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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: PRSS1 (CAeditome ID:5644) |
Gene summary for PRSS1 |
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Gene information | Gene symbol | PRSS1 | Gene ID | 5644 |
Gene name | serine protease 1 | |
Synonyms | TRP1|TRY1|TRY4|TRYP1 | |
Cytomap | 7q34 | |
Type of gene | protein-coding | |
Description | trypsin-1TCR V beta 4.1beta-trypsincationic trypsinogendigestive zymogennonfunctional trypsin 1protease, serine 1trypsinogen 1trypsinogen A | |
Modification date | 20210518 | |
UniProtAcc | P07477 | |
Context |
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Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for PRSS1 |
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CAediting_609905(142751830, +), CAediting_609906(142762906, +), |
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RNA editing positional annotations for PRSS1 using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
CAediting_609905 | chr7_142751830_+ | nonsynonymous SNV | ENST00000311737.10 | c.A257G | p.Q86R | D | D | D |
CAediting_609905 | chr7_142751830_+ | nonsynonymous SNV | ENST00000486171.4 | c.A299G | p.Q100R | D | D | D |
CAediting_609905 | chr7_142751830_+ | nonsynonymous SNV | ENST00000492062.1 | c.A107G | p.Q36R | D | D | D |
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CAeditome ID | Position | Variant type |
CAediting_609905 | chr7_142751830_+ | exonic |
CAediting_609906 | chr7_142762906_+ | ncRNA_exonic |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
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RNA A-to-I editing events in the alternative splicing sites for PRSS1 |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
IR | CAediting_609905 | chr7_142751830_+ | 142751811:142751833 | 3SS | 0+1i | GTCCTGGAGGGGAATGAGCAGTT | -28.81 | GTCCTGGAGGGGAATGAGCGGTT | -20.06 |
IR | CAediting_609905 | chr7_142751830_+ | 142751813:142751835 | 3SS | 0+3i | CCTGGAGGGGAATGAGCAGTTCA | -34.05 | CCTGGAGGGGAATGAGCGGTTCA | -42.8 |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PRSS1 |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for PRSS1 |
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The effects of the RNA editing to the miRNA binding sites for PRSS1 |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_980496 | chr14_31014685_- | ENSG00000204983.11 | ENST00000619214 | hsa-miR-624-3p | 142753059 | 142753065 | 7mer-m8 | 142753040 | 142753066 | 151 | -19.03 |
CAediting_980496 | chr14_31014685_- | ENSG00000204983.11 | ENST00000492062 | hsa-miR-624-3p | 142753059 | 142753065 | 7mer-m8 | 142753040 | 142753066 | 151 | -19.03 |
CAediting_77128 | chr1_85133844_+ | ENSG00000204983.11 | ENST00000492062 | hsa-miR-4423-3p | 142752934 | 142752940 | 7mer-m8 | 142752922 | 142752941 | 141 | -14.82 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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The effects of the RNA editing to the stability of the RNA structures for PRSS1 |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
CAediting_609905 | ENST00000311737.10 | chr7_142751830_+ | -272.90 | -267.40 | -272.90 |
CAediting_609905 | ENST00000463701.1 | chr7_142751830_+ | -451.80 | -446.30 | -451.80 |
CAediting_609905 | ENST00000485223.1 | chr7_142751830_+ | -509.70 | -504.20 | -509.70 |
CAediting_609905 | ENST00000486171.4 | chr7_142751830_+ | -282.30 | -276.80 | -282.30 |
CAediting_609905 | ENST00000492062.1 | chr7_142751830_+ | -206.90 | -201.90 | -206.90 |
CAediting_609905 | ENST00000612126.3 | chr7_142751830_+ | -289.80 | -284.30 | -289.80 |
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Relation with ADAR for PRSS1 |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for PRSS1 |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for PRSS1 |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for PRSS1 |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
PRSS1 | P07477 | DB06692 | Aprotinin | Trypsin-1 | BiotechDrug | approved|investigational|withdrawn |
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RelatedDiseases for PRSS1 |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
PRSS1 | C0238339 | Hereditary pancreatitis | 13 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
PRSS1 | C0267937 | Acute recurrent pancreatitis | 2 | ORPHANET |
PRSS1 | C0030305 | Pancreatitis | 1 | CTD_human |
PRSS1 | C0149521 | Pancreatitis, Chronic | 1 | CTD_human |
PRSS1 | C4080064 | Autosomal Dominant Hereditary Pancreatitis | 1 | CTD_human |