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Editing gene: AHRR (CAeditome ID:57491)

Gene summary for AHRR

Gene summary

Gene information	Gene symbol	AHRR
	Gene ID	57491
	Gene name	aryl-hydrocarbon receptor repressor
	Synonyms	AHH\|AHHR\|bHLHe77
	Cytomap	5p15.33
	Type of gene	protein-coding
	Description	aryl hydrocarbon receptor repressorahR repressoraryl hydrocarbon hydroxylase regulatorclass E basic helix-loop-helix protein 77dioxin receptor repressor
	Modification date	20210518
	UniProtAcc	A9YTQ3
	Context	- 32801256(Expression analysis of aryl hydrocarbon receptor repressor (AHRR) gene in gallbladder cancer)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
AHRR	GO:0005654	Aryl hydrocarbon receptor repressor	0000052
AHRR	GO:0005829	Aryl hydrocarbon receptor repressor	0000052

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RNA A-to-I events for AHRR

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000063438.15

RNA A-to-I editing events in Cancer.

CAediting_395847(311715, +), CAediting_395848(311719, +), CAediting_395849(311733, +), CAediting_395850(311737, +), CAediting_395851(311739, +), CAediting_395852(311749, +), CAediting_395853(311768, +), CAediting_395854(311774, +), CAediting_395855(311793, +), CAediting_395856(311794, +), CAediting_395857(311797, +), CAediting_395858(311811, +), CAediting_395859(311820, +), CAediting_395860(311900, +), CAediting_395861(311924, +), CAediting_395862(311963, +), CAediting_395863(312689, +), CAediting_395864(312695, +), CAediting_395865(312699, +), CAediting_395866(312703, +), CAediting_395867(312706, +), CAediting_395868(312712, +), CAediting_395869(312716, +), CAediting_395870(312719, +), CAediting_395871(312721, +), CAediting_395872(312722, +), CAediting_395873(312725, +), CAediting_395874(312730, +), CAediting_395875(312731, +), CAediting_395876(312760, +), CAediting_395877(312765, +), CAediting_395878(312775, +), CAediting_395879(312780, +), CAediting_395880(312792, +), CAediting_395881(312798, +), CAediting_395882(313494, +), CAediting_395883(313503, +), CAediting_395884(313508, +), CAediting_395885(313515, +), CAediting_395886(313527, +), CAediting_395887(313531, +), CAediting_395888(313554, +), CAediting_395889(313560, +), CAediting_395890(313561, +), CAediting_395891(313590, +), CAediting_395892(313607, +), CAediting_395893(313616, +), CAediting_395894(313697, +), CAediting_395895(313699, +), CAediting_395896(313701, +), CAediting_395897(313715, +), CAediting_395898(313719, +), CAediting_395899(313724, +), CAediting_395900(313726, +), CAediting_395901(313740, +), CAediting_395902(313741, +), CAediting_395903(313743, +), CAediting_395904(313750, +), CAediting_395905(313755, +), CAediting_395906(313762, +), CAediting_395907(313768, +), CAediting_395908(313774, +), CAediting_395909(313775, +), CAediting_395910(313785, +), CAediting_395911(313801, +), CAediting_395912(313802, +), CAediting_395913(324083, +),

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RNA editing positional annotations for AHRR using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_395847	chr5_311715_+	ncRNA_intronic
CAediting_395848	chr5_311719_+	ncRNA_intronic
CAediting_395849	chr5_311733_+	ncRNA_intronic
CAediting_395850	chr5_311737_+	ncRNA_intronic
CAediting_395851	chr5_311739_+	ncRNA_intronic
CAediting_395852	chr5_311749_+	ncRNA_intronic
CAediting_395853	chr5_311768_+	ncRNA_intronic
CAediting_395854	chr5_311774_+	ncRNA_intronic
CAediting_395855	chr5_311793_+	ncRNA_intronic
CAediting_395856	chr5_311794_+	ncRNA_intronic
CAediting_395857	chr5_311797_+	ncRNA_intronic
CAediting_395858	chr5_311811_+	ncRNA_intronic
CAediting_395859	chr5_311820_+	ncRNA_intronic
CAediting_395860	chr5_311900_+	ncRNA_intronic
CAediting_395861	chr5_311924_+	ncRNA_intronic
CAediting_395862	chr5_311963_+	ncRNA_intronic
CAediting_395863	chr5_312689_+	ncRNA_intronic
CAediting_395864	chr5_312695_+	ncRNA_intronic
CAediting_395865	chr5_312699_+	ncRNA_intronic
CAediting_395866	chr5_312703_+	ncRNA_intronic
CAediting_395867	chr5_312706_+	ncRNA_intronic
CAediting_395868	chr5_312712_+	ncRNA_intronic
CAediting_395869	chr5_312716_+	ncRNA_intronic
CAediting_395870	chr5_312719_+	ncRNA_intronic
CAediting_395871	chr5_312721_+	ncRNA_intronic
CAediting_395872	chr5_312722_+	ncRNA_intronic
CAediting_395873	chr5_312725_+	ncRNA_intronic
CAediting_395874	chr5_312730_+	ncRNA_intronic
CAediting_395875	chr5_312731_+	ncRNA_intronic
CAediting_395876	chr5_312760_+	ncRNA_intronic
CAediting_395877	chr5_312765_+	ncRNA_intronic
CAediting_395878	chr5_312775_+	ncRNA_intronic
CAediting_395879	chr5_312780_+	ncRNA_intronic
CAediting_395880	chr5_312792_+	ncRNA_intronic
CAediting_395881	chr5_312798_+	ncRNA_intronic
CAediting_395882	chr5_313494_+	ncRNA_intronic
CAediting_395883	chr5_313503_+	ncRNA_intronic
CAediting_395884	chr5_313508_+	ncRNA_intronic
CAediting_395885	chr5_313515_+	ncRNA_intronic
CAediting_395886	chr5_313527_+	ncRNA_intronic
CAediting_395887	chr5_313531_+	ncRNA_intronic
CAediting_395888	chr5_313554_+	ncRNA_intronic
CAediting_395889	chr5_313560_+	ncRNA_intronic
CAediting_395890	chr5_313561_+	ncRNA_intronic
CAediting_395891	chr5_313590_+	ncRNA_intronic
CAediting_395892	chr5_313607_+	ncRNA_intronic
CAediting_395893	chr5_313616_+	ncRNA_intronic
CAediting_395894	chr5_313697_+	ncRNA_intronic
CAediting_395895	chr5_313699_+	ncRNA_splicing
CAediting_395896	chr5_313701_+	ncRNA_exonic
CAediting_395897	chr5_313715_+	ncRNA_exonic
CAediting_395898	chr5_313719_+	ncRNA_exonic
CAediting_395899	chr5_313724_+	ncRNA_exonic
CAediting_395900	chr5_313726_+	ncRNA_exonic
CAediting_395901	chr5_313740_+	ncRNA_exonic
CAediting_395902	chr5_313741_+	ncRNA_exonic
CAediting_395903	chr5_313743_+	ncRNA_exonic
CAediting_395904	chr5_313750_+	ncRNA_exonic
CAediting_395905	chr5_313755_+	ncRNA_exonic
CAediting_395906	chr5_313762_+	ncRNA_exonic
CAediting_395907	chr5_313768_+	ncRNA_exonic
CAediting_395908	chr5_313774_+	ncRNA_exonic
CAediting_395909	chr5_313775_+	ncRNA_exonic
CAediting_395910	chr5_313785_+	ncRNA_exonic
CAediting_395911	chr5_313801_+	ncRNA_exonic
CAediting_395912	chr5_313802_+	ncRNA_exonic
CAediting_395913	chr5_324083_+	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_395847	chr5_311715_+	SINE	Alu	AluSx1
CAediting_395848	chr5_311719_+	SINE	Alu	AluSx1
CAediting_395849	chr5_311733_+	SINE	Alu	AluSx1
CAediting_395850	chr5_311737_+	SINE	Alu	AluSx1
CAediting_395851	chr5_311739_+	SINE	Alu	AluSx1
CAediting_395852	chr5_311749_+	SINE	Alu	AluSx1
CAediting_395853	chr5_311768_+	SINE	Alu	AluSx1
CAediting_395854	chr5_311774_+	SINE	Alu	AluSx1
CAediting_395855	chr5_311793_+	SINE	Alu	AluSx1
CAediting_395856	chr5_311794_+	SINE	Alu	AluSx1
CAediting_395857	chr5_311797_+	SINE	Alu	AluSx1
CAediting_395858	chr5_311811_+	SINE	Alu	AluSx1
CAediting_395859	chr5_311820_+	SINE	Alu	AluSx1
CAediting_395860	chr5_311900_+	SINE	Alu	AluSx1
CAediting_395861	chr5_311924_+	SINE	Alu	AluSx1
CAediting_395862	chr5_311963_+	SINE	Alu	AluSx1
CAediting_395863	chr5_312689_+	SINE	Alu	AluSx3
CAediting_395864	chr5_312695_+	SINE	Alu	AluSx3
CAediting_395865	chr5_312699_+	SINE	Alu	AluSx3
CAediting_395866	chr5_312703_+	SINE	Alu	AluSx3
CAediting_395867	chr5_312706_+	SINE	Alu	AluSx3
CAediting_395868	chr5_312712_+	SINE	Alu	AluSx3
CAediting_395869	chr5_312716_+	SINE	Alu	AluSx3
CAediting_395870	chr5_312719_+	SINE	Alu	AluSx3
CAediting_395871	chr5_312721_+	SINE	Alu	AluSx3
CAediting_395872	chr5_312722_+	SINE	Alu	AluSx3
CAediting_395873	chr5_312725_+	SINE	Alu	AluSx3
CAediting_395874	chr5_312730_+	SINE	Alu	AluSx3
CAediting_395875	chr5_312731_+	SINE	Alu	AluSx3
CAediting_395876	chr5_312760_+	SINE	Alu	AluSx3
CAediting_395877	chr5_312765_+	SINE	Alu	AluSx3
CAediting_395878	chr5_312775_+	SINE	Alu	AluSx3
CAediting_395879	chr5_312780_+	SINE	Alu	AluSx3
CAediting_395880	chr5_312792_+	SINE	Alu	AluSx3
CAediting_395881	chr5_312798_+	SINE	Alu	AluSx3
CAediting_395882	chr5_313494_+	SINE	Alu	AluJb
CAediting_395883	chr5_313503_+	SINE	Alu	AluJb
CAediting_395884	chr5_313508_+	SINE	Alu	AluJb
CAediting_395885	chr5_313515_+	SINE	Alu	AluJb
CAediting_395886	chr5_313527_+	SINE	Alu	AluJb
CAediting_395887	chr5_313531_+	SINE	Alu	AluJb
CAediting_395888	chr5_313554_+	SINE	Alu	AluJb
CAediting_395889	chr5_313560_+	SINE	Alu	AluJb
CAediting_395890	chr5_313561_+	SINE	Alu	AluJb
CAediting_395891	chr5_313590_+	SINE	Alu	AluJb
CAediting_395892	chr5_313607_+	SINE	Alu	AluJb
CAediting_395893	chr5_313616_+	SINE	Alu	AluJb
CAediting_395894	chr5_313697_+	SINE	Alu	AluJb
CAediting_395895	chr5_313699_+	SINE	Alu	AluJb
CAediting_395896	chr5_313701_+	SINE	Alu	AluJb
CAediting_395897	chr5_313715_+	SINE	Alu	AluJb
CAediting_395898	chr5_313719_+	SINE	Alu	AluJb
CAediting_395899	chr5_313724_+	SINE	Alu	AluJb
CAediting_395900	chr5_313726_+	SINE	Alu	AluJb
CAediting_395901	chr5_313740_+	SINE	Alu	AluJb
CAediting_395902	chr5_313741_+	SINE	Alu	AluJb
CAediting_395903	chr5_313743_+	SINE	Alu	AluJb
CAediting_395904	chr5_313750_+	SINE	Alu	AluJb
CAediting_395905	chr5_313755_+	SINE	Alu	AluJb
CAediting_395906	chr5_313762_+	SINE	Alu	AluJb
CAediting_395907	chr5_313768_+	SINE	Alu	AluJb
CAediting_395908	chr5_313774_+	SINE	Alu	AluJb
CAediting_395909	chr5_313775_+	SINE	Alu	AluJb
CAediting_395910	chr5_313785_+	SINE	Alu	AluJb
CAediting_395911	chr5_313801_+	SINE	Alu	AluJb
CAediting_395912	chr5_313802_+	SINE	Alu	AluJb
CAediting_395913	chr5_324083_+	SINE	Alu	AluSg

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RNA A-to-I editing events in the alternative splicing sites for AHRR

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000063438.15.AHRR.

Correlation between RNA A-to-I editing and PSI for ENSG00000063438.15.AHRR.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for AHRR

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for AHRR

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for AHRR

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_846604	chr11_93733708_-	ENSG00000063438.15	ENST00000316418	hsa-miR-1304-3p	437799	437805	7mer-m8	437786	437806	146	-19.3
CAediting_846604	chr11_93733708_-	ENSG00000063438.15	ENST00000316418	hsa-miR-1304-3p	435140	435146	7mer-m8	435129	435147	143	-18.14
CAediting_393	chr1_1167164_+	ENSG00000063438.15	ENST00000316418	hsa-miR-200b-3p	435069	435075	7mer-m8	435051	435076	149	-11.01
CAediting_688080	chr9_63819626_+	ENSG00000063438.15	ENST00000316418	hsa-miR-4477b	437821	437827	7mer-m8	437807	437828	140	-10.81
CAediting_393	chr1_1167164_+	ENSG00000063438.15	ENST00000506456	hsa-miR-200b-3p	435069	435075	7mer-m8	435051	435076	149	-11.01
CAediting_1054808	chr15_66496985_-	ENSG00000063438.15	ENST00000316418	hsa-miR-4512	436098	436105	8mer-1a	436083	436105	146	-25.1
CAediting_1054808	chr15_66496985_-	ENSG00000063438.15	ENST00000316418	hsa-miR-4512	437468	437475	8mer-1a	437455	437475	146	-22.92
CAediting_1229415	chr17_67471547_+	ENSG00000063438.15	ENST00000316418	hsa-miR-548aa	436338	436344	7mer-m8	436320	436345	146	-11.41
CAediting_1368054	chr19_46709310_-	ENSG00000063438.15	ENST00000316418	hsa-miR-320e	437018	437024	7mer-m8	437008	437025	146	-19.69
CAediting_77128	chr1_85133844_+	ENSG00000063438.15	ENST00000316418	hsa-miR-4423-3p	437014	437020	7mer-m8	437001	437021	140	-12.68
CAediting_1399425	chr20_1392958_-	ENSG00000063438.15	ENST00000316418	hsa-miR-6869-5p	436766	436772	7mer-m8	436752	436773	141	-16.99
CAediting_573001	chr7_92204086_-	ENSG00000063438.15	ENST00000316418	hsa-miR-1285-5p	436694	436700	7mer-m8	436681	436701	141	-17.83
CAediting_1524209	chrX_134546392_-	ENSG00000063438.15	ENST00000316418	hsa-miR-503-5p	435721	435727	7mer-m8	435708	435728	146	-22.22

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_846604	chr11_93733708_-	ENSG00000063438.15	ENST00000316418	hsa-miR-1304-3p	436045	436051	7mer-m8	436029	436052	146	-19.98
CAediting_688080	chr9_63819626_+	ENSG00000063438.15	ENST00000316418	hsa-miR-4477b	437554	437560	7mer-m8	437538	437561	146	-11.45
CAediting_1054808	chr15_66496985_-	ENSG00000063438.15	ENST00000316418	hsa-miR-4512	437646	437652	7mer-m8	437632	437653	140	-15.79
CAediting_524911	chr7_5495852_-	ENSG00000063438.15	ENST00000316418	hsa-miR-589-3p	437264	437271	8mer-1a	437245	437271	143	-17.68
CAediting_468389	chr6_31355314_-	ENSG00000063438.15	ENST00000316418	hsa-miR-6891-5p	437552	437559	8mer-1a	437541	437559	140	-14.86

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for AHRR

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for AHRR

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
BRCA	CAediting_395850	chr5_311737_+	0.0140702098703027	0.22552456992386	.	.	.	.
LUAD	CAediting_395850	chr5_311737_+	0.0294806748088735	0.229610112533147	.	.	.	.
BRCA	CAediting_395856	chr5_311794_+	0.000921625104820444	0.311578735975542	.	.	.	.
BRCA	CAediting_395863	chr5_312689_+	0.0020406284375834	0.289718762906515	.	.	.	.
LUAD	CAediting_395863	chr5_312689_+	0.00436332672101612	0.280034911418383	.	.	.	.
STAD	CAediting_395863	chr5_312689_+	.	.	.	.	0.0274054411234343	0.191293755186283
ESCA	CAediting_395873	chr5_312725_+	.	.	.	.	0.0302751921538758	0.266915419609555
LGG	CAediting_395899	chr5_313724_+	.	.	8.20372452158532e-06	0.498831879551836	.	.
LUSC	CAediting_395899	chr5_313724_+	.	.	4.87004111926803e-05	0.443018323026777	0.0207708281502448	0.261446326309393
BLCA	CAediting_395907	chr5_313768_+	0.00904509612469782	0.348858148208502	.	.	.	.
LGG	CAediting_395907	chr5_313768_+	.	.	4.83907148464185e-05	0.243767655701731	.	.
BRCA	CAediting_395907	chr5_313768_+	5.12450211954959e-07	0.223188921138421	.	.	.	.
LIHC	CAediting_395907	chr5_313768_+	0.0359128649731505	0.286185009604711	.	.	.	.
LUAD	CAediting_395907	chr5_313768_+	0.0238692833809119	0.160529953522211	.	.	.	.
THCA	CAediting_395907	chr5_313768_+	3.04445062992905e-05	0.362405369065348	.	.	.	.
PCPG	CAediting_395907	chr5_313768_+	1.39432782825665e-09	0.506868350726159	.	.	.	.
LGG	CAediting_395909	chr5_313775_+	0.00826845067290189	0.220061033461974	0.00273506120320698	0.248774125109878	.	.

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Relation with cancer stages for AHRR

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
BRCA	pathologic_stage	CAediting_395856	chr5_311794_+	0.00740723512400559	0.258729428972522
BRCA	pathologic_stage	CAediting_395857	chr5_311797_+	0.009181705097184	0.313725462526779
KIRC	pathologic_stage	CAediting_395857	chr5_311797_+	0.037655679573792	0.26680962502256
STAD	pathologic_stage	CAediting_395877	chr5_312765_+	0.0194244396041482	0.30356460355604

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Relation with survival for AHRR

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
LGG	CAediting_395907	chr5_313768_+	0.0164388129160629	0.0133166	0.0612715
LUAD	CAediting_395899	chr5_313724_+	0.00885359547122966	0.0153882	0.000928974

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RelatedDrugs for AHRR

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for AHRR

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene