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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: SLAIN2 (CAeditome ID:57606)

Gene summary for SLAIN2

check button Gene summary
Gene informationGene symbol

SLAIN2

Gene ID

57606

Gene nameSLAIN motif family member 2
SynonymsKIAA1458
Cytomap

4p11

Type of geneprotein-coding
DescriptionSLAIN motif-containing protein 2
Modification date20210518
UniProtAcc

Q9P270

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
SLAIN2

GO:0035371

SLAIN motif-containing protein 2

21646404

SLAIN2

GO:0005813

SLAIN motif-containing protein 2

0000052

SLAIN2

GO:0005813

SLAIN motif-containing protein 2

21399614

SLAIN2

GO:0005829

SLAIN motif-containing protein 2

0000052

SLAIN2

GO:0015630

SLAIN motif-containing protein 2

21646404


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RNA A-to-I events for SLAIN2

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000109171.13

check button RNA A-to-I editing events in Cancer.
CAediting_362915(48346926, +), CAediting_362916(48346936, +), CAediting_362917(48348569, +), CAediting_362918(48348575, +), CAediting_362919(48357738, +), CAediting_362920(48359900, +), CAediting_362921(48360414, +), CAediting_362922(48360415, +), CAediting_362923(48360435, +), CAediting_362924(48360472, +), CAediting_362925(48360485, +), CAediting_362926(48360555, +), CAediting_362927(48365197, +), CAediting_362928(48365205, +), CAediting_362929(48365214, +), CAediting_362930(48365240, +), CAediting_362931(48365255, +), CAediting_362932(48365293, +), CAediting_362933(48365313, +), CAediting_362934(48365323, +), CAediting_362935(48365343, +), CAediting_362936(48365349, +), CAediting_362937(48365350, +), CAediting_362938(48365359, +), CAediting_362939(48365387, +), CAediting_362940(48365388, +), CAediting_362941(48365396, +), CAediting_362942(48365691, +), CAediting_362943(48371161, +), CAediting_362944(48371282, +), CAediting_362945(48371683, +), CAediting_362946(48371693, +), CAediting_362947(48371743, +), CAediting_362948(48371751, +), CAediting_362949(48371756, +), CAediting_362950(48371760, +), CAediting_362951(48371928, +), CAediting_362952(48376275, +), CAediting_362953(48376357, +), CAediting_362954(48376364, +), CAediting_362955(48376375, +), CAediting_362956(48376380, +), CAediting_362957(48376381, +), CAediting_362958(48376387, +), CAediting_362959(48376394, +), CAediting_362960(48377077, +), CAediting_362961(48377099, +), CAediting_362962(48377107, +), CAediting_362963(48385697, +), CAediting_362964(48385782, +), CAediting_362965(48385964, +), CAediting_362966(48385968, +), CAediting_362967(48385971, +), CAediting_362968(48385987, +), CAediting_362969(48386036, +), CAediting_362970(48386043, +), CAediting_362971(48386053, +), CAediting_362972(48386057, +), CAediting_362973(48386063, +), CAediting_362974(48393140, +), CAediting_362975(48393428, +), CAediting_362976(48393533, +), CAediting_362977(48408068, +), CAediting_362978(48408257, +), CAediting_362979(48418495, +), CAediting_362980(48418506, +), CAediting_362981(48418554, +), CAediting_362982(48418564, +),

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RNA editing positional annotations for SLAIN2 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_362915chr4_48346926_+intronic
CAediting_362916chr4_48346936_+intronic
CAediting_362917chr4_48348569_+intronic
CAediting_362918chr4_48348575_+intronic
CAediting_362919chr4_48357738_+intronic
CAediting_362920chr4_48359900_+intronic
CAediting_362921chr4_48360414_+intronic
CAediting_362922chr4_48360415_+intronic
CAediting_362923chr4_48360435_+intronic
CAediting_362924chr4_48360472_+intronic
CAediting_362925chr4_48360485_+intronic
CAediting_362926chr4_48360555_+intronic
CAediting_362927chr4_48365197_+intronic
CAediting_362928chr4_48365205_+intronic
CAediting_362929chr4_48365214_+intronic
CAediting_362930chr4_48365240_+intronic
CAediting_362931chr4_48365255_+intronic
CAediting_362932chr4_48365293_+intronic
CAediting_362933chr4_48365313_+intronic
CAediting_362934chr4_48365323_+intronic
CAediting_362935chr4_48365343_+intronic
CAediting_362936chr4_48365349_+intronic
CAediting_362937chr4_48365350_+intronic
CAediting_362938chr4_48365359_+intronic
CAediting_362939chr4_48365387_+intronic
CAediting_362940chr4_48365388_+intronic
CAediting_362941chr4_48365396_+intronic
CAediting_362942chr4_48365691_+intronic
CAediting_362943chr4_48371161_+ncRNA_intronic
CAediting_362944chr4_48371282_+ncRNA_intronic
CAediting_362945chr4_48371683_+ncRNA_intronic
CAediting_362946chr4_48371693_+ncRNA_intronic
CAediting_362947chr4_48371743_+ncRNA_intronic
CAediting_362948chr4_48371751_+ncRNA_intronic
CAediting_362949chr4_48371756_+ncRNA_intronic
CAediting_362950chr4_48371760_+ncRNA_intronic
CAediting_362951chr4_48371928_+ncRNA_intronic
CAediting_362952chr4_48376275_+ncRNA_intronic
CAediting_362953chr4_48376357_+ncRNA_intronic
CAediting_362954chr4_48376364_+ncRNA_intronic
CAediting_362955chr4_48376375_+ncRNA_intronic
CAediting_362956chr4_48376380_+ncRNA_intronic
CAediting_362957chr4_48376381_+ncRNA_intronic
CAediting_362958chr4_48376387_+ncRNA_intronic
CAediting_362959chr4_48376394_+ncRNA_intronic
CAediting_362960chr4_48377077_+ncRNA_intronic
CAediting_362961chr4_48377099_+ncRNA_intronic
CAediting_362962chr4_48377107_+ncRNA_intronic
CAediting_362963chr4_48385697_+intronic
CAediting_362964chr4_48385782_+intronic
CAediting_362965chr4_48385964_+intronic
CAediting_362966chr4_48385968_+intronic
CAediting_362967chr4_48385971_+intronic
CAediting_362968chr4_48385987_+intronic
CAediting_362969chr4_48386036_+intronic
CAediting_362970chr4_48386043_+intronic
CAediting_362971chr4_48386053_+intronic
CAediting_362972chr4_48386057_+intronic
CAediting_362973chr4_48386063_+intronic
CAediting_362974chr4_48393140_+intronic
CAediting_362975chr4_48393428_+intronic
CAediting_362976chr4_48393533_+intronic
CAediting_362977chr4_48408068_+intronic
CAediting_362978chr4_48408257_+intronic
CAediting_362979chr4_48418495_+intronic
CAediting_362980chr4_48418506_+intronic
CAediting_362981chr4_48418554_+intronic
CAediting_362982chr4_48418564_+intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_362915chr4_48346926_+SINEAluFLAM_C
CAediting_362916chr4_48346936_+SINEAluFLAM_C
CAediting_362917chr4_48348569_+SINEAluAluSx1
CAediting_362918chr4_48348575_+SINEAluAluSx1
CAediting_362919chr4_48357738_+SINEAluAluSp
CAediting_362920chr4_48359900_+SINEAluAluSg
CAediting_362921chr4_48360414_+SINEAluAluSz6
CAediting_362922chr4_48360415_+SINEAluAluSz6
CAediting_362923chr4_48360435_+SINEAluAluSz6
CAediting_362924chr4_48360472_+SINEAluAluSz6
CAediting_362925chr4_48360485_+SINEAluAluSz6
CAediting_362926chr4_48360555_+SINEAluAluSz6
CAediting_362927chr4_48365197_+SINEAluAluSx1
CAediting_362928chr4_48365205_+SINEAluAluSx1
CAediting_362929chr4_48365214_+SINEAluAluSx1
CAediting_362930chr4_48365240_+SINEAluAluSx1
CAediting_362931chr4_48365255_+SINEAluAluSx1
CAediting_362932chr4_48365293_+SINEAluAluSx1
CAediting_362933chr4_48365313_+SINEAluAluSx1
CAediting_362934chr4_48365323_+SINEAluAluSx1
CAediting_362935chr4_48365343_+SINEAluAluSx1
CAediting_362936chr4_48365349_+SINEAluAluSx1
CAediting_362937chr4_48365350_+SINEAluAluSx1
CAediting_362938chr4_48365359_+SINEAluAluSx1
CAediting_362939chr4_48365387_+SINEAluAluSx1
CAediting_362940chr4_48365388_+SINEAluAluSx1
CAediting_362941chr4_48365396_+SINEAluAluSx1
CAediting_362942chr4_48365691_+SINEAluAluSx1
CAediting_362943chr4_48371161_+SINEAluAluSx1
CAediting_362944chr4_48371282_+SINEAluAluSx1
CAediting_362945chr4_48371683_+SINEAluAluJo
CAediting_362946chr4_48371693_+SINEAluAluJo
CAediting_362947chr4_48371743_+SINEAluAluJo
CAediting_362948chr4_48371751_+SINEAluAluJo
CAediting_362949chr4_48371756_+SINEAluAluJo
CAediting_362950chr4_48371760_+SINEAluAluJo
CAediting_362951chr4_48371928_+SINEAluAluJo
CAediting_362952chr4_48376275_+SINEAluAluSz6
CAediting_362953chr4_48376357_+SINEAluAluSz6
CAediting_362954chr4_48376364_+SINEAluAluSz6
CAediting_362955chr4_48376375_+SINEAluAluSz6
CAediting_362956chr4_48376380_+SINEAluAluSz6
CAediting_362957chr4_48376381_+SINEAluAluSz6
CAediting_362958chr4_48376387_+SINEAluAluSz6
CAediting_362959chr4_48376394_+SINEAluAluSz6
CAediting_362960chr4_48377077_+SINEAluAluJb
CAediting_362961chr4_48377099_+SINEAluAluJb
CAediting_362962chr4_48377107_+SINEAluAluJb
CAediting_362963chr4_48385697_+SINEAluAluJb
CAediting_362964chr4_48385782_+SINEAluAluJb
CAediting_362965chr4_48385964_+SINEAluAluJr
CAediting_362966chr4_48385968_+SINEAluAluJr
CAediting_362967chr4_48385971_+SINEAluAluJr
CAediting_362968chr4_48385987_+SINEAluAluJr
CAediting_362969chr4_48386036_+SINEAluAluJr
CAediting_362970chr4_48386043_+SINEAluAluJr
CAediting_362971chr4_48386053_+SINEAluAluJr
CAediting_362972chr4_48386057_+SINEAluAluJr
CAediting_362973chr4_48386063_+SINEAluAluJr
CAediting_362974chr4_48393140_+SINEAluAluSz
CAediting_362975chr4_48393428_+SINEAluAluJo
CAediting_362976chr4_48393533_+SINEAluAluJo
CAediting_362977chr4_48408068_+SINEAluAluJb
CAediting_362978chr4_48408257_+SINEAluAluJb
CAediting_362979chr4_48418495_+LINEL1L1MD
CAediting_362980chr4_48418506_+LINEL1L1MD
CAediting_362981chr4_48418554_+LINEL1L1MD
CAediting_362982chr4_48418564_+LINEL1L1MD

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RNA A-to-I editing events in the alternative splicing sites for SLAIN2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000109171.13.SLAIN2.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000109171.13.SLAIN2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SLAIN2

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for SLAIN2

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for SLAIN2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393chr1_1167164_+ENSG00000109171.13ENST00000512093hsa-miR-200b-3p48423591484235988mer-1a4842357848423598156-16.38
CAediting_393chr1_1167164_+ENSG00000109171.13ENST00000510595hsa-miR-200b-3p48420465484204717mer-m84842045148420472140-9.58

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_77128chr1_85133844_+ENSG00000109171.13ENST00000512093hsa-miR-4423-3p48424376484243827mer-m84842436348424383142-12.16
CAediting_688081chr9_63819627_+ENSG00000109171.13ENST00000512093hsa-miR-4477b48424976484249827mer-m84842496248424983140-9.04
CAediting_414656chr5_72878640_+ENSG00000109171.13ENST00000512093hsa-miR-4804-3p48424898484249058mer-1a4842488548424905144-10.07
CAediting_228905chr2_188297554_+ENSG00000109171.13ENST00000512093hsa-miR-561-3p48423764484237718mer-1a4842375248423771153-13.81
CAediting_228905chr2_188297554_+ENSG00000109171.13ENST00000512093hsa-miR-561-3p48422846484228527mer-1a4842283148422852140-7.57

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SLAIN2

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for SLAIN2

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for SLAIN2

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for SLAIN2

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for SLAIN2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLAIN2

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource