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Editing gene: LYRM4 (CAeditome ID:57128)

Gene summary for LYRM4

Gene summary

Gene information	Gene symbol	LYRM4
	Gene ID	57128
	Gene name	LYR motif containing 4
	Synonyms	C6orf149\|CGI-203\|COXPD19\|ISD11
	Cytomap	6p25.1
	Type of gene	protein-coding
	Description	LYR motif-containing protein 4homolog of yeast Isd11mitochondrial matrix Nfs1 interacting protein
	Modification date	20210518
	UniProtAcc	Q9HD34
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
LYRM4	GO:0016604	LYR motif-containing protein 4	0000052

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RNA A-to-I events for LYRM4

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000214113.9

RNA A-to-I editing events in Cancer.

CAediting_457233(5103699, -), CAediting_457234(5103722, -), CAediting_457235(5103772, -), CAediting_457236(5103909, -), CAediting_457237(5104332, -), CAediting_457238(5104364, -), CAediting_457239(5104372, -), CAediting_457240(5104377, -), CAediting_457241(5104390, -), CAediting_457242(5104403, -), CAediting_457243(5104418, -), CAediting_457244(5104439, -), CAediting_457245(5104444, -), CAediting_457246(5104445, -), CAediting_457247(5104450, -), CAediting_457248(5104491, -), CAediting_457249(5104515, -), CAediting_457250(5104517, -), CAediting_457251(5104547, -), CAediting_457252(5104548, -), CAediting_457253(5104555, -), CAediting_457254(5105638, -), CAediting_457255(5107765, -), CAediting_457256(5107771, -), CAediting_457257(5139900, -), CAediting_457258(5140751, -), CAediting_457259(5155353, -), CAediting_457260(5163822, -), CAediting_457261(5164750, -), CAediting_457262(5164924, -), CAediting_457263(5165751, -), CAediting_457264(5165766, -), CAediting_457265(5179631, -), CAediting_457266(5186718, -), CAediting_457267(5186727, -), CAediting_457268(5186740, -), CAediting_457269(5186741, -), CAediting_457270(5186749, -), CAediting_457271(5186758, -), CAediting_457272(5186779, -), CAediting_457273(5186796, -), CAediting_457274(5186799, -), CAediting_457275(5186818, -), CAediting_457276(5186821, -), CAediting_457277(5186827, -), CAediting_457278(5186835, -), CAediting_457279(5186846, -), CAediting_457280(5186854, -), CAediting_457281(5186862, -), CAediting_457282(5186872, -), CAediting_457283(5186875, -), CAediting_457284(5186884, -), CAediting_457285(5186902, -), CAediting_457286(5186921, -), CAediting_457287(5186951, -), CAediting_457288(5186958, -), CAediting_457289(5186970, -), CAediting_457290(5199211, -), CAediting_457291(5210873, -), CAediting_457292(5210924, -), CAediting_457293(5228373, -), CAediting_457294(5228374, -), CAediting_457295(5236353, -), CAediting_457296(5236356, -), CAediting_457297(5236378, -), CAediting_457298(5236382, -), CAediting_457299(5236402, -), CAediting_457300(5236451, -), CAediting_457301(5255627, -), CAediting_457302(5255628, -), CAediting_457303(5255630, -), CAediting_457304(5255685, -), CAediting_457305(5255695, -), CAediting_457306(5255696, -), CAediting_457307(5255697, -), CAediting_457308(5255705, -), CAediting_457309(5255706, -), CAediting_457310(5255717, -), CAediting_457311(5255773, -), CAediting_457312(5256097, -), CAediting_457313(5256101, -), CAediting_457314(5256102, -), CAediting_457315(5256123, -), CAediting_457316(5256191, -), CAediting_457317(5256192, -),

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RNA editing positional annotations for LYRM4 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_457274	chr6_5186799_-	nonsynonymous SNV	ENST00000500576.4	c.A389G	p.Y130C	D	.	N
CAediting_457275	chr6_5186818_-	nonsynonymous SNV	ENST00000500576.4	c.A370G	p.R124G	T	.	D
CAediting_457278	chr6_5186835_-	nonsynonymous SNV	ENST00000500576.4	c.A353G	p.N118S	D	.	D
CAediting_457281	chr6_5186862_-	nonsynonymous SNV	ENST00000500576.4	c.A326G	p.Y109C	D	.	D
CAediting_457283	chr6_5186875_-	nonsynonymous SNV	ENST00000500576.4	c.A313G	p.S105G	D	.	N
CAediting_457284	chr6_5186884_-	nonsynonymous SNV	ENST00000500576.4	c.A304G	p.S102G	D	.	N
CAediting_457285	chr6_5186902_-	nonsynonymous SNV	ENST00000500576.4	c.A286G	p.K96E	D	.	N
CAediting_457288	chr6_5186958_-	nonsynonymous SNV	ENST00000500576.4	c.A230G	p.Q77R	D	.	N

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_457233	chr6_5103699_-	ncRNA_exonic
CAediting_457234	chr6_5103722_-	ncRNA_exonic
CAediting_457235	chr6_5103772_-	ncRNA_exonic
CAediting_457236	chr6_5103909_-	ncRNA_exonic
CAediting_457237	chr6_5104332_-	ncRNA_intronic
CAediting_457238	chr6_5104364_-	ncRNA_intronic
CAediting_457239	chr6_5104372_-	ncRNA_intronic
CAediting_457240	chr6_5104377_-	ncRNA_intronic
CAediting_457241	chr6_5104390_-	ncRNA_intronic
CAediting_457242	chr6_5104403_-	ncRNA_intronic
CAediting_457243	chr6_5104418_-	ncRNA_intronic
CAediting_457244	chr6_5104439_-	ncRNA_intronic
CAediting_457245	chr6_5104444_-	ncRNA_intronic
CAediting_457246	chr6_5104445_-	ncRNA_intronic
CAediting_457247	chr6_5104450_-	ncRNA_intronic
CAediting_457248	chr6_5104491_-	ncRNA_intronic
CAediting_457249	chr6_5104515_-	ncRNA_intronic
CAediting_457250	chr6_5104517_-	ncRNA_intronic
CAediting_457251	chr6_5104547_-	ncRNA_intronic
CAediting_457252	chr6_5104548_-	ncRNA_intronic
CAediting_457253	chr6_5104555_-	ncRNA_intronic
CAediting_457254	chr6_5105638_-	ncRNA_intronic
CAediting_457255	chr6_5107765_-	ncRNA_intronic
CAediting_457256	chr6_5107771_-	ncRNA_intronic
CAediting_457257	chr6_5139900_-	intronic
CAediting_457258	chr6_5140751_-	intronic
CAediting_457259	chr6_5155353_-	intronic
CAediting_457260	chr6_5163822_-	intronic
CAediting_457261	chr6_5164750_-	intronic
CAediting_457262	chr6_5164924_-	intronic
CAediting_457263	chr6_5165751_-	intronic
CAediting_457264	chr6_5165766_-	intronic
CAediting_457265	chr6_5179631_-	intronic
CAediting_457266	chr6_5186718_-	UTR3
CAediting_457267	chr6_5186727_-	UTR3
CAediting_457268	chr6_5186740_-	UTR3
CAediting_457269	chr6_5186741_-	UTR3
CAediting_457270	chr6_5186749_-	UTR3
CAediting_457271	chr6_5186758_-	UTR3
CAediting_457272	chr6_5186779_-	UTR3
CAediting_457273	chr6_5186796_-	exonic
CAediting_457274	chr6_5186799_-	exonic
CAediting_457275	chr6_5186818_-	exonic
CAediting_457276	chr6_5186821_-	exonic
CAediting_457277	chr6_5186827_-	exonic
CAediting_457278	chr6_5186835_-	exonic
CAediting_457279	chr6_5186846_-	exonic
CAediting_457280	chr6_5186854_-	exonic
CAediting_457281	chr6_5186862_-	exonic
CAediting_457282	chr6_5186872_-	exonic
CAediting_457283	chr6_5186875_-	exonic
CAediting_457284	chr6_5186884_-	exonic
CAediting_457285	chr6_5186902_-	exonic
CAediting_457286	chr6_5186921_-	exonic
CAediting_457287	chr6_5186951_-	exonic
CAediting_457288	chr6_5186958_-	exonic
CAediting_457289	chr6_5186970_-	exonic
CAediting_457290	chr6_5199211_-	intronic
CAediting_457291	chr6_5210873_-	intronic
CAediting_457292	chr6_5210924_-	intronic
CAediting_457293	chr6_5228373_-	intronic
CAediting_457294	chr6_5228374_-	intronic
CAediting_457295	chr6_5236353_-	ncRNA_exonic
CAediting_457296	chr6_5236356_-	ncRNA_exonic
CAediting_457297	chr6_5236378_-	ncRNA_exonic
CAediting_457298	chr6_5236382_-	ncRNA_exonic
CAediting_457299	chr6_5236402_-	ncRNA_exonic
CAediting_457300	chr6_5236451_-	ncRNA_exonic
CAediting_457301	chr6_5255627_-	ncRNA_intronic
CAediting_457302	chr6_5255628_-	ncRNA_intronic
CAediting_457303	chr6_5255630_-	ncRNA_intronic
CAediting_457304	chr6_5255685_-	ncRNA_intronic
CAediting_457305	chr6_5255695_-	ncRNA_intronic
CAediting_457306	chr6_5255696_-	ncRNA_intronic
CAediting_457307	chr6_5255697_-	ncRNA_intronic
CAediting_457308	chr6_5255705_-	ncRNA_intronic
CAediting_457309	chr6_5255706_-	ncRNA_intronic
CAediting_457310	chr6_5255717_-	ncRNA_intronic
CAediting_457311	chr6_5255773_-	ncRNA_intronic
CAediting_457312	chr6_5256097_-	ncRNA_intronic
CAediting_457313	chr6_5256101_-	ncRNA_intronic
CAediting_457314	chr6_5256102_-	ncRNA_intronic
CAediting_457315	chr6_5256123_-	ncRNA_intronic
CAediting_457316	chr6_5256191_-	ncRNA_intronic
CAediting_457317	chr6_5256192_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_457233	chr6_5103699_-	SINE	Alu	AluSg7
CAediting_457234	chr6_5103722_-	SINE	Alu	AluSg7
CAediting_457235	chr6_5103772_-	SINE	Alu	AluSg7
CAediting_457236	chr6_5103909_-	SINE	Alu	AluSg7
CAediting_457237	chr6_5104332_-	SINE	Alu	AluJb
CAediting_457238	chr6_5104364_-	SINE	Alu	AluJb
CAediting_457239	chr6_5104372_-	SINE	Alu	AluJb
CAediting_457240	chr6_5104377_-	SINE	Alu	AluJb
CAediting_457241	chr6_5104390_-	SINE	Alu	AluJb
CAediting_457242	chr6_5104403_-	SINE	Alu	AluJb
CAediting_457243	chr6_5104418_-	SINE	Alu	AluJb
CAediting_457244	chr6_5104439_-	SINE	Alu	AluJb
CAediting_457245	chr6_5104444_-	SINE	Alu	AluJb
CAediting_457246	chr6_5104445_-	SINE	Alu	AluJb
CAediting_457247	chr6_5104450_-	SINE	Alu	AluJb
CAediting_457248	chr6_5104491_-	SINE	Alu	AluJb
CAediting_457249	chr6_5104515_-	SINE	Alu	AluJb
CAediting_457250	chr6_5104517_-	SINE	Alu	AluJb
CAediting_457251	chr6_5104547_-	SINE	Alu	AluJb
CAediting_457252	chr6_5104548_-	SINE	Alu	AluJb
CAediting_457253	chr6_5104555_-	SINE	Alu	AluJb
CAediting_457254	chr6_5105638_-	SINE	Alu	AluSx
CAediting_457255	chr6_5107765_-	SINE	Alu	AluSx3
CAediting_457256	chr6_5107771_-	SINE	Alu	AluSx3
CAediting_457257	chr6_5139900_-	SINE	Alu	AluJb
CAediting_457258	chr6_5140751_-	LINE	L1	L1MB2
CAediting_457259	chr6_5155353_-	SINE	Alu	AluSz
CAediting_457260	chr6_5163822_-	SINE	Alu	AluSx
CAediting_457261	chr6_5164750_-	SINE	Alu	AluSz
CAediting_457262	chr6_5164924_-	SINE	Alu	AluSz
CAediting_457263	chr6_5165751_-	SINE	Alu	AluSx
CAediting_457264	chr6_5165766_-	SINE	Alu	AluSx
CAediting_457265	chr6_5179631_-	LINE	L1	L1MB3
CAediting_457266	chr6_5186718_-	SINE	Alu	AluSz
CAediting_457267	chr6_5186727_-	SINE	Alu	AluSz
CAediting_457268	chr6_5186740_-	SINE	Alu	AluSz
CAediting_457269	chr6_5186741_-	SINE	Alu	AluSz
CAediting_457270	chr6_5186749_-	SINE	Alu	AluSz
CAediting_457271	chr6_5186758_-	SINE	Alu	AluSz
CAediting_457272	chr6_5186779_-	SINE	Alu	AluSz
CAediting_457273	chr6_5186796_-	SINE	Alu	AluSz
CAediting_457274	chr6_5186799_-	SINE	Alu	AluSz
CAediting_457275	chr6_5186818_-	SINE	Alu	AluSz
CAediting_457276	chr6_5186821_-	SINE	Alu	AluSz
CAediting_457277	chr6_5186827_-	SINE	Alu	AluSz
CAediting_457278	chr6_5186835_-	SINE	Alu	AluSz
CAediting_457279	chr6_5186846_-	SINE	Alu	AluSz
CAediting_457280	chr6_5186854_-	SINE	Alu	AluSz
CAediting_457281	chr6_5186862_-	SINE	Alu	AluSz
CAediting_457282	chr6_5186872_-	SINE	Alu	AluSz
CAediting_457283	chr6_5186875_-	SINE	Alu	AluSz
CAediting_457284	chr6_5186884_-	SINE	Alu	AluSz
CAediting_457285	chr6_5186902_-	SINE	Alu	AluSz
CAediting_457286	chr6_5186921_-	SINE	Alu	AluSz
CAediting_457287	chr6_5186951_-	SINE	Alu	AluSz
CAediting_457288	chr6_5186958_-	SINE	Alu	AluSz
CAediting_457289	chr6_5186970_-	SINE	Alu	AluSz
CAediting_457290	chr6_5199211_-	LINE	L1	L1MB8
CAediting_457291	chr6_5210873_-	LINE	L1	L1MB2
CAediting_457292	chr6_5210924_-	LINE	L1	L1MB2
CAediting_457293	chr6_5228373_-	SINE	Alu	AluSx
CAediting_457294	chr6_5228374_-	SINE	Alu	AluSx
CAediting_457295	chr6_5236353_-	SINE	Alu	AluSx1
CAediting_457296	chr6_5236356_-	SINE	Alu	AluSx1
CAediting_457297	chr6_5236378_-	SINE	Alu	AluSx1
CAediting_457298	chr6_5236382_-	SINE	Alu	AluSx1
CAediting_457299	chr6_5236402_-	SINE	Alu	AluSx1
CAediting_457300	chr6_5236451_-	SINE	Alu	AluSx1
CAediting_457310	chr6_5255717_-	DNA	hAT-Charlie	MER20
CAediting_457311	chr6_5255773_-	DNA	hAT-Charlie	MER20
CAediting_457312	chr6_5256097_-	DNA	hAT-Charlie	MER20

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RNA A-to-I editing events in the alternative splicing sites for LYRM4

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000214113.9.LYRM4.

Correlation between RNA A-to-I editing and PSI for ENSG00000214113.9.LYRM4.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for LYRM4

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for LYRM4

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for LYRM4

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_457267	chr6_5186727_-	ENSG00000214113.9	ENST00000500576	hsa-miR-106a-3p	5186725	5186730	6mer	5186724	5186745	141.00	-21.13
CAediting_457268	chr6_5186740_-	ENSG00000214113.9	ENST00000500576	hsa-miR-326	5186738	5186744	7mer-m8	5186737	5186756	140.00	-13.96
CAediting_457268	chr6_5186740_-	ENSG00000214113.9	ENST00000500576	hsa-miR-330-5p	5186738	5186744	7mer-m8	5186737	5186760	143.00	-22.58
CAediting_457268	chr6_5186740_-	ENSG00000214113.9	ENST00000500576	hsa-miR-4314	5186739	5186745	7mer-m8	5186738	5186756	143.00	-24.03
CAediting_457268	chr6_5186740_-	ENSG00000214113.9	ENST00000500576	hsa-miR-514a-5p	5186737	5186743	7mer-m8	5186736	5186759	150.00	-18.62
CAediting_457268	chr6_5186740_-	ENSG00000214113.9	ENST00000500576	hsa-miR-514a-5p	5186737	5186743	7mer-m8	5186736	5186759	150.00	-18.62
CAediting_457268	chr6_5186740_-	ENSG00000214113.9	ENST00000500576	hsa-miR-514a-5p	5186737	5186743	7mer-m8	5186736	5186759	150.00	-18.62
CAediting_457269	chr6_5186741_-	ENSG00000214113.9	ENST00000500576	hsa-miR-6771-5p	5186739	5186746	8mer-1a	5186739	5186758	160.00	-30.26
CAediting_457271	chr6_5186758_-	ENSG00000214113.9	ENST00000500576	hsa-miR-3937	5186754	5186760	7mer-m8	5186753	5186775	142.00	-22.99
CAediting_457272	chr6_5186779_-	ENSG00000214113.9	ENST00000500576	hsa-miR-6861-3p	5186775	5186780	6mer	5186774	5186791	140.00	-19.06

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_457271	chr6_5186758_-	ENSG00000214113.9	ENST00000500576	hsa-miR-12114	5186755	5186761	7mer-m8	5186754	5186773	152	-28.65
CAediting_457266	chr6_5186718_-	ENSG00000214113.9	ENST00000500576	hsa-miR-203a-5p	5186713	5186719	7mer-m8	5186712	5186736	152	-19.38
CAediting_457269	chr6_5186741_-	ENSG00000214113.9	ENST00000500576	hsa-miR-30b-3p	5186740	5186747	8mer-1a	5186740	5186761	151	-18.54
CAediting_457271	chr6_5186758_-	ENSG00000214113.9	ENST00000500576	hsa-miR-3165	5186756	5186762	7mer-m8	5186755	5186774	149	-18.69
CAediting_457271	chr6_5186758_-	ENSG00000214113.9	ENST00000500576	hsa-miR-3665	5186753	5186759	7mer-m8	5186752	5186769	140	-16.03
CAediting_457269	chr6_5186741_-	ENSG00000214113.9	ENST00000500576	hsa-miR-3689a-3p	5186740	5186747	8mer-1a	5186740	5186761	149	-22.05
CAediting_457269	chr6_5186741_-	ENSG00000214113.9	ENST00000500576	hsa-miR-3689b-3p	5186740	5186747	8mer-1a	5186740	5186761	149	-22.1
CAediting_457269	chr6_5186741_-	ENSG00000214113.9	ENST00000500576	hsa-miR-3689c	5186740	5186747	8mer-1a	5186740	5186761	149	-22.1
CAediting_457270	chr6_5186749_-	ENSG00000214113.9	ENST00000500576	hsa-miR-4478	5186745	5186751	7mer-m8	5186744	5186759	149	-22.24
CAediting_457270	chr6_5186749_-	ENSG00000214113.9	ENST00000500576	hsa-miR-4649-3p	5186748	5186754	7mer-m8	5186747	5186767	140	-14.63
CAediting_457270	chr6_5186749_-	ENSG00000214113.9	ENST00000500576	hsa-miR-485-5p	5186744	5186750	7mer-m8	5186743	5186764	149	-16.01
CAediting_457269	chr6_5186741_-	ENSG00000214113.9	ENST00000500576	hsa-miR-6779-5p	5186740	5186747	8mer-1a	5186740	5186758	148	-23.1
CAediting_457270	chr6_5186749_-	ENSG00000214113.9	ENST00000500576	hsa-miR-7160-5p	5186747	5186753	7mer-m8	5186746	5186763	144	-18.41
CAediting_457272	chr6_5186779_-	ENSG00000214113.9	ENST00000500576	hsa-miR-8083	5186774	5186780	7mer-m8	5186773	5186794	148	-21.64
CAediting_457268	chr6_5186740_-	ENSG00000214113.9	ENST00000500576	hsa-miR-887-5p	5186739	5186746	8mer-1a	5186739	5186758	143	-15.14
CAediting_457269	chr6_5186741_-	ENSG00000214113.9	ENST00000500576	hsa-miR-887-5p	5186739	5186746	8mer-1a	5186739	5186758	143	-15.14

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_117844	chr1_162342605_+	ENSG00000214113.9	ENST00000468929	hsa-miR-556-3p	5109090	5109097	8mer-1a	5109090	5109111	145	-10.37
CAediting_77128	chr1_85133844_+	ENSG00000214113.9	ENST00000468929	hsa-miR-4423-3p	5108642	5108649	8mer-1a	5108642	5108662	145	-16.32
CAediting_414656	chr5_72878640_+	ENSG00000214113.9	ENST00000468929	hsa-miR-4804-3p	5108931	5108937	7mer-1a	5108931	5108951	146	-24.03
CAediting_117844	chr1_162342605_+	ENSG00000214113.9	ENST00000464010	hsa-miR-556-3p	5109090	5109097	8mer-1a	5109090	5109111	145	-10.37
CAediting_77128	chr1_85133844_+	ENSG00000214113.9	ENST00000464010	hsa-miR-4423-3p	5108642	5108649	8mer-1a	5108642	5108662	145	-16.32
CAediting_414656	chr5_72878640_+	ENSG00000214113.9	ENST00000464010	hsa-miR-4804-3p	5108931	5108937	7mer-1a	5108931	5108951	146	-24.03
CAediting_86358	chr1_109598906_+	ENSG00000214113.9	ENST00000463032	hsa-miR-197-5p	5113206	5113212	7mer-m8	5113205	5113231	146	-26.46
CAediting_117844	chr1_162342605_+	ENSG00000214113.9	ENST00000463032	hsa-miR-556-3p	5109090	5109097	8mer-1a	5109090	5109111	145	-10.37
CAediting_77128	chr1_85133844_+	ENSG00000214113.9	ENST00000463032	hsa-miR-4423-3p	5108642	5108649	8mer-1a	5108642	5108662	145	-16.32
CAediting_414656	chr5_72878640_+	ENSG00000214113.9	ENST00000463032	hsa-miR-4804-3p	5108931	5108937	7mer-1a	5108931	5108951	146	-24.03
CAediting_86358	chr1_109598906_+	ENSG00000214113.9	ENST00000480566	hsa-miR-197-5p	5136372	5136378	7mer-m8	5136371	5136392	163	-32.92
CAediting_1399425	chr20_1392958_-	ENSG00000214113.9	ENST00000480566	hsa-miR-6869-5p	5136754	5136760	7mer-m8	5136753	5136774	140	-14.27
CAediting_396018	chr5_1062918_-	ENSG00000214113.9	ENST00000500576	hsa-miR-4635	5186765	5186771	7mer-m8	5186764	5186784	167	-24.48
CAediting_1524209	chrX_134546392_-	ENSG00000214113.9	ENST00000468929	hsa-miR-503-5p	5109315	5109321	7mer-m8	5109314	5109336	155	-18.22
CAediting_1524209	chrX_134546392_-	ENSG00000214113.9	ENST00000464010	hsa-miR-503-5p	5109315	5109321	7mer-m8	5109314	5109336	155	-18.22
CAediting_1524209	chrX_134546392_-	ENSG00000214113.9	ENST00000463032	hsa-miR-503-5p	5109315	5109321	7mer-m8	5109314	5109336	155	-18.22

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_117844	chr1_162342605_+	ENSG00000214113.9	ENST00000468929	hsa-miR-556-3p	5108441	5108448	8mer-1a	5108441	5108462	145	-7.02
CAediting_117844	chr1_162342605_+	ENSG00000214113.9	ENST00000464010	hsa-miR-556-3p	5108441	5108448	8mer-1a	5108441	5108462	145	-7.02
CAediting_86358	chr1_109598906_+	ENSG00000214113.9	ENST00000480566	hsa-miR-197-5p	5136754	5136761	8mer-1a	5136754	5136776	140	-11.16

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for LYRM4

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000330636.7	protein_coding
ENST00000606472.1	processed_transcript
ENST00000500576.4	protein_coding
ENST00000455814.2	processed_transcript

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_457233	ENST00000330636.7	chr6_5103699_-	-2838.40	-2833.00	-2864.50
CAediting_457234	ENST00000330636.7	chr6_5103722_-	-2837.70	-2833.00	-2864.50
CAediting_457235	ENST00000330636.7	chr6_5103772_-	-2833.00	-2833.00	-2864.50
CAediting_457236	ENST00000330636.7	chr6_5103909_-	-2833.10	-2833.00	-2864.50
CAediting_457237	ENST00000330636.7	chr6_5104332_-	-2832.60	-2833.00	-2864.50
CAediting_457238	ENST00000330636.7	chr6_5104364_-	-2833.00	-2833.00	-2864.50
CAediting_457239	ENST00000330636.7	chr6_5104372_-	-2832.00	-2833.00	-2864.50
CAediting_457240	ENST00000330636.7	chr6_5104377_-	-2836.60	-2833.00	-2864.50
CAediting_457241	ENST00000330636.7	chr6_5104390_-	-2832.10	-2833.00	-2864.50
CAediting_457242	ENST00000330636.7	chr6_5104403_-	-2833.00	-2833.00	-2864.50
CAediting_457243	ENST00000330636.7	chr6_5104418_-	-2833.40	-2833.00	-2864.50
CAediting_457244	ENST00000330636.7	chr6_5104439_-	-2832.70	-2833.00	-2864.50
CAediting_457245	ENST00000330636.7	chr6_5104444_-	-2833.10	-2833.00	-2864.50
CAediting_457246	ENST00000330636.7	chr6_5104445_-	-2833.10	-2833.00	-2864.50
CAediting_457247	ENST00000330636.7	chr6_5104450_-	-2833.00	-2833.00	-2864.50
CAediting_457248	ENST00000330636.7	chr6_5104491_-	-2832.10	-2833.00	-2864.50
CAediting_457249	ENST00000330636.7	chr6_5104515_-	-2832.40	-2833.00	-2864.50
CAediting_457250	ENST00000330636.7	chr6_5104517_-	-2839.20	-2833.00	-2864.50
CAediting_457251	ENST00000330636.7	chr6_5104547_-	-2833.00	-2833.00	-2864.50
CAediting_457252	ENST00000330636.7	chr6_5104548_-	-2833.10	-2833.00	-2864.50
CAediting_457253	ENST00000330636.7	chr6_5104555_-	-2839.00	-2833.00	-2864.50
CAediting_457254	ENST00000330636.7	chr6_5105638_-	-2839.70	-2833.00	-2864.50
CAediting_457255	ENST00000330636.7	chr6_5107765_-	-2837.20	-2833.00	-2864.50
CAediting_457256	ENST00000330636.7	chr6_5107771_-	-2833.00	-2833.00	-2864.50
CAediting_457233	ENST00000606472.1	chr6_5103699_-	-355.00	-354.70	-358.60
CAediting_457234	ENST00000606472.1	chr6_5103722_-	-356.50	-354.70	-358.60
CAediting_457235	ENST00000606472.1	chr6_5103772_-	-355.30	-354.70	-358.60
CAediting_457236	ENST00000606472.1	chr6_5103909_-	-356.30	-354.70	-358.60
CAediting_457266	ENST00000500576.4	chr6_5186718_-	-161.50	-159.20	-189.60
CAediting_457267	ENST00000500576.4	chr6_5186727_-	-163.20	-159.20	-189.60
CAediting_457268	ENST00000500576.4	chr6_5186740_-	-161.70	-159.20	-189.60
CAediting_457269	ENST00000500576.4	chr6_5186741_-	-159.20	-159.20	-189.60
CAediting_457270	ENST00000500576.4	chr6_5186749_-	-158.50	-159.20	-189.60
CAediting_457271	ENST00000500576.4	chr6_5186758_-	-158.80	-159.20	-189.60
CAediting_457272	ENST00000500576.4	chr6_5186779_-	-165.00	-159.20	-189.60
CAediting_457273	ENST00000500576.4	chr6_5186796_-	-162.90	-159.20	-189.60
CAediting_457274	ENST00000500576.4	chr6_5186799_-	-159.50	-159.20	-189.60
CAediting_457275	ENST00000500576.4	chr6_5186818_-	-161.30	-159.20	-189.60
CAediting_457276	ENST00000500576.4	chr6_5186821_-	-160.40	-159.20	-189.60
CAediting_457277	ENST00000500576.4	chr6_5186827_-	-160.40	-159.20	-189.60
CAediting_457278	ENST00000500576.4	chr6_5186835_-	-160.70	-159.20	-189.60
CAediting_457279	ENST00000500576.4	chr6_5186846_-	-160.90	-159.20	-189.60
CAediting_457280	ENST00000500576.4	chr6_5186854_-	-159.40	-159.20	-189.60
CAediting_457281	ENST00000500576.4	chr6_5186862_-	-164.20	-159.20	-189.60
CAediting_457282	ENST00000500576.4	chr6_5186872_-	-163.20	-159.20	-189.60
CAediting_457283	ENST00000500576.4	chr6_5186875_-	-162.80	-159.20	-189.60
CAediting_457284	ENST00000500576.4	chr6_5186884_-	-162.80	-159.20	-189.60
CAediting_457285	ENST00000500576.4	chr6_5186902_-	-160.90	-159.20	-189.60
CAediting_457286	ENST00000500576.4	chr6_5186921_-	-162.30	-159.20	-189.60
CAediting_457287	ENST00000500576.4	chr6_5186951_-	-161.50	-159.20	-189.60
CAediting_457288	ENST00000500576.4	chr6_5186958_-	-162.30	-159.20	-189.60
CAediting_457289	ENST00000500576.4	chr6_5186970_-	-160.20	-159.20	-189.60
CAediting_457295	ENST00000455814.2	chr6_5236353_-	-143.30	-142.40	-155.80
CAediting_457296	ENST00000455814.2	chr6_5236356_-	-144.00	-142.40	-155.80
CAediting_457297	ENST00000455814.2	chr6_5236378_-	-145.30	-142.40	-155.80
CAediting_457298	ENST00000455814.2	chr6_5236382_-	-144.90	-142.40	-155.80
CAediting_457299	ENST00000455814.2	chr6_5236402_-	-146.00	-142.40	-155.80
CAediting_457300	ENST00000455814.2	chr6_5236451_-	-143.10	-142.40	-155.80

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Relation with ADAR for LYRM4

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for LYRM4

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for LYRM4

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for LYRM4

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for LYRM4

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
LYRM4	C0036341	Schizophrenia	1	PSYGENET
LYRM4	C3810055	COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 19	1	CTD_human;GENOMICS_ENGLAND;UNIPROT
LYRM4	C4750855	Severe neonatal lactic acidosis due to NFS1-ISD11 complex deficiency	1	ORPHANET

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene