947423_+	ncRNA_intronic
CAediting_865777	chr12_6947431_+	ncRNA_intronic
CAediting_865778	chr12_6947442_+	ncRNA_intronic
CAediting_865779	chr12_6947469_+	ncRNA_intronic
CAediting_865780	chr12_6947474_+	ncRNA_intronic
CAediting_865781	chr12_6947488_+	ncRNA_intronic
CAediting_865782	chr12_6947505_+	ncRNA_intronic
CAediting_865783	chr12_6947508_+	ncRNA_intronic
CAediting_865784	chr12_6947514_+	ncRNA_intronic
CAediting_865785	chr12_6947515_+	ncRNA_intronic
CAediting_865786	chr12_6947519_+	ncRNA_intronic
CAediting_865787	chr12_6947522_+	ncRNA_intronic
CAediting_865788	chr12_6947565_+	ncRNA_intronic
CAediting_865789	chr12_6947570_+	ncRNA_intronic
CAediting_865790	chr12_6947571_+	ncRNA_intronic
CAediting_865791	chr12_6947576_+	ncRNA_intronic
CAediting_865792	chr12_6947589_+	ncRNA_intronic
CAediting_865793	chr12_6947597_+	ncRNA_intronic
CAediting_865794	chr12_6947603_+	ncRNA_intronic
CAediting_865795	chr12_6947639_+	ncRNA_intronic
CAediting_865796	chr12_6947649_+	ncRNA_intronic
CAediting_865797	chr12_6947651_+	ncRNA_intronic
CAediting_865798	chr12_6947689_+	ncRNA_intronic
CAediting_865799	chr12_6948022_+	ncRNA_intronic
CAediting_865800	chr12_6948047_+	ncRNA_intronic
CAediting_865801	chr12_6948054_+	ncRNA_intronic
CAediting_865802	chr12_6948061_+	ncRNA_intronic
CAediting_865803	chr12_6948084_+	ncRNA_intronic
CAediting_865804	chr12_6948085_+	ncRNA_intronic
CAediting_865805	chr12_6948086_+	ncRNA_intronic
CAediting_865806	chr12_6948087_+	ncRNA_intronic
CAediting_865807	chr12_6948100_+	ncRNA_intronic
CAediting_865808	chr12_6948102_+	ncRNA_intronic
CAediting_865809	chr12_6948104_+	ncRNA_intronic
CAediting_865810	chr12_6948115_+	ncRNA_intronic
CAediting_865811	chr12_6948141_+	ncRNA_intronic
CAediting_865812	chr12_6948152_+	ncRNA_intronic
CAediting_865813	chr12_6948162_+	ncRNA_intronic
CAediting_865814	chr12_6948171_+	ncRNA_intronic
CAediting_865815	chr12_6948185_+	ncRNA_intronic
CAediting_865816	chr12_6948209_+	ncRNA_intronic
CAediting_865817	chr12_6948211_+	ncRNA_intronic
CAediting_865818	chr12_6948216_+	ncRNA_intronic
CAediting_865819	chr12_6948217_+	ncRNA_intronic
CAediting_865820	chr12_6948231_+	ncRNA_intronic
CAediting_865821	chr12_6948232_+	ncRNA_intronic
CAediting_865822	chr12_6948249_+	ncRNA_intronic
CAediting_865823	chr12_6948289_+	ncRNA_intronic
CAediting_865824	chr12_6948295_+	ncRNA_intronic
CAediting_865825	chr12_6948299_+	ncRNA_intronic
CAediting_865826	chr12_6948332_+	ncRNA_intronic
CAediting_865827	chr12_6948342_+	ncRNA_intronic
CAediting_865828	chr12_6948345_+	ncRNA_intronic
CAediting_865829	chr12_6948351_+	ncRNA_intronic
CAediting_865830	chr12_6948361_+	ncRNA_intronic
CAediting_865831	chr12_6948377_+	ncRNA_intronic
CAediting_865832	chr12_6948381_+	ncRNA_intronic
CAediting_865833	chr12_6948400_+	ncRNA_intronic
CAediting_865834	chr12_6948405_+	ncRNA_intronic
CAediting_865835	chr12_6948418_+	ncRNA_intronic
CAediting_865836	chr12_6948419_+	ncRNA_intronic
CAediting_865837	chr12_6948422_+	ncRNA_intronic
CAediting_865838	chr12_6948423_+	ncRNA_intronic
CAediting_865839	chr12_6948667_+	ncRNA_intronic
CAediting_865840	chr12_6948677_+	ncRNA_intronic
CAediting_865841	chr12_6948678_+	ncRNA_intronic
CAediting_865842	chr12_6948685_+	ncRNA_intronic
CAediting_865843	chr12_6948686_+	ncRNA_intronic
CAediting_865844	chr12_6948691_+	ncRNA_intronic
CAediting_865845	chr12_6948694_+	ncRNA_intronic
CAediting_865846	chr12_6948712_+	ncRNA_intronic
CAediting_865847	chr12_6948724_+	ncRNA_intronic
CAediting_865848	chr12_6948729_+	ncRNA_intronic
CAediting_865849	chr12_6948743_+	ncRNA_intronic
CAediting_865850	chr12_6948755_+	ncRNA_intronic
CAediting_865851	chr12_6948761_+	ncRNA_intronic
CAediting_865852	chr12_6948763_+	ncRNA_intronic
CAediting_865853	chr12_6948779_+	ncRNA_intronic
CAediting_865854	chr12_6948786_+	ncRNA_intronic
CAediting_865855	chr12_6948788_+	ncRNA_intronic
CAediting_865856	chr12_6948792_+	ncRNA_intronic
CAediting_865857	chr12_6948793_+	ncRNA_intronic
CAediting_865858	chr12_6948797_+	ncRNA_intronic
CAediting_865859	chr12_6948805_+	ncRNA_intronic
CAediting_865860	chr12_6948817_+	ncRNA_intronic
CAediting_865861	chr12_6948824_+	ncRNA_intronic
CAediting_865862	chr12_6948830_+	ncRNA_intronic
CAediting_865863	chr12_6948834_+	ncRNA_intronic
CAediting_865864	chr12_6948837_+	ncRNA_intronic
CAediting_865865	chr12_6948841_+	ncRNA_intronic
CAediting_865866	chr12_6948847_+	ncRNA_intronic
CAediting_865867	chr12_6948856_+	ncRNA_intronic
CAediting_865868	chr12_6948857_+	ncRNA_intronic
CAediting_865869	chr12_6948865_+	ncRNA_intronic
CAediting_865870	chr12_6948866_+	ncRNA_intronic
CAediting_865871	chr12_6948873_+	ncRNA_intronic
CAediting_865872	chr12_6948879_+	ncRNA_intronic
CAediting_865873	chr12_6948886_+	ncRNA_intronic
CAediting_865874	chr12_6948890_+	ncRNA_intronic
CAediting_865875	chr12_6948895_+	ncRNA_intronic
CAediting_865876	chr12_6948897_+	ncRNA_intronic
CAediting_865877	chr12_6948905_+	ncRNA_intronic
CAediting_865878	chr12_6948915_+	ncRNA_intronic
CAediting_865879	chr12_6948921_+	ncRNA_intronic
CAediting_865880	chr12_6948932_+	ncRNA_intronic
CAediting_865881	chr12_6948941_+	ncRNA_intronic
CAediting_865882	chr12_6949845_+	ncRNA_intronic
CAediting_865883	chr12_6949878_+	ncRNA_intronic
CAediting_865884	chr12_6949893_+	ncRNA_intronic
CAediting_865885	chr12_6949894_+	ncRNA_intronic
CAediting_865886	chr12_6949911_+	ncRNA_intronic
CAediting_865887	chr12_6949921_+	ncRNA_intronic
CAediting_865888	chr12_6949923_+	ncRNA_intronic
CAediting_865889	chr12_6949927_+	ncRNA_intronic
CAediting_865890	chr12_6949965_+	ncRNA_intronic
CAediting_865891	chr12_6949982_+	ncRNA_intronic
CAediting_865892	chr12_6950041_+	ncRNA_intronic
CAediting_865893	chr12_6950042_+	ncRNA_intronic
CAediting_865894	chr12_6950063_+	ncRNA_intronic
CAediting_865895	chr12_6951168_+	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_865774	chr12_6947406_+	SINE	Alu	AluJo
CAediting_865775	chr12_6947408_+	SINE	Alu	AluJo
CAediting_865776	chr12_6947423_+	SINE	Alu	AluJo
CAediting_865777	chr12_6947431_+	SINE	Alu	AluJo
CAediting_865778	chr12_6947442_+	SINE	Alu	AluJo
CAediting_865779	chr12_6947469_+	SINE	Alu	AluJo
CAediting_865780	chr12_6947474_+	SINE	Alu	AluJo
CAediting_865781	chr12_6947488_+	SINE	Alu	AluJo
CAediting_865782	chr12_6947505_+	SINE	Alu	AluJo
CAediting_865783	chr12_6947508_+	SINE	Alu	AluJo
CAediting_865784	chr12_6947514_+	SINE	Alu	AluJo
CAediting_865785	chr12_6947515_+	SINE	Alu	AluJo
CAediting_865786	chr12_6947519_+	SINE	Alu	AluJo
CAediting_865787	chr12_6947522_+	SINE	Alu	AluJo
CAediting_865788	chr12_6947565_+	SINE	Alu	AluJo
CAediting_865789	chr12_6947570_+	SINE	Alu	AluJo
CAediting_865790	chr12_6947571_+	SINE	Alu	AluJo
CAediting_865791	chr12_6947576_+	SINE	Alu	AluJo
CAediting_865792	chr12_6947589_+	SINE	Alu	AluJo
CAediting_865793	chr12_6947597_+	SINE	Alu	AluJo
CAediting_865794	chr12_6947603_+	SINE	Alu	AluJo
CAediting_865795	chr12_6947639_+	SINE	Alu	AluJo
CAediting_865796	chr12_6947649_+	SINE	Alu	AluJo
CAediting_865797	chr12_6947651_+	SINE	Alu	AluJo
CAediting_865798	chr12_6947689_+	SINE	Alu	AluJo
CAediting_865799	chr12_6948022_+	SINE	Alu	FLAM_C
CAediting_865800	chr12_6948047_+	SINE	Alu	FLAM_C
CAediting_865801	chr12_6948054_+	SINE	Alu	FLAM_C
CAediting_865802	chr12_6948061_+	SINE	Alu	FLAM_C
CAediting_865803	chr12_6948084_+	SINE	Alu	FLAM_C
CAediting_865804	chr12_6948085_+	SINE	Alu	FLAM_C
CAediting_865805	chr12_6948086_+	SINE	Alu	FLAM_C
CAediting_865806	chr12_6948087_+	SINE	Alu	FLAM_C
CAediting_865807	chr12_6948100_+	SINE	Alu	FLAM_C
CAediting_865808	chr12_6948102_+	SINE	Alu	FLAM_C
CAediting_865809	chr12_6948104_+	SINE	Alu	FLAM_C
CAediting_865810	chr12_6948115_+	SINE	Alu	FLAM_C
CAediting_865811	chr12_6948141_+	SINE	Alu	AluJb
CAediting_865812	chr12_6948152_+	SINE	Alu	AluJb
CAediting_865813	chr12_6948162_+	SINE	Alu	AluJb
CAediting_865814	chr12_6948171_+	SINE	Alu	AluJb
CAediting_865815	chr12_6948185_+	SINE	Alu	AluJb
CAediting_865816	chr12_6948209_+	SINE	Alu	AluJb
CAediting_865817	chr12_6948211_+	SINE	Alu	AluJb
CAediting_865818	chr12_6948216_+	SINE	Alu	AluJb
CAediting_865819	chr12_6948217_+	SINE	Alu	AluJb
CAediting_865820	chr12_6948231_+	SINE	Alu	AluJb
CAediting_865821	chr12_6948232_+	SINE	Alu	AluJb
CAediting_865822	chr12_6948249_+	SINE	Alu	AluJb
CAediting_865823	chr12_6948289_+	SINE	Alu	AluJb
CAediting_865824	chr12_6948295_+	SINE	Alu	AluJb
CAediting_865825	chr12_6948299_+	SINE	Alu	AluJb
CAediting_865826	chr12_6948332_+	SINE	Alu	AluJb
CAediting_865827	chr12_6948342_+	SINE	Alu	AluJb
CAediting_865828	chr12_6948345_+	SINE	Alu	AluJb
CAediting_865829	chr12_6948351_+	SINE	Alu	AluJb
CAediting_865830	chr12_6948361_+	SINE	Alu	AluJb
CAediting_865831	chr12_6948377_+	SINE	Alu	AluJb
CAediting_865832	chr12_6948381_+	SINE	Alu	AluJb
CAediting_865833	chr12_6948400_+	SINE	Alu	AluJb
CAediting_865834	chr12_6948405_+	SINE	Alu	AluJb
CAediting_865835	chr12_6948418_+	SINE	Alu	AluJb
CAediting_865836	chr12_6948419_+	SINE	Alu	AluJb
CAediting_865837	chr12_6948422_+	SINE	Alu	AluJb
CAediting_865838	chr12_6948423_+	SINE	Alu	AluJb
CAediting_865839	chr12_6948667_+	SINE	Alu	AluSx3
CAediting_865840	chr12_6948677_+	SINE	Alu	AluSx3
CAediting_865841	chr12_6948678_+	SINE	Alu	AluSx3
CAediting_865842	chr12_6948685_+	SINE	Alu	AluSx3
CAediting_865843	chr12_6948686_+	SINE	Alu	AluSx3
CAediting_865844	chr12_6948691_+	SINE	Alu	AluSx3
CAediting_865845	chr12_6948694_+	SINE	Alu	AluSx3
CAediting_865846	chr12_6948712_+	SINE	Alu	AluSx3
CAediting_865847	chr12_6948724_+	SINE	Alu	AluSx3
CAediting_865848	chr12_6948729_+	SINE	Alu	AluSx3
CAediting_865849	chr12_6948743_+	SINE	Alu	AluSx3
CAediting_865850	chr12_6948755_+	SINE	Alu	AluSx3
CAediting_865851	chr12_6948761_+	SINE	Alu	AluSx3
CAediting_865852	chr12_6948763_+	SINE	Alu	AluSx3
CAediting_865853	chr12_6948779_+	SINE	Alu	AluSx3
CAediting_865854	chr12_6948786_+	SINE	Alu	AluSx3
CAediting_865855	chr12_6948788_+	SINE	Alu	AluSx3
CAediting_865856	chr12_6948792_+	SINE	Alu	AluSx3
CAediting_865857	chr12_6948793_+	SINE	Alu	AluSx3
CAediting_865858	chr12_6948797_+	SINE	Alu	AluSx3
CAediting_865859	chr12_6948805_+	SINE	Alu	AluSx3
CAediting_865860	chr12_6948817_+	SINE	Alu	AluSx3
CAediting_865861	chr12_6948824_+	SINE	Alu	AluSx3
CAediting_865862	chr12_6948830_+	SINE	Alu	AluSx3
CAediting_865863	chr12_6948834_+	SINE	Alu	AluSx3
CAediting_865864	chr12_6948837_+	SINE	Alu	AluSx3
CAediting_865865	chr12_6948841_+	SINE	Alu	AluSx3
CAediting_865866	chr12_6948847_+	SINE	Alu	AluSx3
CAediting_865867	chr12_6948856_+	SINE	Alu	AluSx3
CAediting_865868	chr12_6948857_+	SINE	Alu	AluSx3
CAediting_865869	chr12_6948865_+	SINE	Alu	AluSx3
CAediting_865870	chr12_6948866_+	SINE	Alu	AluSx3
CAediting_865871	chr12_6948873_+	SINE	Alu	AluSx3
CAediting_865872	chr12_6948879_+	SINE	Alu	AluSx3
CAediting_865873	chr12_6948886_+	SINE	Alu	AluSx3
CAediting_865874	chr12_6948890_+	SINE	Alu	AluSx3
CAediting_865875	chr12_6948895_+	SINE	Alu	AluSx3
CAediting_865876	chr12_6948897_+	SINE	Alu	AluSx3
CAediting_865877	chr12_6948905_+	SINE	Alu	AluSx3
CAediting_865878	chr12_6948915_+	SINE	Alu	AluSx3
CAediting_865879	chr12_6948921_+	SINE	Alu	AluSx3
CAediting_865880	chr12_6948932_+	SINE	Alu	AluSx3
CAediting_865881	chr12_6948941_+	SINE	Alu	AluSx3
CAediting_865882	chr12_6949845_+	SINE	Alu	AluSg
CAediting_865883	chr12_6949878_+	SINE	Alu	AluSg
CAediting_865884	chr12_6949893_+	SINE	Alu	AluSg
CAediting_865885	chr12_6949894_+	SINE	Alu	AluSg
CAediting_865886	chr12_6949911_+	SINE	Alu	AluSg
CAediting_865887	chr12_6949921_+	SINE	Alu	AluSg
CAediting_865888	chr12_6949923_+	SINE	Alu	AluSg
CAediting_865889	chr12_6949927_+	SINE	Alu	AluSg
CAediting_865890	chr12_6949965_+	SINE	Alu	AluSg
CAediting_865891	chr12_6949982_+	SINE	Alu	AluSg
CAediting_865892	chr12_6950041_+	SINE	Alu	AluSg
CAediting_865893	chr12_6950042_+	SINE	Alu	AluSg
CAediting_865894	chr12_6950063_+	SINE	Alu	AluSg

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RNA A-to-I editing events in the alternative splicing sites for PTPN6

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000111679.15.PTPN6.

Correlation between RNA A-to-I editing and PSI for ENSG00000111679.15.PTPN6.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PTPN6

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for PTPN6

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for PTPN6

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_980496	chr14_31014685_-	ENSG00000111679.15	ENST00000399448	hsa-miR-624-3p	6961238	6961245	8mer-1a	6961225	6961245	141	-14
CAediting_980496	chr14_31014685_-	ENSG00000111679.15	ENST00000456013	hsa-miR-624-3p	6961238	6961245	8mer-1a	6961225	6961245	141	-14
CAediting_1054808	chr15_66496985_-	ENSG00000111679.15	ENST00000399448	hsa-miR-4512	6961258	6961265	8mer-1a	6961244	6961265	149	-18.55
CAediting_396018	chr5_1062918_-	ENSG00000111679.15	ENST00000456013	hsa-miR-4635	6960904	6960911	8mer-1a	6960894	6960911	153	-22.79
CAediting_1054808	chr15_66496985_-	ENSG00000111679.15	ENST00000456013	hsa-miR-4512	6961258	6961265	8mer-1a	6961244	6961265	149	-18.55
CAediting_396018	chr5_1062918_-	ENSG00000111679.15	ENST00000545153	hsa-miR-4635	6952135	6952141	7mer-m8	6952122	6952142	145	-12.81
CAediting_1160181	chr17_7017644_-	ENSG00000111679.15	ENST00000545153	hsa-miR-195-3p	6955402	6955408	7mer-1a	6955387	6955408	145	-19.25
CAediting_396018	chr5_1062918_-	ENSG00000111679.15	ENST00000535462	hsa-miR-4635	6952135	6952141	7mer-m8	6952122	6952142	145	-12.81

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for PTPN6

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for PTPN6

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for PTPN6

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for PTPN6

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
STAD	CAediting_865787	chr12_6947522_+	0.0142607194600585	0.00997775	35.0608

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RelatedDrugs for PTPN6

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
PTPN6	P29350	DB01133	Tiludronic acid	Tyrosine-protein phosphatase non-receptor type 6	SmallMoleculeDrug	approved\|investigational\|vet_approved

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RelatedDiseases for PTPN6

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
PTPN6	C0006663	Calcinosis	1	CTD_human
PTPN6	C0018824	Heart valve disease	1	CTD_human
PTPN6	C0035228	Respiratory Hypersensitivity	1	CTD_human
PTPN6	C0036341	Schizophrenia	1	PSYGENET
PTPN6	C0263628	Tumoral calcinosis	1	CTD_human
PTPN6	C0521174	Microcalcification	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene