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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: GRAMD1A (CAeditome ID:57655)

Gene summary for GRAMD1A

check button Gene summary
Gene informationGene symbol

GRAMD1A

Gene ID

57655

Gene nameGRAM domain containing 1A
SynonymsKIAA1533
Cytomap

19q13.11

Type of geneprotein-coding
Descriptionprotein Aster-AGRAM domain-containing protein 1A
Modification date20210518
UniProtAcc

Q96CP6

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
GRAMD1A

GO:0005829

Protein Aster-A

0000052

GRAMD1A

GO:0005886

Protein Aster-A

0000052

GRAMD1A

GO:0031227

Protein Aster-A

29469807

GRAMD1A

GO:0031234

Protein Aster-A

29469807

GRAMD1A

GO:0044232

Protein Aster-A

29469807


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RNA A-to-I events for GRAMD1A

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000089351.13

check button RNA A-to-I editing events in Cancer.
CAediting_1337290(34996560, +), CAediting_1337291(34996575, +), CAediting_1337292(34996592, +), CAediting_1337293(34996605, +), CAediting_1337294(34996606, +), CAediting_1337295(34996621, +), CAediting_1337296(34996629, +), CAediting_1337297(34996636, +), CAediting_1337298(34996651, +), CAediting_1337299(34996685, +), CAediting_1337300(34996727, +), CAediting_1337301(34996954, +), CAediting_1337302(34996994, +), CAediting_1337303(34997088, +), CAediting_1337304(34997104, +), CAediting_1337305(34997111, +), CAediting_1337306(34997114, +), CAediting_1337307(34997817, +), CAediting_1337308(34997903, +), CAediting_1337309(34997993, +), CAediting_1337310(34998018, +), CAediting_1337311(35001707, +), CAediting_1337312(35001708, +), CAediting_1337313(35001711, +), CAediting_1337314(35001774, +), CAediting_1337315(35001791, +), CAediting_1337316(35001805, +), CAediting_1337317(35001842, +), CAediting_1337318(35001868, +), CAediting_1337319(35001870, +), CAediting_1337320(35001882, +), CAediting_1337321(35001884, +), CAediting_1337322(35002501, +), CAediting_1337323(35002518, +), CAediting_1337324(35002558, +), CAediting_1337325(35002623, +), CAediting_1337326(35002663, +), CAediting_1337327(35002675, +), CAediting_1337328(35003953, +), CAediting_1337329(35003963, +), CAediting_1337330(35003971, +), CAediting_1337331(35003972, +), CAediting_1337332(35003993, +), CAediting_1337333(35004001, +), CAediting_1337334(35004012, +), CAediting_1337335(35004017, +), CAediting_1337336(35004045, +), CAediting_1337337(35004048, +), CAediting_1337338(35004049, +), CAediting_1337339(35004062, +), CAediting_1337340(35004067, +), CAediting_1337341(35004068, +), CAediting_1337342(35004082, +), CAediting_1337343(35004090, +), CAediting_1337344(35004121, +), CAediting_1337345(35004126, +), CAediting_1337346(35004130, +), CAediting_1337347(35004131, +), CAediting_1337348(35004141, +), CAediting_1337349(35004155, +), CAediting_1337350(35004196, +), CAediting_1337351(35004231, +), CAediting_1337352(35004275, +), CAediting_1337353(35006161, +), CAediting_1337354(35006165, +), CAediting_1337355(35006201, +), CAediting_1337356(35007315, +), CAediting_1337357(35007792, +), CAediting_1337358(35008232, +), CAediting_1337359(35008235, +), CAediting_1337360(35008274, +), CAediting_1337361(35008434, +), CAediting_1337362(35008696, +), CAediting_1337363(35008738, +), CAediting_1337364(35011027, +), CAediting_1337365(35012841, +), CAediting_1337366(35012848, +), CAediting_1337367(35014933, +), CAediting_1337368(35014939, +), CAediting_1337369(35014941, +), CAediting_1337370(35025496, +), CAediting_1337371(35025513, +), CAediting_1337372(35025524, +),

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RNA editing positional annotations for GRAMD1A using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1337290chr19_34996560_+intronic
CAediting_1337291chr19_34996575_+intronic
CAediting_1337292chr19_34996592_+intronic
CAediting_1337293chr19_34996605_+intronic
CAediting_1337294chr19_34996606_+intronic
CAediting_1337295chr19_34996621_+intronic
CAediting_1337296chr19_34996629_+intronic
CAediting_1337297chr19_34996636_+intronic
CAediting_1337298chr19_34996651_+intronic
CAediting_1337299chr19_34996685_+intronic
CAediting_1337300chr19_34996727_+intronic
CAediting_1337301chr19_34996954_+intronic
CAediting_1337302chr19_34996994_+intronic
CAediting_1337303chr19_34997088_+intronic
CAediting_1337304chr19_34997104_+intronic
CAediting_1337305chr19_34997111_+intronic
CAediting_1337306chr19_34997114_+intronic
CAediting_1337307chr19_34997817_+intronic
CAediting_1337308chr19_34997903_+intronic
CAediting_1337309chr19_34997993_+intronic
CAediting_1337310chr19_34998018_+intronic
CAediting_1337311chr19_35001707_+ncRNA_intronic
CAediting_1337312chr19_35001708_+ncRNA_intronic
CAediting_1337313chr19_35001711_+ncRNA_intronic
CAediting_1337314chr19_35001774_+ncRNA_intronic
CAediting_1337315chr19_35001791_+ncRNA_intronic
CAediting_1337316chr19_35001805_+ncRNA_intronic
CAediting_1337317chr19_35001842_+ncRNA_intronic
CAediting_1337318chr19_35001868_+ncRNA_intronic
CAediting_1337319chr19_35001870_+ncRNA_intronic
CAediting_1337320chr19_35001882_+ncRNA_intronic
CAediting_1337321chr19_35001884_+ncRNA_intronic
CAediting_1337322chr19_35002501_+ncRNA_exonic
CAediting_1337323chr19_35002518_+ncRNA_exonic
CAediting_1337324chr19_35002558_+ncRNA_intronic
CAediting_1337325chr19_35002623_+ncRNA_intronic
CAediting_1337326chr19_35002663_+ncRNA_intronic
CAediting_1337327chr19_35002675_+ncRNA_intronic
CAediting_1337328chr19_35003953_+ncRNA_intronic
CAediting_1337329chr19_35003963_+ncRNA_intronic
CAediting_1337330chr19_35003971_+ncRNA_intronic
CAediting_1337331chr19_35003972_+ncRNA_intronic
CAediting_1337332chr19_35003993_+ncRNA_intronic
CAediting_1337333chr19_35004001_+ncRNA_intronic
CAediting_1337334chr19_35004012_+ncRNA_intronic
CAediting_1337335chr19_35004017_+ncRNA_intronic
CAediting_1337336chr19_35004045_+ncRNA_intronic
CAediting_1337337chr19_35004048_+ncRNA_intronic
CAediting_1337338chr19_35004049_+ncRNA_intronic
CAediting_1337339chr19_35004062_+ncRNA_intronic
CAediting_1337340chr19_35004067_+ncRNA_intronic
CAediting_1337341chr19_35004068_+ncRNA_intronic
CAediting_1337342chr19_35004082_+ncRNA_intronic
CAediting_1337343chr19_35004090_+ncRNA_intronic
CAediting_1337344chr19_35004121_+ncRNA_intronic
CAediting_1337345chr19_35004126_+ncRNA_intronic
CAediting_1337346chr19_35004130_+ncRNA_intronic
CAediting_1337347chr19_35004131_+ncRNA_intronic
CAediting_1337348chr19_35004141_+ncRNA_intronic
CAediting_1337349chr19_35004155_+ncRNA_intronic
CAediting_1337350chr19_35004196_+ncRNA_intronic
CAediting_1337351chr19_35004231_+ncRNA_intronic
CAediting_1337352chr19_35004275_+ncRNA_intronic
CAediting_1337353chr19_35006161_+ncRNA_intronic
CAediting_1337354chr19_35006165_+ncRNA_intronic
CAediting_1337355chr19_35006201_+ncRNA_intronic
CAediting_1337356chr19_35007315_+ncRNA_intronic
CAediting_1337357chr19_35007792_+ncRNA_intronic
CAediting_1337358chr19_35008232_+ncRNA_intronic
CAediting_1337359chr19_35008235_+ncRNA_intronic
CAediting_1337360chr19_35008274_+ncRNA_intronic
CAediting_1337361chr19_35008434_+ncRNA_intronic
CAediting_1337362chr19_35008696_+ncRNA_intronic
CAediting_1337363chr19_35008738_+ncRNA_intronic
CAediting_1337364chr19_35011027_+intronic
CAediting_1337365chr19_35012841_+ncRNA_intronic
CAediting_1337366chr19_35012848_+ncRNA_intronic
CAediting_1337367chr19_35014933_+intronic
CAediting_1337368chr19_35014939_+intronic
CAediting_1337369chr19_35014941_+intronic
CAediting_1337370chr19_35025496_+ncRNA_intronic
CAediting_1337371chr19_35025513_+ncRNA_intronic
CAediting_1337372chr19_35025524_+ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1337290chr19_34996560_+SINEAluAluSx1
CAediting_1337291chr19_34996575_+SINEAluAluSx1
CAediting_1337292chr19_34996592_+SINEAluAluSx1
CAediting_1337293chr19_34996605_+SINEAluAluSx1
CAediting_1337294chr19_34996606_+SINEAluAluSx1
CAediting_1337295chr19_34996621_+SINEAluAluSx1
CAediting_1337296chr19_34996629_+SINEAluAluSx1
CAediting_1337297chr19_34996636_+SINEAluAluSx1
CAediting_1337298chr19_34996651_+SINEAluAluSx1
CAediting_1337299chr19_34996685_+SINEAluAluSx1
CAediting_1337300chr19_34996727_+SINEAluAluSx1
CAediting_1337301chr19_34996954_+SINEAluAluSx
CAediting_1337302chr19_34996994_+SINEAluAluSx
CAediting_1337303chr19_34997088_+SINEAluAluSx
CAediting_1337304chr19_34997104_+SINEAluAluSx
CAediting_1337305chr19_34997111_+SINEAluAluSx
CAediting_1337306chr19_34997114_+SINEAluAluSx
CAediting_1337307chr19_34997817_+SINEAluAluSx
CAediting_1337308chr19_34997903_+SINEAluAluSx
CAediting_1337309chr19_34997993_+SINEAluAluSx
CAediting_1337310chr19_34998018_+SINEAluAluSx
CAediting_1337311chr19_35001707_+SINEAluAluSx
CAediting_1337312chr19_35001708_+SINEAluAluSx
CAediting_1337313chr19_35001711_+SINEAluAluSx
CAediting_1337314chr19_35001774_+SINEAluAluSx
CAediting_1337315chr19_35001791_+SINEAluAluSx
CAediting_1337316chr19_35001805_+SINEAluAluSx
CAediting_1337317chr19_35001842_+SINEAluAluSx
CAediting_1337318chr19_35001868_+SINEAluAluSx
CAediting_1337319chr19_35001870_+SINEAluAluSx
CAediting_1337320chr19_35001882_+SINEAluAluSx
CAediting_1337321chr19_35001884_+SINEAluAluSx
CAediting_1337322chr19_35002501_+SINEAluAluSx
CAediting_1337323chr19_35002518_+SINEAluAluSx
CAediting_1337324chr19_35002558_+SINEAluAluSx
CAediting_1337325chr19_35002623_+SINEAluAluSx
CAediting_1337326chr19_35002663_+SINEAluAluSx
CAediting_1337327chr19_35002675_+SINEAluAluSx
CAediting_1337328chr19_35003953_+SINEAluAluJr
CAediting_1337329chr19_35003963_+SINEAluAluJr
CAediting_1337330chr19_35003971_+SINEAluAluJr
CAediting_1337331chr19_35003972_+SINEAluAluJr
CAediting_1337332chr19_35003993_+SINEAluAluJr
CAediting_1337333chr19_35004001_+SINEAluAluJr
CAediting_1337334chr19_35004012_+SINEAluAluJr
CAediting_1337335chr19_35004017_+SINEAluAluJr
CAediting_1337336chr19_35004045_+SINEAluAluJr
CAediting_1337337chr19_35004048_+SINEAluAluJr
CAediting_1337338chr19_35004049_+SINEAluAluJr
CAediting_1337339chr19_35004062_+SINEAluAluJr
CAediting_1337340chr19_35004067_+SINEAluAluJr
CAediting_1337341chr19_35004068_+SINEAluAluJr
CAediting_1337342chr19_35004082_+SINEAluAluJr
CAediting_1337343chr19_35004090_+SINEAluAluJr
CAediting_1337344chr19_35004121_+SINEAluAluJr
CAediting_1337345chr19_35004126_+SINEAluAluJr
CAediting_1337346chr19_35004130_+SINEAluAluJr
CAediting_1337347chr19_35004131_+SINEAluAluJr
CAediting_1337348chr19_35004141_+SINEAluAluJr
CAediting_1337349chr19_35004155_+SINEAluAluJr
CAediting_1337350chr19_35004196_+SINEAluAluJr
CAediting_1337351chr19_35004231_+SINEAluAluJr
CAediting_1337352chr19_35004275_+SINEAluAluJr
CAediting_1337353chr19_35006161_+SINEAluAluSx1
CAediting_1337354chr19_35006165_+SINEAluAluSx1
CAediting_1337355chr19_35006201_+SINEAluAluSx1
CAediting_1337356chr19_35007315_+SINEAluAluSx1
CAediting_1337357chr19_35007792_+SINEAluAluJr
CAediting_1337358chr19_35008232_+SINEAluAluSz
CAediting_1337359chr19_35008235_+SINEAluAluSz
CAediting_1337360chr19_35008274_+SINEAluAluSz
CAediting_1337361chr19_35008434_+SINEAluAluJr
CAediting_1337362chr19_35008696_+SINEAluAluSx1
CAediting_1337363chr19_35008738_+SINEAluAluSx1
CAediting_1337364chr19_35011027_+SINEAluAluJb
CAediting_1337365chr19_35012841_+SINEAluAluSg
CAediting_1337366chr19_35012848_+SINEAluAluSg
CAediting_1337367chr19_35014933_+SINEAluAluJr
CAediting_1337368chr19_35014939_+SINEAluAluJr
CAediting_1337369chr19_35014941_+SINEAluAluJr
CAediting_1337370chr19_35025496_+SINEAluAluSx1
CAediting_1337371chr19_35025513_+SINEAluAluSx1
CAediting_1337372chr19_35025524_+SINEAluAluSx1

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RNA A-to-I editing events in the alternative splicing sites for GRAMD1A

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000089351.13.GRAMD1A.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000089351.13.GRAMD1A.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GRAMD1A

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for GRAMD1A

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for GRAMD1A

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393chr1_1167164_+ENSG00000089351.13ENST00000600231hsa-miR-200b-3p35022029350220357mer-m83502201635022036149-12.88
CAediting_1054808chr15_66496985_-ENSG00000089351.13ENST00000599564hsa-miR-451235026334350263407mer-m83502632035026341141-18.34
CAediting_1054808chr15_66496985_-ENSG00000089351.13ENST00000317991hsa-miR-451235026334350263407mer-m83502632035026341141-18.34
CAediting_1054808chr15_66496985_-ENSG00000089351.13ENST00000600231hsa-miR-451235026334350263407mer-m83502632035026341141-18.34
CAediting_1054808chr15_66496985_-ENSG00000089351.13ENST00000411896hsa-miR-451235026334350263407mer-m83502632035026341141-18.34
CAediting_228905chr2_188297554_+ENSG00000089351.13ENST00000424536hsa-miR-561-3p35010613350106197mer-m83501059835010620145-8.97
CAediting_468389chr6_31355314_-ENSG00000089351.13ENST00000600231hsa-miR-6891-5p35014231350142377mer-m83501422035014238146-20.01
CAediting_468389chr6_31355314_-ENSG00000089351.13ENST00000600231hsa-miR-6891-5p35015860350158678mer-1a3501584935015867153-27.94
CAediting_468389chr6_31355314_-ENSG00000089351.13ENST00000424536hsa-miR-6891-5p35010552350105576mer3501053835010558140-26.08

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for GRAMD1A

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for GRAMD1A

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
BRCACAediting_1337346chr19_35004130_+....0.001991113676067850.342692255039176
LUADCAediting_1337346chr19_35004130_+..0.04718725981782050.2284173972646920.04918750393078770.226438966736221

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Relation with cancer stages for GRAMD1A

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for GRAMD1A

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for GRAMD1A

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GRAMD1A

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource