CAeditome Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: ENY2 (CAeditome ID:56943)

Gene summary for ENY2

check button Gene summary
Gene informationGene symbol

ENY2

Gene ID

56943

Gene nameENY2 transcription and export complex 2 subunit
SynonymsDC6|Sus1|e(y)2
Cytomap

8q23.1

Type of geneprotein-coding
Descriptiontranscription and mRNA export factor ENY2enhancer of yellow 2 homologenhancer of yellow 2 transcription factor homolog
Modification date20210518
UniProtAcc

Q9NPA8

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
ENY2

GO:0003713

Transcription and mRNA export factor ENY2

18206972

ENY2

GO:0030374

Transcription and mRNA export factor ENY2

18206972

ENY2

GO:0016578

Transcription and mRNA export factor ENY2

18206972

ENY2

GO:0045893

Transcription and mRNA export factor ENY2

18206972

ENY2

GO:0005654

Transcription and mRNA export factor ENY2

0000052

ENY2

GO:0005739

Transcription and mRNA export factor ENY2

0000052

ENY2

GO:0000124

Transcription and mRNA export factor ENY2

18206972

ENY2

GO:0000124

Transcription and mRNA export factor ENY2

23591820

ENY2

GO:0000124

Transcription and mRNA export factor ENY2

27601583

ENY2

GO:0044615

Transcription and mRNA export factor ENY2

23591820

ENY2

GO:0070390

Transcription and mRNA export factor ENY2

23591820

ENY2

GO:0071819

Transcription and mRNA export factor ENY2

27601583


Top

RNA A-to-I events for ENY2

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000120533.11

check button RNA A-to-I editing events in Cancer.
CAediting_656932(109342634, +), CAediting_656933(109342660, +), CAediting_656934(109342734, +), CAediting_656935(109342742, +),

Top

RNA editing positional annotations for ENY2 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
CAediting_656934chr8_109342734_+nonsynonymous SNVENST00000520147.4c.A259Gp.T87AD.N

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_656932chr8_109342634_+ncRNA_intronic
CAediting_656933chr8_109342660_+ncRNA_intronic
CAediting_656934chr8_109342734_+exonic
CAediting_656935chr8_109342742_+exonic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_656932chr8_109342634_+SINEAluAluJb
CAediting_656933chr8_109342660_+SINEAluAluJb
CAediting_656934chr8_109342734_+SINEAluAluJb
CAediting_656935chr8_109342742_+SINEAluAluJb

Top

RNA A-to-I editing events in the alternative splicing sites for ENY2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000120533.11.ENY2.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000120533.11.ENY2.

Top

Differntial gene expression between RNA A-to-I edited versus non-edited samples for ENY2

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

Top

Protein coding region RNA A-to-I editings for ENY2

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


Top

The effects of the RNA editing to the miRNA binding sites for ENY2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_688081chr9_63819627_+ENSG00000120533.11ENST00000521662hsa-miR-4477b1093436251093436328mer-1a109343611109343632144-8.45
CAediting_748296chr10_51299626_+ENSG00000120533.11ENST00000517311hsa-miR-605-3p1093447751093447817mer-m8109344757109344782160-18.52
CAediting_393chr1_1167164_+ENSG00000120533.11ENST00000517311hsa-miR-200b-3p1093449601093449678mer-1a109344946109344967148-12.5
CAediting_688081chr9_63819627_+ENSG00000120533.11ENST00000517311hsa-miR-4477b1093436251093436328mer-1a109343611109343632144-8.45
CAediting_688081chr9_63819627_+ENSG00000120533.11ENST00000339942hsa-miR-4477b1093436251093436328mer-1a109343611109343632144-8.45
CAediting_688081chr9_63819627_+ENSG00000120533.11ENST00000520147hsa-miR-4477b1093436251093436328mer-1a109343611109343632144-8.45
CAediting_688081chr9_63819627_+ENSG00000120533.11ENST00000523335hsa-miR-4477b1093436251093436328mer-1a109343611109343632144-8.45
CAediting_1229415chr17_67471547_+ENSG00000120533.11ENST00000517311hsa-miR-548aa1093446731093446808mer-1a109344653109344680149-11.8
CAediting_1306323chr19_13836462_-ENSG00000120533.11ENST00000517311hsa-miR-27a-3p1093444161093444227mer-m8109344400109344423157-20.94
CAediting_86358chr1_109598906_+ENSG00000120533.11ENST00000517311hsa-miR-197-5p1093441231093441308mer-1a109344108109344130150-18.08
CAediting_1399425chr20_1392958_-ENSG00000120533.11ENST00000517311hsa-miR-6869-5p1093455081093455158mer-1a109345494109345515140-15.1
CAediting_442554chr5_154685830_+ENSG00000120533.11ENST00000517311hsa-miR-13031093444541093444618mer-1a109344442109344461152-19
CAediting_1306323chr19_13836462_-ENSG00000120533.11ENST00000523335hsa-miR-27a-3p1093444161093444227mer-m8109344400109344423157-20.94
CAediting_86358chr1_109598906_+ENSG00000120533.11ENST00000523335hsa-miR-197-5p1093441231093441308mer-1a109344108109344130150-18.08
CAediting_442554chr5_154685830_+ENSG00000120533.11ENST00000523335hsa-miR-13031093444541093444618mer-1a109344442109344461152-19
CAediting_468389chr6_31355314_-ENSG00000120533.11ENST00000517311hsa-miR-6891-5p1093442471093442537mer-1a109344235109344253141-30.4
CAediting_468389chr6_31355314_-ENSG00000120533.11ENST00000523335hsa-miR-6891-5p1093442471093442537mer-1a109344235109344253141-30.4

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_228905chr2_188297554_+ENSG00000120533.11ENST00000517311hsa-miR-561-3p1093439131093439197mer-m8109343897109343920154-12.92
CAediting_1399425chr20_1392958_-ENSG00000120533.11ENST00000517311hsa-miR-6869-5p1093440391093440457mer-m8109344026109344046144-14.22
CAediting_228905chr2_188297554_+ENSG00000120533.11ENST00000523335hsa-miR-561-3p1093439131093439197mer-m8109343897109343920154-12.92

check button Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for ENY2

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000520147.4protein_codingSoverviewSoverview

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
CAediting_656934ENST00000520147.4chr8_109342734_+-203.20-200.10-204.60
CAediting_656935ENST00000520147.4chr8_109342742_+-199.80-200.10-204.60

Top

Relation with ADAR for ENY2

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

Top

Relation with cancer stages for ENY2

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

Top

Relation with survival for ENY2

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

Top

RelatedDrugs for ENY2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ENY2

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource