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Editing gene: ALPK3 (CAeditome ID:57538)

Gene summary for ALPK3

Gene summary

Gene information	Gene symbol	ALPK3
	Gene ID	57538
	Gene name	alpha kinase 3
	Synonyms	CMH27\|MAK\|MIDORI
	Cytomap	15q25.3
	Type of gene	protein-coding
	Description	alpha-protein kinase 3muscle alpha-kinasemuscle alpha-protein kinasemyocyte induction differentiation originator
	Modification date	20210518
	UniProtAcc	Q96L96
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for ALPK3

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000136383.6

RNA A-to-I editing events in Cancer.

CAediting_1066746(84842182, +), CAediting_1066747(84843195, +), CAediting_1066748(84844109, +), CAediting_1066749(84844322, +), CAediting_1066750(84844326, +), CAediting_1066751(84844327, +), CAediting_1066752(84844336, +), CAediting_1066753(84845913, +), CAediting_1066754(84845939, +), CAediting_1066755(84846547, +), CAediting_1066756(84846549, +), CAediting_1066757(84846565, +), CAediting_1066758(84846771, +), CAediting_1066759(84846826, +), CAediting_1066760(84846845, +), CAediting_1066761(84846864, +), CAediting_1066762(84846908, +), CAediting_1066763(84846910, +), CAediting_1066764(84846926, +), CAediting_1066765(84846948, +), CAediting_1066766(84847915, +), CAediting_1066767(84847942, +), CAediting_1066768(84847968, +), CAediting_1066769(84847969, +), CAediting_1066770(84847983, +), CAediting_1066771(84850447, +), CAediting_1066772(84850517, +), CAediting_1066773(84850523, +), CAediting_1066774(84854420, +), CAediting_1066775(84860433, +), CAediting_1066776(84862319, +), CAediting_1066777(84862369, +), CAediting_1066778(84865873, +), CAediting_1066779(84867192, +), CAediting_1066780(84867193, +),

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RNA editing positional annotations for ALPK3 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1066746	chr15_84842182_+	intronic
CAediting_1066747	chr15_84843195_+	intronic
CAediting_1066748	chr15_84844109_+	intronic
CAediting_1066749	chr15_84844322_+	intronic
CAediting_1066750	chr15_84844326_+	intronic
CAediting_1066751	chr15_84844327_+	intronic
CAediting_1066752	chr15_84844336_+	intronic
CAediting_1066753	chr15_84845913_+	intronic
CAediting_1066754	chr15_84845939_+	intronic
CAediting_1066755	chr15_84846547_+	intronic
CAediting_1066756	chr15_84846549_+	intronic
CAediting_1066757	chr15_84846565_+	intronic
CAediting_1066758	chr15_84846771_+	intronic
CAediting_1066759	chr15_84846826_+	intronic
CAediting_1066760	chr15_84846845_+	intronic
CAediting_1066761	chr15_84846864_+	intronic
CAediting_1066762	chr15_84846908_+	intronic
CAediting_1066763	chr15_84846910_+	intronic
CAediting_1066764	chr15_84846926_+	intronic
CAediting_1066765	chr15_84846948_+	intronic
CAediting_1066766	chr15_84847915_+	intronic
CAediting_1066767	chr15_84847942_+	intronic
CAediting_1066768	chr15_84847968_+	intronic
CAediting_1066769	chr15_84847969_+	intronic
CAediting_1066770	chr15_84847983_+	intronic
CAediting_1066771	chr15_84850447_+	intronic
CAediting_1066772	chr15_84850517_+	intronic
CAediting_1066773	chr15_84850523_+	intronic
CAediting_1066774	chr15_84854420_+	intronic
CAediting_1066775	chr15_84860433_+	intronic
CAediting_1066776	chr15_84862319_+	intronic
CAediting_1066777	chr15_84862369_+	intronic
CAediting_1066778	chr15_84865873_+	ncRNA_intronic
CAediting_1066779	chr15_84867192_+	ncRNA_intronic
CAediting_1066780	chr15_84867193_+	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1066746	chr15_84842182_+	SINE	Alu	AluSz6
CAediting_1066747	chr15_84843195_+	SINE	Alu	AluSz
CAediting_1066748	chr15_84844109_+	SINE	Alu	AluSg7
CAediting_1066749	chr15_84844322_+	SINE	Alu	AluSz6
CAediting_1066750	chr15_84844326_+	SINE	Alu	AluSz6
CAediting_1066751	chr15_84844327_+	SINE	Alu	AluSz6
CAediting_1066752	chr15_84844336_+	SINE	Alu	AluSz6
CAediting_1066753	chr15_84845913_+	SINE	Alu	AluSz
CAediting_1066754	chr15_84845939_+	SINE	Alu	AluSz
CAediting_1066755	chr15_84846547_+	SINE	Alu	AluJb
CAediting_1066756	chr15_84846549_+	SINE	Alu	AluJb
CAediting_1066757	chr15_84846565_+	SINE	Alu	AluJb
CAediting_1066758	chr15_84846771_+	SINE	Alu	AluSq
CAediting_1066759	chr15_84846826_+	SINE	Alu	AluSq
CAediting_1066760	chr15_84846845_+	SINE	Alu	AluSq
CAediting_1066761	chr15_84846864_+	SINE	Alu	AluSq
CAediting_1066762	chr15_84846908_+	SINE	Alu	AluSq
CAediting_1066763	chr15_84846910_+	SINE	Alu	AluSq
CAediting_1066764	chr15_84846926_+	SINE	Alu	AluSq
CAediting_1066765	chr15_84846948_+	SINE	Alu	AluSq
CAediting_1066766	chr15_84847915_+	SINE	Alu	AluSx1
CAediting_1066767	chr15_84847942_+	SINE	Alu	AluSx1
CAediting_1066768	chr15_84847968_+	SINE	Alu	AluSx1
CAediting_1066769	chr15_84847969_+	SINE	Alu	AluSx1
CAediting_1066770	chr15_84847983_+	SINE	Alu	AluSx1
CAediting_1066771	chr15_84850447_+	SINE	Alu	AluJr
CAediting_1066772	chr15_84850517_+	SINE	Alu	AluJr
CAediting_1066773	chr15_84850523_+	SINE	Alu	AluJr
CAediting_1066774	chr15_84854420_+	SINE	Alu	AluSq
CAediting_1066775	chr15_84860433_+	DNA	hAT-Charlie	MER5A
CAediting_1066778	chr15_84865873_+	SINE	Alu	AluSz6

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RNA A-to-I editing events in the alternative splicing sites for ALPK3

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000136383.6.ALPK3.

Correlation between RNA A-to-I editing and PSI for ENSG00000136383.6.ALPK3.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ALPK3

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for ALPK3

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for ALPK3

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ALPK3

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for ALPK3

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for ALPK3

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for ALPK3

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for ALPK3

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ALPK3

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
ALPK3	C0007194	Hypertrophic Cardiomyopathy	4	CLINGEN

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene