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Editing gene: PSMD3 (CAeditome ID:5709)

Gene summary for PSMD3

Gene summary

Gene information	Gene symbol	PSMD3
	Gene ID	5709
	Gene name	proteasome 26S subunit, non-ATPase 3
	Synonyms	P58\|RPN3\|S3\|TSTA2
	Cytomap	17q21.1
	Type of gene	protein-coding
	Description	26S proteasome non-ATPase regulatory subunit 326S proteasome regulatory subunit RPN326S proteasome regulatory subunit S3proteasome (prosome, macropain) 26S subunit, non-ATPase, 3proteasome subunit p58tissue specific transplantation antigen 2
	Modification date	20210518
	UniProtAcc	O43242
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
PSMD3	GO:0000502	26S proteasome non-ATPase regulatory subunit 3	17323924

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RNA A-to-I events for PSMD3

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000108344.13

RNA A-to-I editing events in Cancer.

CAediting_1192365(39983052, +), CAediting_1192366(39983172, +), CAediting_1192367(39983216, +), CAediting_1192368(39983284, +), CAediting_1192369(39983297, +), CAediting_1192370(39984890, +), CAediting_1192371(39987459, +), CAediting_1192372(39987464, +), CAediting_1192373(39987476, +), CAediting_1192374(39987488, +), CAediting_1192375(39987508, +), CAediting_1192376(39987538, +), CAediting_1192377(39987622, +), CAediting_1192378(39987688, +), CAediting_1192379(39987735, +), CAediting_1192380(39987757, +), CAediting_1192381(39987830, +), CAediting_1192382(39987853, +), CAediting_1192383(39987874, +), CAediting_1192384(39987922, +), CAediting_1192385(39987950, +), CAediting_1192386(39987960, +), CAediting_1192387(39988009, +), CAediting_1192388(39988013, +), CAediting_1192389(39990268, +), CAediting_1192390(39990298, +), CAediting_1192391(39990301, +), CAediting_1192392(39990310, +), CAediting_1192393(39990532, +), CAediting_1192394(39991002, +), CAediting_1192395(39991018, +), CAediting_1192396(39991035, +), CAediting_1192397(39991058, +), CAediting_1192398(39991079, +), CAediting_1192399(39991105, +), CAediting_1192400(39991116, +), CAediting_1192401(39991176, +), CAediting_1192402(39991177, +), CAediting_1192403(39991219, +), CAediting_1192404(39991284, +), CAediting_1192405(39991285, +), CAediting_1192406(39991294, +), CAediting_1192407(39991296, +), CAediting_1192408(39991310, +), CAediting_1192409(39991754, +), CAediting_1192410(39991763, +), CAediting_1192411(39991767, +), CAediting_1192412(39991776, +), CAediting_1192413(39991778, +), CAediting_1192414(39991784, +), CAediting_1192415(39991785, +), CAediting_1192416(39991790, +), CAediting_1192417(39991793, +), CAediting_1192418(39991811, +), CAediting_1192419(39991812, +), CAediting_1192420(39991825, +), CAediting_1192421(39991836, +), CAediting_1192422(39991873, +), CAediting_1192423(39991878, +), CAediting_1192424(39991889, +), CAediting_1192425(39991898, +), CAediting_1192426(39991904, +), CAediting_1192427(39991910, +), CAediting_1192428(39991927, +), CAediting_1192429(39991934, +), CAediting_1192430(39991940, +), CAediting_1192431(39991954, +), CAediting_1192432(39991977, +), CAediting_1192433(39995863, +), CAediting_1192434(39995909, +), CAediting_1192435(39995958, +), CAediting_1192436(39995998, +), CAediting_1192437(39996137, +), CAediting_1192438(39996519, +),

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RNA editing positional annotations for PSMD3 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1192365	chr17_39983052_+	intronic
CAediting_1192366	chr17_39983172_+	intronic
CAediting_1192367	chr17_39983216_+	intronic
CAediting_1192368	chr17_39983284_+	intronic
CAediting_1192369	chr17_39983297_+	intronic
CAediting_1192370	chr17_39984890_+	intronic
CAediting_1192371	chr17_39987459_+	ncRNA_intronic
CAediting_1192372	chr17_39987464_+	ncRNA_intronic
CAediting_1192373	chr17_39987476_+	ncRNA_intronic
CAediting_1192374	chr17_39987488_+	ncRNA_intronic
CAediting_1192375	chr17_39987508_+	ncRNA_intronic
CAediting_1192376	chr17_39987538_+	ncRNA_intronic
CAediting_1192377	chr17_39987622_+	ncRNA_intronic
CAediting_1192378	chr17_39987688_+	ncRNA_intronic
CAediting_1192379	chr17_39987735_+	ncRNA_intronic
CAediting_1192380	chr17_39987757_+	ncRNA_intronic
CAediting_1192381	chr17_39987830_+	ncRNA_intronic
CAediting_1192382	chr17_39987853_+	ncRNA_intronic
CAediting_1192383	chr17_39987874_+	ncRNA_intronic
CAediting_1192384	chr17_39987922_+	ncRNA_intronic
CAediting_1192385	chr17_39987950_+	ncRNA_intronic
CAediting_1192386	chr17_39987960_+	ncRNA_intronic
CAediting_1192387	chr17_39988009_+	ncRNA_intronic
CAediting_1192388	chr17_39988013_+	ncRNA_intronic
CAediting_1192389	chr17_39990268_+	intronic
CAediting_1192390	chr17_39990298_+	intronic
CAediting_1192391	chr17_39990301_+	intronic
CAediting_1192392	chr17_39990310_+	intronic
CAediting_1192393	chr17_39990532_+	intronic
CAediting_1192394	chr17_39991002_+	intronic
CAediting_1192395	chr17_39991018_+	intronic
CAediting_1192396	chr17_39991035_+	intronic
CAediting_1192397	chr17_39991058_+	intronic
CAediting_1192398	chr17_39991079_+	intronic
CAediting_1192399	chr17_39991105_+	intronic
CAediting_1192400	chr17_39991116_+	intronic
CAediting_1192401	chr17_39991176_+	intronic
CAediting_1192402	chr17_39991177_+	intronic
CAediting_1192403	chr17_39991219_+	intronic
CAediting_1192404	chr17_39991284_+	intronic
CAediting_1192405	chr17_39991285_+	intronic
CAediting_1192406	chr17_39991294_+	intronic
CAediting_1192407	chr17_39991296_+	intronic
CAediting_1192408	chr17_39991310_+	intronic
CAediting_1192409	chr17_39991754_+	intronic
CAediting_1192410	chr17_39991763_+	intronic
CAediting_1192411	chr17_39991767_+	intronic
CAediting_1192412	chr17_39991776_+	intronic
CAediting_1192413	chr17_39991778_+	intronic
CAediting_1192414	chr17_39991784_+	intronic
CAediting_1192415	chr17_39991785_+	intronic
CAediting_1192416	chr17_39991790_+	intronic
CAediting_1192417	chr17_39991793_+	intronic
CAediting_1192418	chr17_39991811_+	intronic
CAediting_1192419	chr17_39991812_+	intronic
CAediting_1192420	chr17_39991825_+	intronic
CAediting_1192421	chr17_39991836_+	intronic
CAediting_1192422	chr17_39991873_+	intronic
CAediting_1192423	chr17_39991878_+	intronic
CAediting_1192424	chr17_39991889_+	intronic
CAediting_1192425	chr17_39991898_+	intronic
CAediting_1192426	chr17_39991904_+	intronic
CAediting_1192427	chr17_39991910_+	intronic
CAediting_1192428	chr17_39991927_+	intronic
CAediting_1192429	chr17_39991934_+	intronic
CAediting_1192430	chr17_39991940_+	intronic
CAediting_1192431	chr17_39991954_+	intronic
CAediting_1192432	chr17_39991977_+	intronic
CAediting_1192433	chr17_39995863_+	ncRNA_exonic
CAediting_1192434	chr17_39995909_+	ncRNA_exonic
CAediting_1192435	chr17_39995958_+	ncRNA_exonic
CAediting_1192436	chr17_39995998_+	ncRNA_exonic
CAediting_1192437	chr17_39996137_+	intronic
CAediting_1192438	chr17_39996519_+	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1192365	chr17_39983052_+	SINE	Alu	AluSx1
CAediting_1192366	chr17_39983172_+	SINE	Alu	AluSx1
CAediting_1192367	chr17_39983216_+	SINE	Alu	AluSx1
CAediting_1192368	chr17_39983284_+	SINE	Alu	AluSx1
CAediting_1192369	chr17_39983297_+	SINE	Alu	AluSx1
CAediting_1192370	chr17_39984890_+	SINE	Alu	Alu
CAediting_1192371	chr17_39987459_+	SINE	Alu	AluJb
CAediting_1192372	chr17_39987464_+	SINE	Alu	AluJb
CAediting_1192373	chr17_39987476_+	SINE	Alu	AluJb
CAediting_1192374	chr17_39987488_+	SINE	Alu	AluJb
CAediting_1192375	chr17_39987508_+	SINE	Alu	AluJb
CAediting_1192376	chr17_39987538_+	SINE	Alu	AluJb
CAediting_1192377	chr17_39987622_+	SINE	Alu	AluJb
CAediting_1192378	chr17_39987688_+	SINE	Alu	FLAM_A
CAediting_1192379	chr17_39987735_+	SINE	Alu	FLAM_A
CAediting_1192380	chr17_39987757_+	SINE	Alu	FLAM_A
CAediting_1192381	chr17_39987830_+	SINE	Alu	AluSc
CAediting_1192382	chr17_39987853_+	SINE	Alu	AluSc
CAediting_1192383	chr17_39987874_+	SINE	Alu	AluSc
CAediting_1192384	chr17_39987922_+	SINE	Alu	AluSc
CAediting_1192385	chr17_39987950_+	SINE	Alu	AluSc
CAediting_1192386	chr17_39987960_+	SINE	Alu	AluSc
CAediting_1192387	chr17_39988009_+	SINE	Alu	AluSc
CAediting_1192388	chr17_39988013_+	SINE	Alu	AluSc
CAediting_1192389	chr17_39990268_+	SINE	Alu	FLAM_C
CAediting_1192390	chr17_39990298_+	SINE	Alu	FLAM_C
CAediting_1192391	chr17_39990301_+	SINE	Alu	FLAM_C
CAediting_1192392	chr17_39990310_+	SINE	Alu	FLAM_C
CAediting_1192393	chr17_39990532_+	SINE	Alu	AluJo
CAediting_1192394	chr17_39991002_+	SINE	Alu	AluSx1
CAediting_1192395	chr17_39991018_+	SINE	Alu	AluSx1
CAediting_1192396	chr17_39991035_+	SINE	Alu	AluSx1
CAediting_1192397	chr17_39991058_+	SINE	Alu	AluSx1
CAediting_1192398	chr17_39991079_+	SINE	Alu	AluSx1
CAediting_1192399	chr17_39991105_+	SINE	Alu	AluSx1
CAediting_1192400	chr17_39991116_+	SINE	Alu	AluSx1
CAediting_1192401	chr17_39991176_+	SINE	Alu	AluSx1
CAediting_1192402	chr17_39991177_+	SINE	Alu	AluSx1
CAediting_1192403	chr17_39991219_+	SINE	Alu	AluSx1
CAediting_1192404	chr17_39991284_+	SINE	Alu	AluSx1
CAediting_1192405	chr17_39991285_+	SINE	Alu	AluSx1
CAediting_1192406	chr17_39991294_+	SINE	Alu	AluSx1
CAediting_1192407	chr17_39991296_+	SINE	Alu	AluSx1
CAediting_1192408	chr17_39991310_+	SINE	Alu	AluSx1
CAediting_1192412	chr17_39991776_+	SINE	Alu	AluJr
CAediting_1192413	chr17_39991778_+	SINE	Alu	AluJr
CAediting_1192414	chr17_39991784_+	SINE	Alu	AluJr
CAediting_1192415	chr17_39991785_+	SINE	Alu	AluJr
CAediting_1192416	chr17_39991790_+	SINE	Alu	AluJr
CAediting_1192417	chr17_39991793_+	SINE	Alu	AluJr
CAediting_1192418	chr17_39991811_+	SINE	Alu	AluJr
CAediting_1192419	chr17_39991812_+	SINE	Alu	AluJr
CAediting_1192420	chr17_39991825_+	SINE	Alu	AluJr
CAediting_1192421	chr17_39991836_+	SINE	Alu	AluJr
CAediting_1192422	chr17_39991873_+	SINE	Alu	AluJr
CAediting_1192423	chr17_39991878_+	SINE	Alu	AluJr
CAediting_1192424	chr17_39991889_+	SINE	Alu	AluJr
CAediting_1192425	chr17_39991898_+	SINE	Alu	AluJr
CAediting_1192426	chr17_39991904_+	SINE	Alu	AluJr
CAediting_1192427	chr17_39991910_+	SINE	Alu	AluJr
CAediting_1192428	chr17_39991927_+	SINE	Alu	AluJr
CAediting_1192429	chr17_39991934_+	SINE	Alu	AluJr
CAediting_1192430	chr17_39991940_+	SINE	Alu	AluJr
CAediting_1192431	chr17_39991954_+	SINE	Alu	AluJr
CAediting_1192432	chr17_39991977_+	SINE	Alu	AluJr
CAediting_1192433	chr17_39995863_+	SINE	Alu	AluSx1
CAediting_1192434	chr17_39995909_+	SINE	Alu	AluSx1
CAediting_1192435	chr17_39995958_+	SINE	Alu	AluSx1
CAediting_1192436	chr17_39995998_+	SINE	Alu	AluSx1
CAediting_1192437	chr17_39996137_+	SINE	Alu	AluSx1

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RNA A-to-I editing events in the alternative splicing sites for PSMD3

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000108344.13.PSMD3.

Correlation between RNA A-to-I editing and PSI for ENSG00000108344.13.PSMD3.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PSMD3

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for PSMD3

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for PSMD3

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_980496	chr14_31014685_-	ENSG00000108344.13	ENST00000415039	hsa-miR-624-3p	39989796	39989802	7mer-m8	39989783	39989803	140	-15.73
CAediting_1054808	chr15_66496985_-	ENSG00000108344.13	ENST00000415039	hsa-miR-4512	39990159	39990165	7mer-m8	39990146	39990166	141	-16.59
CAediting_396018	chr5_1062918_-	ENSG00000108344.13	ENST00000415039	hsa-miR-4635	39995027	39995033	7mer-m8	39995015	39995034	141	-11.48
CAediting_86358	chr1_109598906_+	ENSG00000108344.13	ENST00000415039	hsa-miR-197-5p	39996263	39996269	7mer-m8	39996245	39996270	148	-26.06

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for PSMD3

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for PSMD3

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for PSMD3

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for PSMD3

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for PSMD3

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for PSMD3

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
PSMD3	C0019693	HIV Infections	1	CTD_human
PSMD3	C4505456	HIV Coinfection	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene