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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: DNAJC3 (CAeditome ID:5611)

Gene summary for DNAJC3

check button Gene summary
Gene informationGene symbol

DNAJC3

Gene ID

5611

Gene nameDnaJ heat shock protein family (Hsp40) member C3
SynonymsACPHD|ERdj6|HP58|P58|P58IPK|PRKRI|p58(IPK)
Cytomap

13q32.1

Type of geneprotein-coding
DescriptiondnaJ homolog subfamily C member 3DnaJ (Hsp40) homolog, subfamily C, member 3ER-resident protein ERdj6endoplasmic reticulum DNA J domain-containing protein 6interferon-induced, double-stranded RNA-activated protein kinase inhibitorprotein kinase inhib
Modification date20210518
UniProtAcc

Q13217

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for DNAJC3

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000102580.13

check button RNA A-to-I editing events in Cancer.
CAediting_969635(95683840, +), CAediting_969636(95710440, +), CAediting_969637(95710710, +), CAediting_969638(95710912, +), CAediting_969639(95711288, +), CAediting_969640(95711336, +), CAediting_969641(95711394, +), CAediting_969642(95711455, +), CAediting_969643(95712655, +), CAediting_969644(95716011, +), CAediting_969645(95749554, +), CAediting_969646(95749587, +), CAediting_969647(95749596, +), CAediting_969648(95749601, +), CAediting_969649(95749635, +), CAediting_969650(95749658, +), CAediting_969651(95749668, +), CAediting_969652(95749687, +), CAediting_969653(95749698, +), CAediting_969654(95749702, +), CAediting_969655(95749703, +), CAediting_969656(95749716, +), CAediting_969657(95749717, +), CAediting_969658(95749719, +), CAediting_969659(95749732, +), CAediting_969660(95749739, +), CAediting_969661(95749929, +), CAediting_969662(95750014, +), CAediting_969663(95750016, +), CAediting_969664(95750020, +), CAediting_969665(95750028, +), CAediting_969666(95750036, +), CAediting_969667(95750040, +), CAediting_969668(95750044, +), CAediting_969669(95750054, +), CAediting_969670(95750056, +), CAediting_969671(95750065, +), CAediting_969672(95750069, +), CAediting_969673(95750071, +), CAediting_969674(95750073, +), CAediting_969675(95750080, +), CAediting_969676(95750083, +), CAediting_969677(95750087, +), CAediting_969678(95750091, +), CAediting_969679(95750099, +), CAediting_969680(95750104, +), CAediting_969681(95750120, +), CAediting_969682(95750132, +), CAediting_969683(95750133, +), CAediting_969684(95750147, +), CAediting_969685(95750148, +), CAediting_969686(95750150, +), CAediting_969687(95750156, +), CAediting_969688(95750157, +), CAediting_969689(95750164, +), CAediting_969690(95750187, +), CAediting_969691(95750193, +), CAediting_969692(95750251, +), CAediting_969693(95750589, +), CAediting_969694(95750590, +), CAediting_969695(95750603, +), CAediting_969696(95750609, +), CAediting_969697(95750610, +), CAediting_969698(95750613, +), CAediting_969699(95750636, +), CAediting_969700(95750639, +), CAediting_969701(95750649, +), CAediting_969702(95750694, +), CAediting_969703(95750697, +), CAediting_969704(95750785, +), CAediting_969705(95750976, +), CAediting_969706(95750990, +), CAediting_969707(95751044, +), CAediting_969708(95751053, +), CAediting_969709(95751070, +), CAediting_969710(95751080, +), CAediting_969711(95751088, +), CAediting_969712(95751104, +), CAediting_969713(95751175, +), CAediting_969714(95755217, +), CAediting_969715(95755414, +), CAediting_969716(95755503, +), CAediting_969717(95755504, +), CAediting_969718(95755596, +), CAediting_969719(95755598, +), CAediting_969720(95755642, +), CAediting_969721(95755646, +), CAediting_969722(95755650, +), CAediting_969723(95755669, +), CAediting_969724(95755682, +), CAediting_969725(95758217, +), CAediting_969726(95758234, +), CAediting_969727(95766800, +), CAediting_969728(95766801, +), CAediting_969729(95768907, +), CAediting_969730(95768930, +), CAediting_969731(95786047, +), CAediting_969732(95793513, +), CAediting_969733(95793516, +), CAediting_969734(95793545, +), CAediting_969735(95793551, +), CAediting_969736(95793565, +), CAediting_969737(95793568, +), CAediting_969738(95793613, +), CAediting_969739(95793629, +), CAediting_969740(95793644, +), CAediting_969741(95794410, +),

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RNA editing positional annotations for DNAJC3 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
CAediting_969731chr13_95786047_+nonsynonymous SNVENST00000376795.6c.A1031Gp.Y344C.D.
CAediting_969731chr13_95786047_+nonsynonymous SNVENST00000602402.4c.A1184Gp.Y395C.D.

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_969635chr13_95683840_+intronic
CAediting_969636chr13_95710440_+intronic
CAediting_969637chr13_95710710_+intronic
CAediting_969638chr13_95710912_+intronic
CAediting_969639chr13_95711288_+intronic
CAediting_969640chr13_95711336_+intronic
CAediting_969641chr13_95711394_+intronic
CAediting_969642chr13_95711455_+intronic
CAediting_969643chr13_95712655_+intronic
CAediting_969644chr13_95716011_+intronic
CAediting_969645chr13_95749554_+intronic
CAediting_969646chr13_95749587_+intronic
CAediting_969647chr13_95749596_+intronic
CAediting_969648chr13_95749601_+intronic
CAediting_969649chr13_95749635_+intronic
CAediting_969650chr13_95749658_+intronic
CAediting_969651chr13_95749668_+intronic
CAediting_969652chr13_95749687_+intronic
CAediting_969653chr13_95749698_+intronic
CAediting_969654chr13_95749702_+intronic
CAediting_969655chr13_95749703_+intronic
CAediting_969656chr13_95749716_+intronic
CAediting_969657chr13_95749717_+intronic
CAediting_969658chr13_95749719_+intronic
CAediting_969659chr13_95749732_+intronic
CAediting_969660chr13_95749739_+intronic
CAediting_969661chr13_95749929_+intronic
CAediting_969662chr13_95750014_+intronic
CAediting_969663chr13_95750016_+intronic
CAediting_969664chr13_95750020_+intronic
CAediting_969665chr13_95750028_+intronic
CAediting_969666chr13_95750036_+intronic
CAediting_969667chr13_95750040_+intronic
CAediting_969668chr13_95750044_+intronic
CAediting_969669chr13_95750054_+intronic
CAediting_969670chr13_95750056_+intronic
CAediting_969671chr13_95750065_+intronic
CAediting_969672chr13_95750069_+intronic
CAediting_969673chr13_95750071_+intronic
CAediting_969674chr13_95750073_+intronic
CAediting_969675chr13_95750080_+intronic
CAediting_969676chr13_95750083_+intronic
CAediting_969677chr13_95750087_+intronic
CAediting_969678chr13_95750091_+intronic
CAediting_969679chr13_95750099_+intronic
CAediting_969680chr13_95750104_+intronic
CAediting_969681chr13_95750120_+intronic
CAediting_969682chr13_95750132_+intronic
CAediting_969683chr13_95750133_+intronic
CAediting_969684chr13_95750147_+intronic
CAediting_969685chr13_95750148_+intronic
CAediting_969686chr13_95750150_+intronic
CAediting_969687chr13_95750156_+intronic
CAediting_969688chr13_95750157_+intronic
CAediting_969689chr13_95750164_+intronic
CAediting_969690chr13_95750187_+intronic
CAediting_969691chr13_95750193_+intronic
CAediting_969692chr13_95750251_+intronic
CAediting_969693chr13_95750589_+intronic
CAediting_969694chr13_95750590_+intronic
CAediting_969695chr13_95750603_+intronic
CAediting_969696chr13_95750609_+intronic
CAediting_969697chr13_95750610_+intronic
CAediting_969698chr13_95750613_+intronic
CAediting_969699chr13_95750636_+intronic
CAediting_969700chr13_95750639_+intronic
CAediting_969701chr13_95750649_+intronic
CAediting_969702chr13_95750694_+intronic
CAediting_969703chr13_95750697_+intronic
CAediting_969704chr13_95750785_+intronic
CAediting_969705chr13_95750976_+intronic
CAediting_969706chr13_95750990_+intronic
CAediting_969707chr13_95751044_+intronic
CAediting_969708chr13_95751053_+intronic
CAediting_969709chr13_95751070_+intronic
CAediting_969710chr13_95751080_+intronic
CAediting_969711chr13_95751088_+intronic
CAediting_969712chr13_95751104_+intronic
CAediting_969713chr13_95751175_+intronic
CAediting_969714chr13_95755217_+intronic
CAediting_969715chr13_95755414_+intronic
CAediting_969716chr13_95755503_+intronic
CAediting_969717chr13_95755504_+intronic
CAediting_969718chr13_95755596_+intronic
CAediting_969719chr13_95755598_+intronic
CAediting_969720chr13_95755642_+intronic
CAediting_969721chr13_95755646_+intronic
CAediting_969722chr13_95755650_+intronic
CAediting_969723chr13_95755669_+intronic
CAediting_969724chr13_95755682_+intronic
CAediting_969725chr13_95758217_+intronic
CAediting_969726chr13_95758234_+intronic
CAediting_969727chr13_95766800_+intronic
CAediting_969728chr13_95766801_+intronic
CAediting_969729chr13_95768907_+intronic
CAediting_969730chr13_95768930_+intronic
CAediting_969731chr13_95786047_+exonic
CAediting_969732chr13_95793513_+UTR3
CAediting_969733chr13_95793516_+UTR3
CAediting_969734chr13_95793545_+UTR3
CAediting_969735chr13_95793551_+UTR3
CAediting_969736chr13_95793565_+UTR3
CAediting_969737chr13_95793568_+UTR3
CAediting_969738chr13_95793613_+UTR3
CAediting_969739chr13_95793629_+UTR3
CAediting_969740chr13_95793644_+UTR3
CAediting_969741chr13_95794410_+UTR3

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_969635chr13_95683840_+SINEAluAluSg7
CAediting_969636chr13_95710440_+SINEAluAluJo
CAediting_969637chr13_95710710_+SINEAluAluJb
CAediting_969638chr13_95710912_+SINEAluAluJb
CAediting_969639chr13_95711288_+SINEAluAluSx1
CAediting_969640chr13_95711336_+SINEAluAluSx1
CAediting_969641chr13_95711394_+SINEAluAluSx1
CAediting_969642chr13_95711455_+SINEAluAluSx1
CAediting_969643chr13_95712655_+SINEAluAluSz
CAediting_969644chr13_95716011_+SINEAluAluSx1
CAediting_969645chr13_95749554_+LINEL2L2
CAediting_969646chr13_95749587_+LINEL2L2
CAediting_969647chr13_95749596_+LINEL2L2
CAediting_969648chr13_95749601_+LINEL2L2
CAediting_969649chr13_95749635_+LINEL2L2
CAediting_969650chr13_95749658_+LINEL2L2
CAediting_969651chr13_95749668_+LINEL2L2
CAediting_969652chr13_95749687_+LINEL2L2
CAediting_969653chr13_95749698_+LINEL2L2
CAediting_969654chr13_95749702_+LINEL2L2
CAediting_969655chr13_95749703_+LINEL2L2
CAediting_969656chr13_95749716_+LINEL2L2
CAediting_969657chr13_95749717_+LINEL2L2
CAediting_969658chr13_95749719_+LINEL2L2
CAediting_969659chr13_95749732_+LINEL2L2
CAediting_969660chr13_95749739_+LINEL2L2
CAediting_969661chr13_95749929_+SINEAluAluSc8
CAediting_969662chr13_95750014_+LINEL2L2
CAediting_969663chr13_95750016_+LINEL2L2
CAediting_969664chr13_95750020_+LINEL2L2
CAediting_969665chr13_95750028_+LINEL2L2
CAediting_969666chr13_95750036_+LINEL2L2
CAediting_969667chr13_95750040_+LINEL2L2
CAediting_969668chr13_95750044_+LINEL2L2
CAediting_969669chr13_95750054_+LINEL2L2
CAediting_969670chr13_95750056_+LINEL2L2
CAediting_969671chr13_95750065_+LINEL2L2
CAediting_969672chr13_95750069_+LINEL2L2
CAediting_969673chr13_95750071_+LINEL2L2
CAediting_969674chr13_95750073_+LINEL2L2
CAediting_969675chr13_95750080_+LINEL2L2
CAediting_969676chr13_95750083_+LINEL2L2
CAediting_969677chr13_95750087_+LINEL2L2
CAediting_969678chr13_95750091_+LINEL2L2
CAediting_969679chr13_95750099_+LINEL2L2
CAediting_969680chr13_95750104_+LINEL2L2
CAediting_969681chr13_95750120_+LINEL2L2
CAediting_969682chr13_95750132_+LINEL2L2
CAediting_969683chr13_95750133_+LINEL2L2
CAediting_969684chr13_95750147_+LINEL2L2
CAediting_969685chr13_95750148_+LINEL2L2
CAediting_969686chr13_95750150_+LINEL2L2
CAediting_969687chr13_95750156_+LINEL2L2
CAediting_969688chr13_95750157_+LINEL2L2
CAediting_969689chr13_95750164_+LINEL2L2
CAediting_969690chr13_95750187_+LINEL2L2
CAediting_969691chr13_95750193_+LINEL2L2
CAediting_969692chr13_95750251_+SINEAluAluJo
CAediting_969693chr13_95750589_+SINEAluAluSz
CAediting_969694chr13_95750590_+SINEAluAluSz
CAediting_969695chr13_95750603_+SINEAluAluSz
CAediting_969696chr13_95750609_+SINEAluAluSz
CAediting_969697chr13_95750610_+SINEAluAluSz
CAediting_969698chr13_95750613_+SINEAluAluSz
CAediting_969699chr13_95750636_+SINEAluAluSz
CAediting_969700chr13_95750639_+SINEAluAluSz
CAediting_969701chr13_95750649_+SINEAluAluSz
CAediting_969702chr13_95750694_+SINEAluAluSz
CAediting_969703chr13_95750697_+SINEAluAluSz
CAediting_969704chr13_95750785_+SINEAluAluSz
CAediting_969705chr13_95750976_+SINEAluAluJr4
CAediting_969706chr13_95750990_+SINEAluAluJr4
CAediting_969707chr13_95751044_+SINEAluAluJr4
CAediting_969708chr13_95751053_+SINEAluAluJr4
CAediting_969709chr13_95751070_+SINEAluAluJr4
CAediting_969710chr13_95751080_+SINEAluAluJr4
CAediting_969711chr13_95751088_+SINEAluAluJr4
CAediting_969712chr13_95751104_+SINEAluAluJr4
CAediting_969713chr13_95751175_+SINEAluAluJr4
CAediting_969714chr13_95755217_+SINEAluAluJr
CAediting_969715chr13_95755414_+SINEAluAluJr
CAediting_969716chr13_95755503_+SINEAluAluSx4
CAediting_969717chr13_95755504_+SINEAluAluSx4
CAediting_969718chr13_95755596_+SINEAluAluSx4
CAediting_969719chr13_95755598_+SINEAluAluSx4
CAediting_969720chr13_95755642_+SINEAluAluSx4
CAediting_969721chr13_95755646_+SINEAluAluSx4
CAediting_969722chr13_95755650_+SINEAluAluSx4
CAediting_969723chr13_95755669_+SINEAluAluSx4
CAediting_969724chr13_95755682_+SINEAluAluSx4
CAediting_969725chr13_95758217_+SINEAluAluJr
CAediting_969726chr13_95758234_+SINEAluAluJr
CAediting_969727chr13_95766800_+SINEAluAluSg
CAediting_969728chr13_95766801_+SINEAluAluSg
CAediting_969729chr13_95768907_+SINEAluAluSq2
CAediting_969730chr13_95768930_+SINEAluAluSq2
CAediting_969732chr13_95793513_+SINEAluAluSc8
CAediting_969733chr13_95793516_+SINEAluAluSc8
CAediting_969734chr13_95793545_+SINEAluAluSc8
CAediting_969735chr13_95793551_+SINEAluAluSc8
CAediting_969736chr13_95793565_+SINEAluAluSc8
CAediting_969737chr13_95793568_+SINEAluAluSc8
CAediting_969738chr13_95793613_+SINEAluAluSc8
CAediting_969739chr13_95793629_+SINEAluAluSc8
CAediting_969740chr13_95793644_+SINEAluAluSc8

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RNA A-to-I editing events in the alternative splicing sites for DNAJC3

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000102580.13.DNAJC3.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000102580.13.DNAJC3.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for DNAJC3

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for DNAJC3

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.
all structure


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The effects of the RNA editing to the miRNA binding sites for DNAJC3

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for DNAJC3

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for DNAJC3

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for DNAJC3

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for DNAJC3

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for DNAJC3

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNAJC3

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
DNAJC3C0033578Prostatic Neoplasms1CTD_human
DNAJC3C0376358Malignant neoplasm of prostate1CTD_human
DNAJC3C4015436ATAXIA, COMBINED CEREBELLAR AND PERIPHERAL, WITH HEARING LOSS AND DIABETES MELLITUS1CTD_human;GENOMICS_ENGLAND;ORPHANET