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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: PROC (CAeditome ID:5624) |
Gene summary for PROC |
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Gene information | Gene symbol | PROC | Gene ID | 5624 |
Gene name | protein C, inactivator of coagulation factors Va and VIIIa | |
Synonyms | APC|PC|PROC1|THPH3|THPH4 | |
Cytomap | 2q14.3 | |
Type of gene | protein-coding | |
Description | vitamin K-dependent protein CProtein C-Nagoyaactivated protein Canticoagulant protein Cautoprothrombin IIAblood coagulation factor XIVprepro-protein Ctype I protein C | |
Modification date | 20210518 | |
UniProtAcc | P04070 | |
Context |
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Gene | GO ID | GO term | PubMed ID |
PROC | GO:0005783 | Vitamin K-dependent protein C | 25748729 |
PROC | GO:0005794 | Vitamin K-dependent protein C | 25748729 |
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RNA A-to-I events for PROC |
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CAediting_210978(127424299, +), CAediting_210979(127424300, +), CAediting_210980(127424387, +), CAediting_210981(127424409, +), CAediting_210982(127424433, +), CAediting_210983(127424461, +), CAediting_210984(127424561, +), CAediting_210985(127424567, +), CAediting_210986(127424570, +), CAediting_210987(127424577, +), CAediting_210988(127424598, +), |
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RNA editing positional annotations for PROC using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
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CAeditome ID | Position | Variant type |
CAediting_210978 | chr2_127424299_+ | ncRNA_intronic |
CAediting_210979 | chr2_127424300_+ | ncRNA_intronic |
CAediting_210980 | chr2_127424387_+ | ncRNA_intronic |
CAediting_210981 | chr2_127424409_+ | ncRNA_intronic |
CAediting_210982 | chr2_127424433_+ | ncRNA_intronic |
CAediting_210983 | chr2_127424461_+ | ncRNA_intronic |
CAediting_210984 | chr2_127424561_+ | ncRNA_intronic |
CAediting_210985 | chr2_127424567_+ | ncRNA_intronic |
CAediting_210986 | chr2_127424570_+ | ncRNA_intronic |
CAediting_210987 | chr2_127424577_+ | ncRNA_intronic |
CAediting_210988 | chr2_127424598_+ | ncRNA_intronic |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
CAediting_210978 | chr2_127424299_+ | SINE | Alu | AluSp |
CAediting_210979 | chr2_127424300_+ | SINE | Alu | AluSp |
CAediting_210980 | chr2_127424387_+ | SINE | Alu | AluSp |
CAediting_210981 | chr2_127424409_+ | SINE | Alu | AluSp |
CAediting_210982 | chr2_127424433_+ | SINE | Alu | AluSp |
CAediting_210983 | chr2_127424461_+ | SINE | Alu | AluSp |
CAediting_210984 | chr2_127424561_+ | SINE | Alu | FLAM_C |
CAediting_210985 | chr2_127424567_+ | SINE | Alu | FLAM_C |
CAediting_210986 | chr2_127424570_+ | SINE | Alu | FLAM_C |
CAediting_210987 | chr2_127424577_+ | SINE | Alu | FLAM_C |
CAediting_210988 | chr2_127424598_+ | SINE | Alu | FLAM_C |
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RNA A-to-I editing events in the alternative splicing sites for PROC |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PROC |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for PROC |
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The effects of the RNA editing to the miRNA binding sites for PROC |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_1229414 | chr17_67471546_+ | ENSG00000115718.16 | ENST00000419985 | hsa-miR-548aa | 127423048 | 127423054 | 7mer-m8 | 127423034 | 127423055 | 150 | -17.83 |
CAediting_1229414 | chr17_67471546_+ | ENSG00000115718.16 | ENST00000431364 | hsa-miR-548aa | 127423048 | 127423054 | 7mer-m8 | 127423034 | 127423055 | 150 | -17.83 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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The effects of the RNA editing to the stability of the RNA structures for PROC |
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ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for PROC |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for PROC |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for PROC |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for PROC |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
PROC | P04070 | DB09332 | Kappadione | Vitamin K-dependent protein C | SmallMoleculeDrug | approved |
PROC | P04070 | DB13149 | Protein S human | Vitamin K-dependent protein C | BiotechDrug | approved |
PROC | P04070 | DB00464 | Sodium tetradecyl sulfate | Vitamin K-dependent protein C | SmallMoleculeDrug | approved|investigational |
PROC | P04070 | DB09131 | Cupric Chloride | Vitamin K-dependent protein C | SmallMoleculeDrug | approved|investigational |
PROC | P04070 | DB00170 | Menadione | Vitamin K-dependent protein C | SmallMoleculeDrug | approved|nutraceutical |
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RelatedDiseases for PROC |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
PROC | C2674321 | Thrombophilia, Hereditary, Due To Protein C Deficiency, Autosomal Dominant | 16 | GENOMICS_ENGLAND;UNIPROT |
PROC | C2676759 | THROMBOPHILIA DUE TO PROTEIN C DEFICIENCY, AUTOSOMAL RECESSIVE | 7 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
PROC | C0040053 | Thrombosis | 4 | CTD_human |
PROC | C0087086 | Thrombus | 4 | CTD_human |
PROC | C0398625 | Protein C Deficiency | 4 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
PROC | C0034189 | Pyemia | 2 | CTD_human |
PROC | C0036690 | Septicemia | 2 | CTD_human |
PROC | C0042487 | Venous Thrombosis | 2 | CTD_human |
PROC | C0149871 | Deep Vein Thrombosis | 2 | CTD_human |
PROC | C0243026 | Sepsis | 2 | CTD_human |
PROC | C1719672 | Severe Sepsis | 2 | CTD_human |
PROC | C1861172 | Venous Thromboembolism | 2 | CTD_human |
PROC | C2930896 | Congenital thrombotic disease, due to Protein C deficiency | 2 | CTD_human;ORPHANET |
PROC | C0003860 | Arteritis | 1 | CTD_human |
PROC | C0012739 | Disseminated Intravascular Coagulation | 1 | CTD_human |
PROC | C0020538 | Hypertensive disease | 1 | CTD_human |
PROC | C0040038 | Thromboembolism | 1 | CTD_human |
PROC | C0085650 | Purpura Fulminans | 1 | CTD_human |