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Editing gene: CMC2 (CAeditome ID:56942)

Gene summary for CMC2

Gene summary

Gene information	Gene symbol	CMC2
	Gene ID	56942
	Gene name	C-X9-C motif containing 2
	Synonyms	2310061C15Rik\|C16orf61\|DC13
	Cytomap	16q23.2
	Type of gene	protein-coding
	Description	COX assembly mitochondrial protein 2 homologC-x(9)-C motif containing 2
	Modification date	20210518
	UniProtAcc	Q9NRP2
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
CMC2	GO:0005739	COX assembly mitochondrial protein 2 homolog	20220131

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RNA A-to-I events for CMC2

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000103121.7

RNA A-to-I editing events in Cancer.

CAediting_1138553(80968269, -), CAediting_1138554(80968289, -), CAediting_1138555(80968303, -), CAediting_1138556(80975440, -), CAediting_1138557(80975442, -), CAediting_1138558(80977815, -), CAediting_1138559(80977855, -), CAediting_1138560(80977880, -), CAediting_1138561(80979753, -), CAediting_1138562(80979759, -), CAediting_1138563(80979830, -), CAediting_1138564(80979895, -), CAediting_1138565(80979897, -), CAediting_1138566(80980166, -), CAediting_1138567(80980773, -), CAediting_1138568(80980783, -), CAediting_1138569(80980795, -), CAediting_1138570(80980800, -), CAediting_1138571(80980812, -), CAediting_1138572(80980830, -), CAediting_1138573(80980860, -), CAediting_1138574(80980881, -), CAediting_1138575(80982385, -), CAediting_1138576(80987931, -), CAediting_1138577(80990260, -), CAediting_1138578(80990308, -), CAediting_1138579(80990352, -), CAediting_1138580(80990749, -), CAediting_1138581(80990766, -), CAediting_1138582(80990792, -), CAediting_1138583(80990803, -), CAediting_1138584(80990977, -), CAediting_1138585(80991400, -), CAediting_1138586(80991414, -), CAediting_1138587(80991573, -), CAediting_1138588(80991634, -), CAediting_1138589(80992813, -), CAediting_1138590(80992820, -), CAediting_1138591(80992830, -), CAediting_1138592(80992891, -), CAediting_1138593(80998140, -), CAediting_1138594(80998158, -), CAediting_1138595(80998200, -), CAediting_1138596(80998217, -), CAediting_1138597(80998818, -), CAediting_1138598(81002403, -), CAediting_1138599(81004139, -),

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RNA editing positional annotations for CMC2 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_1138571	chr16_80980812_-	nonsynonymous SNV	ENST00000486645.4	c.A149G	p.K50R	D	.	N
CAediting_1138571	chr16_80980812_-	nonsynonymous SNV	ENST00000562713.2	c.A221G	p.K74R	D	.	N
CAediting_1138571	chr16_80980812_-	nonsynonymous SNV	ENST00000565613.4	c.A221G	p.K74R	D	.	N
CAediting_1138571	chr16_80980812_-	nonsynonymous SNV	ENST00000565925.4	c.A221G	p.K74R	D	.	N
CAediting_1138571	chr16_80980812_-	nonsynonymous SNV	ENST00000570195.4	c.A278G	p.K93R	D	.	N
CAediting_1138571	chr16_80980812_-	nonsynonymous SNV	ENST00000630396.1	c.A278G	p.K93R	D	.	N
CAediting_1138572	chr16_80980830_-	nonsynonymous SNV	ENST00000486645.4	c.A131G	p.H44R	D	.	N
CAediting_1138572	chr16_80980830_-	nonsynonymous SNV	ENST00000562713.2	c.A203G	p.H68R	D	.	N
CAediting_1138572	chr16_80980830_-	nonsynonymous SNV	ENST00000565613.4	c.A203G	p.H68R	D	.	N
CAediting_1138572	chr16_80980830_-	nonsynonymous SNV	ENST00000565925.4	c.A203G	p.H68R	D	.	N
CAediting_1138572	chr16_80980830_-	nonsynonymous SNV	ENST00000570195.4	c.A260G	p.H87R	D	.	N
CAediting_1138572	chr16_80980830_-	nonsynonymous SNV	ENST00000630396.1	c.A260G	p.H87R	D	.	N

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1138553	chr16_80968269_-	UTR3
CAediting_1138554	chr16_80968289_-	UTR3
CAediting_1138555	chr16_80968303_-	UTR3
CAediting_1138556	chr16_80975440_-	UTR3
CAediting_1138557	chr16_80975442_-	UTR3
CAediting_1138558	chr16_80977815_-	ncRNA_intronic
CAediting_1138559	chr16_80977855_-	ncRNA_intronic
CAediting_1138560	chr16_80977880_-	ncRNA_intronic
CAediting_1138561	chr16_80979753_-	ncRNA_intronic
CAediting_1138562	chr16_80979759_-	ncRNA_intronic
CAediting_1138563	chr16_80979830_-	ncRNA_intronic
CAediting_1138564	chr16_80979895_-	ncRNA_intronic
CAediting_1138565	chr16_80979897_-	ncRNA_intronic
CAediting_1138566	chr16_80980166_-	ncRNA_intronic
CAediting_1138567	chr16_80980773_-	ncRNA_exonic
CAediting_1138568	chr16_80980783_-	ncRNA_exonic
CAediting_1138569	chr16_80980795_-	ncRNA_exonic
CAediting_1138570	chr16_80980800_-	ncRNA_exonic
CAediting_1138571	chr16_80980812_-	exonic
CAediting_1138572	chr16_80980830_-	exonic
CAediting_1138573	chr16_80980860_-	exonic
CAediting_1138574	chr16_80980881_-	splicing
CAediting_1138575	chr16_80982385_-	ncRNA_exonic
CAediting_1138576	chr16_80987931_-	ncRNA_intronic
CAediting_1138577	chr16_80990260_-	ncRNA_intronic
CAediting_1138578	chr16_80990308_-	ncRNA_intronic
CAediting_1138579	chr16_80990352_-	ncRNA_intronic
CAediting_1138580	chr16_80990749_-	ncRNA_intronic
CAediting_1138581	chr16_80990766_-	ncRNA_intronic
CAediting_1138582	chr16_80990792_-	ncRNA_intronic
CAediting_1138583	chr16_80990803_-	ncRNA_intronic
CAediting_1138584	chr16_80990977_-	ncRNA_intronic
CAediting_1138585	chr16_80991400_-	ncRNA_intronic
CAediting_1138586	chr16_80991414_-	ncRNA_intronic
CAediting_1138587	chr16_80991573_-	ncRNA_intronic
CAediting_1138588	chr16_80991634_-	ncRNA_intronic
CAediting_1138589	chr16_80992813_-	ncRNA_intronic
CAediting_1138590	chr16_80992820_-	ncRNA_intronic
CAediting_1138591	chr16_80992830_-	ncRNA_intronic
CAediting_1138592	chr16_80992891_-	ncRNA_intronic
CAediting_1138593	chr16_80998140_-	ncRNA_exonic
CAediting_1138594	chr16_80998158_-	ncRNA_exonic
CAediting_1138595	chr16_80998200_-	ncRNA_exonic
CAediting_1138596	chr16_80998217_-	ncRNA_exonic
CAediting_1138597	chr16_80998818_-	ncRNA_exonic
CAediting_1138598	chr16_81002403_-	ncRNA_intronic
CAediting_1138599	chr16_81004139_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1138553	chr16_80968269_-	SINE	Alu	AluJr
CAediting_1138554	chr16_80968289_-	SINE	Alu	AluJr
CAediting_1138555	chr16_80968303_-	SINE	Alu	AluJr
CAediting_1138556	chr16_80975440_-	SINE	Alu	AluSx
CAediting_1138557	chr16_80975442_-	SINE	Alu	AluSx
CAediting_1138558	chr16_80977815_-	SINE	Alu	AluSx
CAediting_1138559	chr16_80977855_-	SINE	Alu	AluSx
CAediting_1138560	chr16_80977880_-	SINE	Alu	AluSx
CAediting_1138561	chr16_80979753_-	SINE	Alu	AluSx1
CAediting_1138562	chr16_80979759_-	SINE	Alu	AluSx1
CAediting_1138563	chr16_80979830_-	SINE	Alu	AluSx1
CAediting_1138564	chr16_80979895_-	SINE	Alu	AluSx1
CAediting_1138565	chr16_80979897_-	SINE	Alu	AluSx1
CAediting_1138566	chr16_80980166_-	SINE	Alu	AluJr
CAediting_1138567	chr16_80980773_-	SINE	Alu	AluJr
CAediting_1138568	chr16_80980783_-	SINE	Alu	AluJr
CAediting_1138569	chr16_80980795_-	SINE	Alu	AluJr
CAediting_1138570	chr16_80980800_-	SINE	Alu	AluJr
CAediting_1138571	chr16_80980812_-	SINE	Alu	AluJr
CAediting_1138572	chr16_80980830_-	SINE	Alu	AluJr
CAediting_1138573	chr16_80980860_-	SINE	Alu	AluJr
CAediting_1138574	chr16_80980881_-	SINE	Alu	AluJr
CAediting_1138575	chr16_80982385_-	SINE	Alu	AluSg7
CAediting_1138576	chr16_80987931_-	SINE	Alu	AluJr
CAediting_1138577	chr16_80990260_-	SINE	Alu	AluSz6
CAediting_1138578	chr16_80990308_-	SINE	Alu	AluSz6
CAediting_1138579	chr16_80990352_-	SINE	Alu	AluSz6
CAediting_1138580	chr16_80990749_-	SINE	Alu	AluJb
CAediting_1138581	chr16_80990766_-	SINE	Alu	AluJb
CAediting_1138582	chr16_80990792_-	SINE	Alu	AluJb
CAediting_1138583	chr16_80990803_-	SINE	Alu	AluJb
CAediting_1138584	chr16_80990977_-	SINE	Alu	AluJb
CAediting_1138585	chr16_80991400_-	SINE	Alu	AluJb
CAediting_1138586	chr16_80991414_-	SINE	Alu	AluJb
CAediting_1138587	chr16_80991573_-	SINE	Alu	AluJb
CAediting_1138588	chr16_80991634_-	SINE	Alu	AluJb
CAediting_1138589	chr16_80992813_-	SINE	Alu	AluJr
CAediting_1138590	chr16_80992820_-	SINE	Alu	AluJr
CAediting_1138591	chr16_80992830_-	SINE	Alu	AluJr
CAediting_1138592	chr16_80992891_-	SINE	Alu	AluJr
CAediting_1138593	chr16_80998140_-	SINE	Alu	AluJr
CAediting_1138594	chr16_80998158_-	SINE	Alu	AluJr
CAediting_1138595	chr16_80998200_-	SINE	Alu	AluJr
CAediting_1138596	chr16_80998217_-	SINE	Alu	AluJr
CAediting_1138597	chr16_80998818_-	LINE	L1	L1P4
CAediting_1138598	chr16_81002403_-	SINE	Alu	AluSx1
CAediting_1138599	chr16_81004139_-	SINE	Alu	AluSx1

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RNA A-to-I editing events in the alternative splicing sites for CMC2

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
ES	CAediting_1138574	chr16_80980881_-	80980877:80980899	3SS	0+2i	TCTTTTTTCTTTTGAGACAGGTT	5.47	TCTTTTTTCTTTTGAGACGGGTT	-2.49
ES	CAediting_1138574	chr16_80980881_-	80980881:80980903	3SS	3+0i	TTTTTCTTTTTTCTTTTGAGACA	3.09	TTTTTCTTTTTTCTTTTGAGACG	4.76
MEX_2	CAediting_1138574	chr16_80980881_-	80980881:80980903	3SS	3+0i	TTTTTCTTTTTTCTTTTGAGACA	3.09	TTTTTCTTTTTTCTTTTGAGACG	4.76
MEX_1	CAediting_1138574	chr16_80980881_-	80980877:80980899	3SS	0+2i	TCTTTTTTCTTTTGAGACAGGTT	5.47	TCTTTTTTCTTTTGAGACGGGTT	-2.49
MEX_1	CAediting_1138574	chr16_80980881_-	80980881:80980903	3SS	3+0i	TTTTTCTTTTTTCTTTTGAGACA	3.09	TTTTTCTTTTTTCTTTTGAGACG	4.76

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000103121.7.CMC2.

Correlation between RNA A-to-I editing and PSI for ENSG00000103121.7.CMC2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CMC2

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CMC2

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for CMC2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1138570	chr16_80980800_-	ENSG00000103121.7	ENST00000567593	hsa-miR-6765-5p	80980795	80980801	7mer-m8	80980794	80980815	153.00	-25.88
CAediting_1138553	chr16_80968269_-	ENSG00000103121.7	ENST00000219400	hsa-miR-4716-5p	80968268	80968274	7mer-m8	80968267	80968288	148.00	-14.09
CAediting_1138555	chr16_80968303_-	ENSG00000103121.7	ENST00000219400	hsa-miR-5699-5p	80968300	80968306	7mer-m8	80968299	80968321	146.00	-15.07
CAediting_1138555	chr16_80968303_-	ENSG00000103121.7	ENST00000219400	hsa-miR-874-5p	80968298	80968305	8mer-1a	80968298	80968320	152.00	-19.89
CAediting_1138556	chr16_80975440_-	ENSG00000103121.7	ENST00000219400	hsa-miR-10a-5p	80975438	80975444	7mer-m8	80975437	80975460	148.00	-18.95
CAediting_1138556	chr16_80975440_-	ENSG00000103121.7	ENST00000219400	hsa-miR-10b-5p	80975438	80975444	7mer-m8	80975437	80975460	148.00	-19.97
CAediting_1138556	chr16_80975440_-	ENSG00000103121.7	ENST00000219400	hsa-miR-339-5p	80975439	80975445	7mer-m8	80975438	80975462	159.00	-25.45
CAediting_1138556	chr16_80975440_-	ENSG00000103121.7	ENST00000219400	hsa-miR-4421	80975440	80975446	7mer-m8	80975439	80975460	154.00	-17.19
CAediting_1138556	chr16_80975440_-	ENSG00000103121.7	ENST00000219400	hsa-miR-548as-3p	80975435	80975441	7mer-m8	80975434	80975455	140.00	-11.21
CAediting_1138556	chr16_80975440_-	ENSG00000103121.7	ENST00000219400	hsa-miR-5699-3p	80975440	80975446	7mer-m8	80975439	80975460	149.00	-17.85
CAediting_1138556	chr16_80975440_-	ENSG00000103121.7	ENST00000219400	hsa-miR-6732-3p	80975437	80975443	7mer-m8	80975436	80975457	163.00	-21.86
CAediting_1138557	chr16_80975442_-	ENSG00000103121.7	ENST00000219400	hsa-miR-340-3p	80975440	80975447	8mer-1a	80975440	80975461	145.00	-17.24
CAediting_1138557	chr16_80975442_-	ENSG00000103121.7	ENST00000219400	hsa-miR-6827-3p	80975440	80975447	8mer-1a	80975440	80975460	149.00	-16.74
CAediting_1138571	chr16_80980812_-	ENSG00000103121.7	ENST00000567593	hsa-miR-3622a-3p	80980808	80980815	8mer-1a	80980808	80980829	140.00	-13.58
CAediting_1138571	chr16_80980812_-	ENSG00000103121.7	ENST00000567593	hsa-miR-3622b-3p	80980808	80980815	8mer-1a	80980808	80980828	147.00	-17.65
CAediting_1138571	chr16_80980812_-	ENSG00000103121.7	ENST00000567593	hsa-miR-4682	80980812	80980818	7mer-m8	80980811	80980831	147.00	-17.90
CAediting_1138573	chr16_80980860_-	ENSG00000103121.7	ENST00000567593	hsa-miR-3135a	80980858	80980864	7mer-m8	80980857	80980877	158.00	-20.59
CAediting_1138573	chr16_80980860_-	ENSG00000103121.7	ENST00000567593	hsa-miR-6849-3p	80980854	80980861	8mer-1a	80980854	80980875	148.00	-16.79

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1138556	chr16_80975440_-	ENSG00000103121.7	ENST00000219400	hsa-miR-5582-3p	80975435	80975440	6mer	80975434	80975455	140	-11.27
CAediting_1138557	chr16_80975442_-	ENSG00000103121.7	ENST00000219400	hsa-miR-6818-3p	80975442	80975448	7mer-m8	80975441	80975462	140	-14.76
CAediting_1138555	chr16_80968303_-	ENSG00000103121.7	ENST00000219400	hsa-miR-6878-3p	80968298	80968304	7mer-m8	80968297	80968319	150	-28.61
CAediting_1138556	chr16_80975440_-	ENSG00000103121.7	ENST00000219400	hsa-miR-6888-3p	80975440	80975446	7mer-m8	80975439	80975459	150	-15.21
CAediting_1138557	chr16_80975442_-	ENSG00000103121.7	ENST00000219400	hsa-miR-6888-3p	80975440	80975446	7mer-m8	80975439	80975459	150	-15.21
CAediting_1138570	chr16_80980800_-	ENSG00000103121.7	ENST00000567593	hsa-miR-1233-5p	80980799	80980805	7mer-m8	80980798	80980819	145	-18.92
CAediting_1138570	chr16_80980800_-	ENSG00000103121.7	ENST00000567593	hsa-miR-1233-5p	80980799	80980805	7mer-m8	80980798	80980819	145	-18.92
CAediting_1138570	chr16_80980800_-	ENSG00000103121.7	ENST00000567593	hsa-miR-1273h-5p	80980800	80980806	7mer-m8	80980799	80980820	146	-18.31
CAediting_1138570	chr16_80980800_-	ENSG00000103121.7	ENST00000567593	hsa-miR-30b-3p	80980800	80980806	7mer-m8	80980799	80980819	142	-15.74
CAediting_1138571	chr16_80980812_-	ENSG00000103121.7	ENST00000567593	hsa-miR-3614-5p	80980808	80980814	7mer-1a	80980808	80980829	151	-20.33
CAediting_1138570	chr16_80980800_-	ENSG00000103121.7	ENST00000567593	hsa-miR-3689a-3p	80980800	80980806	7mer-m8	80980799	80980819	142	-14.66
CAediting_1138570	chr16_80980800_-	ENSG00000103121.7	ENST00000567593	hsa-miR-3689b-3p	80980800	80980806	7mer-m8	80980799	80980818	148	-17.28
CAediting_1138570	chr16_80980800_-	ENSG00000103121.7	ENST00000567593	hsa-miR-3689c	80980800	80980806	7mer-m8	80980799	80980818	148	-17.28
CAediting_1138569	chr16_80980795_-	ENSG00000103121.7	ENST00000567593	hsa-miR-4478	80980791	80980797	7mer-m8	80980790	80980806	155	-27.09
CAediting_1138569	chr16_80980795_-	ENSG00000103121.7	ENST00000567593	hsa-miR-485-5p	80980790	80980796	7mer-m8	80980789	80980811	149	-16.49
CAediting_1138570	chr16_80980800_-	ENSG00000103121.7	ENST00000567593	hsa-miR-6778-5p	80980799	80980805	7mer-m8	80980798	80980820	151	-23.79
CAediting_1138570	chr16_80980800_-	ENSG00000103121.7	ENST00000567593	hsa-miR-6780a-5p	80980800	80980806	7mer-m8	80980799	80980823	142	-20.08
CAediting_1138569	chr16_80980795_-	ENSG00000103121.7	ENST00000567593	hsa-miR-7160-5p	80980793	80980799	7mer-m8	80980792	80980812	150	-18.56
CAediting_1138569	chr16_80980795_-	ENSG00000103121.7	ENST00000567593	hsa-miR-7162-3p	80980794	80980800	7mer-m8	80980793	80980811	152	-18.37

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_980496	chr14_31014685_-	ENSG00000103121.7	ENST00000219400	hsa-miR-624-3p	80971115	80971121	7mer-m8	80971114	80971134	140	-15.12
CAediting_980496	chr14_31014685_-	ENSG00000103121.7	ENST00000219400	hsa-miR-624-3p	80968257	80968263	7mer-m8	80968256	80968276	160	-14.85
CAediting_688080	chr9_63819626_+	ENSG00000103121.7	ENST00000219400	hsa-miR-4477b	80967993	80968000	8mer-1a	80967993	80968014	149	-11.67
CAediting_688080	chr9_63819626_+	ENSG00000103121.7	ENST00000219400	hsa-miR-4477b	80967818	80967824	7mer-m8	80967817	80967837	150	-12.87
CAediting_688081	chr9_63819627_+	ENSG00000103121.7	ENST00000219400	hsa-miR-4477b	80970453	80970459	7mer-m8	80970452	80970473	140	-10.32
CAediting_1054808	chr15_66496985_-	ENSG00000103121.7	ENST00000219400	hsa-miR-4512	80973291	80973297	7mer-1a	80973291	80973312	150	-25.81
CAediting_1229414	chr17_67471546_+	ENSG00000103121.7	ENST00000219400	hsa-miR-548aa	80969686	80969692	7mer-m8	80969685	80969709	140	-12.81
CAediting_1229415	chr17_67471547_+	ENSG00000103121.7	ENST00000219400	hsa-miR-548aa	80974231	80974237	7mer-m8	80974230	80974253	156	-16.75
CAediting_1229415	chr17_67471547_+	ENSG00000103121.7	ENST00000219400	hsa-miR-548aa	80972813	80972819	7mer-m8	80972812	80972836	152	-10.81
CAediting_1229415	chr17_67471547_+	ENSG00000103121.7	ENST00000219400	hsa-miR-548aa	80968937	80968944	8mer-1a	80968937	80968961	140	-10.62
CAediting_1229415	chr17_67471547_+	ENSG00000103121.7	ENST00000219400	hsa-miR-548aa	80967255	80967262	8mer-1a	80967255	80967280	151	-13.85
CAediting_1160181	chr17_7017644_-	ENSG00000103121.7	ENST00000219400	hsa-miR-195-3p	80975301	80975308	8mer-1a	80975301	80975322	155	-12.43
CAediting_1351755	chr19_40282625_-	ENSG00000103121.7	ENST00000219400	hsa-miR-641	80974146	80974153	8mer-1a	80974146	80974165	143	-15.46
CAediting_77128	chr1_85133844_+	ENSG00000103121.7	ENST00000219400	hsa-miR-4423-3p	80975335	80975341	7mer-m8	80975334	80975354	140	-12.95
CAediting_77128	chr1_85133844_+	ENSG00000103121.7	ENST00000219400	hsa-miR-4423-3p	80975145	80975152	8mer-1a	80975145	80975166	148	-15.7
CAediting_396018	chr5_1062918_-	ENSG00000103121.7	ENST00000219400	hsa-miR-4635	80969669	80969675	7mer-m8	80969668	80969688	154	-16.66
CAediting_442554	chr5_154685830_+	ENSG00000103121.7	ENST00000219400	hsa-miR-1303	80970340	80970346	7mer-m8	80970339	80970360	144	-10.62
CAediting_524911	chr7_5495852_-	ENSG00000103121.7	ENST00000219400	hsa-miR-589-3p	80972615	80972621	7mer-m8	80972614	80972635	155	-21.22
CAediting_524911	chr7_5495852_-	ENSG00000103121.7	ENST00000219400	hsa-miR-589-3p	80969249	80969255	7mer-m8	80969248	80969274	146	-20.06
CAediting_468389	chr6_31355314_-	ENSG00000103121.7	ENST00000219400	hsa-miR-6891-5p	80972209	80972215	7mer-m8	80972208	80972228	157	-24.7
CAediting_468389	chr6_31355314_-	ENSG00000103121.7	ENST00000219400	hsa-miR-6891-5p	80969540	80969547	8mer-1a	80969540	80969558	146	-28.08

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_573000	chr7_92204081_-	ENSG00000103121.7	ENST00000219400	hsa-miR-1285-5p	80970286	80970292	7mer-m8	80970285	80970307	150	-12
CAediting_573001	chr7_92204086_-	ENSG00000103121.7	ENST00000219400	hsa-miR-1285-5p	80970286	80970292	7mer-m8	80970285	80970307	150	-12
CAediting_846604	chr11_93733708_-	ENSG00000103121.7	ENST00000219400	hsa-miR-1304-3p	80973702	80973708	7mer-m8	80973701	80973721	150	-17.99
CAediting_1160181	chr17_7017644_-	ENSG00000103121.7	ENST00000219400	hsa-miR-195-3p	80973396	80973402	7mer-m8	80973395	80973415	154	-12.74
CAediting_1160181	chr17_7017644_-	ENSG00000103121.7	ENST00000219400	hsa-miR-195-3p	80972307	80972313	7mer-1a	80972307	80972329	145	-13.13
CAediting_1160181	chr17_7017644_-	ENSG00000103121.7	ENST00000219400	hsa-miR-195-3p	80967652	80967659	8mer-1a	80967652	80967673	143	-10.05
CAediting_1160181	chr17_7017644_-	ENSG00000103121.7	ENST00000219400	hsa-miR-195-3p	80966594	80966600	7mer-m8	80966593	80966614	146	-6.1
CAediting_1306323	chr19_13836462_-	ENSG00000103121.7	ENST00000219400	hsa-miR-27a-3p	80975007	80975012	6mer	80975006	80975027	142	-19.91
CAediting_1306323	chr19_13836462_-	ENSG00000103121.7	ENST00000219400	hsa-miR-27a-3p	80967263	80967268	6mer	80967262	80967285	141	-16.21
CAediting_1368054	chr19_46709310_-	ENSG00000103121.7	ENST00000219400	hsa-miR-320e	80973756	80973762	7mer-m8	80973755	80973774	142	-15.59
CAediting_1368054	chr19_46709310_-	ENSG00000103121.7	ENST00000219400	hsa-miR-320e	80968279	80968285	7mer-m8	80968278	80968296	149	-15.66
CAediting_414656	chr5_72878640_+	ENSG00000103121.7	ENST00000219400	hsa-miR-4804-3p	80967233	80967239	7mer-m8	80967232	80967252	140	-7.61
CAediting_1229413	chr17_67471544_+	ENSG00000103121.7	ENST00000219400	hsa-miR-548aa	80975461	80975467	7mer-m8	80975460	80975484	140	-12.99
CAediting_1229414	chr17_67471546_+	ENSG00000103121.7	ENST00000219400	hsa-miR-548aa	80975461	80975467	7mer-m8	80975460	80975484	140	-12.99
CAediting_1229415	chr17_67471547_+	ENSG00000103121.7	ENST00000219400	hsa-miR-548aa	80975461	80975467	7mer-m8	80975460	80975484	140	-12.99
CAediting_228905	chr2_188297554_+	ENSG00000103121.7	ENST00000219400	hsa-miR-561-3p	80973924	80973930	7mer-m8	80973923	80973942	149	-15.38
CAediting_228905	chr2_188297554_+	ENSG00000103121.7	ENST00000219400	hsa-miR-561-3p	80972713	80972719	7mer-m8	80972712	80972735	150	-10.13
CAediting_228905	chr2_188297554_+	ENSG00000103121.7	ENST00000219400	hsa-miR-561-3p	80970709	80970715	7mer-m8	80970708	80970732	151	-9.48
CAediting_228905	chr2_188297554_+	ENSG00000103121.7	ENST00000219400	hsa-miR-561-3p	80966611	80966618	8mer-1a	80966611	80966632	145	-3.99
CAediting_748296	chr10_51299626_+	ENSG00000103121.7	ENST00000219400	hsa-miR-605-3p	80970384	80970390	7mer-m8	80970383	80970403	154	-16.86
CAediting_748296	chr10_51299626_+	ENSG00000103121.7	ENST00000219400	hsa-miR-605-3p	80968097	80968103	7mer-m8	80968096	80968120	147	-16
CAediting_1351755	chr19_40282625_-	ENSG00000103121.7	ENST00000219400	hsa-miR-641	80972939	80972945	7mer-m8	80972938	80972961	154	-21.01
CAediting_580943	chr7_100356700_+	ENSG00000103121.7	ENST00000219400	hsa-miR-6840-3p	80969519	80969526	8mer-1a	80969519	80969540	145	-23.14
CAediting_468389	chr6_31355314_-	ENSG00000103121.7	ENST00000219400	hsa-miR-6891-5p	80970397	80970403	7mer-m8	80970396	80970416	151	-20.8

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CMC2

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for CMC2

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
LGG	CAediting_1138568	chr16_80980783_-	0.0241416974169297	0.185940674426608	.	.	.	.

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Relation with cancer stages for CMC2

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for CMC2

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for CMC2

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CMC2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
CMC2	C0006142	Malignant neoplasm of breast	1	CTD_human
CMC2	C0678222	Breast Carcinoma	1	CTD_human
CMC2	C1257931	Mammary Neoplasms, Human	1	CTD_human
CMC2	C1458155	Mammary Neoplasms	1	CTD_human
CMC2	C4704874	Mammary Carcinoma, Human	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene