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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: METTL3 (CAeditome ID:56339) |
Gene summary for METTL3 |
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Gene information | Gene symbol | METTL3 | Gene ID | 56339 |
Gene name | methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit | |
Synonyms | IME4|M6A|MT-A70|Spo8|hMETTL3 | |
Cytomap | 14q11.2 | |
Type of gene | protein-coding | |
Description | N6-adenosine-methyltransferase catalytic subunitN6-adenosine-methyltransferase 70 kDa subunitadoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferasemRNA (2'-O-methyladenosine-N(6)-)-methyltransferasemRNA m(6)A methyltransferasemethy | |
Modification date | 20210524 | |
UniProtAcc | Q86U44 | |
Context |
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Gene | GO ID | GO term | PubMed ID |
METTL3 | GO:0001734 | N6-adenosine-methyltransferase catalytic subunit | 24316715 |
METTL3 | GO:0001734 | N6-adenosine-methyltransferase catalytic subunit | 27281194 |
METTL3 | GO:0001734 | N6-adenosine-methyltransferase catalytic subunit | 27373337 |
METTL3 | GO:0001734 | N6-adenosine-methyltransferase catalytic subunit | 27627798 |
METTL3 | GO:0003729 | N6-adenosine-methyltransferase catalytic subunit | 27281194 |
METTL3 | GO:0003729 | N6-adenosine-methyltransferase catalytic subunit | 27373337 |
METTL3 | GO:0003729 | N6-adenosine-methyltransferase catalytic subunit | 30559377 |
METTL3 | GO:0008173 | N6-adenosine-methyltransferase catalytic subunit | 25799998 |
METTL3 | GO:0008173 | N6-adenosine-methyltransferase catalytic subunit | 27602518 |
METTL3 | GO:0008173 | N6-adenosine-methyltransferase catalytic subunit | 29348140 |
METTL3 | GO:0008173 | N6-adenosine-methyltransferase catalytic subunit | 29506078 |
METTL3 | GO:0046982 | N6-adenosine-methyltransferase catalytic subunit | 27373337 |
METTL3 | GO:1904047 | N6-adenosine-methyltransferase catalytic subunit | 27281194 |
METTL3 | GO:1904047 | N6-adenosine-methyltransferase catalytic subunit | 27373337 |
METTL3 | GO:0006974 | N6-adenosine-methyltransferase catalytic subunit | 28297716 |
METTL3 | GO:0009048 | N6-adenosine-methyltransferase catalytic subunit | 27602518 |
METTL3 | GO:0031053 | N6-adenosine-methyltransferase catalytic subunit | 25799998 |
METTL3 | GO:0034644 | N6-adenosine-methyltransferase catalytic subunit | 28297716 |
METTL3 | GO:0080009 | N6-adenosine-methyltransferase catalytic subunit | 24316715 |
METTL3 | GO:0080009 | N6-adenosine-methyltransferase catalytic subunit | 27281194 |
METTL3 | GO:0080009 | N6-adenosine-methyltransferase catalytic subunit | 27373337 |
METTL3 | GO:0080009 | N6-adenosine-methyltransferase catalytic subunit | 27627798 |
METTL3 | GO:0080009 | N6-adenosine-methyltransferase catalytic subunit | 28297716 |
METTL3 | GO:1990744 | N6-adenosine-methyltransferase catalytic subunit | 25799998 |
METTL3 | GO:0005634 | N6-adenosine-methyltransferase catalytic subunit | 24316715 |
METTL3 | GO:0005634 | N6-adenosine-methyltransferase catalytic subunit | 26458103 |
METTL3 | GO:0005634 | N6-adenosine-methyltransferase catalytic subunit | 29348140 |
METTL3 | GO:0005634 | N6-adenosine-methyltransferase catalytic subunit | 29506078 |
METTL3 | GO:0005634 | N6-adenosine-methyltransferase catalytic subunit | 9409616 |
METTL3 | GO:0016607 | N6-adenosine-methyltransferase catalytic subunit | 24407421 |
METTL3 | GO:0036396 | N6-adenosine-methyltransferase catalytic subunit | 24316715 |
METTL3 | GO:0036396 | N6-adenosine-methyltransferase catalytic subunit | 24407421 |
METTL3 | GO:0036396 | N6-adenosine-methyltransferase catalytic subunit | 24981863 |
METTL3 | GO:0036396 | N6-adenosine-methyltransferase catalytic subunit | 27602518 |
METTL3 | GO:0036396 | N6-adenosine-methyltransferase catalytic subunit | 27627798 |
METTL3 | GO:0036396 | N6-adenosine-methyltransferase catalytic subunit | 29348140 |
METTL3 | GO:0036396 | N6-adenosine-methyltransferase catalytic subunit | 29506078 |
METTL3 | GO:0036396 | N6-adenosine-methyltransferase catalytic subunit | 29507755 |
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RNA A-to-I events for METTL3 |
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CAediting_976710(21499200, -), CAediting_976711(21500087, -), CAediting_976712(21500170, -), CAediting_976713(21500192, -), CAediting_976714(21500236, -), CAediting_976715(21500252, -), CAediting_976716(21500255, -), CAediting_976717(21500278, -), CAediting_976718(21500282, -), CAediting_976719(21500312, -), CAediting_976720(21500323, -), CAediting_976721(21500601, -), CAediting_976722(21500622, -), CAediting_976723(21502084, -), CAediting_976724(21502122, -), CAediting_976725(21502135, -), CAediting_976726(21502161, -), CAediting_976727(21502184, -), CAediting_976728(21502243, -), CAediting_976729(21502256, -), CAediting_976730(21502274, -), CAediting_976731(21502288, -), CAediting_976732(21502313, -), CAediting_976733(21502319, -), CAediting_976734(21503519, -), CAediting_976735(21503770, -), CAediting_976736(21503850, -), CAediting_976737(21504713, -), CAediting_976738(21506804, -), CAediting_976739(21506899, -), CAediting_976740(21506903, -), CAediting_976741(21506907, -), CAediting_976742(21506909, -), CAediting_976743(21507032, -), CAediting_976744(21507629, -), CAediting_976745(21508037, -), CAediting_976746(21508083, -), CAediting_976747(21508086, -), CAediting_976748(21508139, -), CAediting_976749(21508216, -), CAediting_976750(21508229, -), CAediting_976751(21509697, -), |
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RNA editing positional annotations for METTL3 using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
CAediting_976721 | chr14_21500601_- | nonsynonymous SNV | ENST00000298717.7 | c.A1198G | p.I400V | D | D | N |
CAediting_976722 | chr14_21500622_- | nonsynonymous SNV | ENST00000298717.7 | c.A1177G | p.M393V | D | P | D |
CAediting_976734 | chr14_21503519_- | nonsynonymous SNV | ENST00000298717.7 | c.A377G | p.Q126R | D | D | N |
CAediting_976734 | chr14_21503519_- | nonsynonymous SNV | ENST00000537163.4 | c.A377G | p.Q126R | D | D | N |
CAediting_976734 | chr14_21503519_- | nonsynonymous SNV | ENST00000543235.4 | c.A377G | p.Q126R | D | D | N |
CAediting_976734 | chr14_21503519_- | nonsynonymous SNV | ENST00000544248.1 | c.A377G | p.Q126R | D | D | N |
CAediting_976735 | chr14_21503770_- | nonsynonymous SNV | ENST00000298717.7 | c.A212G | p.E71G | D | B | N |
CAediting_976735 | chr14_21503770_- | nonsynonymous SNV | ENST00000537163.4 | c.A212G | p.E71G | D | B | N |
CAediting_976735 | chr14_21503770_- | nonsynonymous SNV | ENST00000543235.4 | c.A212G | p.E71G | D | B | N |
CAediting_976735 | chr14_21503770_- | nonsynonymous SNV | ENST00000544248.1 | c.A212G | p.E71G | D | B | N |
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CAeditome ID | Position | Variant type |
CAediting_976710 | chr14_21499200_- | ncRNA_exonic |
CAediting_976711 | chr14_21500087_- | ncRNA_intronic |
CAediting_976712 | chr14_21500170_- | ncRNA_intronic |
CAediting_976713 | chr14_21500192_- | ncRNA_intronic |
CAediting_976714 | chr14_21500236_- | ncRNA_intronic |
CAediting_976715 | chr14_21500252_- | ncRNA_intronic |
CAediting_976716 | chr14_21500255_- | ncRNA_intronic |
CAediting_976717 | chr14_21500278_- | ncRNA_intronic |
CAediting_976718 | chr14_21500282_- | ncRNA_intronic |
CAediting_976719 | chr14_21500312_- | ncRNA_intronic |
CAediting_976720 | chr14_21500323_- | ncRNA_intronic |
CAediting_976721 | chr14_21500601_- | exonic |
CAediting_976722 | chr14_21500622_- | exonic |
CAediting_976723 | chr14_21502084_- | ncRNA_intronic |
CAediting_976724 | chr14_21502122_- | ncRNA_intronic |
CAediting_976725 | chr14_21502135_- | ncRNA_intronic |
CAediting_976726 | chr14_21502161_- | ncRNA_intronic |
CAediting_976727 | chr14_21502184_- | ncRNA_intronic |
CAediting_976728 | chr14_21502243_- | ncRNA_intronic |
CAediting_976729 | chr14_21502256_- | ncRNA_intronic |
CAediting_976730 | chr14_21502274_- | ncRNA_intronic |
CAediting_976731 | chr14_21502288_- | ncRNA_intronic |
CAediting_976732 | chr14_21502313_- | ncRNA_intronic |
CAediting_976733 | chr14_21502319_- | ncRNA_intronic |
CAediting_976734 | chr14_21503519_- | exonic |
CAediting_976735 | chr14_21503770_- | exonic |
CAediting_976736 | chr14_21503850_- | exonic |
CAediting_976737 | chr14_21504713_- | ncRNA_exonic |
CAediting_976738 | chr14_21506804_- | ncRNA_intronic |
CAediting_976739 | chr14_21506899_- | ncRNA_intronic |
CAediting_976740 | chr14_21506903_- | ncRNA_intronic |
CAediting_976741 | chr14_21506907_- | ncRNA_intronic |
CAediting_976742 | chr14_21506909_- | ncRNA_intronic |
CAediting_976743 | chr14_21507032_- | ncRNA_intronic |
CAediting_976744 | chr14_21507629_- | ncRNA_intronic |
CAediting_976745 | chr14_21508037_- | ncRNA_exonic |
CAediting_976746 | chr14_21508083_- | ncRNA_exonic |
CAediting_976747 | chr14_21508086_- | ncRNA_exonic |
CAediting_976748 | chr14_21508139_- | ncRNA_exonic |
CAediting_976749 | chr14_21508216_- | ncRNA_exonic |
CAediting_976750 | chr14_21508229_- | ncRNA_exonic |
CAediting_976751 | chr14_21509697_- | ncRNA_intronic |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
CAediting_976711 | chr14_21500087_- | SINE | Alu | AluSc8 |
CAediting_976712 | chr14_21500170_- | SINE | Alu | AluSc8 |
CAediting_976713 | chr14_21500192_- | SINE | Alu | AluSc8 |
CAediting_976714 | chr14_21500236_- | SINE | Alu | AluSc8 |
CAediting_976715 | chr14_21500252_- | SINE | Alu | AluSc8 |
CAediting_976716 | chr14_21500255_- | SINE | Alu | AluSc8 |
CAediting_976717 | chr14_21500278_- | SINE | Alu | AluSc8 |
CAediting_976718 | chr14_21500282_- | SINE | Alu | AluSc8 |
CAediting_976719 | chr14_21500312_- | SINE | Alu | AluSc8 |
CAediting_976720 | chr14_21500323_- | SINE | Alu | AluSc8 |
CAediting_976723 | chr14_21502084_- | SINE | Alu | AluJr |
CAediting_976724 | chr14_21502122_- | SINE | Alu | AluJr |
CAediting_976725 | chr14_21502135_- | SINE | Alu | AluJr |
CAediting_976726 | chr14_21502161_- | SINE | Alu | AluJr |
CAediting_976727 | chr14_21502184_- | SINE | Alu | AluJr |
CAediting_976728 | chr14_21502243_- | SINE | Alu | AluJr |
CAediting_976729 | chr14_21502256_- | SINE | Alu | AluJr |
CAediting_976730 | chr14_21502274_- | SINE | Alu | AluJr |
CAediting_976731 | chr14_21502288_- | SINE | Alu | AluJr |
CAediting_976732 | chr14_21502313_- | SINE | Alu | AluJr |
CAediting_976737 | chr14_21504713_- | SINE | Alu | AluSz |
CAediting_976738 | chr14_21506804_- | SINE | Alu | AluJb |
CAediting_976739 | chr14_21506899_- | SINE | Alu | AluJb |
CAediting_976740 | chr14_21506903_- | SINE | Alu | AluJb |
CAediting_976741 | chr14_21506907_- | SINE | Alu | AluJb |
CAediting_976742 | chr14_21506909_- | SINE | Alu | AluJb |
CAediting_976743 | chr14_21507032_- | SINE | Alu | AluSq10 |
CAediting_976744 | chr14_21507629_- | SINE | Alu | AluY |
CAediting_976745 | chr14_21508037_- | SINE | Alu | AluJo |
CAediting_976746 | chr14_21508083_- | SINE | Alu | AluJo |
CAediting_976747 | chr14_21508086_- | SINE | Alu | AluJo |
CAediting_976748 | chr14_21508139_- | SINE | Alu | AluJo |
CAediting_976749 | chr14_21508216_- | SINE | Alu | AluJo |
CAediting_976750 | chr14_21508229_- | SINE | Alu | AluJo |
CAediting_976751 | chr14_21509697_- | SINE | Alu | AluJr4 |
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RNA A-to-I editing events in the alternative splicing sites for METTL3 |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for METTL3 |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for METTL3 |
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The effects of the RNA editing to the miRNA binding sites for METTL3 |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_976710 | chr14_21499200_- | ENSG00000165819.10 | ENST00000537163 | hsa-miR-96-3p | 21499197 | 21499204 | 8mer-1a | 21499197 | 21499219 | 141.00 | -10.01 |
CAediting_976710 | chr14_21499200_- | ENSG00000165819.10 | ENST00000543235 | hsa-miR-96-3p | 21499197 | 21499204 | 8mer-1a | 21499197 | 21499219 | 141.00 | -10.01 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_976722 | chr14_21500622_- | ENSG00000165819.10 | ENST00000537163 | hsa-miR-6884-3p | 21500619 | 21500625 | 7mer-m8 | 21500618 | 21500640 | 143 | -15.22 |
CAediting_976722 | chr14_21500622_- | ENSG00000165819.10 | ENST00000543235 | hsa-miR-6884-3p | 21500619 | 21500625 | 7mer-m8 | 21500618 | 21500640 | 143 | -15.22 |
CAediting_976722 | chr14_21500622_- | ENSG00000165819.10 | ENST00000544248 | hsa-miR-6884-3p | 21500619 | 21500625 | 7mer-m8 | 21500618 | 21500640 | 143 | -15.22 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_980496 | chr14_31014685_- | ENSG00000165819.10 | ENST00000537163 | hsa-miR-624-3p | 21501745 | 21501751 | 7mer-m8 | 21501744 | 21501766 | 166 | -21.12 |
CAediting_980496 | chr14_31014685_- | ENSG00000165819.10 | ENST00000543235 | hsa-miR-624-3p | 21501745 | 21501751 | 7mer-m8 | 21501744 | 21501766 | 166 | -21.12 |
CAediting_1054808 | chr15_66496985_- | ENSG00000165819.10 | ENST00000537163 | hsa-miR-4512 | 21501004 | 21501010 | 7mer-m8 | 21501003 | 21501022 | 154 | -20.51 |
CAediting_1229415 | chr17_67471547_+ | ENSG00000165819.10 | ENST00000537163 | hsa-miR-548aa | 21500518 | 21500524 | 7mer-m8 | 21500517 | 21500540 | 157 | -11.14 |
CAediting_1054808 | chr15_66496985_- | ENSG00000165819.10 | ENST00000543235 | hsa-miR-4512 | 21501004 | 21501010 | 7mer-m8 | 21501003 | 21501022 | 154 | -20.51 |
CAediting_1229415 | chr17_67471547_+ | ENSG00000165819.10 | ENST00000543235 | hsa-miR-548aa | 21500518 | 21500524 | 7mer-m8 | 21500517 | 21500540 | 157 | -11.14 |
CAediting_1054808 | chr15_66496985_- | ENSG00000165819.10 | ENST00000544248 | hsa-miR-4512 | 21501004 | 21501010 | 7mer-m8 | 21501003 | 21501022 | 154 | -20.51 |
CAediting_1229415 | chr17_67471547_+ | ENSG00000165819.10 | ENST00000544248 | hsa-miR-548aa | 21500518 | 21500524 | 7mer-m8 | 21500517 | 21500540 | 157 | -11.14 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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The effects of the RNA editing to the stability of the RNA structures for METTL3 |
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ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for METTL3 |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for METTL3 |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for METTL3 |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for METTL3 |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for METTL3 |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |